DE60019100D1 - Im wesentlichen ölfreie cyclosporin zusammensetzungen - Google Patents

Im wesentlichen ölfreie cyclosporin zusammensetzungen

Info

Publication number: DE60019100D1
Authority: DE; Germany
Prior art keywords: essentially oil; cyclosporin compositions; free cyclosporin; free; compositions
Prior art date: 1999-05-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE60019100T

Other languages

English (en)

Other versions

DE60019100T2 (de

Inventor

Michael Ambuehl

Barbara Lueckel

Barbara Haeberlin

Armin Meinzer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-05-28

Filing date

2000-05-26

Publication date

2005-05-04

2000-05-26 Application filed by Novartis AG filed Critical Novartis AG

2005-05-04 Application granted granted Critical

2005-05-04 Publication of DE60019100D1 publication Critical patent/DE60019100D1/de

2006-03-23 Publication of DE60019100T2 publication Critical patent/DE60019100T2/de

2020-05-27 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
229930105110 Cyclosporin A Natural products 0.000 title abstract 2
108010036949 Cyclosporine Proteins 0.000 title abstract 2
229960001265 ciclosporin Drugs 0.000 title abstract 2
229930182912 cyclosporin Natural products 0.000 title abstract 2
239000000203 mixture Substances 0.000 title abstract 2

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Dispersion Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Rheumatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Transplantation (AREA)
Pain & Pain Management (AREA)
Toxicology (AREA)
Surgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Fats And Perfumes (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

DE60019100T 1999-05-28 2000-05-26 Im wesentlichen ölfreie cyclosporin zusammensetzungen Expired - Fee Related DE60019100T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9912476		1999-05-28
GBGB9912476.0A GB9912476D0 (en)	1999-05-28	1999-05-28	Organic compounds
PCT/EP2000/004829 WO2000072867A2 (en)	1999-05-28	2000-05-26	Substantially oil-free cyclosporin compositions

Publications (2)

Publication Number	Publication Date
DE60019100D1 true DE60019100D1 (de)	2005-05-04
DE60019100T2 DE60019100T2 (de)	2006-03-23

Family

ID=10854362

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60019100T Expired - Fee Related DE60019100T2 (de)	1999-05-28	2000-05-26	Im wesentlichen ölfreie cyclosporin zusammensetzungen
DE10084671T Withdrawn DE10084671T1 (de)	1999-05-28	2000-05-26	Pharmazeutische Zusammensetzungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE10084671T Withdrawn DE10084671T1 (de)	1999-05-28	2000-05-26	Pharmazeutische Zusammensetzungen

Country Status (26)

Country	Link
US (2)	US6432445B1 (de)
EP (1)	EP1181035B1 (de)
JP (1)	JP2003500454A (de)
KR (1)	KR20010111587A (de)
CN (1)	CN1353613A (de)
AT (1)	ATE291926T1 (de)
AU (1)	AU765935B2 (de)
BR (1)	BR0011030A (de)
CA (1)	CA2371247A1 (de)
CZ (1)	CZ20014214A3 (de)
DE (2)	DE60019100T2 (de)
ES (1)	ES2239605T3 (de)
GB (2)	GB9912476D0 (de)
HK (1)	HK1045642B (de)
HU (1)	HUP0201372A3 (de)
IL (1)	IL146186A0 (de)
MX (1)	MXPA01012222A (de)
NO (1)	NO20015785L (de)
NZ (1)	NZ515154A (de)
PL (1)	PL199591B1 (de)
PT (1)	PT1181035E (de)
RU (1)	RU2249461C2 (de)
SK (1)	SK285471B6 (de)
TR (1)	TR200103276T2 (de)
WO (1)	WO2000072867A2 (de)
ZA (1)	ZA200109658B (de)

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EP1331002A3 (de) *	1997-01-30	2004-01-14	Novartis AG	Ölfreie pharmazeutische Zusammensetzung welche Cyclosporin A enthält
US7026290B1 (en)	1998-12-30	2006-04-11	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosprin
GB9912476D0 (en)	1999-05-28	1999-07-28	Novartis Ag	Organic compounds
AR033711A1 (es) *	2001-05-09	2004-01-07	Novartis Ag	Composiciones farmaceuticas
CA2471241A1 (en) *	2001-12-20	2003-07-03	Bernard Charles Sherman	Pharmaceutical compositions comprising a cyclosporin, a hydrophilic surfactant and a lipophilic surfactant
US20040115287A1 (en) *	2002-12-17	2004-06-17	Lipocine, Inc.	Hydrophobic active agent compositions and methods
US7538084B2 (en) *	2003-03-17	2009-05-26	Amr Technology, Inc.	Cyclosporins
JP2005255677A (ja) *	2004-02-12	2005-09-22	Nof Corp	シクロスポリン製剤
US20060014677A1 (en) *	2004-07-19	2006-01-19	Isotechnika International Inc.	Method for maximizing efficacy and predicting and minimizing toxicity of calcineurin inhibitor compounds
US7511013B2 (en) *	2004-09-29	2009-03-31	Amr Technology, Inc.	Cyclosporin analogues and their pharmaceutical uses
US7378391B2 (en) *	2004-09-29	2008-05-27	Amr Technology, Inc.	Cyclosporin alkyne analogues and their pharmaceutical uses
JP2008515886A (ja) *	2004-10-06	2008-05-15	エーエムアールテクノロジーインコーポレイテッド	シクロスポリンアルキンおよびそれらの医用薬剤としての有用性
BRPI0609071A2 (pt) *	2005-04-12	2010-11-16	Elan Pharma Int Ltd	composicão estável de ciclosporina nanoparticulada, método para preparar uma ciclosporina nanoparticulada, uso da composição de ciclosporina nanoparticulada estável, e, composição de liberação controlada
EP1874855A1 (de) *	2005-04-27	2008-01-09	Kingsplan Holdings (IRL) Limited	Tensid für phenolharzschaumstoff
US7696166B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders
US7696165B2 (en) *	2006-03-28	2010-04-13	Albany Molecular Research, Inc.	Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders
US11304960B2 (en)	2009-01-08	2022-04-19	Chandrashekar Giliyar	Steroidal compositions
MY158809A (en) *	2010-09-22	2016-11-15	Craun Res Sdn Bhd	Pharmaceutical compositions for calanolides, their derivatives and analogues, and process for producing the same
US9034858B2 (en)	2010-11-30	2015-05-19	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20180153904A1 (en)	2010-11-30	2018-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US9358241B2 (en)	2010-11-30	2016-06-07	Lipocine Inc.	High-strength testosterone undecanoate compositions
US20120148675A1 (en)	2010-12-10	2012-06-14	Basawaraj Chickmath	Testosterone undecanoate compositions
US20170246187A1 (en)	2014-08-28	2017-08-31	Lipocine Inc.	(17-ß)-3-OXOANDROST-4-EN-17-YL TRIDECANOATE COMPOSITIONS AND METHODS OF THEIR PREPARATION AND USE
WO2016033556A1 (en)	2014-08-28	2016-03-03	Lipocine Inc.	BIOAVAILABLE SOLID STATE (17-β)-HYDROXY-4-ANDROSTEN-3-ONE ESTERS
WO2016205423A2 (en)	2015-06-15	2016-12-22	Lipocine Inc.	Composition and method for oral delivery of androgen prodrugs
US11559530B2 (en)	2016-11-28	2023-01-24	Lipocine Inc.	Oral testosterone undecanoate therapy
CA3107214A1 (en)	2018-07-20	2020-01-23	Lipocine Inc.	Liver disease

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HU215966B (hu)	1994-11-21	1999-07-28	BIOGAL Gyógyszergyár Rt.	Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
EP0825849A1 (de)	1995-05-19	1998-03-04	Abbott Laboratories	Selbstemulgierbare arzneiformulierungen für lipophile arzneimittel
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DE19537836A1 (de)	1995-10-11	1997-04-17	Henkel Kgaa	Aerosolemulsionen
KR970064620A (ko)	1996-03-05	1997-10-13	임성기	사이클로스포린-함유 외용약제 조성물
DE19615271A1 (de)	1996-04-18	1997-10-23	Huels Chemische Werke Ag	Tensidhaltige Reinigungsmittel in Form einer Mikroemulsion
KR980008239A (ko)	1996-07-26	1998-04-30	김충환	사이클로스포린-함유 약학적 조성물
EP1331002A3 (de) *	1997-01-30	2004-01-14	Novartis AG	Ölfreie pharmazeutische Zusammensetzung welche Cyclosporin A enthält
CA2283780A1 (en)	1997-03-12	1998-09-17	Abbott Laboratories	Lipophilic binary systems for the administration of lipophilic compounds
SI0969856T1 (en) *	1997-03-12	2005-06-30	Abbott Laboratories	Hydrophilic binary systems for the administration of cyclosporine
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AU1509799A (en)	1997-12-05	1999-06-28	Chong Kun Dang Corporation	Pharmaceutical composition containing cyclosporin
JP4761093B2 (ja)	1997-12-10	2011-08-31	シクロスポリンセラポイティクスリミテッド	オメガ−３脂肪酸油を含む医薬組成物
NZ329929A (en) *	1998-03-09	1999-10-28	Bernard Charles Sherman	Pharmaceutical emulsion preconcentrate containing cyclosporin in a solvent system containing glycerides, propylene or polyethylene glycol, a surfactant and a co-surfactant
US7026290B1 (en) *	1998-12-30	2006-04-11	Dexcel Ltd.	Dispersible concentrate for the delivery of cyclosprin
GB9912476D0 (en)	1999-05-28	1999-07-28	Novartis Ag	Organic compounds

1999
- 1999-05-28 GB GBGB9912476.0A patent/GB9912476D0/en not_active Ceased
2000
- 2000-05-26 HK HK02105374.3A patent/HK1045642B/en not_active IP Right Cessation
- 2000-05-26 CZ CZ20014214A patent/CZ20014214A3/cs unknown
- 2000-05-26 KR KR1020017013293A patent/KR20010111587A/ko not_active Ceased
- 2000-05-26 JP JP2000620976A patent/JP2003500454A/ja active Pending
- 2000-05-26 IL IL14618600A patent/IL146186A0/xx unknown
- 2000-05-26 HU HU0201372A patent/HUP0201372A3/hu unknown
- 2000-05-26 ES ES00943742T patent/ES2239605T3/es not_active Expired - Lifetime
- 2000-05-26 TR TR2001/03276T patent/TR200103276T2/xx unknown
- 2000-05-26 CA CA002371247A patent/CA2371247A1/en not_active Abandoned
- 2000-05-26 BR BR0011030-2A patent/BR0011030A/pt not_active Application Discontinuation
- 2000-05-26 PL PL351593A patent/PL199591B1/pl not_active IP Right Cessation
- 2000-05-26 NZ NZ515154A patent/NZ515154A/en unknown
- 2000-05-26 AT AT00943742T patent/ATE291926T1/de not_active IP Right Cessation
- 2000-05-26 MX MXPA01012222A patent/MXPA01012222A/es active IP Right Grant
- 2000-05-26 SK SK1722-2001A patent/SK285471B6/sk not_active IP Right Cessation
- 2000-05-26 WO PCT/EP2000/004829 patent/WO2000072867A2/en not_active Application Discontinuation
- 2000-05-26 CN CN00808183A patent/CN1353613A/zh active Pending
- 2000-05-26 PT PT00943742T patent/PT1181035E/pt unknown
- 2000-05-26 RU RU2001133455/15A patent/RU2249461C2/ru not_active IP Right Cessation
- 2000-05-26 EP EP00943742A patent/EP1181035B1/de not_active Expired - Lifetime
- 2000-05-26 GB GB0128277A patent/GB2367004B/en not_active Expired - Fee Related
- 2000-05-26 US US09/579,372 patent/US6432445B1/en not_active Expired - Fee Related
- 2000-05-26 DE DE60019100T patent/DE60019100T2/de not_active Expired - Fee Related
- 2000-05-26 DE DE10084671T patent/DE10084671T1/de not_active Withdrawn
- 2000-05-26 AU AU58100/00A patent/AU765935B2/en not_active Ceased
2001
- 2001-11-23 ZA ZA200109658A patent/ZA200109658B/xx unknown
- 2001-11-27 NO NO20015785A patent/NO20015785L/no not_active Application Discontinuation
2002
- 2002-08-13 US US10/217,732 patent/US6767555B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
SK285471B6 (sk)	2007-02-01
PL351593A1 (en)	2003-05-05
NO20015785D0 (no)	2001-11-27
HK1045642B (en)	2005-10-28
BR0011030A (pt)	2002-02-26
HUP0201372A2 (en)	2002-09-28
US20020068083A1 (en)	2002-06-06
AU5810000A (en)	2000-12-18
CZ20014214A3 (cs)	2002-03-13
DE10084671T1 (de)	2002-06-06
RU2249461C2 (ru)	2005-04-10
ATE291926T1 (de)	2005-04-15
GB0128277D0 (en)	2002-01-16
JP2003500454A (ja)	2003-01-07
MXPA01012222A (es)	2002-07-02
TR200103276T2 (tr)	2002-05-21
NZ515154A (en)	2003-08-29
EP1181035B1 (de)	2005-03-30
US20020188134A1 (en)	2002-12-12
US6432445B1 (en)	2002-08-13
EP1181035A2 (de)	2002-02-27
GB2367004A (en)	2002-03-27
PL199591B1 (pl)	2008-10-31
WO2000072867A2 (en)	2000-12-07
IL146186A0 (en)	2002-07-25
WO2000072867A3 (en)	2001-04-05
CA2371247A1 (en)	2000-12-07
AU765935B2 (en)	2003-10-02
SK17222001A3 (sk)	2002-03-05
ES2239605T3 (es)	2005-10-01
DE60019100T2 (de)	2006-03-23
GB2367004B (en)	2004-04-14
CN1353613A (zh)	2002-06-12
NO20015785L (no)	2002-01-23
KR20010111587A (ko)	2001-12-19
HUP0201372A3 (en)	2002-10-28
US6767555B2 (en)	2004-07-27
ZA200109658B (en)	2002-08-20
PT1181035E (pt)	2005-08-31
HK1045642A1 (en)	2002-12-06
GB9912476D0 (en)	1999-07-28

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DE60019100D1 (de)	2005-05-04	Im wesentlichen ölfreie cyclosporin zusammensetzungen
AU7931301A (en)	2002-02-18	Method of using diketopiperazines and composition containing them
AP2001002225A0 (en)	2001-09-30	1-heterocycle substituted diarylamines.
MY125333A (en)	2006-07-31	Antibacterial compositions containing a solvent, hydrotrope and surfactant.
YU15299A (sh)	2002-06-19	Farmaceutski sastavi
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WO2001070242A3 (en)	2002-01-03	Compositions containing molecular iodine
WO2002038718A3 (en)	2003-01-03	Solvent compositions
AU8738401A (en)	2002-02-25	Novel kallikrein gene
AU1074902A (en)	2002-05-15	Kahalalide f
DE60025494D1 (de)	2006-04-06	Epothilon zusammensetzungen
MXPA03011128A (es)	2004-03-19	Composicion de sabor y fragancia.
PT929299E (pt)	2004-02-27	1,2,3,4-tetra-hidro-2-dibenzofuranaminas e 2-aminociclo-hepta ¬b\| benzofuranos substituidos
IL139604A0 (en)	2002-02-10	Novel peptides
NZ517872A (en)	2003-03-28	Multidrug efflux pumps
AU1392000A (en)	2000-06-19	Preparation of dry compositions soluble in the presence of water and avoiding maillard reaction in dry state and uses
TR199801835A3 (tr)	1999-04-21	Antimikrobiyal kompozisyonlar.
WO2000078274A3 (en)	2001-07-05	Hairdye composition comprising indoline and/or an indoline compound and laccase
GB0113920D0 (en)	2001-08-01	Composition
TR200002675T2 (tr)	2000-12-21	Paroksetinin kristalin formu.
PL353003A1 (en)	2003-09-22	The use of the protein uk 114 for inhibiting organ transplant rejection
ATE227571T1 (de)	2002-11-15	Thrombin inhibitoren
MXPA03001440A (es)	2003-06-06	Compuestos de trioxepano novedosos.
YU47301A (sh)	2005-06-10	Diarilamini sa supstituisanim 1-heterociklom
GB2399210A (en)	2004-09-08	Entertainment machines

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