DE60008862D1 - Thienopyrimidin verbindungen, ihre herstellung und verwendung - Google Patents

Thienopyrimidin verbindungen, ihre herstellung und verwendung

Info

Publication number: DE60008862D1
Authority: DE; Germany
Prior art keywords: production; thienopyrimidine compounds; thienopyrimidine; compounds
Prior art date: 1999-03-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60008862T

Other languages

English (en)

Other versions

DE60008862T2 (de

Inventor

Shuichi Furuya

Nobuhiro Suzuki

Nobuo Choh

Yoshi Nara

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-03-24

Filing date

2000-03-23

Publication date

2004-04-15

2000-03-23 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2004-04-15 Publication of DE60008862D1 publication Critical patent/DE60008862D1/de

2005-01-27 Application granted granted Critical

2005-01-27 Publication of DE60008862T2 publication Critical patent/DE60008862T2/de

2020-03-24 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DE60008862T 1999-03-24 2000-03-23 Thienopyrimidin verbindungen, ihre herstellung und verwendung Expired - Lifetime DE60008862T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
JP7937199		1999-03-24
JP7937199		1999-03-24
JP2000018019		2000-01-25
JP2000018019		2000-01-25
PCT/JP2000/001777 WO2000056739A1 (en)	1999-03-24	2000-03-23	Thienopyrimidine compounds, their production and use

Publications (2)

Publication Number	Publication Date
DE60008862D1 true DE60008862D1 (de)	2004-04-15
DE60008862T2 DE60008862T2 (de)	2005-01-27

Family

ID=26420391

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60008862T Expired - Lifetime DE60008862T2 (de)	1999-03-24	2000-03-23	Thienopyrimidin verbindungen, ihre herstellung und verwendung

Country Status (28)

Country	Link
US (1)	US6340686B1 (de)
EP (1)	EP1163244B1 (de)
JP (1)	JP3240293B2 (de)
KR (2)	KR100533483B1 (de)
CN (1)	CN1349536A (de)
AR (1)	AR023152A1 (de)
AT (1)	ATE261449T1 (de)
AU (1)	AU764019B2 (de)
BR (1)	BR0009297A (de)
CA (1)	CA2368108C (de)
CZ (1)	CZ294747B6 (de)
DE (1)	DE60008862T2 (de)
DK (1)	DK1163244T3 (de)
ES (1)	ES2212992T3 (de)
HK (1)	HK1042495B (de)
HU (1)	HUP0200550A3 (de)
ID (1)	ID30393A (de)
IL (1)	IL145549A (de)
MX (1)	MXPA01009566A (de)
MY (1)	MY124726A (de)
NO (1)	NO20014603L (de)
NZ (1)	NZ514737A (de)
OA (1)	OA11920A (de)
PL (1)	PL351202A1 (de)
PT (1)	PT1163244E (de)
SK (1)	SK13552001A3 (de)
TW (1)	TWI225863B (de)
WO (1)	WO2000056739A1 (de)

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US6849738B2 (en) *	2000-02-29	2005-02-01	Takeda Chemical Industries, Ltd.	Processes for the production of thienopyrimidine derivatives
CA2406832A1 (en) *	2000-04-13	2002-10-10	Takeda Chemical Industries, Ltd.	Preventives/remedies for alzheimer's disease
US20040023987A1 (en) *	2000-06-14	2004-02-05	Yoshio Hata	Sustained release compositions
CA2423329A1 (en) *	2000-09-22	2003-03-20	Takeda Chemical Industries, Ltd.	Solid preparations
WO2002043766A1 (fr) *	2000-11-29	2002-06-06	Takeda Chemical Industries, Ltd.	Compositions medicinales et leur procede de preparation
AU2002221139A1 (en) *	2000-12-15	2002-06-24	Takeda Chemical Industries Ltd.	Medicinal compositions of nonpeptidyl gonadotropin-releasing hormone agonist or antagonist, process for producing the same and use thereof
WO2002078669A1 (fr) *	2001-03-30	2002-10-10	Takeda Chemical Industries, Ltd.	Solutions medicinales
US6750350B2 (en)	2001-08-02	2004-06-15	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
US6673796B2 (en)	2001-08-02	2004-01-06	Neurocrine Biosciences, Inc.	Gonadotropin-releasing hormone receptor antagonists and methods relating thereto
EP1412363A1 (de) *	2001-08-02	2004-04-28	Neurocrine Biosciences, Inc.	Rezeptor antagonisten für gonadotropin-freisetzende hormone
EP1411945A1 (de)	2001-08-02	2004-04-28	Neurocrine Biosciences, Inc.	Substituierte pyridin-4-on und ihre verwendung als antagonisten des gonadotropin-releasinghormons
AU2002324586B2 (en)	2001-08-02	2008-04-24	Neurocrine Biosciences, Inc.	1,3,5-triazine-2,4,6-triones, preparation and use as gonadotropin-releasing hormone receptor antagonists
WO2003064429A1 (fr)	2002-01-30	2003-08-07	Takeda Chemical Industries, Ltd.	Thienopyrimidines, procedes de fabrication et d'utilisation correspondants
CA2481391A1 (en) *	2002-04-12	2003-10-23	Takeda Pharmaceutical Company Limited	Preventives/remedies for hotflash
JP2006508050A (ja) *	2002-08-21	2006-03-09	アストラゼネカアクチボラグ	ゴナドトロピン放出ホルモンのアンタゴニストとしてのチエノピロール化合物
CN100360538C (zh)	2003-01-29	2008-01-09	武田药品工业株式会社	噻吩并嘧啶化合物及其用途
GB0307777D0 (en)	2003-04-04	2003-05-07	Medical Res Council	Conjugate compounds
WO2006044902A2 (en) *	2004-10-18	2006-04-27	Bwt Property, Inc.	A solid-state lighting apparatus for navigational aids
JPWO2007011072A1 (ja)	2005-07-22	2009-02-05	武田薬品工業株式会社	早発排卵の防止剤
US20110172249A1 (en)	2008-09-03	2011-07-14	Takeda Pharmaceutical Company Limted	Method for improving absorbability of preparation, and preparation having improved absorbability
KR101495260B1 (ko) *	2012-02-28	2015-02-26	에스케이케미칼주식회사	고나도트로핀 방출 호르몬 수용체 길항제, 이의 제조방법 및 이를 함유하는 약제학적 조성물
CN109053766B (zh) *	2012-09-28	2021-06-22	武田药品工业株式会社	噻吩并嘧啶衍生物的制备方法
CA2978223A1 (en) *	2015-02-26	2016-09-01	Takeda Pharmaceutical Company Limited	Formulations of n-(4-(1-(2,6-difluorobenzyl)-5-((dimethyl amino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'-methoxyurea
HRP20241740T1 (hr)	2016-09-30	2025-02-28	Sumitomo Pharma Switzerland Gmbh	Liječenje raka prostate
RS63300B1 (sr)	2016-09-30	2022-07-29	Myovant Sciences Gmbh	Postupci lečenja fibroida materice i endometrioze
KR101973074B1 (ko)	2018-11-30	2019-04-26	주식회사 티움바이오	퓨로피리미딘 화합물의 염 및 결정형, 및 이를 포함하는 약학적 조성물
EP4004001A4 (de) *	2019-07-29	2023-08-30	Sunshine Lake Pharma Co., Ltd.	Substituierte pyrimidindionverbindungen und verwendungen davon
CN111574534B (zh) *	2020-05-25	2021-06-04	东莞市东阳光新药研发有限公司	苯基取代的噻吩并[2,3-d]嘧啶-2,4(1H,3H)-二酮类化合物及其用途
CN111925379B (zh) *	2020-07-31	2022-02-15	广东东阳光药业有限公司	含氮杂芳基取代的嘧啶二酮类化合物及其用途
CN111909168B (zh) *	2020-07-31	2022-02-01	广东东阳光药业有限公司	含氮杂环基取代的嘧啶二酮类化合物及其用途
CN112047957B (zh) *	2020-09-09	2022-02-01	广东东阳光药业有限公司	取代的嘧啶二酮类化合物及其用途
CN113754679B (zh) *	2020-09-09	2023-04-07	广东东阳光药业有限公司	取代的嘧啶二酮类化合物及其用途
CN113563303B (zh) *	2020-12-30	2022-04-12	上海博志研新药物技术有限公司	瑞卢戈利中间体及其制备方法
CN115260211B (zh) *	2021-04-29	2024-02-06	长春金赛药业有限责任公司	含噻吩稠环类衍生物、药物组合物及其制备方法和应用
CN113717149A (zh) *	2021-09-29	2021-11-30	成都伊诺达博医药科技有限公司	一种瑞卢戈利关键中间体及其制备方法

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UY23948A1 (es) *	1995-02-08	2001-10-25	Takeda Chemical Industries Ltd	Derivados de anillos condensados de tiofeno su producción y uso.
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EP0816316A4 (de) *	1995-03-10	1999-06-02	Nitto Chemical Industry Co Ltd	Verfahren zur herstellung von 1,2-ethandiolderivaten

2000
- 2000-03-08 TW TW089104127A patent/TWI225863B/zh not_active IP Right Cessation
- 2000-03-21 MY MYPI20001112 patent/MY124726A/en unknown
- 2000-03-23 WO PCT/JP2000/001777 patent/WO2000056739A1/en active IP Right Grant
- 2000-03-23 ID IDW00200102298A patent/ID30393A/id unknown
- 2000-03-23 HU HU0200550A patent/HUP0200550A3/hu unknown
- 2000-03-23 ES ES00911308T patent/ES2212992T3/es not_active Expired - Lifetime
- 2000-03-23 CA CA002368108A patent/CA2368108C/en not_active Expired - Fee Related
- 2000-03-23 MX MXPA01009566A patent/MXPA01009566A/es active IP Right Grant
- 2000-03-23 KR KR10-2000-7011511A patent/KR100533483B1/ko not_active IP Right Cessation
- 2000-03-23 AU AU33262/00A patent/AU764019B2/en not_active Ceased
- 2000-03-23 JP JP2000087051A patent/JP3240293B2/ja not_active Expired - Fee Related
- 2000-03-23 CZ CZ20013419A patent/CZ294747B6/cs not_active IP Right Cessation
- 2000-03-23 DE DE60008862T patent/DE60008862T2/de not_active Expired - Lifetime
- 2000-03-23 IL IL14554900A patent/IL145549A/xx not_active IP Right Cessation
- 2000-03-23 BR BR0009297-5A patent/BR0009297A/pt not_active IP Right Cessation
- 2000-03-23 PL PL00351202A patent/PL351202A1/xx not_active Application Discontinuation
- 2000-03-23 CN CN00807210A patent/CN1349536A/zh active Pending
- 2000-03-23 EP EP00911308A patent/EP1163244B1/de not_active Expired - Lifetime
- 2000-03-23 OA OA1200100243A patent/OA11920A/en unknown
- 2000-03-23 NZ NZ514737A patent/NZ514737A/en unknown
- 2000-03-23 KR KR10-2000-7011508A patent/KR100370981B1/ko not_active IP Right Cessation
- 2000-03-23 AT AT00911308T patent/ATE261449T1/de not_active IP Right Cessation
- 2000-03-23 SK SK1355-2001A patent/SK13552001A3/sk unknown
- 2000-03-23 DK DK00911308T patent/DK1163244T3/da active
- 2000-03-23 PT PT00911308T patent/PT1163244E/pt unknown
- 2000-03-24 AR ARP000101320A patent/AR023152A1/es not_active Application Discontinuation
- 2000-05-16 US US09/571,215 patent/US6340686B1/en not_active Expired - Lifetime
2001
- 2001-09-21 NO NO20014603A patent/NO20014603L/no unknown
2002
- 2002-06-07 HK HK02104325.6A patent/HK1042495B/zh not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1349536A (zh)	2002-05-15
PT1163244E (pt)	2004-07-30
KR100533483B1 (ko)	2005-12-05
ID30393A (id)	2001-11-29
CZ20013419A3 (cs)	2002-02-13
EP1163244A1 (de)	2001-12-19
JP3240293B2 (ja)	2001-12-17
KR20010090430A (ko)	2001-10-18
AU3326200A (en)	2000-10-09
CZ294747B6 (cs)	2005-03-16
HUP0200550A2 (en)	2002-06-29
KR20010015920A (ko)	2001-02-26
NO20014603L (no)	2001-11-26
IL145549A (en)	2005-11-20
CA2368108A1 (en)	2000-09-28
HK1042495A1 (en)	2002-08-16
MY124726A (en)	2006-06-30
HK1042495B (zh)	2004-10-08
CA2368108C (en)	2009-12-22
US6340686B1 (en)	2002-01-22
ES2212992T3 (es)	2004-08-16
OA11920A (en)	2006-04-12
WO2000056739A1 (en)	2000-09-28
NZ514737A (en)	2003-10-31
NO20014603D0 (no)	2001-09-21
HUP0200550A3 (en)	2004-07-28
IL145549A0 (en)	2002-06-30
JP2001278884A (ja)	2001-10-10
EP1163244B1 (de)	2004-03-10
MXPA01009566A (es)	2002-05-14
AR023152A1 (es)	2002-09-04
BR0009297A (pt)	2001-12-18
ATE261449T1 (de)	2004-03-15
TWI225863B (en)	2005-01-01
AU764019B2 (en)	2003-08-07
KR100370981B1 (ko)	2003-02-06
DE60008862T2 (de)	2005-01-27
DK1163244T3 (da)	2004-07-12
PL351202A1 (en)	2003-03-24
SK13552001A3 (sk)	2002-03-05

Publication	Publication Date	Title
DE60008862D1 (de)	2004-04-15	Thienopyrimidin verbindungen, ihre herstellung und verwendung
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ATE339440T1 (de)	2006-10-15	Entzündungshemmende verbindungen und ihre verwendung
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ATE251170T1 (de)	2003-10-15	Titanverbindungen, deren herstellung und verwendung
ID26478A (id)	2001-01-11	Penggambaran kelima macam langkah produksi
ATE505459T1 (de)	2011-04-15	Dibenzoäb,füazepin-derivate und ihre herstellung
DE59802922D1 (de)	2002-03-14	3-substituierte tetrahydropyridopyrimidinon-derivate, ihre herstellung und verwendung
ATE248846T1 (de)	2003-09-15	Phosphororganische verbindungen und ihre verwendung
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ATE223921T1 (de)	2002-09-15	Phosphororganische verbindungen und ihre verwendung

Legal Events

Date	Code	Title	Description
2005-04-07	8364	No opposition during term of opposition
2005-08-04	8327	Change in the person/name/address of the patent owner	Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP