DE60005682D1 - Verfahren zur herstellung von naproxennitroxyalkylestern - Google Patents

Verfahren zur herstellung von naproxennitroxyalkylestern

Info

Publication number: DE60005682D1
Authority: DE; Germany
Prior art keywords: naproxennitroxyalkylesters; producing; naphthyl; methoxy; equal
Prior art date: 1999-08-04
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60005682T

Other languages

English (en)

Other versions

DE60005682T2 (de

Inventor

Francesca Benedini

Erminio Oldani

Graziano Castaldi

Antonio Tarquini

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Nicox SA

Original Assignee

Nicox SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-08-04

Filing date

2000-07-27

Publication date

2003-11-06

2000-07-27 Application filed by Nicox SA filed Critical Nicox SA

2003-11-06 Publication of DE60005682D1 publication Critical patent/DE60005682D1/de

2004-09-16 Application granted granted Critical

2004-09-16 Publication of DE60005682T2 publication Critical patent/DE60005682T2/de

2020-07-28 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DE60005682T 1999-08-04 2000-07-27 Verfahren zur herstellung von naproxennitroxyalkylestern Expired - Lifetime DE60005682T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
ITMI991753		1999-08-04
IT1999MI001753A IT1313596B1 (it)	1999-08-04	1999-08-04	Processo per la preparazione di nitrossialchil esteri del naproxene
PCT/EP2000/007222 WO2001010814A1 (en)	1999-08-04	2000-07-27	Process for the preparation of naproxene nitroxyalkylesters

Publications (2)

Publication Number	Publication Date
DE60005682D1 true DE60005682D1 (de)	2003-11-06
DE60005682T2 DE60005682T2 (de)	2004-09-16

Family

ID=11383500

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60020753T Expired - Lifetime DE60020753T2 (de)	1999-08-04	2000-07-27	4-Nitroxybutylester von Naproxen
DE60005682T Expired - Lifetime DE60005682T2 (de)	1999-08-04	2000-07-27	Verfahren zur herstellung von naproxennitroxyalkylestern

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DE60020753T Expired - Lifetime DE60020753T2 (de)	1999-08-04	2000-07-27	4-Nitroxybutylester von Naproxen

Country Status (23)

Country	Link
US (2)	US6700011B1 (de)
EP (2)	EP1384707B1 (de)
JP (2)	JP4667691B2 (de)
KR (1)	KR100687820B1 (de)
CN (1)	CN1198786C (de)
AT (2)	ATE297372T1 (de)
AU (1)	AU778694B2 (de)
BR (1)	BRPI0012915B1 (de)
CA (1)	CA2380116C (de)
DE (2)	DE60020753T2 (de)
DK (2)	DK1384707T3 (de)
ES (2)	ES2208390T3 (de)
HU (1)	HU227109B1 (de)
IL (1)	IL147639A0 (de)
IT (1)	IT1313596B1 (de)
MX (1)	MXPA02001256A (de)
NO (1)	NO327669B1 (de)
PL (1)	PL200165B1 (de)
PT (2)	PT1200386E (de)
RU (1)	RU2248348C2 (de)
TR (1)	TR200200290T2 (de)
WO (1)	WO2001010814A1 (de)
ZA (2)	ZA200200478B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1126838A4 (de)	1998-10-30	2005-02-16	Nitromed Inc	Nitrosierte und nitrosylierte nichtsteroidale antiphlogistishe verbindungen, zusammenstellungen und verwendungsmethoden
CA2393724A1 (en)	1999-12-23	2001-06-28	Nitromed, Inc.	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
CA2432642A1 (en)	2000-12-21	2002-08-08	Subhash P. Khanapure	Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1451140A1 (de) *	2001-11-27	2004-09-01	AstraZeneca AB	Neues verfahren
WO2003103602A2 (en)	2002-06-11	2003-12-18	Nitromed, Inc.	Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
EP1539729A4 (de)	2002-07-03	2008-02-20	Nitromed Inc	Nitrosierte nichtsteroide entz ndungshemmende verbindungen, zusammensetzungen und anwendungsverfahren
WO2004010945A2 (en)	2002-07-29	2004-02-05	Nitromed, Inc.	Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
ITMI20021861A1 (it) *	2002-08-29	2004-02-29	Nicox Sa	Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
ITMI20022409A1 (it) *	2002-11-14	2004-05-15	Dinamite Dipharma S P A	Procedimento per la purificazione di 1, 4-butandiolo mononitrato.
RU2560144C2 (ru) *	2006-02-03	2015-08-20	Никокс Сайенс Ирландия	Выделяющие оксид азота соединения
CN100427475C (zh) *	2006-11-30	2008-10-22	华南理工大学	萘普生-2-芳基吗啉乙酯及其制备方法与应用
AU2008267865A1 (en) *	2007-06-28	2008-12-31	Nicox S.A.	Process for preparing 1,4-butandiol mononitrate
WO2009149053A2 (en) *	2008-06-02	2009-12-10	Dr. Reddy's Laboratories Ltd.	Naproxcinod process and solid dispersion
ITRM20080325A1 (it)	2008-06-20	2009-12-21	Nicox Sa	Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato
TW201139337A (en)	2010-03-31	2011-11-16	Lonza Ag	Process for the production of esters of nitric acid
TWI417276B (zh)	2011-03-01	2013-12-01	Everlight Chem Ind Corp	２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途
CA2897571C (en)	2013-01-21	2018-12-18	Apparao Satyam	Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group
CA3167343A1 (en)	2020-02-10	2021-08-19	Brigitte DUQUESROIX-CHAKROUN	Method for treating vaso occlusive crises associated with sickle cell disease

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS57145841A (en) *	1981-03-05	1982-09-09	Nissan Chem Ind Ltd	L-menthyl naphthylpropionate and its preparation
IT1243367B (it) *	1990-07-26	1994-06-10	Italfarmaco Spa	Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
DK0722434T3 (da) *	1993-10-06	1998-11-16	Nicox Sa	Salpetersyreestere, der har anti-inflammatorisk og/eller analgetisk aktivitet og fremgangsmåder til deres fremstilling
ES2139199T3 (es) *	1994-05-10	2000-02-01	Nicox Sa	Compuestos nitro y composiciones que los contienen que presentan una actividad anti-inflamatoria, analgesica y antitrombotica.
US5703073A (en) *	1995-04-19	1997-12-30	Nitromed, Inc.	Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs
CN1144092A (zh) *	1995-08-25	1997-03-05	蔡雄	可释放一氧化氮的新型非类固醇类抗炎药、它们的制备方法和用途
WO1997013519A1 (en) *	1995-10-09	1997-04-17	Russinsky Limited	Esters of cyclooxygenase inhibitors and terpene derivatives as pharmaceutical products
IT1276071B1 (it) *	1995-10-31	1997-10-24	Nicox Ltd	Compositi ad attivita' anti-infiammatoria
FR2757159B1 (fr)	1996-12-12	1999-12-17	Hoechst Marion Roussel Inc	Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments

1999
- 1999-08-04 IT IT1999MI001753A patent/IT1313596B1/it active
2000
- 2000-07-27 US US10/031,412 patent/US6700011B1/en not_active Expired - Lifetime
- 2000-07-27 KR KR1020027000946A patent/KR100687820B1/ko not_active Expired - Fee Related
- 2000-07-27 PL PL353092A patent/PL200165B1/pl unknown
- 2000-07-27 HU HU0202435A patent/HU227109B1/hu not_active IP Right Cessation
- 2000-07-27 IL IL14763900A patent/IL147639A0/xx not_active IP Right Cessation
- 2000-07-27 AT AT03102132T patent/ATE297372T1/de active
- 2000-07-27 AU AU64385/00A patent/AU778694B2/en not_active Ceased
- 2000-07-27 PT PT00951456T patent/PT1200386E/pt unknown
- 2000-07-27 BR BRPI0012915-1A patent/BRPI0012915B1/pt not_active IP Right Cessation
- 2000-07-27 DK DK03102132T patent/DK1384707T3/da active
- 2000-07-27 DE DE60020753T patent/DE60020753T2/de not_active Expired - Lifetime
- 2000-07-27 JP JP2001515282A patent/JP4667691B2/ja not_active Expired - Lifetime
- 2000-07-27 AT AT00951456T patent/ATE251109T1/de active
- 2000-07-27 CN CNB008111588A patent/CN1198786C/zh not_active Expired - Fee Related
- 2000-07-27 RU RU2002102860/04A patent/RU2248348C2/ru active
- 2000-07-27 EP EP03102132A patent/EP1384707B1/de not_active Expired - Lifetime
- 2000-07-27 ES ES00951456T patent/ES2208390T3/es not_active Expired - Lifetime
- 2000-07-27 DE DE60005682T patent/DE60005682T2/de not_active Expired - Lifetime
- 2000-07-27 WO PCT/EP2000/007222 patent/WO2001010814A1/en not_active Ceased
- 2000-07-27 EP EP00951456A patent/EP1200386B1/de not_active Expired - Lifetime
- 2000-07-27 TR TR2002/00290T patent/TR200200290T2/xx unknown
- 2000-07-27 ES ES03102132T patent/ES2243859T3/es not_active Expired - Lifetime
- 2000-07-27 CA CA2380116A patent/CA2380116C/en not_active Expired - Lifetime
- 2000-07-27 PT PT03102132T patent/PT1384707E/pt unknown
- 2000-07-27 DK DK00951456T patent/DK1200386T3/da active
- 2000-07-27 MX MXPA02001256A patent/MXPA02001256A/es active IP Right Grant
2002
- 2002-01-18 ZA ZA200200478A patent/ZA200200478B/en unknown
- 2002-02-01 NO NO20020515A patent/NO327669B1/no not_active IP Right Cessation
2003
- 2003-06-10 ZA ZA200304525A patent/ZA200304525B/xx unknown
- 2003-07-24 US US10/625,558 patent/US7238829B2/en not_active Expired - Lifetime
2010
- 2010-11-30 JP JP2010266860A patent/JP2011042690A/ja active Pending

Also Published As

Publication number	Publication date
JP4667691B2 (ja)	2011-04-13
US7238829B2 (en)	2007-07-03
EP1200386A1 (de)	2002-05-02
NO20020515D0 (no)	2002-02-01
KR100687820B1 (ko)	2007-02-28
IT1313596B1 (it)	2002-09-09
NO327669B1 (no)	2009-09-07
JP2011042690A (ja)	2011-03-03
ITMI991753A1 (it)	2001-02-04
ZA200200478B (en)	2003-10-29
CA2380116A1 (en)	2001-02-15
WO2001010814A1 (en)	2001-02-15
EP1384707B1 (de)	2005-06-08
ATE251109T1 (de)	2003-10-15
DK1200386T3 (da)	2003-12-22
US20050119339A1 (en)	2005-06-02
PL200165B1 (pl)	2008-12-31
HUP0202435A2 (hu)	2002-11-28
KR20020013974A (ko)	2002-02-21
JP2003506425A (ja)	2003-02-18
IL147639A0 (en)	2002-08-14
ZA200304525B (en)	2004-04-28
MXPA02001256A (es)	2005-06-06
PT1384707E (pt)	2005-08-31
RU2248348C2 (ru)	2005-03-20
CN1198786C (zh)	2005-04-27
US6700011B1 (en)	2004-03-02
HU227109B1 (en)	2010-07-28
ATE297372T1 (de)	2005-06-15
NO20020515L (no)	2002-02-01
ES2243859T3 (es)	2005-12-01
CA2380116C (en)	2011-07-05
EP1200386B1 (de)	2003-10-01
TR200200290T2 (tr)	2002-05-21
DK1384707T3 (da)	2005-08-15
DE60020753D1 (de)	2005-07-14
DE60005682T2 (de)	2004-09-16
ES2208390T3 (es)	2004-06-16
EP1384707A1 (de)	2004-01-28
AU778694B2 (en)	2004-12-16
DE60020753T2 (de)	2006-03-16
AU6438500A (en)	2001-03-05
PL353092A1 (en)	2003-10-06
HUP0202435A3 (en)	2004-03-01
PT1200386E (pt)	2004-02-27
BR0012915A (pt)	2002-06-04
BRPI0012915B1 (pt)	2015-09-01
ITMI991753A0 (it)	1999-08-04
CN1367773A (zh)	2002-09-04

Publication	Publication Date	Title
DE60005682D1 (de)	2003-11-06	Verfahren zur herstellung von naproxennitroxyalkylestern
DE69801797D1 (de)	2001-10-31	Verfahren zur Herstellung von Acrylsäure
DE69702354D1 (de)	2000-08-03	Verfahren zur Herstellung von Acrylsäure
DE59704095D1 (de)	2001-08-30	Verfahren zur kontinuierlichen Herstellung von Alkylestern der (Meth)acrylsäure
DE59709118D1 (de)	2003-02-13	Verfahren zur herstellung von aluminumsalzen organischer phosphorsäuren
DE69920568D1 (de)	2004-11-04	Verfahren zur Herstellung von optisch aktivem 4-Halo-3-hydroxybuttersäureester
ATE327219T1 (de)	2006-06-15	Verfahren zur herstellung von hydroxymethylthiobuttersäure
DE69906607D1 (de)	2003-05-15	Verfahren zur Herstellung von optisch aktiven Chrysanthemumsäure
DE59400025D1 (de)	1995-11-09	Verfahren zur Herstellung von 2-Alkyl-4-fluormethyl-thiazolcarbonsäure-alkylestern.
ATE230722T1 (de)	2003-01-15	Verfahren zur herstellung von cyanvaleriansäure oder -estern
DE59704450D1 (de)	2001-10-11	Verfahren zur herstellung von 2-(2-methylphenyl)-3-methoxyacrylsäure-methylester
DE69407973D1 (de)	1998-02-19	Verfahren zur herstellung weisser mikrokieselsäure
DE59804673D1 (de)	2002-08-08	Verfahren zur herstellung von vinylphosphonsäure-verbindungen
DE59914298D1 (de)	2007-05-31	Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
DE59407019D1 (de)	1998-11-05	Verfahren zur herstellung von fettsäureniedrigalkylestern
DE69819335D1 (de)	2003-12-04	Verfahren zur herstellung von phosphorsäureester-verbindungen
DE69715955D1 (de)	2002-11-07	Verfahren zur Herstellung von optisch-aktiven Aminopolycarbonsäuren
DE59902581D1 (de)	2002-10-10	Verfahren zur herstellung von vinylphosphonsäure-verbindungen
ATE241605T1 (de)	2003-06-15	Verfahren zur herstellung von phenoxy- propionsäure derivate
DE69512329D1 (de)	1999-10-28	Verfahren zur Herstellung von optisch aktiver Gamma-hydroxy-L-Glutaminsäure
DE59804451D1 (de)	2002-07-18	Verfahren zur herstellung von hellfarbigen ethercarbonsäuren
DE69930275D1 (de)	2006-05-04	Verfahren zur herstellung von sorbinsäuren oder sorbinsäuresalzen
DE69709654D1 (de)	2002-02-21	Verfahren zur herstellung von 2-(3-benzoyl-phenyl)-propionsäure aus arylolefinen
DE69821755D1 (de)	2004-03-25	Verfahren zur Herstellung von alpha-Tocopherol-4-aminobenzoesäureester-Verbindungen
DE59804586D1 (de)	2002-08-01	Verfahren zur herstellung von 2-alkinsäureestern

Legal Events

Date	Code	Title	Description
2004-10-28	8364	No opposition during term of opposition
2007-02-15	8327	Change in the person/name/address of the patent owner	Owner name: NICOX S.A., SOPHIA ANTIPOLIS, FR