DE59903402D1 - Verfahren und vorrichtung zur manipulierung von mikropartikeln in fluidströmungen - Google Patents
Verfahren und vorrichtung zur manipulierung von mikropartikeln in fluidströmungenInfo
- Publication number
- DE59903402D1 DE59903402D1 DE59903402T DE59903402T DE59903402D1 DE 59903402 D1 DE59903402 D1 DE 59903402D1 DE 59903402 T DE59903402 T DE 59903402T DE 59903402 T DE59903402 T DE 59903402T DE 59903402 D1 DE59903402 D1 DE 59903402D1
- Authority
- DE
- Germany
- Prior art keywords
- microparticles
- fluid flows
- channel
- manipulating microparticles
- manipulating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000011859 microparticle Substances 0.000 title abstract 4
- 239000012530 fluid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000004888 barrier function Effects 0.000 abstract 1
- 230000005684 electric field Effects 0.000 abstract 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C5/00—Separating dispersed particles from liquids by electrostatic effect
- B03C5/02—Separators
- B03C5/022—Non-uniform field separators
- B03C5/026—Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
Landscapes
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Sustainable Development (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Electrostatic Separation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19815882A DE19815882A1 (de) | 1998-04-08 | 1998-04-08 | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
PCT/EP1999/002380 WO1999052640A1 (de) | 1998-04-08 | 1999-04-08 | Verfahren und vorrichtung zur manipulierung von mikropartikeln in fluidströmungen |
Publications (1)
Publication Number | Publication Date |
---|---|
DE59903402D1 true DE59903402D1 (de) | 2002-12-19 |
Family
ID=7864074
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19815882A Ceased DE19815882A1 (de) | 1998-04-08 | 1998-04-08 | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
DE59903402T Expired - Lifetime DE59903402D1 (de) | 1998-04-08 | 1999-04-08 | Verfahren und vorrichtung zur manipulierung von mikropartikeln in fluidströmungen |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19815882A Ceased DE19815882A1 (de) | 1998-04-08 | 1998-04-08 | Verfahren und Vorrichtung zur Manipulierung von Mikropartikeln in Fluidströmungen |
Country Status (6)
Country | Link |
---|---|
US (1) | US6727451B1 (de) |
EP (1) | EP1069955B1 (de) |
JP (1) | JP2002511337A (de) |
AT (1) | ATE227607T1 (de) |
DE (2) | DE19815882A1 (de) |
WO (1) | WO1999052640A1 (de) |
Families Citing this family (94)
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US7118676B2 (en) * | 2003-09-04 | 2006-10-10 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US7699767B2 (en) | 2002-07-31 | 2010-04-20 | Arryx, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
US11243494B2 (en) | 2002-07-31 | 2022-02-08 | Abs Global, Inc. | Multiple laminar flow-based particle and cellular separation with laser steering |
EP2889879B1 (de) | 2002-07-31 | 2017-09-06 | Premium Genetics (UK) Limited | System und Verfahren zum Sortieren von Materialien mit Hilfe holografischer Lasersteuerung |
DE10255858A1 (de) * | 2002-11-29 | 2004-06-17 | Evotec Oai Ag | Fluidisches Mikrosystem mit feldformenden Passivierungsschichten auf Mikroelektroden |
JP4276891B2 (ja) * | 2003-05-15 | 2009-06-10 | 東芝機械株式会社 | 微細流路およびこれを含むマイクロ化学チップ |
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US7390388B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells on a biodevice |
US7390387B2 (en) * | 2004-03-25 | 2008-06-24 | Hewlett-Packard Development Company, L.P. | Method of sorting cells in series |
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DE102004040785B4 (de) * | 2004-08-23 | 2006-09-21 | Kist-Europe Forschungsgesellschaft Mbh | Mikrofluidisches System zur Isolierung biologischer Partikel unter Verwendung der immunomagnetischen Separation |
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US8778160B2 (en) * | 2005-06-27 | 2014-07-15 | Cfd Research Corporation | Method and apparatus for separating particles by dielectrophoresis |
EP1764418B1 (de) * | 2005-09-14 | 2012-08-22 | STMicroelectronics Srl | Verfahren und Vorrichtung zur Behandlung biologischer Proben mittels Dielektrophorese |
TWI304752B (en) * | 2005-12-09 | 2009-01-01 | Ind Tech Res Inst | Multi-sample microfluidic dielectrophoresis separator |
EP1984723B1 (de) | 2006-02-01 | 2019-05-15 | Ecole Polytechnique Federale de Lausanne (EPFL) | Vorrichtung zur impedanzmessung von partikeln in einem mikrokanal |
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KR100726339B1 (ko) | 2006-06-15 | 2007-06-11 | 한국과학기술원 | 미세입자 정렬분리용 미세유체칩 및 이를 이용한 미세입자분리방법 |
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KR100788458B1 (ko) | 2006-09-08 | 2007-12-24 | 한국과학기술원 | 유체영동기반 세포분리용 미세유체칩 및 이를 이용한혈액분리방법 |
US7807454B2 (en) * | 2006-10-18 | 2010-10-05 | The Regents Of The University Of California | Microfluidic magnetophoretic device and methods for using the same |
US20080245740A1 (en) * | 2007-01-29 | 2008-10-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Fluidic methods |
US10001496B2 (en) | 2007-01-29 | 2018-06-19 | Gearbox, Llc | Systems for allergen detection |
US8361296B2 (en) * | 2007-05-18 | 2013-01-29 | University Of Washington | Shaped electrodes for microfluidic dielectrophoretic particle manipulation |
US20080302732A1 (en) * | 2007-05-24 | 2008-12-11 | Hyongsok Soh | Integrated fluidics devices with magnetic sorting |
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KR101063871B1 (ko) | 2009-03-04 | 2011-09-08 | 한국생명공학연구원 | 유체 내 입자 분리용 입·출구 개방형 케피러리 채널, 이의 제조방법 및 이를 이용한 유체 내 입자의 분리방법 |
JP4915426B2 (ja) * | 2009-03-26 | 2012-04-11 | 富士ゼロックス株式会社 | 分級方法及び分級装置 |
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US10908066B2 (en) | 2010-11-16 | 2021-02-02 | 1087 Systems, Inc. | Use of vibrational spectroscopy for microfluidic liquid measurement |
US9752114B2 (en) | 2012-03-15 | 2017-09-05 | Flodesign Sonics, Inc | Bioreactor using acoustic standing waves |
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US10953436B2 (en) | 2012-03-15 | 2021-03-23 | Flodesign Sonics, Inc. | Acoustophoretic device with piezoelectric transducer array |
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US9687847B1 (en) * | 2013-02-13 | 2017-06-27 | University Of South Florida | Microfluidic platforms for optical biosensing |
CN105339064B (zh) * | 2013-04-25 | 2017-06-16 | 弗洛设计声能学公司 | 赋形剂从药物样品中的去除 |
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US10106770B2 (en) | 2015-03-24 | 2018-10-23 | Flodesign Sonics, Inc. | Methods and apparatus for particle aggregation using acoustic standing waves |
US11021699B2 (en) | 2015-04-29 | 2021-06-01 | FioDesign Sonics, Inc. | Separation using angled acoustic waves |
US11708572B2 (en) | 2015-04-29 | 2023-07-25 | Flodesign Sonics, Inc. | Acoustic cell separation techniques and processes |
US11377651B2 (en) | 2016-10-19 | 2022-07-05 | Flodesign Sonics, Inc. | Cell therapy processes utilizing acoustophoresis |
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US10710006B2 (en) | 2016-04-25 | 2020-07-14 | Flodesign Sonics, Inc. | Piezoelectric transducer for generation of an acoustic standing wave |
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US11085035B2 (en) | 2016-05-03 | 2021-08-10 | Flodesign Sonics, Inc. | Therapeutic cell washing, concentration, and separation utilizing acoustophoresis |
US11214789B2 (en) | 2016-05-03 | 2022-01-04 | Flodesign Sonics, Inc. | Concentration and washing of particles with acoustics |
CA3041517A1 (en) | 2016-10-19 | 2018-04-26 | Flodesign Sonics, Inc. | Affinity cell extraction by acoustics |
AU2018385759B2 (en) | 2017-12-14 | 2021-10-21 | Flodesign Sonics, Inc. | Acoustic transducer driver and controller |
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BR112021020390A2 (pt) | 2019-04-18 | 2022-01-18 | Abs Global Inc | Sistema de distribuição de crioprotetor, sistema de criopreservação para distribuir um crioprotetor a um espécime biológico, método para distribuir um crioprotetor a um espécime biológico, sistema de distribuição e método para preparar um espécime biológico para criopreservação |
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-
1998
- 1998-04-08 DE DE19815882A patent/DE19815882A1/de not_active Ceased
-
1999
- 1999-04-08 EP EP99917967A patent/EP1069955B1/de not_active Expired - Lifetime
- 1999-04-08 AT AT99917967T patent/ATE227607T1/de not_active IP Right Cessation
- 1999-04-08 WO PCT/EP1999/002380 patent/WO1999052640A1/de active IP Right Grant
- 1999-04-08 US US09/673,034 patent/US6727451B1/en not_active Expired - Lifetime
- 1999-04-08 JP JP2000543245A patent/JP2002511337A/ja active Pending
- 1999-04-08 DE DE59903402T patent/DE59903402D1/de not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
ATE227607T1 (de) | 2002-11-15 |
EP1069955B1 (de) | 2002-11-13 |
EP1069955A1 (de) | 2001-01-24 |
US6727451B1 (en) | 2004-04-27 |
WO1999052640A1 (de) | 1999-10-21 |
JP2002511337A (ja) | 2002-04-16 |
DE19815882A1 (de) | 1999-10-14 |
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Owner name: EVOTEC TECHNOLOGIES GMBH, 40225 DUESSELDORF, DE |