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DE4301401A1 - Chromatography separation column identification - Google Patents

Chromatography separation column identification

Info

Publication number
DE4301401A1
DE4301401A1 DE19934301401 DE4301401A DE4301401A1 DE 4301401 A1 DE4301401 A1 DE 4301401A1 DE 19934301401 DE19934301401 DE 19934301401 DE 4301401 A DE4301401 A DE 4301401A DE 4301401 A1 DE4301401 A1 DE 4301401A1
Authority
DE
Germany
Prior art keywords
circuit
information
antenna
column
stored
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19934301401
Other languages
German (de)
Other versions
DE4301401C2 (en
Inventor
Werner Roepke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agilent Technologies Inc
Original Assignee
Techlab Produkte fur Wissenschaft und Technik 38173 Erkerode GmbH
Techlab Produkte fur Wis GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techlab Produkte fur Wissenschaft und Technik 38173 Erkerode GmbH, Techlab Produkte fur Wis GmbH filed Critical Techlab Produkte fur Wissenschaft und Technik 38173 Erkerode GmbH
Priority to DE19934301401 priority Critical patent/DE4301401C2/en
Publication of DE4301401A1 publication Critical patent/DE4301401A1/en
Application granted granted Critical
Publication of DE4301401C2 publication Critical patent/DE4301401C2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G07—CHECKING-DEVICES
    • G07C—TIME OR ATTENDANCE REGISTERS; REGISTERING OR INDICATING THE WORKING OF MACHINES; GENERATING RANDOM NUMBERS; VOTING OR LOTTERY APPARATUS; ARRANGEMENTS, SYSTEMS OR APPARATUS FOR CHECKING NOT PROVIDED FOR ELSEWHERE
    • G07C3/00—Registering or indicating the condition or the working of machines or other apparatus, other than vehicles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6052—Construction of the column body
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8804—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 automated systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/50—Conditioning of the sorbent material or stationary liquid
    • G01N30/56—Packing methods or coating methods

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

For the electronic and non-contact identification of separating columns for chromatography, the alpha-numeric data are transmitted by wireless to the microelectronic circuit, to be stored durably without a current supply. The circuit with an antenna is durably fixed to a separation column for chromatography, and the data matching the column are stored electronically.

Description

Bei der chemischen Analyse mittels der Hochdruckflüssigkeitschromatografie (HPLC) werden Stoffgemische nach physikalisch-chemischen Kriterien auf sog. Trennsäulen zerlegt. Diese Trennsäulen bestehen aus einem homogenen Füllmaterial, an dem sich die zu untersuchende, in einem Flüssigkeitsstrom befindliche Probe in ihre Bestandteile auftrennt.In chemical analysis using high pressure liquid chromatography (HPLC) are mixtures of substances based on physicochemical criteria So-called separation columns disassembled. These columns consist of one homogeneous filling material, on which the material to be examined, in one Liquid sample separated into its components.

Die Trennung ist sehr stark abhängig von der Art des Füllmaterials, ferner von der Weise der Herstellung dieses Materials sowie von der Anzahl der auf eine solche Säule aufgebrachten Proben.The separation is very dependent on the type of filler, furthermore the way in which this material is made and the number of samples applied to such a column.

Jede Säule wird bei der Füllung mit einer Probesubstanz getestet und das Testergebnis als Ausdruck beigelegt. Ferner wird an der Säule ein Aufkleber oder ein Anhänger befestigt, der die wichtigsten Informationen über Art und Größe des Füllmaterials und der verwendeten Charge trägt.Each column is tested with a test substance and that Test result enclosed as a printout. There is also a sticker on the column or attached a trailer that contains the most important information about type and Size of the filling material and the batch used.

Bei der Analyse von Proben im chemischen Labor wird die Trennsäule in die HPLC-Apparatur eingesetzt und meist für mehrere Proben verwendet.When analyzing samples in the chemical laboratory, the separation column is placed in the HPLC apparatus used and mostly used for several samples.

Um eine spätere Kontrolle zu ermöglichen, müssen die Kenndaten der Säule schriftlich auf jedem Analysenprotokoll vermerkt werden.To enable a later check, the characteristics of the column must be be noted in writing on each analysis protocol.

Die erfindungsgemäße Einrichtung erlaubt es erstmals, die Trennsäule schon bei der Füllung mit einem elektronischen Kennblatt zu versehen, auf dem alle wichtiger Parameter gespeichert sind.The device according to the invention allows the separation column for the first time when filling, to be provided with an electronic identification sheet on which all important parameters are saved.

Dazu wird ein normaler Computer mit dem Sende- und Empfangsgerät über die serielle Schnittstelle verbunden. Die gewünschten Informationen werden vom Computer als ASCII-Zeichen an das Sende-Empfangsgerät übertragen.To do this, a normal computer with the transmitting and receiving device is used the serial interface connected. The information you want will be transferred from the computer to the transceiver as ASCII characters.

Die zu kennzeichnende Trennsäule wird mit dem Schaltkreis versehen und in die Nähe der Antenne des Sende-Empfangsgerätes gebracht.The separating column to be labeled is provided with the circuit and in brought the proximity of the antenna of the transceiver.

Durch elektromagnetische Strahlung wird der Schaltkreis über die Antenne aktiviert und gibt seine Informationen an die Antenne weiter, von dort werden sie drahtlos auf die Antenne des Sende-Empfangsgerätes übertragen.Due to electromagnetic radiation, the circuit is over the antenna activates and passes its information on to the antenna, from there they transmit wirelessly to the antenna of the transceiver.

Nun werden vom Anwender die gewünschten Informationen ebenfalls drahtlos auf den aktivierten Schaltkreis übertragen und dort gespeichert. The user now also receives the desired information wirelessly transferred to the activated circuit and saved there.  

Nach Abschalten der Sende-Empfangsvorrichtung bleibt die Information auf dem Schaltkreis ohne zusätzliche Energiezufuhr erhalten.The information remains on after the transceiver is switched off the circuit without additional power supply.

Soll nun eine chemische Analyse unter Verwendung der so gekennzeichneten Säule stattfinden, wird diese wieder in das Sende- Empfangsgerät eingelegt bzw. in die Nähe zu diesem gebracht, so daß sich über die Antenne eine Kopplung ergibt. Alle gespeicherten Informationen werden ausgelesen und an das Analysensystem übertragen.A chemical analysis should now be carried out using the so marked column will take place again in the broadcast Receiving device inserted or brought close to it, so that there is a coupling via the antenna. All saved information are read out and transferred to the analysis system.

Das Analysensystem speichert die Informationen für spätere Verwendung bzw. ordnet sie einer bestimmten Probe zu.The analysis system stores the information for later use or assigns it to a specific sample.

Zusätzlich kann rückwärts auf den Schaltkreis die Anzahl der Proben um jeweils eine erhöht werden, um die Belastung der Säule zu dokumentieren.In addition, the number of samples can be reversed on the circuit be increased one at a time to document the load on the column.

Mit diesem System läßt sich jederzeit die Zuordnung einer bestimmten Säule zu einer bestimmten Probe durchführen, ferner können mit jeder Probe alle relevanten Parameter der Säule automatisch erfaßt und dem Datensystem zugänglich gemacht werden. Ferner wird bereits während der Analyse die Säuleninformation bereitgestellt und nicht erst nach Erstellung eines Protokolls. Damit kann das Analysensystem fehlerhafte Säulen schon vor der Probenaufgabe erkennen und entsprechend reagieren.With this system it is possible to assign a specific column at any time to perform on a particular sample, and each sample can all relevant parameters of the column are automatically recorded and the data system be made accessible. Furthermore, the Column information provided and not only after creating one Protocol. This enables the analysis system to identify faulty columns even before the Recognize sample task and react accordingly.

Durch geeignete Abschirmmaßnahmen zwischen Säule mit Schaltkreis und Sende-Empfangsgerät wird sichergestellt, daß nur die Information der anliegenden Säule gelesen oder geschrieben wird.By means of suitable shielding measures between the column with the circuit and Transceiver ensures that only the information of the adjacent column is read or written.

Claims (6)

1. Vorrichtung und Verfahren für die elektronische und berührungslose Identifizierung von Trennsäulen für die Chromatografie, bestehend aus einem mikroelektronischen Schaltkreis mit einer Antenne sowie einer Sende- und Empfangseinrichtung für elektromagnetische Wellen, dadurch gekennzeichnet, daß alphanumerische Informationen auf drahtlosem Wege zu diesem Schaltkreis übertragen und dort dauerhaft und ohne Stromquelle gespeichert werden können.1. Apparatus and method for the electronic and contactless identification of separation columns for chromatography, consisting of a microelectronic circuit with an antenna and a transmitting and receiving device for electromagnetic waves, characterized in that alphanumeric information is transmitted wirelessly to this circuit and there can be stored permanently and without a power source. 2. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß der Schaltkreis mit Antenne dauerhaft an einer Trennsäule für die Chromatografie befestigt wird und somit die zur Trennsäule passenden Informationen elektronisch gespeichert sind.2. Device according to claim 1, characterized in that the Circuit with antenna permanently on a separation column for the Chromatography is attached and thus the matching column Information is stored electronically. 3. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß die Informationen auf dem Schaltkreis ohne Energiequelle dauerhaft gespeichert werden.3. Device according to claim 1, characterized in that the Information permanently stored on the circuit without an energy source become. 4. Vorrichtung nach Anspruch 1, dadurch gekennzeichnet, daß durch die elektromagnetische Sende- und Empfangseinheit der Schaltkreis über die Antenne angesprochen und die enthaltenen Informationen ausgelesen werden können.4. The device according to claim 1, characterized in that by the electromagnetic transmitter and receiver unit of the circuit via the Antenna addressed and the information contained read out can be. 5. Vorrichtung nach Anspruch 1 und 4, dadurch gekennzeichnet, daß die Informationen auch von der Sende- und Empfangseinheit auf den Schaltkreis geschrieben werden oder bestehende Informationen geändert werden können.5. Apparatus according to claim 1 and 4, characterized in that the Information also from the sending and receiving unit to the circuit written or existing information changed can. 6. Vorrichtung nach Anspruch 1, 4 und 5, dadurch gekennzeichnet, daß die Informationen auf dem Schaltkreis in komprimierter Form gespeichert werden können.6. The device according to claim 1, 4 and 5, characterized in that the Information is stored on the circuit in a compressed form can.
DE19934301401 1993-01-20 1993-01-20 Device and method for the electronic and contactless identification of separation columns for chromatography Expired - Fee Related DE4301401C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE19934301401 DE4301401C2 (en) 1993-01-20 1993-01-20 Device and method for the electronic and contactless identification of separation columns for chromatography

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19934301401 DE4301401C2 (en) 1993-01-20 1993-01-20 Device and method for the electronic and contactless identification of separation columns for chromatography

Publications (2)

Publication Number Publication Date
DE4301401A1 true DE4301401A1 (en) 1994-07-21
DE4301401C2 DE4301401C2 (en) 2002-10-02

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Family Applications (1)

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Country Status (1)

Country Link
DE (1) DE4301401C2 (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19540527A1 (en) * 1995-10-31 1997-05-07 Hewlett Packard Gmbh Identification modules for exchangeable components in analytical instruments
DE19631425A1 (en) * 1996-08-06 1998-02-12 Wolf & Beck Gmbh Dr Identification method for interchangeable accessories of machines tools
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
NL1005914C2 (en) * 1997-04-28 1998-10-29 Sgt Exploitatie Bv Device for storing and / or treating chemicals.
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
NL1016403C2 (en) * 2000-10-13 2002-04-16 Varian B V Information carrier for a chromatography column.
DE19521044C2 (en) * 1994-06-10 2003-10-16 Hitachi Ltd analyzing system
WO2019150544A1 (en) * 2018-02-02 2019-08-08 株式会社島津製作所 Chromatography system
WO2020183760A1 (en) * 2019-03-13 2020-09-17 株式会社島津製作所 Chromatography system
WO2020183761A1 (en) * 2019-03-13 2020-09-17 株式会社島津製作所 Chromatography system

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10335504B4 (en) 2003-07-31 2008-11-27 Carl Zeiss Nts Gmbh Electron beam device with specimen holder

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4975647A (en) * 1987-06-01 1990-12-04 Nova Biomedical Corporation Controlling machine operation with respect to consumable accessory units
DE4010194A1 (en) * 1990-03-30 1991-10-02 Schreiber Hans Procedure and device for electronic detection vehicles - uses vehicle mounted antenna with electronic chip and memory to store transmissions

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19521044C2 (en) * 1994-06-10 2003-10-16 Hitachi Ltd analyzing system
US6331273B1 (en) 1995-04-25 2001-12-18 Discovery Partners International Remotely programmable matrices with memories
US5751629A (en) 1995-04-25 1998-05-12 Irori Remotely programmable matrices with memories
US5925562A (en) * 1995-04-25 1999-07-20 Irori Remotely programmable matrices with memories
US6017496A (en) 1995-06-07 2000-01-25 Irori Matrices with memories and uses thereof
DE19540527A1 (en) * 1995-10-31 1997-05-07 Hewlett Packard Gmbh Identification modules for exchangeable components in analytical instruments
US5892458A (en) * 1995-10-31 1999-04-06 Hewlett-Packard Company Apparatus for recognition of exchangeable parts in analytical measuring instruments
DE19631425A1 (en) * 1996-08-06 1998-02-12 Wolf & Beck Gmbh Dr Identification method for interchangeable accessories of machines tools
US6136274A (en) * 1996-10-07 2000-10-24 Irori Matrices with memories in automated drug discovery and units therefor
US6475443B1 (en) 1997-04-28 2002-11-05 Sgt Exploitatie B.V. Device for storing and/or treating chemicals
US6733731B2 (en) 1997-04-28 2004-05-11 Sgt Exploitatie B.V. Device for storing and/or treating chemicals
US7097812B2 (en) 1997-04-28 2006-08-29 Sgt Exploitatie B.V. Device for storing and/or treating chemicals
EP0875292A1 (en) * 1997-04-28 1998-11-04 SGT Exploitatie B.V. Device for storing and/or treating chemicals
NL1005914C2 (en) * 1997-04-28 1998-10-29 Sgt Exploitatie Bv Device for storing and / or treating chemicals.
EP1197752A3 (en) * 2000-10-13 2004-03-24 Varian B.V. Carrier for a chromatographic column
US6730216B2 (en) 2000-10-13 2004-05-04 Varian, B.V. Carrier for a chromatographic column
NL1016403C2 (en) * 2000-10-13 2002-04-16 Varian B V Information carrier for a chromatography column.
EP1197752A2 (en) * 2000-10-13 2002-04-17 Varian B.V. Carrier for a chromatographic column
WO2019150544A1 (en) * 2018-02-02 2019-08-08 株式会社島津製作所 Chromatography system
JPWO2019150544A1 (en) * 2018-02-02 2020-11-26 株式会社島津製作所 Chromatography system
WO2020183760A1 (en) * 2019-03-13 2020-09-17 株式会社島津製作所 Chromatography system
WO2020183761A1 (en) * 2019-03-13 2020-09-17 株式会社島津製作所 Chromatography system
JPWO2020183760A1 (en) * 2019-03-13 2021-12-23 株式会社島津製作所 Chromatography system
JPWO2020183761A1 (en) * 2019-03-13 2021-12-23 株式会社島津製作所 Chromatography system
JP7173283B2 (en) 2019-03-13 2022-11-16 株式会社島津製作所 chromatography system

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Owner name: HEWLETT-PACKARD CO., PALO ALTO, CALIF., US

8128 New person/name/address of the agent

Representative=s name: HARBACH, T., DIPL.-PHYS., 71034 BOEBLINGEN

8110 Request for examination paragraph 44
8127 New person/name/address of the applicant

Owner name: HEWLETT-PACKARD CO. (N.D.GES.D.STAATES DELAWARE),

8127 New person/name/address of the applicant

Owner name: AGILENT TECHNOLOGIES, INC. (N.D.GES.D.STAATES DELA

D2 Grant after examination
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AGILENT TECHNOLOGIES, INC. (N.D.GES.D. STAATES, US

R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee

Effective date: 20110802