DE3862272D1 - Etodolac mit anhaltender freigabe. - Google Patents
Etodolac mit anhaltender freigabe.Info
- Publication number
- DE3862272D1 DE3862272D1 DE8888308564T DE3862272T DE3862272D1 DE 3862272 D1 DE3862272 D1 DE 3862272D1 DE 8888308564 T DE8888308564 T DE 8888308564T DE 3862272 T DE3862272 T DE 3862272T DE 3862272 D1 DE3862272 D1 DE 3862272D1
- Authority
- DE
- Germany
- Prior art keywords
- etodolac
- lasting release
- weight
- content
- ethylcellulose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005293 etodolac Drugs 0.000 title abstract 3
- 230000002045 lasting effect Effects 0.000 title 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940061607 dibasic sodium phosphate Drugs 0.000 abstract 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- -1 hydroxypropoxyl Chemical group 0.000 abstract 1
- GRVDJDISBSALJP-UHFFFAOYSA-N methyloxidanyl Chemical group [O]C GRVDJDISBSALJP-UHFFFAOYSA-N 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicinal Preparation (AREA)
- Indole Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Ceramic Products (AREA)
- Two-Way Televisions, Distribution Of Moving Picture Or The Like (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10050187A | 1987-09-24 | 1987-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE3862272D1 true DE3862272D1 (de) | 1991-05-08 |
Family
ID=22280080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8888308564T Expired - Lifetime DE3862272D1 (de) | 1987-09-24 | 1988-09-16 | Etodolac mit anhaltender freigabe. |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4966768A (de) |
| EP (1) | EP0309157B1 (de) |
| JP (1) | JP2879061B2 (de) |
| KR (1) | KR960009410B1 (de) |
| AT (1) | ATE62132T1 (de) |
| AU (1) | AU613663B2 (de) |
| CA (1) | CA1318600C (de) |
| DE (1) | DE3862272D1 (de) |
| DK (1) | DK168421B1 (de) |
| ES (1) | ES2021838B3 (de) |
| FI (1) | FI89005C (de) |
| GB (1) | GB2209940B (de) |
| GR (1) | GR3001739T3 (de) |
| HK (1) | HK41994A (de) |
| HU (1) | HU200920B (de) |
| IE (1) | IE60311B1 (de) |
| IL (1) | IL87757A (de) |
| MX (1) | MX171463B (de) |
| PH (1) | PH26146A (de) |
| PT (1) | PT88564B (de) |
| ZA (1) | ZA887162B (de) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993017673A1 (en) * | 1992-03-03 | 1993-09-16 | Top Gold Pty., Limited | Sustained release analgesics |
| US5314697A (en) * | 1992-10-23 | 1994-05-24 | Schering Corporation | Stable extended release oral dosage composition comprising loratadine and pseudoephedrine |
| US6746691B2 (en) | 1993-09-20 | 2004-06-08 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia having unique biopharmaceutical characteristics |
| US6676967B1 (en) | 1993-09-20 | 2004-01-13 | Kos Pharmaceuticals, Inc. | Methods for reducing flushing in individuals being treated with nicotinic acid for hyperlipidemia |
| US6080428A (en) | 1993-09-20 | 2000-06-27 | Bova; David J. | Nicotinic acid compositions for treating hyperlipidemia and related methods therefor |
| US6129930A (en) | 1993-09-20 | 2000-10-10 | Bova; David J. | Methods and sustained release nicotinic acid compositions for treating hyperlipidemia at night |
| US6818229B1 (en) | 1993-09-20 | 2004-11-16 | Kos Pharmaceuticals, Inc. | Intermediate release nicotinic acid compositions for treating hyperlipidemia |
| US5419917A (en) * | 1994-02-14 | 1995-05-30 | Andrx Pharmaceuticals, Inc. | Controlled release hydrogel formulation |
| PE10898A1 (es) * | 1995-06-13 | 1998-03-20 | American Home Prod | Formulaciones orales de etodolac s (+)- |
| US20030215507A1 (en) * | 1996-03-25 | 2003-11-20 | Wyeth | Extended release formulation |
| PE57198A1 (es) | 1996-03-25 | 1998-10-10 | American Home Prod | Formula de liberacion prolongada |
| US6274171B1 (en) | 1996-03-25 | 2001-08-14 | American Home Products Corporation | Extended release formulation of venlafaxine hydrochloride |
| US20060067999A1 (en) * | 1996-03-25 | 2006-03-30 | Wyeth | Extended release formulation |
| US6251430B1 (en) | 1998-02-04 | 2001-06-26 | Guohua Zhang | Water insoluble polymer based sustained release formulation |
| US6090411A (en) * | 1998-03-09 | 2000-07-18 | Temple University | Monolithic tablet for controlled drug release |
| US6106862A (en) * | 1998-08-13 | 2000-08-22 | Andrx Corporation | Once daily analgesic tablet |
| DE69940557D1 (de) | 1998-12-11 | 2009-04-23 | Nostrum Pharmaceuticals Inc | Ein hydrokolloid und einen celluloseether enthaltende tablette mit verzögerter freisetzung |
| US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
| US7151100B1 (en) * | 1999-07-23 | 2006-12-19 | The Regents Of The University Of California | Indole compounds useful for the treatment of cancer |
| IN190974B (de) * | 1999-09-10 | 2003-09-06 | Ranbaxy Lab Ltd | |
| US20040152672A1 (en) * | 2000-08-09 | 2004-08-05 | Carson Dennis A. | Indole compounds useful for the treatment of cancer |
| US20070098784A1 (en) * | 2001-09-28 | 2007-05-03 | Nutraceutix, Inc. | Delivery system for biological component |
| PT1429802E (pt) * | 2001-09-28 | 2013-01-24 | Tntgamble Inc | Sistema de entrega para componente biológico |
| HUP0401978A3 (en) * | 2001-11-07 | 2008-07-28 | Synthon Bv | Tamsulosin tablets |
| IL146462A (en) * | 2001-11-13 | 2015-02-26 | Lycored Bio Ltd | Prolonged-release preparations containing as an active compound and analapaxin hydrochloride |
| DE60312642T2 (de) * | 2002-01-09 | 2007-11-29 | Ucb Farchim S.A. | Pharmazeutische zusammensetzung mit modifizierter freisetzung |
| AU2003217676B2 (en) | 2002-02-22 | 2009-06-11 | Takeda Pharmaceutical Company Limited | Active agent delivery systems and methods for protecting and administering active agents |
| US7211599B2 (en) * | 2002-09-19 | 2007-05-01 | The Regents Of The University Of California | Use of etodolac to treat hyperplasia |
| US6703044B1 (en) | 2002-10-25 | 2004-03-09 | Dexcel Pharma Tech, Ltd | Venlafaxine formulations |
| US7018658B2 (en) * | 2002-11-14 | 2006-03-28 | Synthon Bv | Pharmaceutical pellets comprising tamsulosin |
| US20040185097A1 (en) * | 2003-01-31 | 2004-09-23 | Glenmark Pharmaceuticals Ltd. | Controlled release modifying complex and pharmaceutical compositions thereof |
| WO2004112756A1 (en) | 2003-06-26 | 2004-12-29 | Isa Odidi | Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient |
| US20050106253A1 (en) * | 2003-11-13 | 2005-05-19 | Platteeuw Johannes J. | Pharmaceutical pellets comprising tamsulosin |
| US8394409B2 (en) | 2004-07-01 | 2013-03-12 | Intellipharmaceutics Corp. | Controlled extended drug release technology |
| US10624858B2 (en) | 2004-08-23 | 2020-04-21 | Intellipharmaceutics Corp | Controlled release composition using transition coating, and method of preparing same |
| US10064828B1 (en) | 2005-12-23 | 2018-09-04 | Intellipharmaceutics Corp. | Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems |
| JP5457830B2 (ja) | 2006-04-03 | 2014-04-02 | オディディ，イサ | オルガノゾル被膜を含む制御放出送達デバイス |
| HUE029173T2 (hu) * | 2006-04-26 | 2017-02-28 | Alphapharm Pty Ltd | Szabályozott hatóanyag-leadású készítmények, amelyek tartalmaznak nem bevont diszkrét egység(ek)et és egy késleltetett hatóanyag-leadású mátrixot |
| US10960077B2 (en) | 2006-05-12 | 2021-03-30 | Intellipharmaceutics Corp. | Abuse and alcohol resistant drug composition |
| WO2007131804A1 (en) | 2006-05-17 | 2007-11-22 | Synthon B.V. | Tablet composition with a prolonged release of tamsulosin |
| US8465770B2 (en) | 2008-12-24 | 2013-06-18 | Synthon Bv | Low dose controlled release tablet |
| TR200908308A1 (tr) | 2010-01-18 | 2011-08-22 | Turgut İlaçlari A.Ş. | Etodolak içeren sürekli salım tablet formulasyonu |
| CN102485215B (zh) * | 2010-12-03 | 2013-05-15 | 沈阳药科大学 | 依托度酸定时释药微丸制剂及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3939178A (en) * | 1971-06-01 | 1976-02-17 | American Home Products Corporation | Certain pyrano [3,4-b]indoles and thiopyrano[3,4-b]indoles |
| US3954959A (en) * | 1973-03-28 | 1976-05-04 | A/S Alfred Benzon | Oral drug preparations |
| GB1468172A (en) * | 1973-03-28 | 1977-03-23 | Benzon As Alfred | Oral drug preparations |
| US4309406A (en) * | 1979-07-10 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4309405A (en) * | 1979-08-09 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4309404A (en) * | 1979-08-09 | 1982-01-05 | American Home Products Corporation | Sustained release pharmaceutical compositions |
| US4369172A (en) * | 1981-12-18 | 1983-01-18 | Forest Laboratories Inc. | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose |
| US4389393A (en) * | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
| US4533551A (en) * | 1984-02-17 | 1985-08-06 | American Home Products Corporation | Method of treating arthritis with etodolac |
| US4657757A (en) * | 1985-03-29 | 1987-04-14 | Schering Corporation | Controlled release dosage form comprising acetaminophen, pseudoephedrine sulfate and dexbrompheniramine maleate |
-
1988
- 1988-09-07 IE IE270988A patent/IE60311B1/en not_active IP Right Cessation
- 1988-09-09 CA CA000576957A patent/CA1318600C/en not_active Expired - Lifetime
- 1988-09-13 AU AU22153/88A patent/AU613663B2/en not_active Expired
- 1988-09-15 FI FI884245A patent/FI89005C/fi not_active IP Right Cessation
- 1988-09-15 IL IL87757A patent/IL87757A/xx active Protection Beyond IP Right Term
- 1988-09-16 AT AT88308564T patent/ATE62132T1/de not_active IP Right Cessation
- 1988-09-16 DE DE8888308564T patent/DE3862272D1/de not_active Expired - Lifetime
- 1988-09-16 GB GB8821749A patent/GB2209940B/en not_active Expired - Lifetime
- 1988-09-16 ES ES88308564T patent/ES2021838B3/es not_active Expired - Lifetime
- 1988-09-16 EP EP88308564A patent/EP0309157B1/de not_active Expired - Lifetime
- 1988-09-17 JP JP63233366A patent/JP2879061B2/ja not_active Expired - Lifetime
- 1988-09-21 PT PT88564A patent/PT88564B/pt not_active IP Right Cessation
- 1988-09-21 MX MX013091A patent/MX171463B/es unknown
- 1988-09-23 HU HU884992A patent/HU200920B/hu unknown
- 1988-09-23 KR KR88012298A patent/KR960009410B1/ko not_active Expired - Lifetime
- 1988-09-23 PH PH37584A patent/PH26146A/en unknown
- 1988-09-23 ZA ZA887162A patent/ZA887162B/xx unknown
- 1988-09-23 DK DK531088A patent/DK168421B1/da not_active IP Right Cessation
- 1988-11-07 US US07/268,646 patent/US4966768A/en not_active Expired - Lifetime
-
1991
- 1991-04-04 GR GR91400364T patent/GR3001739T3/el unknown
-
1994
- 1994-04-28 HK HK41994A patent/HK41994A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU613663B2 (en) | 1991-08-08 |
| PH26146A (en) | 1992-03-18 |
| HUT50631A (en) | 1990-03-28 |
| FI884245A0 (fi) | 1988-09-15 |
| HK41994A (en) | 1994-05-06 |
| PT88564A (pt) | 1988-10-01 |
| IE60311B1 (en) | 1994-06-29 |
| IL87757A0 (en) | 1989-02-28 |
| MX171463B (es) | 1993-10-28 |
| JPH02270820A (ja) | 1990-11-05 |
| GB8821749D0 (en) | 1988-10-19 |
| DK168421B1 (da) | 1994-03-28 |
| ES2021838B3 (es) | 1991-11-16 |
| IL87757A (en) | 1992-06-21 |
| KR890004686A (ko) | 1989-05-09 |
| GR3001739T3 (en) | 1992-11-23 |
| CA1318600C (en) | 1993-06-01 |
| US4966768A (en) | 1990-10-30 |
| EP0309157B1 (de) | 1991-04-03 |
| DK531088A (da) | 1989-03-25 |
| AU2215388A (en) | 1989-05-11 |
| GB2209940A (en) | 1989-06-01 |
| ATE62132T1 (de) | 1991-04-15 |
| FI89005C (fi) | 1993-08-10 |
| ZA887162B (en) | 1990-05-30 |
| DK531088D0 (da) | 1988-09-23 |
| FI884245L (fi) | 1989-03-25 |
| HU200920B (en) | 1990-09-28 |
| JP2879061B2 (ja) | 1999-04-05 |
| KR960009410B1 (en) | 1996-07-19 |
| GB2209940B (en) | 1991-08-14 |
| IE882709L (en) | 1989-03-24 |
| PT88564B (pt) | 1992-11-30 |
| EP0309157A1 (de) | 1989-03-29 |
| FI89005B (fi) | 1993-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J. |