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DE3850407D1 - Protein mit inhibierender wirkung auf die entzündungserregende phospholipase a2. - Google Patents

Protein mit inhibierender wirkung auf die entzündungserregende phospholipase a2.

Info

Publication number
DE3850407D1
DE3850407D1 DE3850407T DE3850407T DE3850407D1 DE 3850407 D1 DE3850407 D1 DE 3850407D1 DE 3850407 T DE3850407 T DE 3850407T DE 3850407 T DE3850407 T DE 3850407T DE 3850407 D1 DE3850407 D1 DE 3850407D1
Authority
DE
Germany
Prior art keywords
flammabilizing
phospholipase
protein
inhibiting effect
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE3850407T
Other languages
English (en)
Other versions
DE3850407T2 (de
Inventor
Keizo Inoue
Atsushi Imaizumi
Takashi Kamimura
Yorimasa Suwa
Masahiro Okada
Yoji Suzuki
Ichiro Kudo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Publication of DE3850407D1 publication Critical patent/DE3850407D1/de
Application granted granted Critical
Publication of DE3850407T2 publication Critical patent/DE3850407T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE3850407T 1987-04-02 1988-03-30 Protein mit inhibierender wirkung auf die entzündungserregende phospholipase a2. Expired - Fee Related DE3850407T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP62079693A JPH06799B2 (ja) 1987-04-02 1987-04-02 起炎性フオスフオリパ−ゼａ▲下２▼阻害活性を有する蛋白
PCT/JP1988/000318 WO1988007552A1 (en) 1987-04-02 1988-03-30 Protein having activity of inhibiting inflammation-inducing phospholipase a2

Publications (2)

Publication Number Publication Date
DE3850407D1 true DE3850407D1 (de) 1994-07-28
DE3850407T2 DE3850407T2 (de) 1995-03-09

Family

ID=13697288

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3850407T Expired - Fee Related DE3850407T2 (de) 1987-04-02 1988-03-30 Protein mit inhibierender wirkung auf die entzündungserregende phospholipase a2.

Country Status (5)

Country Link
US (1) US5116942A (de)
EP (1) EP0413024B1 (de)
JP (1) JPH06799B2 (de)
DE (1) DE3850407T2 (de)
WO (1) WO1988007552A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264550A (en) * 1985-04-15 1993-11-23 Scios Nova Inc. Human anti-inflammatory phospholipase inhibitor protein
WO1991001999A1 (en) * 1989-08-03 1991-02-21 Teijin Limited Phospholipase a2 inhibiting protein originating in inflamed region, production thereof, and gene therefor
JPH0365187A (ja) * 1989-08-03 1991-03-20 Teijin Ltd 起炎性ホスホリパーゼａ↓２阻害蛋白、その製造方法およびその遺伝子
US5344764A (en) * 1989-08-03 1994-09-06 Teijin Limited Protein inhibitors of phospholipase A2 purified from inflammatory sites and production process
CA2096520C (en) * 1990-11-20 2000-12-19 Hiroshi Nakao Therapeutic agent for skin or corneal disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN86100721A (zh) * 1985-01-10 1987-02-11 比奥根公司 为人类脂皮质激素多肽编码的脱氧核糖核酸顺序，含有它的重组脱氧核糖核酸分子及制造该多肽的方法
US4879224A (en) * 1985-01-10 1989-11-07 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor polypeptides
US4874743A (en) * 1985-01-10 1989-10-17 Biogen, Inc. DNA sequences, recombinant DNA molecules and processes for producing human phospholipase inhibitor-like polypeptides
AU5770786A (en) * 1985-04-15 1986-11-05 Biotechnology Research Partners Limited Human anti-inflammatory phospholipase inhibitor protein
JPS6256429A (ja) * 1985-09-04 1987-03-12 Teijin Ltd フオスフオリパ−ゼａ↓２阻害活性を有する蛋白
US4937324A (en) * 1987-02-06 1990-06-26 Zymogenetics, Inc. Chromatographic purification of human proteins having anticoagulant and anti-inflammatory activity

Also Published As

Publication number Publication date
EP0413024B1 (de) 1994-06-22
JPH06799B2 (ja) 1994-01-05
WO1988007552A1 (en) 1988-10-06
EP0413024A1 (de) 1991-02-20
JPS63246397A (ja) 1988-10-13
US5116942A (en) 1992-05-26
DE3850407T2 (de) 1995-03-09
EP0413024A4 (de) 1990-03-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee