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DE3787502D1 - Pharmazeutische zusammensetzungen zum einatmen. - Google Patents

Pharmazeutische zusammensetzungen zum einatmen.

Info

Publication number
DE3787502D1
DE3787502D1 DE87901468T DE3787502T DE3787502D1 DE 3787502 D1 DE3787502 D1 DE 3787502D1 DE 87901468 T DE87901468 T DE 87901468T DE 3787502 T DE3787502 T DE 3787502T DE 3787502 D1 DE3787502 D1 DE 3787502D1
Authority
DE
Germany
Prior art keywords
inhalation
pharmaceutical compositions
microgranules
conglomerate
lubricant
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE87901468T
Other languages
English (en)
Other versions
DE3787502T2 (de
Inventor
Paolo Chiesi
Luciana Pavesi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chiesi Farmaceutici SpA
Original Assignee
Chiesi Farmaceutici SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici SpA filed Critical Chiesi Farmaceutici SpA
Publication of DE3787502D1 publication Critical patent/DE3787502D1/de
Application granted granted Critical
Publication of DE3787502T2 publication Critical patent/DE3787502T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE87901468T 1986-03-04 1987-02-27 Pharmazeutische zusammensetzungen zum einatmen. Expired - Fee Related DE3787502T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT19625/86A IT1204826B (it) 1986-03-04 1986-03-04 Composizioni farmaceutiche per inalazione

Publications (2)

Publication Number Publication Date
DE3787502D1 true DE3787502D1 (de) 1993-10-28
DE3787502T2 DE3787502T2 (de) 1994-01-20

Family

ID=11159814

Family Applications (2)

Application Number Title Priority Date Filing Date
DE198787901468T Pending DE258356T1 (de) 1986-03-04 1987-02-27 Pharmazeutische zusammensetzungen zum einatmen.
DE87901468T Expired - Fee Related DE3787502T2 (de) 1986-03-04 1987-02-27 Pharmazeutische zusammensetzungen zum einatmen.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE198787901468T Pending DE258356T1 (de) 1986-03-04 1987-02-27 Pharmazeutische zusammensetzungen zum einatmen.

Country Status (17)

Country Link
EP (2) EP0239798B1 (de)
JP (1) JPS63502895A (de)
KR (1) KR940000099B1 (de)
AT (1) ATE94755T1 (de)
AU (1) AU597964B2 (de)
CA (1) CA1297012C (de)
DE (2) DE258356T1 (de)
ES (1) ES2031839T3 (de)
FI (1) FI90015C (de)
GR (2) GR880300017T1 (de)
HU (1) HU202748B (de)
IT (1) IT1204826B (de)
MY (1) MY102928A (de)
NO (1) NO874590L (de)
NZ (1) NZ219484A (de)
WO (1) WO1987005213A1 (de)
ZA (1) ZA871523B (de)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208226A (en) * 1989-09-08 1993-05-04 Glaxo Group Limited Medicaments
US5270305A (en) * 1989-09-08 1993-12-14 Glaxo Group Limited Medicaments
US5376386A (en) * 1990-01-24 1994-12-27 British Technology Group Limited Aerosol carriers
GB9001635D0 (en) * 1990-01-24 1990-03-21 Ganderton David Aerosol carriers
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
JPH0558911A (ja) * 1991-08-27 1993-03-09 N D Shinyaku Kaihatsu Kenkyusho:Kk 鎮咳去痰剤
US6794357B1 (en) 1993-06-24 2004-09-21 Astrazeneca Ab Compositions for inhalation
US6632456B1 (en) 1993-06-24 2003-10-14 Astrazeneca Ab Compositions for inhalation
US5830853A (en) 1994-06-23 1998-11-03 Astra Aktiebolag Systemic administration of a therapeutic preparation
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
AUPM411494A0 (en) * 1994-02-25 1994-03-24 Central Sydney Area Health Service Method and device for the provocation of upper or lower airway narrowing and/or the induction of sputum
GB9404945D0 (en) 1994-03-15 1994-04-27 Glaxo Group Ltd Pharmaceutical composition
DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
US6524557B1 (en) 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
SE9404468D0 (sv) * 1994-12-22 1994-12-22 Astra Ab Powder formulations
CA2206782C (en) 1994-12-22 2007-04-03 Astra Aktiebolag Aerosol drug formulations
GB9501841D0 (en) 1995-01-31 1995-03-22 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9515182D0 (en) * 1995-07-24 1995-09-20 Co Ordinated Drug Dev Improvements in and relating to powders for use in dry powder inhalers
US6503537B2 (en) * 1997-03-20 2003-01-07 Schering Corporation Preparation of powder agglomerates
US6599883B1 (en) * 1998-10-30 2003-07-29 Nastech Pharmaceutical Company, Inc. Nasal delivery of xylitol
ES2192866T3 (es) * 1998-11-13 2003-10-16 Jago Res Ag Polvo seco para inhalacion.
ATE363892T1 (de) * 1999-03-05 2007-06-15 Chiesi Farma Spa Verbesserte pulverformulierungen zur inhalation
ITMI991582A1 (it) 1999-07-16 2001-01-16 Chiesi Farma Spa Polveri costituite da particelle aventi la superficie perfettamente levigata da utilizzare come veicoli per la preparazione di miscele inala
GB0009469D0 (en) 2000-04-17 2000-06-07 Vectura Ltd Improvements in or relating to formalities for use in inhaler devices
PE20011227A1 (es) 2000-04-17 2002-01-07 Chiesi Farma Spa Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros
DK1296651T3 (da) * 2000-06-27 2008-02-11 Vectura Ltd Fremgangsmåde til fremstilling af partikler til anvendelse i et farmaceutisk præparat
EP1296651B2 (de) 2000-06-27 2019-07-17 Vectura Limited Herstellungsverfahren für partikel zur verwendung in einer arzneizusammensetzung
US8048451B2 (en) 2000-11-30 2011-11-01 Vectura Limited Pharmaceutical compositions for inhalation
EP1337241B1 (de) † 2000-11-30 2008-01-02 Vectura Limited Verfahren zur vorbereitung von mikropartikeln zur verwendung in pharmazeutischen zusammensetzungen zur inhalation
EP2168571B1 (de) 2000-11-30 2018-08-22 Vectura Limited Inhalierbare Arzneizusammensetzung
US6681768B2 (en) 2001-06-22 2004-01-27 Sofotec Gmbh & Co. Kg Powder formulation disintegrating system and method for dry powder inhalers
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
US8337816B2 (en) 2001-09-17 2012-12-25 Glaxo Group Limited Dry powder medicament formulations
EP1417961A1 (de) * 2002-11-08 2004-05-12 Boehringer Ingelheim International GmbH Neue pharmazeutische Zubereitung enthaltend eine Kombination von Ambroxol oder Bromhexin und Isopropamid Jodid
EP1643973A1 (de) * 2003-07-11 2006-04-12 Glaxo Group Limited Pharmazeutische zusammensetzungen enthaltend magnesiumstearat
TW200519108A (en) 2003-07-17 2005-06-16 Glaxo Group Ltd Muscarinic acetylcholine receptor antagonists
KR20080067023A (ko) 2003-10-14 2008-07-17 글락소 그룹 리미티드 무스카린성 아세틸콜린 수용체 길항제
US7507747B2 (en) 2003-10-17 2009-03-24 Glaxo Group Limited Muscarinic acetylcholine receptor antagonists
AR046225A1 (es) 2003-11-04 2005-11-30 Glaxo Group Ltd Compuesto de 8-azoniabiciclo(3.2.1)octano, composicion farmaceutica para el tratamiento de enfermedades mediadas por receptores de acetilcolina muscarinicos que lo comprende y uso del compuesto para preparar dicha composicion
GB0326632D0 (en) 2003-11-14 2003-12-17 Jagotec Ag Dry powder formulations
EP1725564A4 (de) 2004-03-17 2007-09-12 Glaxo Group Ltd Antagonisten des m3-muscarinischen acetylcholinrezeptors
AR050902A1 (es) 2004-04-27 2006-12-06 Glaxo Group Ltd Compuesto de quinuclidina, composicion farmaceutica que lo comprende y su usopara preparar dicha composicion
JP2007537261A (ja) 2004-05-13 2007-12-20 グラクソ　グループ　リミテッド ムスカリン性アセチルコリン受容体アンタゴニスト
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
WO2006125132A2 (en) 2005-05-18 2006-11-23 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
JP2009504768A (ja) 2005-08-18 2009-02-05 グラクソ グループ リミテッド ムスカリン性アセチルコリン受容体アンタゴニスト
GB0525254D0 (en) 2005-12-12 2006-01-18 Jagotec Ag Powder compositions for inhalation
US7832397B2 (en) 2005-12-28 2010-11-16 Philip Morris Usa Inc. Aerosol powder delivery device
GB0605723D0 (en) * 2006-03-23 2006-05-03 3M Innovative Properties Co Powder filling processes
JP2012505223A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 薬物動態の改善のためのエアゾールフルオロキノロン配合物
JP2012505222A (ja) 2008-10-07 2012-03-01 エムペックス・ファーマシューティカルズ・インコーポレーテッド 肺炎症を低減するためのレボフロキサシンの吸入
LT3578169T (lt) 2009-02-26 2024-08-26 Glaxo Group Limited Farmaciniai preparatai, apimantys 4-{(1r)-2-[(6-{2-[(2,6-dichlorbenzil) oksi]etoksi}heksil)amino]-1-hidroksietil}-2-(hidroksimetil)fenolį
KR20120100904A (ko) 2009-09-04 2012-09-12 엠펙스 파마슈티컬즈, 인코포레이티드 낭포성 섬유증을 치료하기 위한 에어로졸화된 레보플록사신의 용도
GB0918249D0 (en) 2009-10-19 2009-12-02 Respivert Ltd Compounds
GB0921075D0 (en) 2009-12-01 2010-01-13 Glaxo Group Ltd Novel combination of the therapeutic agents
AU2011244384B2 (en) * 2010-04-21 2016-06-23 Chiesi Farmaceutici S.P.A. "Process for providing particles with reduced electrostatic charges"
TR201007250A2 (tr) 2010-09-01 2012-03-21 Bi̇lgi̇ç Mahmut Selobioz içeren formülasyon.
UY33337A (es) 2010-10-18 2011-10-31 Respivert Ltd DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS
LT2670242T (lt) 2011-01-31 2022-06-27 Avalyn Pharma Inc. Aerozoliniai pirfenidono ir piridono anologų junginiai, ir jų panaudojimas
ES2650791T3 (es) 2012-03-13 2018-01-22 Respivert Limited Estabilización de composiciones farmacéuticas
EP2641900A1 (de) 2012-03-20 2013-09-25 Almirall, S.A. Neuartige polymorphe Kristallformen von 5-(2-{[6-(2,2-difluor-2-phenylethoxy)hexyl]amino}-1-hydroxyethyl)-8-hydroxychinolin-2(1H)-on, Heminapadisylat als Agonist des beta2-adrenergen Rezeptors
NZ703866A (en) 2012-07-19 2016-05-27 Adamis Pharmaceuticals Corp Powder feeding apparatus
GB201305825D0 (en) 2013-03-28 2013-05-15 Vectura Ltd New use
EP3782604A1 (de) 2013-07-31 2021-02-24 Windward Pharma, Inc. Tyrosinkinase-inhibitor-aerosolverbindungen und verwendungen davon
NZ722927A (en) 2014-01-10 2022-07-29 Avalyn Pharma Inc Aerosol pirfenidone and pyridone analog compounds and uses thereof
DE102016218604A1 (de) 2016-09-27 2018-03-29 Constantin Adams Partikuläres Stoffgemisch, vorzugsweise zur Verwendung bei der Prophylaxe und/oder Behandlung einer Atemwegsstörung
WO2022240897A1 (en) 2021-05-10 2022-11-17 Sepelo Therapeutics, Llc Pharmaceutical composition comprising delafloxacin for administration into the lung
WO2023028364A1 (en) 2021-08-27 2023-03-02 Sepelo Therapeutics, Llc Targeted compositions and uses therof
WO2023128916A1 (en) * 2021-12-31 2023-07-06 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi An apparatus with a grid (10) for the preparation of dry powder compositions for inhalation

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957965A (en) * 1967-08-08 1976-05-18 Fisons Limited Sodium chromoglycate inhalation medicament
DE3012136C2 (de) * 1980-03-28 1984-02-16 Bauer, Kurt Heinz, Prof. Dr., 7800 Freiburg Verfahren zur Herstellung eines Granulats

Also Published As

Publication number Publication date
WO1987005213A1 (en) 1987-09-11
EP0239798A1 (de) 1987-10-07
EP0239798B1 (de) 1990-09-26
HUT46533A (en) 1988-11-28
KR940000099B1 (ko) 1994-01-05
NZ219484A (en) 1989-10-27
EP0258356A1 (de) 1988-03-09
FI874710A0 (fi) 1987-10-26
GR3000879T3 (en) 1991-11-15
ATE94755T1 (de) 1993-10-15
GR880300017T1 (en) 1988-10-18
MY102928A (en) 1993-03-31
DE3787502T2 (de) 1994-01-20
NO874590D0 (no) 1987-11-03
EP0258356B1 (de) 1993-09-22
HU202748B (en) 1991-04-29
IT8619625A0 (it) 1986-03-04
AU7164587A (en) 1987-09-28
DE258356T1 (de) 1988-09-01
ZA871523B (en) 1987-08-24
CA1297012C (en) 1992-03-10
FI90015B (fi) 1993-09-15
JPS63502895A (ja) 1988-10-27
ES2031839T3 (es) 1993-01-01
NO874590L (no) 1987-12-30
IT1204826B (it) 1989-03-10
FI874710L (fi) 1987-10-26
KR880700666A (ko) 1988-04-11
AU597964B2 (en) 1990-06-14
FI90015C (fi) 1993-12-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee