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DE3787044D1 - Transformant einer tierischen zelle, verfahren zur herstellung des transformanten und dessen verwendung zur praeparation eines gewuenschten fremdgenproduktes. - Google Patents

Transformant einer tierischen zelle, verfahren zur herstellung des transformanten und dessen verwendung zur praeparation eines gewuenschten fremdgenproduktes.

Info

Publication number
DE3787044D1
DE3787044D1 DE8787304152T DE3787044T DE3787044D1 DE 3787044 D1 DE3787044 D1 DE 3787044D1 DE 8787304152 T DE8787304152 T DE 8787304152T DE 3787044 T DE3787044 T DE 3787044T DE 3787044 D1 DE3787044 D1 DE 3787044D1
Authority
DE
Germany
Prior art keywords
transformant
transformer
preparing
producing
gene product
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787304152T
Other languages
English (en)
Other versions
DE3787044T2 (de
Inventor
Noboru Tomioka
Fumio Omae
Eriko Mine
Tomoko Ishii
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Toatsu Chemicals Inc
Original Assignee
Mitsui Toatsu Chemicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Toatsu Chemicals Inc filed Critical Mitsui Toatsu Chemicals Inc
Application granted granted Critical
Publication of DE3787044D1 publication Critical patent/DE3787044D1/de
Publication of DE3787044T2 publication Critical patent/DE3787044T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DE87304152T 1986-05-10 1987-05-11 Transformant einer tierischen Zelle, Verfahren zur Herstellung des Transformanten und dessen Verwendung zur Präparation eines gewünschten Fremdgenproduktes. Expired - Fee Related DE3787044T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61105824A JP2585532B2 (ja) 1986-05-10 1986-05-10 動物細胞の形質転換体及びそれを得る方法並びにその形質転換体を用いてｔ−ＰＡを生産する方法

Publications (2)

Publication Number Publication Date
DE3787044D1 true DE3787044D1 (de) 1993-09-23
DE3787044T2 DE3787044T2 (de) 1993-12-09

Family

ID=14417809

Family Applications (1)

Application Number Title Priority Date Filing Date
DE87304152T Expired - Fee Related DE3787044T2 (de) 1986-05-10 1987-05-11 Transformant einer tierischen Zelle, Verfahren zur Herstellung des Transformanten und dessen Verwendung zur Präparation eines gewünschten Fremdgenproduktes.

Country Status (9)

Country Link
US (1) US5219738A (de)
EP (1) EP0246049B1 (de)
JP (1) JP2585532B2 (de)
AU (1) AU599977B2 (de)
DE (1) DE3787044T2 (de)
DK (1) DK235587A (de)
FI (1) FI872013A (de)
NO (1) NO871912L (de)
ZA (1) ZA873211B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550036A (en) * 1986-04-09 1996-08-27 Eli Lilly And Company Method for co-amplification of human protein C genes in human cells
EP0319206A3 (de) * 1987-11-30 1990-04-18 Berlex Laboratories, Inc. Gen-Vermehrung
EP0555203B1 (de) * 1988-12-08 1995-10-18 Abbott Laboratories Verfahren zur induzierbaren genexpression unter verwendung eines dhfr-gens
MX2011009023A (es) 2009-02-27 2011-09-28 Novartis Ag Metodos para seleccionar celulas eucarioticas que expresan una proteina heterologa.
SG11201510625TA (en) 2013-07-31 2016-02-26 Novartis Ag Novel selection vectors and methods of selecting eukaryotic host cells
US11242551B2 (en) 2013-12-20 2022-02-08 Novartis Ag Eukaryotic cells and methods for recombinantly expressing a product of interest
AU2014369175B2 (en) 2013-12-20 2017-03-02 Novartis Ag Novel eukaryotic cells and methods for recombinantly expressing a product of interest
JP6245299B2 (ja) * 2016-04-27 2017-12-13 バクスアルタ ゲーエムベーハー 組換え安定細胞クローン、その産生およびその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE223230C (de) *
US4399216A (en) * 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
AU2353384A (en) * 1983-01-19 1984-07-26 Genentech Inc. Amplification in eukaryotic host cells
IE56716B1 (en) * 1983-01-19 1991-11-20 Genentech Inc Method for producing human tpa and expression vectors therefor
US4713339A (en) * 1983-01-19 1987-12-15 Genentech, Inc. Polycistronic expression vector construction
US4965199A (en) * 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
IL71691A (en) * 1984-04-27 1991-04-15 Yeda Res & Dev Production of interferon-ypsilon
GB2183662B (en) * 1985-04-01 1989-01-25 Celltech Ltd Transformed myeloma cell-line and a process for the expression of a gene coding for a eukaryotic polypeptide employing same
JPH0714341B2 (ja) * 1985-11-20 1995-02-22 鐘淵化学工業株式会社 蛋白質の高生産株の取得方法

Also Published As

Publication number Publication date
JP2585532B2 (ja) 1997-02-26
ZA873211B (en) 1987-10-28
NO871912D0 (no) 1987-05-08
AU599977B2 (en) 1990-08-02
DK235587D0 (da) 1987-05-08
NO871912L (no) 1987-11-11
DE3787044T2 (de) 1993-12-09
US5219738A (en) 1993-06-15
FI872013A0 (fi) 1987-05-06
AU7265087A (en) 1987-11-12
FI872013A (fi) 1987-11-11
EP0246049A1 (de) 1987-11-19
EP0246049B1 (de) 1993-08-18
DK235587A (da) 1987-11-11
JPS62262988A (ja) 1987-11-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee