DE3786229D1 - Prolinalderivate. - Google Patents

Prolinalderivate.

Info

Publication number: DE3786229D1
Authority: DE; Germany
Prior art keywords: prolinal derivatives; prolinal; derivatives
Prior art date: 1986-11-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE8787116613T

Other languages

English (en)

Other versions

DE3786229T2 (de

Inventor

Masaaki Toda

Shuichi Ohuchida

Hiroyuki Ohno

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ono Pharmaceutical Co Ltd

Original Assignee

Ono Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-11-20

Filing date

1987-11-10

Publication date

1993-07-22

1987-11-10 Application filed by Ono Pharmaceutical Co Ltd filed Critical Ono Pharmaceutical Co Ltd

1993-07-22 Publication of DE3786229D1 publication Critical patent/DE3786229D1/de

1993-10-07 Application granted granted Critical

1993-10-07 Publication of DE3786229T2 publication Critical patent/DE3786229T2/de

2007-11-11 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyrrole Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE87116613T 1986-11-20 1987-11-10 Prolinalderivate. Expired - Fee Related DE3786229T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP27537586		1986-11-20
JP22845287		1987-09-14

Publications (2)

Publication Number	Publication Date
DE3786229D1 true DE3786229D1 (de)	1993-07-22
DE3786229T2 DE3786229T2 (de)	1993-10-07

Family

ID=26528260

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE87116613T Expired - Fee Related DE3786229T2 (de)	1986-11-20	1987-11-10	Prolinalderivate.

Country Status (6)

Country	Link
US (3)	US4956380A (de)
EP (1)	EP0268190B1 (de)
JP (1)	JPH064583B2 (de)
KR (1)	KR950013849B1 (de)
DE (1)	DE3786229T2 (de)
ES (1)	ES2058089T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0268190B1 (de) *	1986-11-20	1993-06-16	Ono Pharmaceutical Co., Ltd.	Prolinalderivate
ES2046195T3 (es) *	1986-12-29	1994-02-01	Ono Pharmaceutical Co., Ltd.	Un procedimiento para la preparacion de los derivados de prolinal.
US5262431A (en) *	1986-12-29	1993-11-16	Ono Pharmaceutical Co., Ltd.	Prolinal derivatives and pharmaceutical compositions thereof
EP0277588B1 (de) *	1987-02-04	1993-03-24	Ono Pharmaceutical Co., Ltd.	Prolinalderivate
US5212191A (en) *	1988-04-08	1993-05-18	Ono Pharmaceutical Co., Ltd.	Heterocyclic compounds
US5053414A (en) *	1988-04-08	1991-10-01	Ono Pharmaceutical Co., Ltd.	Heterocyclic compounds
US5118811A (en) *	1989-04-13	1992-06-02	Japan Tobacco Inc.	Amino acid derivatives possessing prolyl endopeptidase-inhibitory activities
WO1991018891A1 (en) *	1990-06-04	1991-12-12	Pfizer Inc.	Aromatic pyrrolidine and thiazolidine amides
EP0468469A2 (de) *	1990-07-27	1992-01-29	Japan Tobacco Inc.	Prolinderivate
US5506256A (en) *	1990-07-27	1996-04-09	Yoshitomi Pharmaceutical Industries, Ltd.	Proline derivatives possessing prolyl endopeptidase-inhibitory activity
FR2703050B1 (fr) *	1993-03-24	1995-04-28	Adir	Nouveaux dérivés bicycliques azotés, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
US6348488B1 (en)	1998-10-02	2002-02-19	Ono Pharmaceutical Co., Ltd.	Remedies for motor dysfunction and GAPDH expression inhibitors
US6121311A (en) *	1999-04-28	2000-09-19	Japan Tobacco Inc.	Method for treating cocainism
NZ534757A (en)	2002-03-12	2006-07-28	Merck & Co Inc	Substituted amides
WO2004098591A2 (en)	2003-05-05	2004-11-18	Probiodrug Ag	Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases
ZA200603165B (en)	2003-11-03	2007-07-25	Probiodrug Ag	Combinations useful for the treatment of neuronal disorders
WO2006058720A2 (en)	2003-11-03	2006-06-08	Probiodrug Ag	Novel compounds for the treatment of neurological disorders
CA2554809C (en)	2004-02-05	2014-04-29	Probiodrug Ag	Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase
US8278345B2 (en)	2006-11-09	2012-10-02	Probiodrug Ag	Inhibitors of glutaminyl cyclase
DK2091948T3 (da)	2006-11-30	2012-07-23	Probiodrug Ag	Nye inhibitorer af glutaminylcyclase
AU2008220785B2 (en)	2007-03-01	2013-02-21	Vivoryon Therapeutics N.V.	New use of glutaminyl cyclase inhibitors
ES2533484T3 (es)	2007-04-18	2015-04-10	Probiodrug Ag	Derivados de tiourea como inhibidores de la glutaminil ciclasa
US8486940B2 (en)	2009-09-11	2013-07-16	Probiodrug Ag	Inhibitors
US9181233B2 (en)	2010-03-03	2015-11-10	Probiodrug Ag	Inhibitors of glutaminyl cyclase
DK2545047T3 (da)	2010-03-10	2014-07-28	Probiodrug Ag	Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en)	2010-04-21	2011-10-27	Probiodrug Ag	Novel inhibitors
WO2012123563A1 (en)	2011-03-16	2012-09-20	Probiodrug Ag	Benz imidazole derivatives as inhibitors of glutaminyl cyclase
ES2812698T3 (es)	2017-09-29	2021-03-18	Probiodrug Ag	Inhibidores de glutaminil ciclasa

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0080822A1 (de) *	1981-11-27	1983-06-08	Beecham Group Plc	Antihypertensive auf Prolin basierende Peptide
JPS60188317A (ja) *	1984-03-09	1985-09-25	Yakult Honsha Co Ltd	抗健忘症剤
JPS6137764A (ja) *	1984-07-31	1986-02-22	Suntory Ltd	抗プロリルエンドペプチダ−ゼ活性を有する新規生理活性化合物
JPH0680077B2 (ja) *	1985-02-08	1994-10-12	サントリー株式会社	プロリンエンドペプチダ−ゼインヒビタ−活性を有する新規ペプチド化合物
US4772587A (en) *	1985-04-16	1988-09-20	Suntory Limited	Dipeptide derivative of fatty acid
JPH0623191B2 (ja) *	1985-04-16	1994-03-30	サントリー株式会社	ペプチダ−ゼ阻害活性化合物およびその製法ならびに用途
US4873342A (en) *	1985-04-16	1989-10-10	Suntory Limited	Dipeptide derivative and synthesis and use thereof
JPH0623190B2 (ja) *	1985-04-16	1994-03-30	サントリー株式会社	インヒビタ−活性を有するｎ−アシルピロリジン誘導体及びその製法並びに用途
EP0268190B1 (de) *	1986-11-20	1993-06-16	Ono Pharmaceutical Co., Ltd.	Prolinalderivate
JP2589163B2 (ja) *	1988-09-28	1997-03-12	日東化成株式会社	非対称トリオルガノ錫ハライドの製法

1987
- 1987-11-10 EP EP87116613A patent/EP0268190B1/de not_active Expired - Lifetime
- 1987-11-10 ES ES87116613T patent/ES2058089T3/es not_active Expired - Lifetime
- 1987-11-10 DE DE87116613T patent/DE3786229T2/de not_active Expired - Fee Related
- 1987-11-19 JP JP62290631A patent/JPH064583B2/ja not_active Expired - Fee Related
- 1987-11-20 US US07/123,410 patent/US4956380A/en not_active Expired - Lifetime
- 1987-11-20 KR KR1019870013053A patent/KR950013849B1/ko not_active Expired - Fee Related
1990
- 1990-06-05 US US07/533,648 patent/US5100904A/en not_active Expired - Lifetime
1993
- 1993-08-17 US US08/107,314 patent/US5340832A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5100904A (en)	1992-03-31
JPH01156957A (ja)	1989-06-20
JPH064583B2 (ja)	1994-01-19
DE3786229T2 (de)	1993-10-07
EP0268190A1 (de)	1988-05-25
EP0268190B1 (de)	1993-06-16
KR880006190A (ko)	1988-07-22
ES2058089T3 (es)	1994-11-01
US5340832A (en)	1994-08-23
KR950013849B1 (ko)	1995-11-17
US4956380A (en)	1990-09-11

Publication	Publication Date	Title
DE3786229D1 (de)	1993-07-22	Prolinalderivate.
MX8358A (es)	1993-12-01	Derivados de sacarosa.
IT8619169A0 (it)	1986-01-23	Azolilderivati fungicidi.
FI870474A7 (fi)	1987-08-08	Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat.
FI871632A0 (fi)	1987-04-14	Heterocykliska karboxamider.
DE3787815D1 (de)	1993-11-25	Azetidinonderivate.
DE3777997D1 (de)	1992-05-07	Piperidinderivate.
DE3761308D1 (de)	1990-02-08	18-phenylestrane-derivate.
DE3872153D1 (de)	1992-07-23	25-hydroxy-vitamin-d3-derivate.
FI874492A7 (fi)	1988-04-14	3-propenylcefemderivat.
FI883963A7 (fi)	1989-03-01	Isoxazol- -karbolinderivat.
DE3787042D1 (de)	1993-09-23	Tripeptid-derivate.
DE3778624D1 (de)	1992-06-04	Glucosylmoranoline-derivate.
FI872566A7 (fi)	1987-12-10	Fusionerade heterocykliska imidazofoereningar.
DE3881755D1 (de)	1993-07-22	Pyrrolidin-derivate.
FI880814A7 (fi)	1988-09-11	Imidazodiazepin-derivat.
IT8622828A0 (it)	1986-12-23	Azolilderivati fungicidi.
FI893041L (fi)	1989-06-21	Substituerade azacyklohexylderivat.
ATE78251T1 (de)	1992-08-15	Indenopyrimidin-derivate.
DE3781831D1 (de)	1992-10-29	Aralkylimidazolderivate.
DE3774759D1 (de)	1992-01-09	Alkenamid-derivate.
DE3861208D1 (de)	1991-01-17	Hydroxyalkyl-triazolyl-derivate.
FI881802L (fi)	1988-10-18	Tiadiazolylacetamidocefemderivat.
FI885920L (fi)	1989-06-23	Piperidinylcyklopentylheptensyra -derivat innehaollande vattenhaltiga sammansaettningar.
DE3785480D1 (de)	1993-05-27	Macrolid-derivate.

Legal Events

Date	Code	Title	Description
1994-07-14	8364	No opposition during term of opposition
2004-09-23	8339	Ceased/non-payment of the annual fee