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DE3780726D1 - Verfahren und zwischenverbindungen fuer n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine. - Google Patents

Verfahren und zwischenverbindungen fuer n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine.

Info

Publication number
DE3780726D1
DE3780726D1 DE8787307492T DE3780726T DE3780726D1 DE 3780726 D1 DE3780726 D1 DE 3780726D1 DE 8787307492 T DE8787307492 T DE 8787307492T DE 3780726 T DE3780726 T DE 3780726T DE 3780726 D1 DE3780726 D1 DE 3780726D1
Authority
DE
Germany
Prior art keywords
alkyl
glycyl
glutamyl
alanine
gamma
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787307492T
Other languages
English (en)
Other versions
DE3780726T2 (de
Inventor
Charles William Murtiashaw
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of DE3780726D1 publication Critical patent/DE3780726D1/de
Application granted granted Critical
Publication of DE3780726T2 publication Critical patent/DE3780726T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/353Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by isomerisation; by change of size of the carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58Preparation of carboxylic acid halides
    • C07C51/60Preparation of carboxylic acid halides by conversion of carboxylic acids or their anhydrides or esters, lactones, salts into halides with the same carboxylic acid part
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/58Preparation of carboxylic acid halides
    • C07C51/62Preparation of carboxylic acid halides by reactions not involving the carboxylic acid halide group
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/27Preparation of carboxylic acid esters from ortho-esters
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00Preparation of carboxylic acid esters
    • C07C67/30Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/303Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by hydrogenation of unsaturated carbon-to-carbon bonds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/533Monocarboxylic acid esters having only one carbon-to-carbon double bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE8787307492T 1986-08-27 1987-08-25 Verfahren und zwischenverbindungen fuer n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine. Expired - Lifetime DE3780726T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1986/001772 WO1988001612A1 (en) 1986-08-27 1986-08-27 Processes and intermediates for n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine

Publications (2)

Publication Number Publication Date
DE3780726D1 true DE3780726D1 (de) 1992-09-03
DE3780726T2 DE3780726T2 (de) 1992-12-17

Family

ID=22195617

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787307492T Expired - Lifetime DE3780726T2 (de) 1986-08-27 1987-08-25 Verfahren und zwischenverbindungen fuer n-(s-3-alkyl-heptanoyl)-d-gamma-glutamyl-glycyl-d-alanine.

Country Status (11)

Country Link
EP (1) EP0258032B1 (de)
AT (2) ATE78828T1 (de)
AU (1) AU589543B2 (de)
DE (1) DE3780726T2 (de)
ES (1) ES2042572T3 (de)
FI (1) FI890885A (de)
GR (1) GR3005495T3 (de)
IE (1) IE60040B1 (de)
NO (1) NO881811L (de)
WO (1) WO1988001612A1 (de)
ZA (1) ZA876354B (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295784C (en) * 1985-11-25 1992-02-11 James Patrick Rizzi Peptide immunostimulants

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US45475A (en) * 1864-12-20 Improved submarine port-hole
US3985722A (en) * 1973-12-12 1976-10-12 Ajinomoto Co., Inc. Process for preparing N-higher aliphatic acyl derivatives of amino acids, peptides or proteins
US4113968A (en) * 1974-10-03 1978-09-12 Kuraray Co., Ltd. Process for preparation of substituted cyclopropane carboxylic acids and esters thereof and intermediates of said acids and esters
US4374264A (en) * 1980-06-02 1983-02-15 Ici Australia Limited Process for the preparation of γ-unsaturated carboxylates
FR2496654A1 (fr) * 1980-12-19 1982-06-25 Rhone Poulenc Sante Nouveaux tri-, tetra- et pentapeptides, leur preparation et les medicaments qui les contiennent
JPS57144276A (en) * 1981-03-03 1982-09-06 Toray Ind Inc 5,6,7-trinor-4,8-inter-m-phenylene pgi2 derivative
US4565653A (en) * 1984-03-30 1986-01-21 Pfizer Inc. Acyltripeptide immunostimulants
EP0191079B1 (de) * 1984-08-29 1989-03-15 Optische Werke G. Rodenstock Projektionseinrichtung für einen leitstrahl
DE3665593D1 (en) * 1985-11-25 1989-10-19 Pfizer Peptide immunostimulants
WO1988001613A1 (en) * 1986-08-27 1988-03-10 Pfizer Inc. Crystalline n-(s-3-methylheptanoyl)-d-gamma-glutamyl-glycyl-d-alanine, and processes and intermediates therefor

Also Published As

Publication number Publication date
NO881811D0 (no) 1988-04-26
NO881811L (no) 1988-04-26
EP0258032A3 (en) 1989-10-11
GR3005495T3 (de) 1993-05-24
FI890885A0 (fi) 1989-02-24
ZA876354B (en) 1989-03-29
ATA262887A (de) 1988-06-15
AU589543B2 (en) 1989-10-12
IE872278L (en) 1988-02-27
ES2042572T3 (es) 1993-12-16
ATE78828T1 (de) 1992-08-15
AU7746287A (en) 1988-03-03
WO1988001612A1 (en) 1988-03-10
AT387380B (de) 1989-01-10
DE3780726T2 (de) 1992-12-17
EP0258032B1 (de) 1992-07-29
FI890885A (fi) 1989-02-24
EP0258032A2 (de) 1988-03-02
IE60040B1 (en) 1994-05-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee