DE3750846D1 - Mitomycin-derivate. - Google Patents

Mitomycin-derivate.

Info

Publication number: DE3750846D1
Authority: DE; Germany
Prior art keywords: mitomycin derivatives; mitomycin; derivatives
Prior art date: 1986-08-29
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE3750846T

Other languages

English (en)

Other versions

DE3750846T2 (de

Inventor

Motomichi Kono

Yutaka Saito

Yutaka Kanda

Masaji - - Kasai

Akira Sato

Makoto Morimoto

Tadashi Ashizawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

KH Neochem Co Ltd

Original Assignee

Kyowa Hakko Kogyo Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-08-29

Filing date

1987-08-28

Publication date

1995-01-19

1987-08-28 Application filed by Kyowa Hakko Kogyo Co Ltd filed Critical Kyowa Hakko Kogyo Co Ltd

1995-01-19 Publication of DE3750846D1 publication Critical patent/DE3750846D1/de

1995-05-11 Application granted granted Critical

1995-05-11 Publication of DE3750846T2 publication Critical patent/DE3750846T2/de

2007-08-29 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DE3750846T 1986-08-29 1987-08-28 Mitomycin-derivate. Expired - Fee Related DE3750846T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP20323086		1986-08-29
PCT/JP1987/000640 WO1988001622A1 (en)	1986-08-29	1987-08-28	Mitomycin derivatives

Publications (2)

Publication Number	Publication Date
DE3750846D1 true DE3750846D1 (de)	1995-01-19
DE3750846T2 DE3750846T2 (de)	1995-05-11

Family

ID=16470603

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE3750846T Expired - Fee Related DE3750846T2 (de)	1986-08-29	1987-08-28	Mitomycin-derivate.

Country Status (5)

Country	Link
US (1)	US5103018A (de)
EP (1)	EP0280741B1 (de)
DE (1)	DE3750846T2 (de)
HK (1)	HK1001329A1 (de)
WO (1)	WO1988001622A1 (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5629427A (en) *	1993-08-26	1997-05-13	Peterson; Dwight M.	2,7-diaminomitosene analogues
WO2002085908A1 (en)	2001-04-24	2002-10-31	Purdue Research Foundation	Folate mimetics and folate-receptor binding conjugates thereof
SE0101702D0 (sv)	2001-05-15	2001-05-15	Ardenia Investments Ltd	Novel potentiating compounds
AUPR644301A0 (en) *	2001-07-17	2001-08-09	Unisearch Limited	Method and composition for treatment of cancer
DE60326833D1 (de) *	2002-05-15	2009-05-07	Endocyte Inc	Vitamin-mitomycin-konjugate
EP1592457B1 (de)	2003-01-27	2012-07-25	Endocyte, Inc.	Folat-vinblastin konjugat als arzneimittel
JP5149620B2 (ja)	2004-07-23	2013-02-20	エンドサイト，インコーポレイテッド	２価リンカーおよびその結合体
EP1863816B1 (de)	2005-03-16	2014-06-25	Endocyte, Inc.	Synthese und aufreinigung von pteroinsäure und konjugaten davon
CN103893779A (zh)	2005-08-19	2014-07-02	恩多塞特公司	多药物配体缀合物
WO2008101231A2 (en)	2007-02-16	2008-08-21	Endocyte, Inc.	Methods and compositions for treating and diagnosing kidney disease
NZ599239A (en)	2007-03-14	2013-10-25	Endocyte Inc	Binding ligand linked drug delivery conjugates of tubulysins
US9877965B2 (en)	2007-06-25	2018-01-30	Endocyte, Inc.	Vitamin receptor drug delivery conjugates for treating inflammation
JP5690589B2 (ja)	2007-06-25	2015-03-25	エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ，Ｉｎｃ．	親水性スペーサーリンカーを含有する結合体
ES2768224T3 (es)	2007-08-17	2020-06-22	Purdue Research Foundation	Conjugados ligando-enlazador de unión a PSMA y métodos para su uso
JP2011500835A (ja)	2007-10-25	2011-01-06	エンドサイト，インコーポレイテッド	チューブリシン類および調製プロセス
US9951324B2 (en)	2010-02-25	2018-04-24	Purdue Research Foundation	PSMA binding ligand-linker conjugates and methods for using
WO2013126797A1 (en)	2012-02-24	2013-08-29	Purdue Research Foundation	Cholecystokinin b receptor targeting for imaging and therapy
US20140080175A1 (en)	2012-03-29	2014-03-20	Endocyte, Inc.	Processes for preparing tubulysin derivatives and conjugates thereof
JP2015536323A (ja)	2012-10-16	2015-12-21	エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ，Ｉｎｃ．	非天然アミノ酸を含む薬物送達結合体および使用方法
CA2891476C (en)	2012-11-15	2022-07-05	Endocyte, Inc.	Drug delivery conjugates, and methods for treating diseases caused by psma expressing cells
ES2977715T3 (es)	2013-10-18	2024-08-29	Novartis Ag	Inhibidores marcados de antígeno prostático específico de membrana (psma), su uso como agentes formadores de imágenes y agentes farmacéuticos para el tratamiento de cáncer de próstata
BR112016010927A2 (pt)	2013-11-14	2017-08-08	Endocyte Inc	Conjugado de fórmula
US10188759B2 (en)	2015-01-07	2019-01-29	Endocyte, Inc.	Conjugates for imaging
WO2019204335A1 (en)	2018-04-17	2019-10-24	Endocyte, Inc.	Methods of treating cancer
WO2024219743A1 (ko) *	2023-04-17	2024-10-24	동국대학교 산학협력단	삼중음성유방암이 다른 장기로 전이되는 것을 억제하기 위한 자연살해 세포의 표면 개질용 고분자 화합물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59175493A (ja) *	1983-03-25	1984-10-04	Kyowa Hakko Kogyo Co Ltd	マイトマイシン誘導体
JPS59104386A (ja) *	1982-12-07	1984-06-16	Kyowa Hakko Kogyo Co Ltd	マイトマイシン誘導体
KR840008362A (ko) *	1983-04-11	1984-12-14	사무엘 제이. 두보프	아미노 이황산염
JPS60255789A (ja) *	1984-06-01	1985-12-17	Kyowa Hakko Kogyo Co Ltd	マイトマイシン誘導体，その製造法および抗腫瘍剤
US4927943A (en) *	1984-09-04	1990-05-22	Bristol-Myers Company	Substituted 7-oxomitosanes

1987
- 1987-08-28 EP EP87905655A patent/EP0280741B1/de not_active Expired - Lifetime
- 1987-08-28 WO PCT/JP1987/000640 patent/WO1988001622A1/ja active IP Right Grant
- 1987-08-28 US US07/204,429 patent/US5103018A/en not_active Expired - Fee Related
- 1987-08-28 DE DE3750846T patent/DE3750846T2/de not_active Expired - Fee Related
1998
- 1998-01-16 HK HK98100361A patent/HK1001329A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
HK1001329A1 (en)	1998-06-12
EP0280741A1 (de)	1988-09-07
DE3750846T2 (de)	1995-05-11
US5103018A (en)	1992-04-07
EP0280741B1 (de)	1994-12-07
WO1988001622A1 (en)	1988-03-10
EP0280741A4 (de)	1990-02-21

Publication	Publication Date	Title
MX8358A (es)	1993-12-01	Derivados de sacarosa.
DE3750846D1 (de)	1995-01-19	Mitomycin-derivate.
DE3786229D1 (de)	1993-07-22	Prolinalderivate.
DE3767816D1 (de)	1991-03-07	1-acylsubstituierte piperidinderivate.
DE3777997D1 (de)	1992-05-07	Piperidinderivate.
FI904258A0 (fi)	1990-08-29	Mitomycin c stabila loesningar.
DE3761308D1 (de)	1990-02-08	18-phenylestrane-derivate.
DE3872153D1 (de)	1992-07-23	25-hydroxy-vitamin-d3-derivate.
FI883963A0 (fi)	1988-08-26	Isoxazol- -karbolinderivat.
DE3768114D1 (de)	1991-04-04	Phenylpyridinderivate.
DE3787042D1 (de)	1993-09-23	Tripeptid-derivate.
DE3778624D1 (de)	1992-06-04	Glucosylmoranoline-derivate.
DE68914223D1 (de)	1994-05-05	Mitomycinderivate.
FI893041L (fi)	1989-06-21	Substituerade azacyklohexylderivat.
ATE78251T1 (de)	1992-08-15	Indenopyrimidin-derivate.
DE3781831D1 (de)	1992-10-29	Aralkylimidazolderivate.
DE3871836D1 (de)	1992-07-16	Mitomycin-derivate.
DE3774759D1 (de)	1992-01-09	Alkenamid-derivate.
FI861720A (fi)	1986-10-30	Foerfarande foer framstaellning av n7-amidinosubstituerade mitomycin c-derivat.
DE3861208D1 (de)	1991-01-17	Hydroxyalkyl-triazolyl-derivate.
FI885920L (fi)	1989-06-23	Piperidinylcyklopentylheptensyra -derivat innehaollande vattenhaltiga sammansaettningar.
FI881802L (fi)	1988-10-18	Tiadiazolylacetamidocefemderivat.
ATE79874T1 (de)	1992-09-15	Thiazinon-derivate.
DE3785247D1 (de)	1993-05-13	Mitomycin-derivate.
DE3770113D1 (de)	1991-06-20	Mitomycin-derivate.

Legal Events

Date	Code	Title	Description
1996-01-11	8364	No opposition during term of opposition
2002-09-26	8339	Ceased/non-payment of the annual fee