[go: up one dir, main page]

DE3681570D1 - Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. - Google Patents

Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.

Info

Publication number
DE3681570D1
DE3681570D1 DE8686308248T DE3681570T DE3681570D1 DE 3681570 D1 DE3681570 D1 DE 3681570D1 DE 8686308248 T DE8686308248 T DE 8686308248T DE 3681570 T DE3681570 T DE 3681570T DE 3681570 D1 DE3681570 D1 DE 3681570D1
Authority
DE
Germany
Prior art keywords
drug
flux
medical device
administration
period
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686308248T
Other languages
English (en)
Inventor
Robert M Gale
Randall G Berggren
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alza Corp
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Application granted granted Critical
Publication of DE3681570D1 publication Critical patent/DE3681570D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M35/00—Devices for applying media, e.g. remedies, on the human body

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Dermatology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
DE8686308248T 1985-10-30 1986-10-23 Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen. Expired - Fee Related DE3681570D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/792,941 US4698062A (en) 1985-10-30 1985-10-30 Medical device for pulsatile transdermal delivery of biologically active agents

Publications (1)

Publication Number Publication Date
DE3681570D1 true DE3681570D1 (de) 1991-10-24

Family

ID=25158559

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686308248T Expired - Fee Related DE3681570D1 (de) 1985-10-30 1986-10-23 Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.

Country Status (11)

Country Link
US (1) US4698062A (de)
EP (1) EP0227252B1 (de)
JP (1) JPS62129058A (de)
KR (1) KR870003798A (de)
AT (1) ATE67417T1 (de)
AU (1) AU582075B2 (de)
CA (1) CA1275216C (de)
DE (1) DE3681570D1 (de)
ES (1) ES2024423B3 (de)
GR (1) GR3002747T3 (de)
ZA (1) ZA868070B (de)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5135477A (en) * 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
JPS63135179A (ja) * 1986-11-26 1988-06-07 立花　俊郎 薬物の経皮投与具
US4788062A (en) * 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
JPS6425717A (en) * 1987-05-08 1989-01-27 Eastman Kodak Co Method and apparatus for preventing organic nitric acid ester resistance
US5013293A (en) * 1987-05-28 1991-05-07 Drug Delivery Systems Inc. Pulsating transdermal drug delivery system
US5312325A (en) * 1987-05-28 1994-05-17 Drug Delivery Systems Inc Pulsating transdermal drug delivery system
JPH0429618Y2 (de) * 1987-09-11 1992-07-17
IE64726B1 (en) 1987-11-20 1995-08-23 Elan Corp Plc Pharmaceutical formulations for preventing drug tolerance
US4906475A (en) 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
DE3809978A1 (de) * 1988-03-24 1989-10-05 Lohmann Gmbh & Co Kg Reservoir fuer gesteuerte wirkstoffabgabe, dieses enthaltende vorrichtung, sowie verfahren zu deren herstellung und verwendung der vorrichtung
US4927408A (en) * 1988-10-03 1990-05-22 Alza Corporation Electrotransport transdermal system
US5496266A (en) * 1990-04-30 1996-03-05 Alza Corporation Device and method of iontophoretic drug delivery
DE3908432A1 (de) * 1989-03-14 1990-09-27 Lohmann Therapie Syst Lts Pflaster als therapeutisches system zur verabreichung von wirkstoffen an die haut mit einer abgestuften wirkstoffabgabe, verfahren zu seiner herstellung sowie verwendung
DE3908431A1 (de) * 1989-03-15 1990-09-27 Lohmann Therapie Syst Lts Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung
US5028435A (en) * 1989-05-22 1991-07-02 Advanced Polymer Systems, Inc. System and method for transdermal drug delivery
US5091186A (en) * 1989-08-15 1992-02-25 Cygnus Therapeutic Systems Biphasic transdermal drug delivery device
AU647103B2 (en) * 1990-03-30 1994-03-17 Alza Corporation Iontophoretic delivery device
US5207752A (en) * 1990-03-30 1993-05-04 Alza Corporation Iontophoretic drug delivery system with two-stage delivery profile
US5202125A (en) * 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5352456A (en) * 1991-10-10 1994-10-04 Cygnus Therapeutic Systems Device for administering drug transdermally which provides an initial pulse of drug
KR960006859B1 (ko) * 1992-03-06 1996-05-23 주식회사 태평양 티로시나제 저해 활성을 갖는 약물의 안정성을 개선하는 방법
GB2273044B (en) * 1992-12-02 1997-04-09 Pacific Chem Co Ltd Medicinal patches for percutaneous administration
US5613958A (en) * 1993-05-12 1997-03-25 Pp Holdings Inc. Transdermal delivery systems for the modulated administration of drugs
KR960011044B1 (ko) * 1993-09-27 1996-08-16 재단법인 한국화학연구소 알칸올 투과가 우수한 고분자막
DE4423850A1 (de) * 1994-07-07 1996-01-11 Labtec Gmbh Transdermales therapeutisches System zur Applikation von Naloxon
US5902603A (en) * 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US5891461A (en) * 1995-09-14 1999-04-06 Cygnus, Inc. Transdermal administration of olanzapine
US5968547A (en) 1997-02-24 1999-10-19 Euro-Celtique, S.A. Method of providing sustained analgesia with buprenorphine
US6660295B2 (en) 1997-09-30 2003-12-09 Alza Corporation Transdermal drug delivery device package with improved drug stability
US6918901B1 (en) * 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CN1161164C (zh) * 1997-12-11 2004-08-11 阿尔扎有限公司 用于通过体表导入或提取质剂的装置
EP1911488A3 (de) 1997-12-11 2008-12-03 Alza Corporation Vorrichtung zur Verstärkung des Flusses transdermaler Mittel
AU757230B2 (en) 1997-12-11 2003-02-06 Alza Corporation Device for enhancing transdermal agent flux
ES2244106T3 (es) * 1997-12-11 2005-12-01 Alza Corporation Dispositivo para mejorar el flujo transdermico de agentes.
JP4215188B2 (ja) 1997-12-22 2009-01-28 インターシア セラピューティクス，インコーポレイティド 薬剤供給を調節するデバイスのための速度調節膜
US6699497B1 (en) 1998-07-24 2004-03-02 Alza Corporation Formulations for the transdermal administration of fenoldopam
US6348210B1 (en) 1998-11-13 2002-02-19 Alza Corporation Methods for transdermal drug administration
CN1331586A (zh) 1998-12-18 2002-01-16 阿尔扎有限公司 透明的透皮烟碱输送装置
US20070196490A1 (en) * 1999-01-22 2007-08-23 Powderject Research Limited Method of enhancing needleless transdermal powered drug delivery
ATE302598T1 (de) * 1999-04-01 2005-09-15 Alza Corp Transdermale vorrichtung zur arzneistoffverabreichung mit einem polyurethanwirkstoffreservoir
DK1239916T3 (da) 1999-12-10 2006-04-03 Alza Corp Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
US20040029959A1 (en) * 2002-08-08 2004-02-12 John Devane Isosorbide mononitrate compositions and methods of their use
US20040258742A1 (en) * 2003-04-11 2004-12-23 Van Osdol William Woodson Transdermal administration of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methyl guanidines
DE102004062614B4 (de) * 2004-12-24 2011-12-29 Lts Lohmann Therapie-Systeme Ag Transdermales therapeutisches System mit aktivierbarer Übersättigung und kontrollierter Permeationförderung sowie Verfahren zu dessen Herstellung
WO2007031973A2 (en) * 2005-09-15 2007-03-22 Visible Assets, Inc. Active low frequency radio tag and patch drug delivery system
US8518926B2 (en) 2006-04-10 2013-08-27 Knopp Neurosciences, Inc. Compositions and methods of using (R)-pramipexole
WO2007121188A2 (en) * 2006-04-10 2007-10-25 Knopp Neurosciences, Inc. Compositions and methods of using r(+) pramipexole
CN102160865A (zh) * 2006-05-16 2011-08-24 诺普神经科学股份有限公司 R(+)和s(-)普拉克索的组合物以及使用该组合物的方法
US8524695B2 (en) 2006-12-14 2013-09-03 Knopp Neurosciences, Inc. Modified release formulations of (6R)-4,5,6,7-tetrahydro-N6-propyl-2,6-benzothiazole-diamine and methods of using the same
US8519148B2 (en) * 2007-03-14 2013-08-27 Knopp Neurosciences, Inc. Synthesis of chirally purified substituted benzothiazole diamines
AU2008283929B2 (en) * 2007-08-06 2013-10-10 Serenity Pharmaceuticals, Llc Methods and devices for desmopressin drug delivery
CN102186350A (zh) 2008-08-19 2011-09-14 诺普神经科学股份有限公司 使用(r)-普拉克索的组合物与方法
US9387033B2 (en) * 2008-08-28 2016-07-12 Roche Diabetes Care, Inc. Device and method for enhanced subcutaneous insulin absorption
GB0817486D0 (en) * 2008-09-24 2008-10-29 Smith & Nephew Delivery system
MX2011013577A (es) * 2009-06-19 2012-04-10 Knopp Neurosciences Inc Composiciones y metodos para tratar esclerosis lateral amiotrofica.
AU2011311255B2 (en) 2010-04-28 2015-10-08 Sorrento Therapeutics, Inc. Method for increasing permeability of an epithelial barrier
CN102958557B (zh) 2010-04-28 2016-08-03 金伯利-克拉克环球有限公司 其上含有纳米结构的复合微针阵列
EP2563450B1 (de) 2010-04-28 2017-07-26 Kimberly-Clark Worldwide, Inc. Vorrichtung zur verabreichung eines medikaments gegen rheumatoide arthritis
US9522262B2 (en) 2010-04-28 2016-12-20 Kimberly-Clark Worldwide, Inc. Medical devices for delivery of siRNA
AU2012205791B2 (en) 2011-01-10 2016-11-03 Invion, Ltd. Use of beta-adrenergic inverse agonists for smoking cessation
US8696637B2 (en) 2011-02-28 2014-04-15 Kimberly-Clark Worldwide Transdermal patch containing microneedles
CA2850931A1 (en) 2011-10-27 2013-05-02 Kimberly-Clark Worldwide, Inc. Implantable devices for delivery of bioactive agents
US20170246439A9 (en) 2011-10-27 2017-08-31 Kimberly-Clark Worldwide, Inc. Increased Bioavailability of Transdermally Delivered Agents
MX343262B (es) 2011-10-27 2016-10-28 Kimberly Clark Co Administración transdérmica de agentes bioactivos de alta viscosidad.
WO2013096816A1 (en) 2011-12-22 2013-06-27 Biogen Idec Ma Inc. Improved synthesis of amine substituted 4,5,6,7-tetrahydrobenzothiazole compounds
US9675754B2 (en) 2012-10-24 2017-06-13 Nuance Designs, LLC Autoinjector
US9662313B2 (en) 2013-02-28 2017-05-30 Knopp Biosciences Llc Compositions and methods for treating amyotrophic lateral sclerosis in responders
US9682068B2 (en) 2013-05-20 2017-06-20 Mylan Inc. Transdermal therapeutic system for extended dosing of pramipexole in treating neurological disorders
SMT202100119T1 (it) 2013-07-12 2021-05-07 Knopp Biosciences Llc Trattamento dei livelli elevati di eosinofili e/o basofili
US9468630B2 (en) 2013-07-12 2016-10-18 Knopp Biosciences Llc Compositions and methods for treating conditions related to increased eosinophils
PT3033081T (pt) 2013-08-13 2021-06-01 Knopp Biosciences Llc Composições e métodos para o tratamento da urticária crónica
WO2015023786A1 (en) 2013-08-13 2015-02-19 Knopp Biosciences Llc Compositions and methods for treating plasma cell disorders and b-cell prolymphocytic disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US3625214A (en) * 1970-05-18 1971-12-07 Alza Corp Drug-delivery device
US4031894A (en) * 1975-12-08 1977-06-28 Alza Corporation Bandage for transdermally administering scopolamine to prevent nausea
US4291015A (en) * 1979-08-14 1981-09-22 Key Pharmaceuticals, Inc. Polymeric diffusion matrix containing a vasodilator
US4336243A (en) * 1980-08-11 1982-06-22 G. D. Searle & Co. Transdermal nitroglycerin pad
US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4486193A (en) * 1981-07-22 1984-12-04 Alza Corporation Method for treating ischemic conditions by administering drug by two routes
US4576604A (en) * 1983-03-04 1986-03-18 Alza Corporation Osmotic system with instant drug availability
US4559054A (en) * 1984-08-09 1985-12-17 Research Corporation Rate-controlled drug release system
US4615699A (en) * 1985-05-03 1986-10-07 Alza Corporation Transdermal delivery system for delivering nitroglycerin at high transdermal fluxes

Also Published As

Publication number Publication date
CA1275216C (en) 1990-10-16
EP0227252A2 (de) 1987-07-01
EP0227252B1 (de) 1991-09-18
JPS62129058A (ja) 1987-06-11
ZA868070B (en) 1987-06-24
ATE67417T1 (de) 1991-10-15
GR3002747T3 (en) 1993-01-25
AU6432086A (en) 1987-05-07
US4698062A (en) 1987-10-06
ES2024423B3 (es) 1992-03-01
KR870003798A (ko) 1987-05-04
EP0227252A3 (en) 1989-04-05
AU582075B2 (en) 1989-03-09

Similar Documents

Publication Publication Date Title
DE3681570D1 (de) Medizinische einrichtung zur pulsatilen transdermalen verabreichung von biologisch aktiven wirkstoffen.
ES2011185A6 (es) Una forma de dosificacion transdermica para la liberacoon de un farmaco a una velocidad terapeuticamente efectiva .
KR890003413A (ko) 이중 침투증대제를 가진 경피식 약물투여장치
ATE87471T1 (de) Eine fluessige verabreichungsform fuer orale verabreichung einer pharmazeutischen substanz.
ATE108680T1 (de) Therapeutisches system zur verzögerten und gesteuerten transdermalen oder transmucosalen verabreichung von wirkstoffen (ii).
ZA946698B (en) Medical device for the administration of active ingredients or drugs at very low doses particularly homeopathic drugs
LV10196A (lv) Olbaltumviela biologiski aktivais hormons olbaltumvielas iegusanas panemiens farmaceitisks preparats
DE3868037D1 (de) Pharmazeutische zusammensetzung mit verzoegerter wirkstoffabgabe.
EP0570916A3 (de) Menschliches rekombinantes Serum-Albumin, Verfahren zur dessen Herstellung und diese enthaltende pharmazeutischen Präparate.
NO951592L (no) Fremgangsmåte for fremstilling av et transdermalt terapeutisk system
DE69434418D1 (de) Orale Dareichungsform
DK642587A (da) Insulinpraeparat
ATE74519T1 (de) Waessrige loesung von fettloeslichen wirkstoffen.
DE3575076D1 (de) Katheter fuer rueckinfusion von pharmazeutischen agenten.
DE3769707D1 (de) Therapeutisches system mit geregelter wirkstoffabgabe.
NZ320237A (en) Stable pharmaceutical forms of administration containing parathormone
ZA87472B (en) System for delivering drug with enhanced bioacceptability
ATE361772T1 (de) Behalter zur iontophoretischen verabreichung von medikamenten mit inerten material-bestandteilen
DE3787477D1 (de) Nasal applizierbares Arzneimittel, Verfahren zu seiner Herstellung und seine Verwendung.
PT88539A (pt) Stabilisierung von therapeutisch wirksamen proteinen in pharmazeutischen zubereitungen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee