DE3588225D1 - Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung - Google Patents

Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung

Info

Publication number: DE3588225D1
Authority: DE; Germany
Prior art keywords: production; lymphotoxin; antibodies; lymphotoxin antibodies
Prior art date: 1984-05-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE3588225T

Other languages

English (en)

Other versions

DE3588225T2 (de

Inventor

Bharat Bhushan Aggarwal

Patrick William Gray

Timothy Scott Bringman

Glenn Evan Nedwin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Genentech Inc

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-05-31

Filing date

1985-05-30

Publication date

2000-09-14

1984-05-31 Priority claimed from US06/616,502 external-priority patent/US4959457A/en

1985-05-30 Application filed by Genentech Inc filed Critical Genentech Inc

2000-09-14 Publication of DE3588225D1 publication Critical patent/DE3588225D1/de

2001-04-05 Application granted granted Critical

2001-04-05 Publication of DE3588225T2 publication Critical patent/DE3588225T2/de

2005-05-31 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- C07K16/242—Lymphotoxin [LT]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/525—Tumour necrosis factor [TNF]
- C07K14/5255—Lymphotoxin [LT]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Gastroenterology & Hepatology (AREA)
Veterinary Medicine (AREA)
Toxicology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Zoology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)

DE3588225T 1984-05-31 1985-05-30 Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung Expired - Lifetime DE3588225T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US61650384A	1984-05-31	1984-05-31
US06/616,502 US4959457A (en)	1984-05-31	1984-05-31	Anti-lymphotoxin
US73231285A	1985-05-09	1985-05-09

Publications (2)

Publication Number	Publication Date
DE3588225D1 true DE3588225D1 (de)	2000-09-14
DE3588225T2 DE3588225T2 (de)	2001-04-05

Family

ID=27417179

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE3588225T Expired - Lifetime DE3588225T2 (de)	1984-05-31	1985-05-30	Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung
DE3587597T Expired - Lifetime DE3587597T2 (de)	1984-05-31	1985-05-30	Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE3587597T Expired - Lifetime DE3587597T2 (de)	1984-05-31	1985-05-30	Lymphotoxin, dafür kodierende Nukleinsäure, die Nukleinsäure enthaltenden Vektoren und damit transformierte Zellen, Verfahren zum Erhalten von Lymphotoxin und Lymphotoxin neutralisierender Antikörper.

Country Status (23)

Country	Link
EP (2)	EP0164965B1 (de)
JP (3)	JP2521703B2 (de)
AR (1)	AR245219A1 (de)
AT (2)	ATE95243T1 (de)
AU (1)	AU599303B2 (de)
BG (1)	BG60256B2 (de)
CA (1)	CA1340641C (de)
CZ (1)	CZ283148B6 (de)
DE (2)	DE3588225T2 (de)
DK (1)	DK171531B1 (de)
ES (1)	ES8802182A1 (de)
FI (1)	FI93025C (de)
GR (1)	GR851317B (de)
HU (1)	HU204085B (de)
IE (1)	IE63487B1 (de)
IL (1)	IL75318A (de)
NO (1)	NO179075C (de)
NZ (1)	NZ212207A (de)
PL (1)	PL155410B1 (de)
PT (1)	PT80573B (de)
RO (1)	RO100383A2 (de)
SK (1)	SK278333B6 (de)
YU (1)	YU47735B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN156128B (de)	1980-04-03	1985-05-18	Biogen Nv
US5683688A (en)	1984-05-31	1997-11-04	Genentech, Inc.	Unglycosylated recombinant human lymphotoxin polypeptides and compositions
NZ212207A (en)	1984-05-31	1991-07-26	Genentech Inc	Recombinant lymphotoxin
IL73883A (en) *	1984-12-20	1990-12-23	Yeda Res & Dev	Monoclonal antibodies against tnf-alpha,hybridomas producing them and method for the purification of tnf-alpha
DE3585690D1 (de) *	1984-12-21	1992-04-23	Biogen Inc	Reinigung, herstellung und verwendung von tumor-nekrosisfaktoren.
JPS62195285A (ja) *	1986-02-19	1987-08-28	Kanegafuchi Chem Ind Co Ltd	リンホトキシン発現ベクタ−及びそれを用いるリンホトキシンの製造方法
JPS62111928A (ja) *	1985-10-15	1987-05-22	Kanegafuchi Chem Ind Co Ltd	新規リンホトキシン
AU603768B2 (en) *	1985-07-04	1990-11-29	Kanegafuchi Kagaku Kogyo Kabushiki Kaisha	Lymphotoxin dna, lymphotoxin expression vector, lymphotoxin resistant cell, transformant with lymphotoxin expression vector and process for preparing lymphotoxin
EP0230781B1 (de) *	1985-12-24	1992-07-22	Denki Kagaku Kogyo Kabushiki Kaisha	Lymphotoxin-Gen, Verfahren zu dessen Herstellung und Lymphotoxin
JP2548204B2 (ja) *	1987-06-27	1996-10-30	電気化学工業株式会社	新生理活性ポリペプチド
US5403725A (en) *	1985-12-24	1995-04-04	Denki Kagaku Kogyo Kabushiki Kaisha	Method for production of lymphotoxin (TNFB) in cell line A-C5-8
EP0230574A3 (de) *	1986-01-31	1989-03-22	Yale University	Pharmazeutische Zusammensetzungen gegen durch LAV/HTLV-III-Virus verursachte Infektionen und ihre Verwendung
JPS62181298A (ja) *	1986-02-05	1987-08-08	Kyowa Hakko Kogyo Co Ltd	ヒトリンホトキシンポリペプチド誘導体
DE3620656A1 (de) *	1986-06-20	1987-12-23	Basf Ag	Polypeptide mit lymphotoxin-aktivitaet oder lymphotoxin-aehnlicher aktivitaet, ihre herstellung und verwendung
JPS63105680A (ja) *	1986-10-22	1988-05-10	Kanegafuchi Chem Ind Co Ltd	ヒト・リンホトキシン発現ベクタ−、該発現ベクタ−による形質転換細胞および該細胞を用いるリンホトキシンの製造方法
JP2636862B2 (ja) *	1986-12-24	1997-07-30	武田薬品工業株式会社	組み換え型ヒトリンホトキシン
US5175268A (en) *	1986-12-24	1992-12-29	Takeda Chemical Industries, Ltd.	DNA encoding recombinant human lymphotoxin
FI884798A (fi) *	1987-10-28	1989-04-29	Eisai Co Ltd	Rekombinantlymfotoxin.
DE3837012A1 (de) *	1988-01-15	1989-07-27	Knoll Ag	Verwendung von tnf und lt zur herstellung von arzneimitteln
GB2217326B (en) *	1988-04-08	1991-11-20	British Bio Technology	Synthetic gene encoding human tumour necrosis factor beta.
EP0338497A3 (de) *	1988-04-22	1990-05-16	Takeda Chemical Industries, Ltd.	Bispezifische hybride monoklonale Antikörper
JPH023698A (ja) *	1988-06-20	1990-01-09	Denki Kagaku Kogyo Kk	ヒトリンホトキシンに対するモノクローナル抗体及びそれら抗体を産生するハイブリドーマ、並びにそれら抗体を用いたヒトリンホトキシンの精製方法、測定方法及び測定試薬
CA2001756A1 (en) *	1988-10-31	1991-04-30	Seiichi Uesugi	New human lymphotoxin n-end deletion mutant
JPH03106821A (ja) *	1989-09-20	1991-05-07	Denki Kagaku Kogyo Kk	抗腫瘍剤
US5370870A (en) *	1989-10-06	1994-12-06	Genentech, Inc.	Method for protection against reactive oxygen species
US5200176A (en) *	1989-10-06	1993-04-06	Genentech, Inc.	Method for protection of ischemic tissues using tumor nerosis factor
IL97779A (en) *	1990-04-10	2000-01-31	Genentech Inc	Compositions for cytoprotection against radiation and chemotherapy injury or risk thereof
US5747023A (en) *	1994-07-01	1998-05-05	Genentech, Inc.	Cancer therapy using lymphotoxin
EP0813423B1 (de) *	1995-01-23	2002-07-03	Xenotech Incorporated	Zusammensetzung zur verhinderung von osteolyse und metastasen
US5925351A (en)	1995-07-21	1999-07-20	Biogen, Inc.	Soluble lymphotoxin-β receptors and anti-lymphotoxin receptor and ligand antibodies as therapeutic agents for the treatment of immunological disease
US6998116B1 (en)	1996-01-09	2006-02-14	Genentech, Inc.	Apo-2 ligand
JP2002508962A (ja)	1998-01-15	2002-03-26	ジェネンテク・インコーポレイテッド	Ａｐｏ−２リガンド
EP2179742A1 (de) *	2002-11-26	2010-04-28	Genentech, Inc.	Zusammensetzungen und Verfahren zur Behandlung von Immunerkrankungen
NZ544924A (en)	2003-06-27	2009-03-31	Biogen Idec Inc	Modified binding molecules comprising connecting peptides
WO2005067477A2 (en) *	2003-12-08	2005-07-28	Centocor, Inc.	Anti-human lymphotoxin alpha antibodies, compositions, methods and uses
EP1756162A1 (de)	2004-03-23	2007-02-28	Biogen Idec MA Inc.	Rezeptor-kupplungsmittel und ihre therapeutischen verwendungen
WO2006074399A2 (en)	2005-01-05	2006-07-13	Biogen Idec Ma Inc.	Multispecific binding molecules comprising connecting peptides
PE20080980A1 (es) *	2006-10-12	2008-09-02	Genentech Inc	Anticuerpos anti-linfotoxina alfa
US8338376B2 (en)	2006-10-20	2012-12-25	Biogen Idec Ma Inc.	Compositions comprising variant LT-B-R-IG fusion proteins
SG178002A1 (en)	2006-10-20	2012-02-28	Biogen Idec Inc	Treatment of demyelinating disorders
CN106535913B (zh) *	2014-04-25	2021-01-26	诺雷克斯股份有限公司	神经活性肽的稳定组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ192465A (en) *	1978-12-22	1983-09-30	Biogen Nv	Recombinant dna molecule comprising gene coding for polypeptide displaying hbv (hepatitis b virus) antigenicity usesthereof
NZ201918A (en)	1981-09-18	1987-04-30	Genentech Inc	N-terminal methionyl analogues of bovine growth hormone
ZA834976B (en) *	1982-07-30	1984-08-29	Genentech Inc	Human lymphotoxin
IE56026B1 (en) *	1982-10-19	1991-03-27	Cetus Corp	Cysteine-depleted muteins of biologically active proteins
DE3331108A1 (de) *	1983-08-30	1985-05-02	Boehringer Ingelheim International GmbH, 6507 Ingelheim	Verfahren zur herstellung von lymphotoxin und von lymphotoxin-mrna
EP0135797A3 (de) *	1983-08-30	1987-11-11	BOEHRINGER INGELHEIM INTERNATIONAL GmbH	Verfahren zur Herstellung von Lymphotoxin und von Lymphotoxin-mRNA
NZ212207A (en)	1984-05-31	1991-07-26	Genentech Inc	Recombinant lymphotoxin

1985
- 1985-05-27 NZ NZ212207A patent/NZ212207A/en unknown
- 1985-05-27 IL IL7531885A patent/IL75318A/en unknown
- 1985-05-28 IE IE132185A patent/IE63487B1/en not_active IP Right Cessation
- 1985-05-29 FI FI852143A patent/FI93025C/fi not_active IP Right Cessation
- 1985-05-29 GR GR851317A patent/GR851317B/el unknown
- 1985-05-30 AT AT85303818T patent/ATE95243T1/de not_active IP Right Cessation
- 1985-05-30 ES ES543695A patent/ES8802182A1/es not_active Expired
- 1985-05-30 DE DE3588225T patent/DE3588225T2/de not_active Expired - Lifetime
- 1985-05-30 DE DE3587597T patent/DE3587597T2/de not_active Expired - Lifetime
- 1985-05-30 DK DK241385A patent/DK171531B1/da not_active IP Right Cessation
- 1985-05-30 BG BG70460A patent/BG60256B2/bg unknown
- 1985-05-30 HU HU852076A patent/HU204085B/hu unknown
- 1985-05-30 EP EP85303818A patent/EP0164965B1/de not_active Expired - Lifetime
- 1985-05-30 NO NO852173A patent/NO179075C/no unknown
- 1985-05-30 AT AT92110196T patent/ATE195323T1/de not_active IP Right Cessation
- 1985-05-30 EP EP92110196A patent/EP0509553B1/de not_active Expired - Lifetime
- 1985-05-31 CZ CS853930A patent/CZ283148B6/cs not_active IP Right Cessation
- 1985-05-31 JP JP60119648A patent/JP2521703B2/ja not_active Expired - Lifetime
- 1985-05-31 CA CA000482995A patent/CA1340641C/en not_active Expired - Lifetime
- 1985-05-31 SK SK3930-85A patent/SK278333B6/sk unknown
- 1985-05-31 YU YU91985A patent/YU47735B/sh unknown
- 1985-05-31 PL PL1985253739A patent/PL155410B1/pl unknown
- 1985-05-31 AU AU43203/85A patent/AU599303B2/en not_active Expired
- 1985-05-31 PT PT80573A patent/PT80573B/pt unknown
1986
- 1986-10-14 AR AR86305572A patent/AR245219A1/es active
1988
- 1988-01-19 RO RO131846A patent/RO100383A2/ro unknown
1995
- 1995-01-19 JP JP7006665A patent/JP2804237B2/ja not_active Expired - Lifetime
- 1995-01-19 JP JP7006657A patent/JPH07291995A/ja active Pending

Also Published As

Publication number	Publication date
IL75318A0 (en)	1985-09-29
RO100383A2 (ro)	1991-10-17
ES8802182A1 (es)	1988-04-16
ATE95243T1 (de)	1993-10-15
SK393085A3 (en)	1996-11-06
IE63487B1 (en)	1995-05-03
ATE195323T1 (de)	2000-08-15
DK171531B1 (da)	1996-12-23
PL155410B1 (en)	1991-11-29
FI93025B (fi)	1994-10-31
ES543695A0 (es)	1988-04-16
NO179075C (no)	1996-07-31
SK278333B6 (en)	1996-11-06
FI93025C (fi)	1995-02-10
DK241385A (da)	1985-12-01
IE851321L (en)	1985-11-30
JPH07291995A (ja)	1995-11-07
AR245219A1 (es)	1993-12-30
EP0509553B1 (de)	2000-08-09
JPH07250692A (ja)	1995-10-03
DK241385D0 (da)	1985-05-30
DE3588225T2 (de)	2001-04-05
CZ283148B6 (cs)	1998-01-14
JPS6156197A (ja)	1986-03-20
DE3587597T2 (de)	1994-06-01
CZ393085A3 (en)	1997-07-16
IL75318A (en)	1994-08-26
NZ212207A (en)	1991-07-26
YU91985A (en)	1988-12-31
GR851317B (de)	1985-11-25
JP2804237B2 (ja)	1998-09-24
EP0509553A1 (de)	1992-10-21
PL253739A1 (en)	1986-03-11
EP0164965A3 (en)	1988-04-06
FI852143L (fi)	1985-12-01
AU4320385A (en)	1985-12-05
BG60256B1 (bg)	1994-03-24
CA1340641C (en)	1999-07-13
RO100383B1 (ro)	1991-03-01
NO852173L (no)	1985-12-02
AU599303B2 (en)	1990-07-19
JP2521703B2 (ja)	1996-08-07
YU47735B (sh)	1996-01-08
NO179075B (no)	1996-04-22
HU204085B (en)	1991-11-28
BG60256B2 (bg)	1994-03-24
HUT37814A (en)	1986-02-28
FI852143A0 (fi)	1985-05-29
EP0164965A2 (de)	1985-12-18
DE3587597D1 (de)	1993-11-04
IE930589L (en)	1985-11-30
EP0164965B1 (de)	1993-09-29
PT80573B (pt)	1987-08-19
PT80573A (en)	1985-06-01

Publication	Publication Date	Title
DE3588225D1 (de)	2000-09-14	Anti-Lymphotoxin-Antikörper, Herstellung und Verwendung
DE3581578D1 (de)	1991-03-07	Antikoerper, herstellung und verwendung.
PT85616A (de)	1987-09-01	Aryloxycarbonsaurederivate ihre herstellung und verwendung
DE3682654D1 (de)	1992-01-09	Acylaminosiliciumverbindungen, deren verwendung und herstellung.
DE3579888D1 (de)	1990-10-31	Carbapenemverbindungen und deren herstellung.
DE3580163D1 (de)	1990-11-22	Beta-lactame und ihre herstellung.
DE3584410D1 (de)	1991-11-21	Reaktivfarbstoffe, deren herstellung und verwendung.
DE3577719D1 (de)	1990-06-21	Reaktivfarbstoffe, deren herstellung und verwendung.
DE3576697D1 (de)	1990-04-26	Perfluoralkylvinylpolymer und seine herstellung.
DE3577707D1 (de)	1990-06-21	3-pyrazolo(1,5-a)pyridinium-cephemverbindungen, deren herstellung und verwendung.
DE3484531D1 (de)	1991-06-06	Tetrahydrobenzotriazole, deren herstellung und verwendung.
DE3682491D1 (de)	1991-12-19	Immobilisierter c-peptid-antikoerper, seine herstellung und verwendung.
DE3774718D1 (de)	1992-01-09	Benzothiazolylazolidine und ihre herstellung und verwendung.
PT85396B (de)	1989-10-26	Neue 1,4-benzodiazepine ihre herstellung und verwendung
DE3673474D1 (de)	1990-09-20	Reaktivfarbstoffe, deren herstellung und verwendung.
DE3766441D1 (de)	1991-01-10	Anilinotriazine und deren verwendung.
DE3583296D1 (de)	1991-07-25	Oncofetal spezifische monoklonale antikoerper, deren herstellung und verwendung.
DE3789352D1 (de)	1994-04-21	Neue biphenylabkömmlinge, deren herstellung und verwendung.
DE68908389D1 (de)	1993-09-16	Amidofluoroverbindungen, ihre herstellung und ihre verwendung.
DE3581481D1 (de)	1991-02-28	Beta-lactame und ihre herstellung.
DE3879328D1 (de)	1993-04-22	Stannosilikate, ihre herstellung und verwendung.
ATE43356T1 (de)	1989-06-15	Reaktivfarbstoffe, deren herstellung und verwendung.
DE3578557D1 (de)	1990-08-09	Substituierte thiophen-2-sulfonamide und ihre herstellung.
DE3584156D1 (de)	1991-10-24	Gif-2 und dessen herstellung.
DE3676838D1 (de)	1991-02-21	Dehydrierungskatalysator und dessen verwendung.

Legal Events

Date	Code	Title	Description
2001-08-30	8364	No opposition during term of opposition