DE3588008D1 - Hefestämme zur erzeugung cellulolytischer enzyme und verfahren und mittel zu deren herstellung. - Google Patents
Hefestämme zur erzeugung cellulolytischer enzyme und verfahren und mittel zu deren herstellung.Info
- Publication number
- DE3588008D1 DE3588008D1 DE3588008T DE3588008T DE3588008D1 DE 3588008 D1 DE3588008 D1 DE 3588008D1 DE 3588008 T DE3588008 T DE 3588008T DE 3588008 T DE3588008 T DE 3588008T DE 3588008 D1 DE3588008 D1 DE 3588008D1
- Authority
- DE
- Germany
- Prior art keywords
- yeast
- production
- cellulolytic enzymes
- yeast strains
- cellulolytic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 240000004808 Saccharomyces cerevisiae Species 0.000 title abstract 4
- 230000001461 cytolytic effect Effects 0.000 title abstract 4
- 108090000790 Enzymes Proteins 0.000 title abstract 3
- 102000004190 Enzymes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 229920001503 Glucan Polymers 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 241000499912 Trichoderma reesei Species 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 230000002759 chromosomal effect Effects 0.000 abstract 1
- 239000002299 complementary DNA Substances 0.000 abstract 1
- 108020004999 messenger RNA Proteins 0.000 abstract 1
- 230000003362 replicative effect Effects 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
- 210000005253 yeast cell Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/034—Fusion polypeptide containing a localisation/targetting motif containing a motif for targeting to the periplasmic space of Gram negative bacteria as a soluble protein, i.e. signal sequence should be cleaved
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/945—Trichoderma
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- External Artificial Organs (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI841500A FI841500A0 (fi) | 1984-04-13 | 1984-04-13 | Foerfarande foer uppbygnande av cellulolytiska jaeststammar. |
PCT/FI1985/000039 WO1985004672A1 (en) | 1984-04-13 | 1985-04-12 | Yeast strains producing cellulolytic enzymes and methods and means for constructing them |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3588008D1 true DE3588008D1 (de) | 1995-05-18 |
DE3588008T2 DE3588008T2 (de) | 1995-10-12 |
Family
ID=8518918
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE3588008T Expired - Fee Related DE3588008T2 (de) | 1984-04-13 | 1985-04-12 | Hefestämme zur erzeugung cellulolytischer enzyme und verfahren und mittel zu deren herstellung. |
Country Status (8)
Country | Link |
---|---|
US (3) | US4894338A (de) |
EP (2) | EP0312121A3 (de) |
AT (1) | ATE121132T1 (de) |
CA (1) | CA1305931C (de) |
DE (1) | DE3588008T2 (de) |
DK (1) | DK580385D0 (de) |
FI (2) | FI841500A0 (de) |
WO (1) | WO1985004672A1 (de) |
Families Citing this family (63)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5472864A (en) * | 1984-04-19 | 1995-12-05 | Genencor International, Inc. | Method of preparing solution enriched in EG III using low molecular weight alcohol, organic salt and inorganic salt |
US5320960A (en) * | 1992-04-03 | 1994-06-14 | Genencor International, Inc. | Method of preparing solution enriched in xylanase using low molecular weight alcohol, organic salt and inorganic salt |
US5298405A (en) * | 1986-04-30 | 1994-03-29 | Alko Limited | Enzyme preparations with recombinantly-altered cellulose profiles and methods for their production |
US5610034A (en) * | 1987-04-29 | 1997-03-11 | Alko Group Ltd. | Immunoglobulin production by trichoderma |
EP0406314B1 (de) * | 1988-03-24 | 1993-12-01 | Novo Nordisk A/S | Cellulosezubereitung |
US5648263A (en) * | 1988-03-24 | 1997-07-15 | Novo Nordisk A/S | Methods for reducing the harshness of a cotton-containing fabric |
US5688290A (en) * | 1989-10-19 | 1997-11-18 | Genencor International, Inc. | Degradation resistant detergent compositions based on cellulase enzymes |
US5866382A (en) | 1990-04-06 | 1999-02-02 | Xyrofin Oy | Xylose utilization by recombinant yeasts |
US5168064A (en) * | 1990-04-20 | 1992-12-01 | The Regents Of The University Of California | Endo-1,4-β-glucanase gene and its use in plants |
NL9001388A (nl) * | 1990-06-19 | 1992-01-16 | Unilever Nv | Recombinant dna, cel die daarvan afgeleid dna bevat, enzym waarvoor het recombinant dna codeert en toepassingen daarvan. |
US5290474A (en) * | 1990-10-05 | 1994-03-01 | Genencor International, Inc. | Detergent composition for treating cotton-containing fabrics containing a surfactant and a cellulase composition containing endolucanase III from trichoderma ssp |
WO1992006209A1 (en) * | 1990-10-05 | 1992-04-16 | Genencor International Inc. | Trichoderma reesei containing deleted and/or enriched cellulase and other enzyme genes and cellulase compositions derived therefrom |
US5654193A (en) * | 1990-10-05 | 1997-08-05 | Genencor International, Inc. | Methods for treating cotton containing fabrics with cellulase |
US5525507A (en) * | 1990-10-05 | 1996-06-11 | Genencor International, Inc. | Methods for treating cotton-containing fabric with cellulase composition containing endoglucanase component and which is free of all CBH I component |
US5246853A (en) * | 1990-10-05 | 1993-09-21 | Genencor International, Inc. | Method for treating cotton-containing fabric with a cellulase composition containing endoglucanase components and which composition is free of exo-cellobiohydrolase I |
WO1992006183A1 (en) * | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
US5650322A (en) * | 1990-10-05 | 1997-07-22 | Genencor International, Inc. | Methods for stonewashing fabrics using endoglucanases |
US5328841A (en) * | 1990-10-05 | 1994-07-12 | Genencor International, Inc. | Methods for isolating EG III cellulase component and EG III cellulase in polyethylene glycol using inorganic salt and polyethylene glycol |
US5475101A (en) * | 1990-10-05 | 1995-12-12 | Genencor International, Inc. | DNA sequence encoding endoglucanase III cellulase |
WO1992006221A1 (en) * | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
CA2093422C (en) * | 1990-10-05 | 2001-04-03 | DETERGENT COMPOSITIONS CONTAINING LOW CBH I CONTENT CELLULASE COMPOSITIONS | |
US5443750A (en) * | 1991-01-16 | 1995-08-22 | The Procter & Gamble Company | Detergent compositions with high activity cellulase and softening clays |
US5863783A (en) * | 1991-03-27 | 1999-01-26 | Gist-Brocades, N.V. | Cloning and expression of DNA molecules encoding arabinan-degrading enzymes of fungal origin |
CA2107208A1 (en) | 1991-03-29 | 1992-09-30 | Kathleen A. Clarkson | Methods for treating cotton-containing fabrics with cellulase |
US6512166B1 (en) | 1991-06-17 | 2003-01-28 | Cornell Research Foundation, Inc. | Combinations of fungal cell wall degrading enzyme and fungal cell membrane affecting compound |
CA2134446A1 (en) * | 1992-05-01 | 1993-11-11 | Kathleen A. Clarkson | Methods for treating cotton-containing fabrics with cbh i enriched cellulase |
FI92500C (fi) * | 1993-03-03 | 1994-11-25 | Valtion Teknillinen | Menetelmä mekaanisen massan valmistamiseksi |
US7005128B1 (en) | 1993-12-17 | 2006-02-28 | Genencor International, Inc. | Enzyme feed additive and animal feed including it |
US5861271A (en) * | 1993-12-17 | 1999-01-19 | Fowler; Timothy | Cellulase enzymes and systems for their expressions |
US6268196B1 (en) | 1993-12-17 | 2001-07-31 | Genencor International, Inc. | Method and compositions for treating cellulose containing fabrics using truncated cellulase enzyme compositions |
US6117664A (en) * | 1994-03-03 | 2000-09-12 | Novo Nordisk A/S | Alkaline cellulases |
CA2185101A1 (en) * | 1994-03-08 | 1995-09-14 | Martin Schulein | Novel alkaline cellulases |
US7816129B2 (en) | 1994-07-29 | 2010-10-19 | Ab Enzymes Gmbh | Production and secretion of proteins of bacterial origin in filamentous fungi |
US6723549B2 (en) * | 1995-10-17 | 2004-04-20 | Ab Enzymes Oy | Cellulases, the genes encoding them and uses thereof |
US6184019B1 (en) | 1995-10-17 | 2001-02-06 | Röhm Enzyme Finland OY | Cellulases, the genes encoding them and uses thereof |
TR199800934T2 (xx) * | 1995-11-27 | 1999-02-22 | Unilever N.V. | Enzimatik deterjan bile�imleri. |
WO1997033982A1 (fr) * | 1996-03-14 | 1997-09-18 | JAPAN, represented by DIRECTOR GENERAL OF AGENCY OF INDUSTRIAL SCIENCE AND TECHNOLOGY | Proteine ayant une activite de cellulase et son procede de production |
US7465571B1 (en) | 1996-05-22 | 2008-12-16 | Verenium Corporation | Endoglucanases |
US5789228A (en) * | 1996-05-22 | 1998-08-04 | Diversa Corporation | Endoglucanases |
ES2242234T3 (es) * | 1996-09-12 | 2005-11-01 | Syngenta Participations Ag | Plantas transgenicas que expresan enzimas celuloliticas. |
US5981835A (en) * | 1996-10-17 | 1999-11-09 | Wisconsin Alumni Research Foundation | Transgenic plants as an alternative source of lignocellulosic-degrading enzymes |
FI964692A0 (fi) * | 1996-11-25 | 1996-11-25 | Primalco Ltd | Foerbaettrad cellulassammansaettning foer bioefterbehandling av textilmaterial som innehaoller cellulosa |
FI964691A0 (fi) * | 1996-11-25 | 1996-11-25 | Primalco Ltd | Foerbaettrad cellulassammasaettning foer behandling av textilmaterial som innehaoller cellulosa |
US6001595A (en) * | 1996-11-29 | 1999-12-14 | Rohm Enzyme GmbH | Promoters and uses thereof |
US6818803B1 (en) | 1997-06-26 | 2004-11-16 | Wisconsin Alumni Research Foundation | Transgenic plants as an alternative source of lignocellulosic-degrading enzymes |
DE69827712T3 (de) * | 1997-07-31 | 2009-07-09 | Dsm Ip Assets B.V. | Zusammensetzung für Brotverbesserung |
NZ502444A (en) * | 1997-07-31 | 2001-11-30 | Dsm N | Polypeptides with cellobiohydrolase activity (CBH A and CBH B) from Aspergillus |
US6222028B1 (en) | 1999-10-15 | 2001-04-24 | Academia Sinica | Polynucleotides encoding cellulase enzymes from Piromyces rhizinflata |
US6428996B1 (en) | 1999-10-27 | 2002-08-06 | Academia Sinica | Cellulase enzymes |
ATE327322T1 (de) * | 2000-09-25 | 2006-06-15 | Iogen Energy Corp | Verfahren zur herstellung von glucose mit ein ermodifizierten zellulase |
AR036370A1 (es) | 2001-08-27 | 2004-09-01 | Syngenta Participations Ag | Plantas con auto-procesamiento y partes de las mismas |
EP1485495B1 (de) * | 2002-03-15 | 2010-09-15 | Iogen Energy Corporation | Verfahren zur herstellung von glukose durch verwendung von endoglucanase-core-protein zur verbesserten rückgewinnung und wiederverwendung des enzyms |
AU2003291962A1 (en) | 2002-12-20 | 2004-07-14 | Novozymes A/S | Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same |
CA2558603A1 (en) * | 2004-03-08 | 2005-10-20 | Syngenta Participations Ag | Self-processing plants and plant parts |
DE602006010051D1 (de) * | 2005-04-27 | 2009-12-10 | Novozymes Inc | Polypeptide mit endoglucanase-aktivtät und dafür codierende polynukleotide |
CN101652381B (zh) * | 2007-01-30 | 2014-04-09 | 维莱尼姆公司 | 用于处理木质纤维素的酶、编码它们的核酸及其制备和应用方法 |
US9068176B2 (en) | 2011-01-26 | 2015-06-30 | Novozymes A/S | Polypeptides having endoglucanase activity and polynucleotides encoding same |
WO2012103322A1 (en) | 2011-01-26 | 2012-08-02 | Novozymes A/S | Polypeptides having endoglucanase activity and polynucleotides encoding same |
WO2013016207A2 (en) * | 2011-07-22 | 2013-01-31 | California Institute Of Technology | Stable fungal cel6 enzyme variants |
US8778639B1 (en) * | 2013-02-12 | 2014-07-15 | Novozymes Inc. | Polypeptides having endoglucanase activity and polynucleotides encoding same |
US8771993B1 (en) * | 2013-02-12 | 2014-07-08 | Novozymes A/S | Polypeptides having endoglucanse activity and polynucleotides encoding same |
FR3022558B1 (fr) * | 2014-06-20 | 2019-01-25 | Proteus | Variants d'exoglucanases a activite amelioree et leurs utilisations |
CN113322190B (zh) * | 2021-06-24 | 2023-07-18 | 西北农林科技大学 | 里氏木霉与酿酒酵母混合发酵白酒糟生产单细胞蛋白的方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4165974A (en) * | 1973-03-16 | 1979-08-28 | Goodwin George I | Mold lubricant and method |
US4275163A (en) * | 1978-11-20 | 1981-06-23 | The United States Of America As Represented By The Secretary Of The Army | Cellulase-producing microorganism |
US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
IE54046B1 (en) * | 1981-08-25 | 1989-05-24 | Celltech Ltd | Expression vectors |
US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
FR2529569B1 (fr) * | 1982-07-02 | 1985-07-05 | Pasteur Institut | Microorganismes, notamment e. coli, transformes par une sequence d'adn originaire de c. thermocellum, compositions a activite cellulolytique issues de ces micro-organismes et procede pour les obtenir |
CA1338400C (en) * | 1983-08-31 | 1996-06-18 | David H. Gelfand | Recombinant fungal cellulases |
US4794175A (en) * | 1983-12-20 | 1988-12-27 | Cetus Corporation | Glucoamylase CDNA |
EP0191058B1 (de) * | 1984-08-01 | 1989-03-29 | Cl Pharma Aktiengesellschaft | Immunwirksame verbindungen |
-
1984
- 1984-04-13 FI FI841500A patent/FI841500A0/fi not_active Application Discontinuation
-
1985
- 1985-04-12 CA CA000478959A patent/CA1305931C/en not_active Expired - Lifetime
- 1985-04-12 EP EP88118230A patent/EP0312121A3/de not_active Withdrawn
- 1985-04-12 WO PCT/FI1985/000039 patent/WO1985004672A1/en active IP Right Grant
- 1985-04-12 EP EP85902041A patent/EP0214971B1/de not_active Expired - Lifetime
- 1985-04-12 DE DE3588008T patent/DE3588008T2/de not_active Expired - Fee Related
- 1985-04-12 AT AT85902041T patent/ATE121132T1/de not_active IP Right Cessation
- 1985-04-12 US US06/817,942 patent/US4894338A/en not_active Expired - Lifetime
- 1985-12-13 DK DK580385A patent/DK580385D0/da unknown
-
1986
- 1986-10-10 FI FI864110A patent/FI86745C/fi not_active IP Right Cessation
-
1993
- 1993-07-23 US US08/095,253 patent/US5393670A/en not_active Expired - Fee Related
-
1994
- 1994-06-23 US US08/264,492 patent/US5529919A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ATE121132T1 (de) | 1995-04-15 |
FI86745C (fi) | 1992-10-12 |
DK580385A (da) | 1985-12-13 |
CA1305931C (en) | 1992-08-04 |
FI864110A (fi) | 1986-10-10 |
EP0214971A1 (de) | 1987-03-25 |
US4894338A (en) | 1990-01-16 |
DK580385D0 (da) | 1985-12-13 |
EP0312121A2 (de) | 1989-04-19 |
FI864110A0 (fi) | 1986-10-10 |
EP0312121A3 (de) | 1989-12-13 |
EP0214971B1 (de) | 1995-04-12 |
FI841500A0 (fi) | 1984-04-13 |
FI86745B (fi) | 1992-06-30 |
DE3588008T2 (de) | 1995-10-12 |
US5529919A (en) | 1996-06-25 |
WO1985004672A1 (en) | 1985-10-24 |
US5393670A (en) | 1995-02-28 |
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