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DE3581423D1 - Herstellung von noroxymorphon aus morphin. - Google Patents

Herstellung von noroxymorphon aus morphin.

Info

Publication number
DE3581423D1
DE3581423D1 DE8585302103T DE3581423T DE3581423D1 DE 3581423 D1 DE3581423 D1 DE 3581423D1 DE 8585302103 T DE8585302103 T DE 8585302103T DE 3581423 T DE3581423 T DE 3581423T DE 3581423 D1 DE3581423 D1 DE 3581423D1
Authority
DE
Germany
Prior art keywords
noroxymorphone
morphine
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585302103T
Other languages
English (en)
Inventor
Rebecca A Wallace
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Application granted granted Critical
Publication of DE3581423D1 publication Critical patent/DE3581423D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE8585302103T 1984-03-27 1985-03-26 Herstellung von noroxymorphon aus morphin. Expired - Lifetime DE3581423D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59374484A 1984-03-27 1984-03-27
US71393285A 1985-03-20 1985-03-20

Publications (1)

Publication Number Publication Date
DE3581423D1 true DE3581423D1 (de) 1991-02-28

Family

ID=27081787

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585302103T Expired - Lifetime DE3581423D1 (de) 1984-03-27 1985-03-26 Herstellung von noroxymorphon aus morphin.

Country Status (6)

Country Link
EP (1) EP0158476B1 (de)
JP (1) JPH0651705B2 (de)
DE (1) DE3581423D1 (de)
ES (1) ES8606356A1 (de)
FR (1) FR2562072B1 (de)
IT (1) IT1199871B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
CN1271072C (zh) 2001-08-23 2006-08-23 阿克佐诺贝尔公司 14－羟基去吗啡酮衍生物的制备方法
WO2006084389A1 (de) * 2005-02-11 2006-08-17 Cilag Ltd. Verfahren zur reinigung von noroxymorphon-verbindungen
WO2006138020A2 (en) * 2005-06-16 2006-12-28 Mallinckrodt Inc. A synthetic route to 14-hydroxyl opiates through 1-halo-thebaine or analogs
AU2008338906B2 (en) * 2007-12-17 2013-06-27 SpecGx LLC Processes for the production of (+)-'nal' morphinan compounds
EP2231674A1 (de) * 2007-12-17 2010-09-29 Mallinckrodt Inc. Verfahren zur herstellung von normorphinan-salzen
WO2009078987A1 (en) * 2007-12-17 2009-06-25 Mallinckrodt Inc. Process and compounds for the production of (+) opiates
NZ586187A (en) * 2007-12-17 2013-07-26 Mallinckrodt Llc Processes for the synthesis of sinomenine derivatives and their intermediate
WO2009122436A2 (en) * 2008-03-31 2009-10-08 Sun Pharmaceutical Industries Ltd. An improved process for the preparation of morphinane analogues
PL2896614T3 (pl) * 2008-05-27 2018-02-28 Mallinckrodt Llc Sposoby i związki do wytwarzania normorfinanów
CA2802295C (en) 2010-06-11 2016-09-20 Rhodes Technologies Transition metal-catalyzed processes for the preparation of n-allyl compounds and use thereof
AU2012304484B2 (en) 2011-09-08 2016-07-28 SpecGx LLC Production of alkaloids without the isolation of intermediates
EP2829541A1 (de) 2013-07-26 2015-01-28 Siegfried AG Neuartige Synthese von Noroxymorphon aus Morphin
CN104230945B (zh) * 2014-08-23 2016-05-18 成都天台山制药有限公司 盐酸纳洛酮的合成方法
KR20230127222A9 (ko) * 2020-12-28 2024-03-25 나빈 삭세나 리서치 앤드 테크놀로지 피브이티. 엘티디. 모르핀으로부터 노르옥시모르폰의 합성을 위한 신규의 제조방법
US11247999B1 (en) 2021-07-02 2022-02-15 Joseph DeGraw Facile conversion of morphine to normorphine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE408870C (de) * 1923-09-11 1925-01-24 Merck Chem Fab E Verfahren zur Darstellung von Kodeienon
DE1938219A1 (de) * 1968-07-26 1970-02-12 Sankyo Co Verfahren zur Herstellung von 14-Hydroxy-normorphinonderivaten
DE2727805A1 (de) * 1977-06-21 1979-01-04 Goedecke Ag Verfahren zur herstellung von oxynormorphon
US4472253A (en) * 1981-08-17 1984-09-18 The Florida Board Of Regents On Behalf Of The Florida State University Process for the preparation of an N-substituted 3-O-alkyl-14-hydroxynormorphinone derivative

Also Published As

Publication number Publication date
ES541631A0 (es) 1986-04-01
IT1199871B (it) 1989-01-05
EP0158476B1 (de) 1991-01-23
JPH0651705B2 (ja) 1994-07-06
ES8606356A1 (es) 1986-04-01
FR2562072A1 (fr) 1985-10-04
IT8567297A0 (it) 1985-03-26
FR2562072B1 (fr) 1989-07-07
EP0158476A1 (de) 1985-10-16
IT8567297A1 (it) 1986-09-26
JPS60252481A (ja) 1985-12-13

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Legal Events

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8364 No opposition during term of opposition