DE3575730D1 - Modifizierte adeninegruppe enthaltende sonde, ihre herstellung und verwendungen. - Google Patents
Modifizierte adeninegruppe enthaltende sonde, ihre herstellung und verwendungen.Info
- Publication number
- DE3575730D1 DE3575730D1 DE8585401665T DE3575730T DE3575730D1 DE 3575730 D1 DE3575730 D1 DE 3575730D1 DE 8585401665 T DE8585401665 T DE 8585401665T DE 3575730 T DE3575730 T DE 3575730T DE 3575730 D1 DE3575730 D1 DE 3575730D1
- Authority
- DE
- Germany
- Prior art keywords
- production
- group containing
- modified adenine
- containing probe
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical group NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 title abstract 3
- 239000000523 sample Substances 0.000 title abstract 3
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 abstract 2
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 abstract 2
- 108091034117 Oligonucleotide Proteins 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229940113082 thymine Drugs 0.000 abstract 1
- 229940035893 uracil Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Saccharide Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8413095A FR2569407B1 (fr) | 1984-08-22 | 1984-08-22 | Sondes comportant des groupements adenine modifiee, leur preparation et leurs utilisations |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3575730D1 true DE3575730D1 (de) | 1990-03-08 |
Family
ID=9307172
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8585401665T Expired - Lifetime DE3575730D1 (de) | 1984-08-22 | 1985-08-21 | Modifizierte adeninegruppe enthaltende sonde, ihre herstellung und verwendungen. |
Country Status (10)
Country | Link |
---|---|
US (1) | US4842996A (de) |
EP (1) | EP0176396B1 (de) |
JP (1) | JPS6169788A (de) |
AT (1) | ATE49976T1 (de) |
DE (1) | DE3575730D1 (de) |
DK (1) | DK380085A (de) |
ES (1) | ES8701777A1 (de) |
FR (1) | FR2569407B1 (de) |
GR (1) | GR852029B (de) |
PT (1) | PT81009B (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ212024A (en) * | 1984-05-15 | 1988-08-30 | Smithkline Beckman Corp | A preparation procedure for polynucleotide hybridisation probes |
US4734363A (en) * | 1984-11-27 | 1988-03-29 | Molecular Diagnostics, Inc. | Large scale production of DNA probes |
FR2575751B1 (fr) * | 1985-01-08 | 1987-04-03 | Pasteur Institut | Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques |
FR2601956B1 (fr) * | 1986-07-22 | 1989-11-03 | Pasteur Institut | Nouveaux derives de desoxy-2' adenosine, leur procede d'obtention par voie de synthese et leurs applications biologiques |
GB9119378D0 (en) * | 1991-09-11 | 1991-10-23 | Medical Res Council | Improvements in oligonucleotide primers |
FR2750435B1 (fr) * | 1996-06-27 | 1998-08-28 | Appligene Oncor | Procede de formation de complexes d'hybridation dont la stabilite depend peu de la composition en base des deux molecules d'acides nucleiques hybridees |
EP2821085B1 (de) * | 2003-09-12 | 2020-04-29 | University of Massachusetts | Rna-interferenz zur behandlung von funktionszunahmestörungen |
US8680063B2 (en) | 2003-09-12 | 2014-03-25 | University Of Massachusetts | RNA interference for the treatment of gain-of-function disorders |
CA2619534A1 (en) | 2005-08-18 | 2007-02-22 | Alnylam Pharmaceuticals, Inc. | Methods and compositions for treating neurological disease |
US20070259827A1 (en) * | 2006-01-25 | 2007-11-08 | University Of Massachusetts | Compositions and methods for enhancing discriminatory RNA interference |
WO2008143774A2 (en) * | 2007-05-01 | 2008-11-27 | University Of Massachusetts | Methods and compositions for locating snp heterozygosity for allele specific diagnosis and therapy |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4556643A (en) * | 1982-07-26 | 1985-12-03 | Agracetus | Assay method and probe for polynucleotide sequences |
US4563417A (en) * | 1984-08-31 | 1986-01-07 | Miles Laboratories, Inc. | Nucleic acid hybridization assay employing antibodies to intercalation complexes |
-
1984
- 1984-08-22 FR FR8413095A patent/FR2569407B1/fr not_active Expired
-
1985
- 1985-08-21 ES ES547038A patent/ES8701777A1/es not_active Expired
- 1985-08-21 DE DE8585401665T patent/DE3575730D1/de not_active Expired - Lifetime
- 1985-08-21 DK DK380085A patent/DK380085A/da not_active Application Discontinuation
- 1985-08-21 AT AT85401665T patent/ATE49976T1/de active
- 1985-08-21 EP EP85401665A patent/EP0176396B1/de not_active Expired - Lifetime
- 1985-08-21 GR GR852029A patent/GR852029B/el unknown
- 1985-08-22 US US06/768,042 patent/US4842996A/en not_active Expired - Fee Related
- 1985-08-22 JP JP60184986A patent/JPS6169788A/ja active Pending
- 1985-08-22 PT PT81009A patent/PT81009B/pt unknown
Also Published As
Publication number | Publication date |
---|---|
PT81009B (fr) | 1987-02-06 |
DK380085D0 (da) | 1985-08-21 |
PT81009A (fr) | 1985-09-01 |
EP0176396B1 (de) | 1990-01-31 |
ES547038A0 (es) | 1986-12-16 |
GR852029B (de) | 1985-12-19 |
ES8701777A1 (es) | 1986-12-16 |
FR2569407A1 (fr) | 1986-02-28 |
ATE49976T1 (de) | 1990-02-15 |
EP0176396A1 (de) | 1986-04-02 |
FR2569407B1 (fr) | 1989-02-17 |
US4842996A (en) | 1989-06-27 |
DK380085A (da) | 1986-02-23 |
JPS6169788A (ja) | 1986-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |