[go: up one dir, main page]

DE3569529D1 - Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them - Google Patents

Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them

Info

Publication number
DE3569529D1
DE3569529D1 DE8585400927T DE3569529T DE3569529D1 DE 3569529 D1 DE3569529 D1 DE 3569529D1 DE 8585400927 T DE8585400927 T DE 8585400927T DE 3569529 T DE3569529 T DE 3569529T DE 3569529 D1 DE3569529 D1 DE 3569529D1
Authority
DE
Germany
Prior art keywords
preparation
reductase inhibitors
aldose reductase
heterocyclic derivatives
inhibitors containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8585400927T
Other languages
English (en)
Inventor
Jean-Marie Teulon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Carpibem SA
Original Assignee
Carpibem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR8407791A external-priority patent/FR2564463B1/fr
Priority claimed from FR8503236A external-priority patent/FR2578542B2/fr
Application filed by Carpibem SA filed Critical Carpibem SA
Application granted granted Critical
Publication of DE3569529D1 publication Critical patent/DE3569529D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Quinoline Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DE8585400927T 1984-05-18 1985-05-13 Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them Expired DE3569529D1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8407791A FR2564463B1 (fr) 1984-05-18 1984-05-18 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
FR8503236A FR2578542B2 (fr) 1985-03-05 1985-03-05 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase

Publications (1)

Publication Number Publication Date
DE3569529D1 true DE3569529D1 (en) 1989-05-24

Family

ID=26223971

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585400927T Expired DE3569529D1 (en) 1984-05-18 1985-05-13 Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them

Country Status (14)

Country Link
US (1) US4755509A (de)
EP (1) EP0162776B1 (de)
JP (1) JPH0692371B2 (de)
KR (1) KR900004320B1 (de)
AU (1) AU586972B2 (de)
CA (1) CA1306747C (de)
DE (1) DE3569529D1 (de)
DK (1) DK219685A (de)
ES (1) ES8607263A1 (de)
GR (1) GR851159B (de)
IE (1) IE58312B1 (de)
NZ (1) NZ212060A (de)
PH (1) PH21118A (de)
PT (1) PT80489B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU602641B2 (en) * 1986-04-17 1990-10-18 Senju Pharmaceutical Co., Ltd. Thiolactam-N-acetic acid derivatives, their production and use
EP0290863A3 (en) * 1987-05-09 1989-03-15 Nihon Tokushu Noyaku Seizo K.K. Benzoxazine derivative, process and intermediates for its preparation and its use as herbicide
IE914455A1 (en) * 1990-12-27 1992-07-01 Green Cross Corp 1,4-benzothiazine-2-acetic acid derivatives, processes for production thereof
ATE197297T1 (de) * 1992-08-31 2000-11-15 Santen Pharmaceutical Co Ltd 3-oxo-1,4-benzothiazin-derivate
TW274550B (de) * 1992-09-26 1996-04-21 Hoechst Ag
JPH06279453A (ja) * 1993-03-29 1994-10-04 Green Cross Corp:The ピリドチアジン酢酸誘導体，その製法及びその用途
WO1995013269A1 (fr) * 1993-11-12 1995-05-18 Santen Pharmaceutical Co., Ltd. Derive de 1,4-benzothiazine
US5556841A (en) * 1994-02-04 1996-09-17 Santen Pharmaceutical Co., Ltd. Thiazine or thiomorpholine derivatives
WO1997021689A1 (fr) * 1995-12-08 1997-06-19 Ube Industries, Ltd. Composes de n-phenylcarbamate, procede de production et bactericides agricoles ou horticoles
US6713477B1 (en) 2000-04-19 2004-03-30 Sumitomo Pharmaceuticals Company, Limited Hydroxamic acid derivatives
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
ATE479668T1 (de) * 2004-03-02 2010-09-15 Dainippon Sumitomo Pharma Co Benzothiazin-3-one verbindung und zwischenprodukt dafür
KR20140026532A (ko) * 2011-04-29 2014-03-05 이칸 스쿨 오브 메디슨 엣 마운트 시나이 키나제 억제제

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173942A (en) * 1967-06-06 1969-12-10 Bellon Labor Sa Roger New 2,3-Dihydro-1,4-Benzoxazines
US3923709A (en) * 1974-08-30 1975-12-02 Monsanto Co 3,4-Dihydro-3-oxo-2H-1,4-benzothiazines and benzoxazines
US4512990A (en) * 1982-02-18 1985-04-23 Syntex (U.S.A.), Inc. Benzthiazine analogs as antiinflammatory agents
US4584300A (en) * 1983-02-07 1986-04-22 Santen Pharmaceutical Co., Ltd. Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor
JPS60166674A (ja) * 1984-02-09 1985-08-29 Santen Pharmaceut Co Ltd ベンゾチアジン誘導体

Also Published As

Publication number Publication date
JPS6140264A (ja) 1986-02-26
NZ212060A (en) 1989-10-27
PH21118A (en) 1987-07-27
EP0162776B1 (de) 1989-04-19
AU4251885A (en) 1985-11-21
KR900004320B1 (ko) 1990-06-22
IE851126L (en) 1985-11-18
AU586972B2 (en) 1989-08-03
JPH0692371B2 (ja) 1994-11-16
IE58312B1 (en) 1993-09-08
CA1306747C (en) 1992-08-25
DK219685D0 (da) 1985-05-17
PT80489B (fr) 1986-12-12
DK219685A (da) 1985-11-19
GR851159B (de) 1985-11-25
PT80489A (fr) 1985-06-01
EP0162776A2 (de) 1985-11-27
US4755509A (en) 1988-07-05
ES8607263A1 (es) 1986-05-16
ES543266A0 (es) 1986-05-16
KR850008165A (ko) 1985-12-13
EP0162776A3 (en) 1987-05-06

Similar Documents

Publication Publication Date Title
DE3168037D1 (en) Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient
PT81000A (en) Process for the preparation of heterocyclic derivatives
DE3571131D1 (en) Nitromethylene derivatives, intermediates, and process for their preparation as insecticides
AU5328586A (en) Benzoyl urea compounds, process for their production and antitumorous compositions containing them
CS410491A3 (en) Heterocyclic derivatives, process of their preparation and pharmaceutical containing them
DE3569529D1 (en) Heterocyclic derivatives, process for their preparation and medicaments useful as aldose reductase inhibitors containing them
DE3062586D1 (en) 2-imidazoline derivatives, process for the preparation thereof and the pharmaceutical composition of the same
HUT41611A (en) Herbicides containing as active substance derivatives of phenil triazolinon and process for production of the active substance
AU584920B2 (en) N-substituted triazole derivatives, and their production and use
GR860382B (en) Process for the preparation of heterocyclic derivatives
EP0335409A3 (en) Pyrimidine derivatives, processes for their production and herbicidal compositions containing them
EP0177287A3 (en) Pyrimidine derivatives, processes for preparation thereof and composition of the same
DE3361610D1 (en) Enzyme derivatives, process for preparing them and pharmaceutical compositions containing them
ZA858951B (en) Flavolignane derivatives,process for preparation thereof and pharmaceuticals,which contain these combinations
ZA865328B (en) Oxa-thia and d1-azabicycloalkane derivatives;process for their preparation and their use as pharmaceuticals
ZA85550B (en) Benzopyran derivatives,compositions containing them and process for their preparation
HUT39451A (en) Process for producing 6-substituted mitomycin derivatives and pharmaceutical compositions containing them as active agents
GR862252B (en) Xanthine derivatives, processes for their production and their use as pharmaceuticals
HK86292A (en) Dihydroorotic acid derivatives,processes for their prepararing and pharmaceutical composition containing them
IL77105A (en) N-(dialkylaminoethyl)-cyanobenzamide derivatives,process for their manufacture and pharmaceutical compositions containing them
EP0322765A3 (en) New thiazolidine derivatives, process for preparing same and anti-amnestic composition containing same
HUT41218A (en) Fungicides containing as active substance derivatives of phenil-sulphonil-asole and process for production of the active substance
ZA855245B (en) Aminoeburnanecarboxylic acid derivatives,pharmaceutical compositions containing them and process for preparing same
ZA855244B (en) Nitrovincaminic acid derivatives,pharmaceutical compositions containing them and process for preparing same
DE3571987D1 (en) Cephalosporin derivatives, process for preparing them and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
8380 Miscellaneous part iii

Free format text: DER PATENTINHABER LAUTET RICHTIG: LABORATOIRES UPSA, AGEN, FR

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee