[go: up one dir, main page]

DE3366623D1 - Piperidine dione derivatives with a myocardium protecting and antiarrhytmic activity, process for their preparation and medicines containing them - Google Patents

Piperidine dione derivatives with a myocardium protecting and antiarrhytmic activity, process for their preparation and medicines containing them

Info

Publication number
DE3366623D1
DE3366623D1 DE8383402142T DE3366623T DE3366623D1 DE 3366623 D1 DE3366623 D1 DE 3366623D1 DE 8383402142 T DE8383402142 T DE 8383402142T DE 3366623 T DE3366623 T DE 3366623T DE 3366623 D1 DE3366623 D1 DE 3366623D1
Authority
DE
Germany
Prior art keywords
antiarrhytmic
activity
preparation
dione derivatives
medicines containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383402142T
Other languages
English (en)
Inventor
Claude Bernhart
Werner Cautreels
Patrick Gautier
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi SA
Original Assignee
Sanofi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi SA filed Critical Sanofi SA
Application granted granted Critical
Publication of DE3366623D1 publication Critical patent/DE3366623D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/57—Nitriles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE8383402142T 1982-11-08 1983-11-04 Piperidine dione derivatives with a myocardium protecting and antiarrhytmic activity, process for their preparation and medicines containing them Expired DE3366623D1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8218706A FR2535721A1 (fr) 1982-11-08 1982-11-08 Derives de la piperidinedione protecteurs du myocarde presentant une acticite antiarythmique, leur procede de preparation et les medicaments qui contiennent lesdits derives

Publications (1)

Publication Number Publication Date
DE3366623D1 true DE3366623D1 (en) 1986-11-06

Family

ID=9279000

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383402142T Expired DE3366623D1 (en) 1982-11-08 1983-11-04 Piperidine dione derivatives with a myocardium protecting and antiarrhytmic activity, process for their preparation and medicines containing them

Country Status (29)

Country Link
US (1) US4721710A (de)
EP (1) EP0110755B1 (de)
JP (1) JPS59161377A (de)
KR (1) KR900006721B1 (de)
AT (1) ATE22561T1 (de)
AU (1) AU565519B2 (de)
CA (1) CA1221967A (de)
CS (1) CS244681B2 (de)
DD (3) DD219770A5 (de)
DE (1) DE3366623D1 (de)
DK (1) DK511383A (de)
ES (1) ES8406070A1 (de)
FI (1) FI79536C (de)
FR (1) FR2535721A1 (de)
GR (1) GR78747B (de)
HU (1) HU191494B (de)
IE (1) IE56209B1 (de)
IL (1) IL70099A (de)
MA (1) MA19948A1 (de)
NO (1) NO159852C (de)
NZ (1) NZ206177A (de)
OA (1) OA07582A (de)
PH (1) PH20421A (de)
PL (3) PL140992B1 (de)
PT (1) PT77607B (de)
SG (1) SG1989G (de)
SU (3) SU1333237A3 (de)
YU (3) YU221183A (de)
ZA (1) ZA838065B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4668689A (en) * 1984-07-19 1987-05-26 National Research Development Corporation Glutarimide derivatives for treating oestrogen-dependent tumors
US5238947A (en) * 1990-04-12 1993-08-24 University Of Georgia Research Foundation, Inc. Synthetic piperidinediones with cytostatic activity
US5463063A (en) * 1993-07-02 1995-10-31 Celgene Corporation Ring closure of N-phthaloylglutamines
DE19703763C1 (de) * 1997-02-01 1998-10-01 Gruenenthal Gmbh Thalidomidanaloge Verbindungen aus der Klasse der Piperidin-2,6-Dione
JP5974084B2 (ja) 2011-05-17 2016-08-23 プリンシピア バイオファーマ インコーポレイテッド チロシンキナーゼ阻害剤
KR102052670B1 (ko) 2011-05-17 2019-12-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 키나아제 저해제
US9376438B2 (en) 2011-05-17 2016-06-28 Principia Biopharma, Inc. Pyrazolopyrimidine derivatives as tyrosine kinase inhibitors
SMT201900344T1 (it) 2012-09-10 2019-07-11 Principia Biopharma Inc Composti di pirazolopirimidina come inibitori di chinasi
US8957080B2 (en) 2013-04-09 2015-02-17 Principia Biopharma Inc. Tyrosine kinase inhibitors
BR112016018948B1 (pt) 2014-02-21 2023-01-17 Principia Biopharma Inc Uso de composto ou sal farmaceuticamente aceitável, ácido sulfônico ou sal de ácido carboxílico de composto, forma amorfa de sal farmaceuticamente aceitável de composto, composição farmacêutica e respectivo uso
EP3233103B1 (de) 2014-12-18 2020-10-14 Principia Biopharma Inc. Behandlung von pemphigus
MA42242A (fr) 2015-06-24 2018-05-02 Principia Biopharma Inc Inhibiteurs de la tyrosine kinase
CN115054586B (zh) 2016-06-29 2024-08-02 普林斯匹亚生物制药公司 改性的释放制剂
IL291994A (en) 2019-10-14 2022-06-01 Principia Biopharma Inc Methods for treating immune thrombocytopenia by administering (r)-2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664424A (en) * 1953-12-29 Dioxo-piperidines
GB1455687A (en) * 1972-12-28 1976-11-17 Aspro Nicholas Ltd Pharmacologically active 3-phenyl-3-aminoalkyl-2,6-dioxo-hydro genated pyridines
FR2467200A1 (fr) * 1979-10-11 1981-04-17 Clin Midy Derives du pyrrole actifs sur les troubles du rythme cardiovasculaire

Also Published As

Publication number Publication date
YU221183A (en) 1986-06-30
FI79536B (fi) 1989-09-29
NO159852B (no) 1988-11-07
FR2535721B1 (de) 1985-05-17
MA19948A1 (fr) 1984-07-01
PT77607A (fr) 1983-12-01
PH20421A (en) 1987-01-05
CA1221967A (en) 1987-05-19
EP0110755B1 (de) 1986-10-01
KR900006721B1 (ko) 1990-09-20
HU191494B (en) 1987-02-27
PL244462A1 (en) 1985-02-13
ZA838065B (en) 1984-06-27
ES527091A0 (es) 1984-07-01
DK511383D0 (da) 1983-11-08
SU1333238A3 (ru) 1987-08-23
ATE22561T1 (de) 1986-10-15
NO834057L (no) 1984-05-09
DD229407A5 (de) 1985-11-06
IE56209B1 (en) 1991-05-22
PT77607B (fr) 1986-03-18
SU1333237A3 (ru) 1987-08-23
AU565519B2 (en) 1987-09-17
DK511383A (da) 1984-05-09
IL70099A0 (en) 1984-01-31
SG1989G (en) 1989-06-02
FI834087L (fi) 1984-05-09
SU1316558A3 (ru) 1987-06-07
FI834087A0 (fi) 1983-11-08
YU184285A (en) 1986-06-30
YU184185A (en) 1986-06-30
PL140992B1 (en) 1987-06-30
OA07582A (fr) 1985-03-31
DD229402A5 (de) 1985-11-06
PL140021B1 (en) 1987-03-31
ES8406070A1 (es) 1984-07-01
FI79536C (fi) 1990-01-10
FR2535721A1 (fr) 1984-05-11
AU2089883A (en) 1984-05-17
IE832581L (en) 1984-05-08
NO159852C (no) 1989-02-15
NZ206177A (en) 1985-11-08
CS244681B2 (en) 1986-08-14
PL249750A1 (en) 1985-03-12
DD219770A5 (de) 1985-03-13
JPS59161377A (ja) 1984-09-12
EP0110755A1 (de) 1984-06-13
PL139946B1 (en) 1987-03-31
PL249749A1 (en) 1985-03-12
KR840006641A (ko) 1984-12-01
US4721710A (en) 1988-01-26
IL70099A (en) 1987-10-20
GR78747B (de) 1984-10-02

Similar Documents

Publication Publication Date Title
DE3366623D1 (en) Piperidine dione derivatives with a myocardium protecting and antiarrhytmic activity, process for their preparation and medicines containing them
IE891379L (en) Benzopyrido piperidine, piperidylidene and piperazine¹compounds
HU905859D0 (en) Process for producing amino acid derivatives and pharmaceutical preparatives containing them
NO822705L (no) Fremgangsmaate for fremstilling av 4-metyl-6-fenyl-pyridazinderivater
IL91244A0 (en) Pharmaceutical compositions containing 2-amino-4-morpholino-6-propyl-1,3,5-triazines
HUT65943A (en) Process for producing benzothiazolylmethyl- and pyperazinomethyl-2,4,6-cycloheptatriene-1-one derivatives and pharmaceutical preparations containing them
DE3160360D1 (en) 5-subsituted 5,10-dihydro-11h-dibenzo(b,e)(1,4)diazepin-11-ones, process for preparing them and medicaments containing them
MTP882B (en) Crystalline salto
FR2514765B1 (de)
JPS5625160A (en) Substituted piperazines and piperidines having immunity control activity
FI844423A0 (fi) Eter av ett n-propanolaminderivat.
HU904582D0 (en) Process for producing amino-oligohydroxi derivatives and pharmaceutical preparatives containing those compounds
JPS57200370A (en) 1-acyl group substituted-4-hydroxyalkylhomopiperazine derivative
IL67146A0 (en) 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydropyridazine derivatives,their production and pharmaceutical compositions containing them
HU905030D0 (en) Process for producing new 1,3-oxazines and pharmaceutical preparatives containing these compounds

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee