DE3024768C2 - Parenteral liq. prepn. appts. - comprises closed system including mixing container selectively supplied from substrate containers by dosing syringe - Google Patents

Abstract

At least two containers hold different substrates of parenteral liq., and are connected to a multi-way valve by pipes selectively closable by respective clamps, the valve also communicating with a dosing syringe and a flexible mixing container. Opening a pipe clamp allows the syringe to extract a dose, and deliver it to the mixing container, from any one substrate container at a time, until a desired number of doses are in the mixing container. The whole system is closed against infection penetration, and pref. the syringe barrel and plunger rod are encompassed by an elastic sleeve.

Description

45

The invention relates to an arrangement for the production of parenteral nutrient solutions with a syringe-like suction device for the dosed drawing up of substrates of the nutrient solution from at least two storage containers.

So far, the production of parenteral nutrient solutions has been carried out using a syringe-like suction device, which is initially connected to a first storage container for a first substrate, e.g. B. an amino acid attached to take out a predetermined amount of substrate therefrom. Then the suction device of the first storage container separated and connected to a second storage container for mounting a second substrate, z. B. a carbohydrate solution or an electrolyte connected. The nutrient solution consists of three different substrates, this process is repeated one more time. After the individual Substrates from the storage containers using the syringe οϊ like suction device are drawn, the content of which is constant via a perfusion pump Dosing rate administered. After emptying the syringe-like The suction unit, the procedure described for drawing up and administering is repeated, about 4 to 10 may, depending on the needs of the patient Every day. It is evident that the use of the known arrangement, as it is for. B. in the prospectus "Travenol Wound Irrigation System, 1979" described is - especially in the pediatric field Intensive care medicine - extremely cumbersome to manipulate and highly prone to contamination Dangerous sources of infection are also the opened storage containers, which are provided with a cannula left in a hospital ward, standing around for a longer period of time, as well as possible introduction of germs due to contact contamination during frequent manipulations. The arrangement described and handling have often resulted in patient death. There are above all Premature babies are very much at risk from the infusion therapy described

The invention is therefore based on the object of a To create arrangement for the preparation of parenteral nutrient solutions, in which the risk of contamination Minimum is and which is also characterized by very easy handling

This object is achieved by the characterizing features of claim 1.

The preparation of the mixed solution or nutrient solution takes place in the claimed arrangement in the »closed System «, whereby a whole daily ration can be prepared in the mixing container. The system is therefore largely free of contamination and much easier to handle than the one described at the beginning known arrangement. A repeated procedure of drawing up and administering, interrupted throughout the day by means of a syringe, is omitted in the case of the solution according to the application.

The mixing container is also the administration container from which the nutrient or infusion solution by means of a z. B. permanently connected administration syringe can be removed as required. The mixing container is preferably designed as a flexible bag made of transparent plastic.

The storage containers can also be flexible bags made of transparent plastic, whereby they can be removed are preferably suspended in a sterilization chamber with their connections facing downwards.

With regard to the structural design of the multiple valve used, reference is made to DE-OS 25 18 091 pointed out.

Preferred structural developments of the arrangement are detailed in the subclaims described.

A preferred embodiment of the claimed arrangement is described below with reference to the drawing explained in more detail. It shows

F i g. 1 a closed system for manufacturing or preparation of small and medium-volume parenteral nutrient or infusion solutions, and

F i g. 2 shows a syringe-like suction device, as it is in the arrangement according to FIG. 1 preferred for use should come.

The arrangement shown schematically in Fig. 1 comprises three storage containers 28, 30, 32 ζ. B. for Amino acids. Sugar solution, carbohydrate solution. These storage containers are connected via hose connections 22,24, 26 connected to an inlet 14 of a multiple valve 10. The hose connections 22, 24, 26 are individually by means of hose clamps, preferential

wise roller clamps 34, lockable or clampable. The multiple valve, which is described in detail in DE-OS 25 18 091, comprises, in addition to the inlet 14, an outlet 18 as well as a connection 16 which acts as an inlet and an outlet and to which a metering syringe 14 is connected a so-called umbrella check valve is arranged, which defines a first fluid flow path between the inlet 14 and the connection 16 during a suction stroke of a dosing syringe 12 serving as a suction device and a second fluid flow path between the connection 16 and the outlet 18 when the sucked in fluid is forced out of the syringe 12 again. At the outlet 18 is connected to a mixing tank 20, which is ⁵ dimensioned 'large enough to z. B. one or two daily rations of a nutrient or infusion solution take kanr ;. the storage and Mixing containers are each designed as flexible bags made of transparent plastic, and the entire arrangement is contained within a clean Workbench or within the purity range of the same to the Kontar. inatior.sgefahr to reduce even further.

In the front right in the workbench, which is marked with the reference number 11, there is an already filled one Mixed bag 21 deposited This filled mixed bag 21 is for the administration of the nutrient or infusion solution done.

The administration of the nutrient or infusion solution from the mixing container 20 can by means of a with a Administration syringe coupled to a perfusion pump or in the usual manner with a drip.

In Fig.2 is the solution to the problem promoting construction of a dosing or administration syringe shown, in which the outward protruding part of the piston rod 38 by an elastic sleeve 40, preferably a rubber sleeve known Type, is covered so that this piston rod part has no contact with the environment. In order to the penetration of bacteria via the plunger rod into the interior of the syringe or into the nutrient resp. Infusion solution safely avoided. An inert gas filling is preferably also located inside the cuff. The cuff 40 is by means of hose clips or the like on the cylinder and on the piston rod attached.

For this purpose 2 sheets of drawings

Claims (8)

Patent claims: 1. Arrangement for the production of parenteral nutrient solutions with a syringe-like suction device for the dosed drawing up of substrates of the nutrient solution from at least two storage containers, characterized by a multiple valve (10), the inlet (14) of which with individually lockable hose connections (22,24,26) for connection to the storage container (28, 30, 32) ίο connected and the outlet (18) is connected to a mixing container (20) and one has further both as inlet and outlet effective connection (16) to which the syringe-like Suction device (12) is connected. Z arrangement according to claim 1, characterized in that that the hose connections (22, 24, 26) to the storage containers (28, 30, 32) by means of Hose clamps are lockable. 3. Arrangement according to claim 2, characterized in that φι β the hose clamps (34) as roller clamps are trained. 4. Arrangement according to claim 1, characterized in that the mixing container (20) and the Storage container (28,30,32) made of flexible transparent Plastic bags are made. 5. Arrangement according to claim 1, characterized in that that the hose connections (22, 24, 26) upstream of the inlet (14) of the multiple valve (10) are combined with a connector. 6. Arrangement according to claim 1 or 4, characterized in that the mixing container (20) has a has a second connection (36) for the withdrawal of the mixed nutrient solution through an administration syringe. 7. Arrangement according to claim 1, characterized in that the outwardly protruding part of the Piston rod (38) of the syringe-like suction device (12) through an elastic sleeve (40) is covered. 8. Arrangement according to claim 7, characterized in that the sleeve (40) is a rubber sleeve known design is.