DE2862139D1 - Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for making and using them - Google Patents
Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for making and using themInfo
- Publication number
- DE2862139D1 DE2862139D1 DE7878300753T DE2862139T DE2862139D1 DE 2862139 D1 DE2862139 D1 DE 2862139D1 DE 7878300753 T DE7878300753 T DE 7878300753T DE 2862139 T DE2862139 T DE 2862139T DE 2862139 D1 DE2862139 D1 DE 2862139D1
- Authority
- DE
- Germany
- Prior art keywords
- hexahydroazepine
- piperidine
- processes
- making
- pyrrolidine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 2
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical compound C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 title 1
- 150000003235 pyrrolidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB53370/77A GB1593888A (en) | 1977-12-22 | 1977-12-22 | Hexahydroazepine piperidine and pyrrolidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DE2862139D1 true DE2862139D1 (en) | 1983-01-27 |
Family
ID=10467561
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE7878300753T Expired DE2862139D1 (en) | 1977-12-22 | 1978-12-06 | Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for making and using them |
Country Status (33)
Country | Link |
---|---|
US (2) | US4197239A (de) |
EP (1) | EP0003253B1 (de) |
JP (1) | JPS5488286A (de) |
AR (1) | AR221710A1 (de) |
AT (1) | AT373586B (de) |
AU (1) | AU519653B2 (de) |
CA (2) | CA1113092A (de) |
CS (1) | CS207748B2 (de) |
CY (2) | CY1145A (de) |
DD (2) | DD149515A5 (de) |
DE (1) | DE2862139D1 (de) |
DK (1) | DK156302C (de) |
EG (1) | EG13745A (de) |
ES (2) | ES476160A1 (de) |
FI (1) | FI70575C (de) |
GB (1) | GB1593888A (de) |
GR (1) | GR64029B (de) |
HK (2) | HK18182A (de) |
HU (1) | HU181997B (de) |
IE (1) | IE47631B1 (de) |
IL (1) | IL55924A (de) |
IN (1) | IN150193B (de) |
IT (1) | IT1102761B (de) |
KE (2) | KE3207A (de) |
MX (1) | MX5628E (de) |
MY (2) | MY8200278A (de) |
NZ (1) | NZ188863A (de) |
PH (2) | PH14412A (de) |
PL (1) | PL126008B1 (de) |
PT (1) | PT68962A (de) |
SU (1) | SU1301311A3 (de) |
YU (1) | YU40543B (de) |
ZA (1) | ZA786244B (de) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2051806B (en) * | 1979-07-03 | 1983-04-27 | Wyeth John & Brother Ltd | Hexahydrazepine piperidine and pyrrolidine derivatives |
IE54154B1 (en) * | 1981-12-02 | 1989-07-05 | Wyeth John & Brother Ltd | M-hydroxyphenyl substituted compounds |
US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
SE0001438D0 (sv) * | 2000-04-18 | 2000-04-18 | Axon Chemicals Bv | New chemical compounds and their use in therapy |
KR100421282B1 (ko) * | 2001-08-22 | 2004-03-09 | 부광약품 주식회사 | 1-메틸헥사히드로-4-아제피논 염산염의 제조방법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2524643A (en) * | 1947-12-04 | 1950-10-03 | Maltbie Lab Inc | 3-phenyl-2-piperidones |
US3149123A (en) * | 1961-01-04 | 1964-09-15 | Parke Davis & Co | 1, 3-dialkyl-3-oxyphenylpyrrolidine compounds |
NL265485A (de) * | 1961-06-02 | |||
FR1337793A (fr) * | 1962-06-19 | 1963-09-20 | Parke Davis & Co | Composés de pyrrolidine et procédé de préparation de ces composés |
GB1285025A (en) * | 1968-08-16 | 1972-08-09 | Wyeth John & Brother Ltd | Hexahydroazepines |
CH526536A (de) * | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer 3-Phenylpyrrolidinderivate |
CH526535A (de) * | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate |
CH526534A (de) * | 1970-02-05 | 1972-08-15 | Sandoz Ag | Verfahren zur Herstellung neuer Pyrrolidin-1-carboxamidinderivate |
US3729465A (en) * | 1971-02-03 | 1973-04-24 | Wyeth John & Brother Ltd | Hexahydroazepines |
JPS4911844A (de) * | 1972-05-09 | 1974-02-01 | ||
BE850777A (fr) * | 1976-01-28 | 1977-07-26 | Sandoz Sa | Nouveaux derives de la pyrrolidine |
-
1977
- 1977-12-22 GB GB53370/77A patent/GB1593888A/en not_active Expired
-
1978
- 1978-05-30 CY CY1145A patent/CY1145A/en unknown
- 1978-05-30 CY CY1144A patent/CY1144A/en unknown
- 1978-11-06 ZA ZA786244A patent/ZA786244B/xx unknown
- 1978-11-08 NZ NZ188863A patent/NZ188863A/xx unknown
- 1978-11-09 CA CA316,049A patent/CA1113092A/en not_active Expired
- 1978-11-09 CA CA316,048A patent/CA1113465A/en not_active Expired
- 1978-11-10 IL IL55924A patent/IL55924A/xx unknown
- 1978-11-10 AU AU41479/78A patent/AU519653B2/en not_active Expired
- 1978-11-15 US US05/961,086 patent/US4197239A/en not_active Expired - Lifetime
- 1978-11-15 US US05/961,087 patent/US4197241A/en not_active Expired - Lifetime
- 1978-11-15 IE IE2252/78A patent/IE47631B1/en unknown
- 1978-11-20 IN IN1249/CAL/78A patent/IN150193B/en unknown
- 1978-11-28 AR AR274561A patent/AR221710A1/es active
- 1978-11-30 DK DK546578A patent/DK156302C/da not_active IP Right Cessation
- 1978-11-30 MX MX787562U patent/MX5628E/es unknown
- 1978-12-06 EP EP78300753A patent/EP0003253B1/de not_active Expired
- 1978-12-06 DE DE7878300753T patent/DE2862139D1/de not_active Expired
- 1978-12-08 PH PH21913A patent/PH14412A/en unknown
- 1978-12-08 PH PH21914A patent/PH14517A/en unknown
- 1978-12-15 AT AT0898578A patent/AT373586B/de not_active IP Right Cessation
- 1978-12-19 YU YU2997/78A patent/YU40543B/xx unknown
- 1978-12-19 GR GR57927A patent/GR64029B/el unknown
- 1978-12-20 DD DD78219713A patent/DD149515A5/de unknown
- 1978-12-20 PL PL1978211970A patent/PL126008B1/pl unknown
- 1978-12-20 SU SU782699100A patent/SU1301311A3/ru active
- 1978-12-20 ES ES476160A patent/ES476160A1/es not_active Expired
- 1978-12-20 FI FI783922A patent/FI70575C/fi not_active IP Right Cessation
- 1978-12-20 DD DD78209990A patent/DD141308A5/de unknown
- 1978-12-20 EG EG724/78A patent/EG13745A/xx active
- 1978-12-21 CS CS788756A patent/CS207748B2/cs unknown
- 1978-12-21 PT PT68962A patent/PT68962A/pt unknown
- 1978-12-21 HU HU78WI298A patent/HU181997B/hu unknown
- 1978-12-21 JP JP15695778A patent/JPS5488286A/ja active Granted
- 1978-12-22 IT IT31286/78A patent/IT1102761B/it active
-
1979
- 1979-05-31 ES ES481125A patent/ES481125A1/es not_active Expired
-
1982
- 1982-04-06 KE KE3207A patent/KE3207A/xx unknown
- 1982-04-06 KE KE3206A patent/KE3206A/xx unknown
- 1982-04-29 HK HK181/82A patent/HK18182A/xx not_active IP Right Cessation
- 1982-04-29 HK HK180/82A patent/HK18082A/xx not_active IP Right Cessation
- 1982-12-30 MY MY278/82A patent/MY8200278A/xx unknown
- 1982-12-30 MY MY279/82A patent/MY8200279A/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ186431A (en) | Pyrrolidine derivatives | |
YU40322B (en) | Process for obtaining pyrrolidine derivatives | |
AU3635278A (en) | 3, 3, 3-triarylalkyl-4-phenylalkl-4-hydroxy piperidine derivatives | |
PH13661A (en) | Pyrrolidine derivatives | |
DE2862139D1 (en) | Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for making and using them | |
GB1542823A (en) | Piperidine derivatives | |
AU510454B2 (en) | N-substituted pyrrolidines | |
YU85979A (en) | Process for obtaining pyrrolidine carboxaldehyde and piperidine carboxaldehyde derivatives | |
ZA78493B (en) | Azacycloalkanes,azacycloalkenes and derivatives thereof | |
GB2055835B (en) | Pyrrolidine derivatives | |
DE2862170D1 (en) | Hexahydroazepine, piperidine and pyrrolidine derivatives and processes for preparing them | |
GB2007219B (en) | 4-phenyl-thieno piperidine derivatives | |
AU4274678A (en) | 3,4-methano pyrrolidine derivatives | |
GB2056439B (en) | Hexahydroazepine derivatives | |
IE812267L (en) | Hexahydr0azepine, piperidine and pyrrolidine derivatives. | |
MTP874B (en) | Pyrrolidine derivatives |