DE19581804T1 - Pharmazeutische Zusammensetzungen - Google Patents
Pharmazeutische ZusammensetzungenInfo
- Publication number
- DE19581804T1 DE19581804T1 DE19581804T DE19581804T DE19581804T1 DE 19581804 T1 DE19581804 T1 DE 19581804T1 DE 19581804 T DE19581804 T DE 19581804T DE 19581804 T DE19581804 T DE 19581804T DE 19581804 T1 DE19581804 T1 DE 19581804T1
- Authority
- DE
- Germany
- Prior art keywords
- provides
- macrolide
- class
- compound
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000002191 fatty alcohols Chemical class 0.000 abstract 2
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- -1 ether diol Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 239000012049 topical pharmaceutical composition Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Dispersion Chemistry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9421612A GB9421612D0 (en) | 1994-10-26 | 1994-10-26 | Organic compounds |
GB9422306A GB9422306D0 (en) | 1994-11-04 | 1994-11-04 | Organic compounds |
GBGB9503553.1A GB9503553D0 (en) | 1995-02-22 | 1995-02-22 | Organic compounds |
PCT/EP1995/004208 WO1996013249A1 (en) | 1994-10-26 | 1995-10-26 | Pharmaceutical compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
DE19581804T1 true DE19581804T1 (de) | 1998-01-22 |
Family
ID=27267447
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE19581804T Ceased DE19581804T1 (de) | 1994-10-26 | 1995-10-26 | Pharmazeutische Zusammensetzungen |
DE69534306T Expired - Lifetime DE69534306T2 (de) | 1994-10-26 | 1995-10-26 | Arzneimittel |
DE69525957T Expired - Lifetime DE69525957T2 (de) | 1994-10-26 | 1995-10-26 | Verwendung eines ungesättigten Fettalkohols |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69534306T Expired - Lifetime DE69534306T2 (de) | 1994-10-26 | 1995-10-26 | Arzneimittel |
DE69525957T Expired - Lifetime DE69525957T2 (de) | 1994-10-26 | 1995-10-26 | Verwendung eines ungesättigten Fettalkohols |
Country Status (26)
Country | Link |
---|---|
US (1) | US6352998B2 (de) |
EP (2) | EP0786986B1 (de) |
JP (3) | JP4155593B2 (de) |
KR (1) | KR100434682B1 (de) |
CN (2) | CN100335063C (de) |
AT (2) | ATE214593T1 (de) |
AU (1) | AU714254B2 (de) |
BR (1) | BR9509530A (de) |
CA (1) | CA2200966C (de) |
CY (1) | CY2211B1 (de) |
CZ (1) | CZ289773B6 (de) |
DE (3) | DE19581804T1 (de) |
DK (2) | DK0786986T3 (de) |
ES (2) | ES2243369T3 (de) |
FI (2) | FI119754B (de) |
GB (1) | GB2308546B (de) |
HK (1) | HK1053611A1 (de) |
HU (1) | HU223840B1 (de) |
MX (1) | MX9702699A (de) |
NO (2) | NO316963B1 (de) |
NZ (2) | NZ331824A (de) |
PL (1) | PL184750B1 (de) |
PT (2) | PT1147766E (de) |
SI (1) | SI0786986T1 (de) |
SK (1) | SK284591B6 (de) |
WO (1) | WO1996013249A1 (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR004480A1 (es) * | 1995-04-06 | 1998-12-16 | Amico Derin C D | Compuestos de ascomicina que poseen actividad antiinflamatoria, pro cedimiento para prepararlos, uso de dichos compuestos para preparar agentesfarmaceuticos y composiciones farmaceuticas que los incluyen |
GB9601120D0 (en) * | 1996-01-19 | 1996-03-20 | Sandoz Ltd | Organic compounds |
CZ283516B6 (cs) * | 1996-09-12 | 1998-04-15 | Galena A.S. | Léčivé přípravky, zejména pro vnitřní aplikaci, ve formě samomikroemulgujících terapeutických systémů |
US6495579B1 (en) * | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
TW450810B (en) * | 1997-02-20 | 2001-08-21 | Fujisawa Pharmaceutical Co | Macrolides antibiotic pharmaceutical composition for preventing and treating skin diseases |
DE19744621A1 (de) * | 1997-10-09 | 1999-04-15 | Muehlbauer Ernst Kg | Mischung zur Verwendung als Wundverband |
GB9723669D0 (en) * | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
DE19802205A1 (de) * | 1998-01-22 | 1999-07-29 | Beiersdorf Ag | Kosmetische und dermatologische Zubereitungen, enthaltend erhöhte Elektrolytkonzentrationen |
ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
JP3732525B2 (ja) * | 1998-04-27 | 2006-01-05 | アステラス製薬株式会社 | 医薬組成物 |
GB9814640D0 (en) * | 1998-07-06 | 1998-09-02 | Fujisawa Pharmaceutical Co | New use |
GB9826656D0 (en) * | 1998-12-03 | 1999-01-27 | Novartis Ag | Organic compounds |
US20070032853A1 (en) | 2002-03-27 | 2007-02-08 | Hossainy Syed F | 40-O-(2-hydroxy)ethyl-rapamycin coated stent |
GB0003932D0 (en) * | 2000-02-18 | 2000-04-12 | Novartis Ag | Pharmaceutical compositions |
CA2435306C (en) * | 2001-02-16 | 2010-12-21 | Stephan Wnendt | Implants with fk506 |
GB0108498D0 (en) * | 2001-04-04 | 2001-05-23 | Novartis Ag | Organic Compounds |
AR035293A1 (es) * | 2001-08-23 | 2004-05-05 | Novartis Ag | Composicion oftalmica. |
PE20030828A1 (es) * | 2002-03-04 | 2003-11-04 | Novartis Ag | Composicion oftalmica que comprende ascomicina |
GB0218996D0 (en) * | 2002-08-14 | 2002-09-25 | Novartis Ag | Organic compounds |
EP1594484A2 (de) * | 2003-02-17 | 2005-11-16 | Cipla Ltd. | Pharmazeutisches pflaster |
GB0307869D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
GB0307867D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
GB0307866D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
MXPA06001288A (es) * | 2003-07-31 | 2006-04-11 | Upjohn Co | Formulacion dispersable de un agente anti-inflamatorio. |
GB0408070D0 (en) * | 2004-04-08 | 2004-05-12 | Novartis Ag | Pharmaceutical formulations |
JP5021456B2 (ja) * | 2004-04-08 | 2012-09-05 | ノバルティス アーゲー | ヘキシレングリコール、所望によりオレイルアルコール、ジメチルイソソルバイドおよび/または中鎖トリグリセリドを含むピメクロリムス泡状組成物 |
GB0508827D0 (en) * | 2005-04-29 | 2005-06-08 | Novartis Ag | Cosmeceutical composition |
WO2008063563A2 (en) | 2006-11-16 | 2008-05-29 | Transderm, Inc. | Methods of treating keratin hyperproliferation disorders using mtor inhibitors |
EP2016935A1 (de) * | 2007-07-09 | 2009-01-21 | Intendis GmbH | Pharmazeutische Zusammensetzung zur topischen Anwendung schwer löslicher Verbindungen |
CN101288643B (zh) * | 2008-06-17 | 2012-11-14 | 杨喜鸿 | 含有他克莫司的凝胶剂组合物及其制备方法和药物应用 |
EP2308468A1 (de) * | 2009-10-08 | 2011-04-13 | Novaliq GmbH | Neuartige pharmazeutische Zusammensetzung mit einem Makrolid-Immunosuppressivum |
GB0917817D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
GB0917816D0 (en) | 2009-10-12 | 2009-11-25 | Biotica Tech Ltd | Novel compounds and methods for their production |
EP2366378A1 (de) | 2010-03-01 | 2011-09-21 | Dexcel Pharma Technologies Ltd. | Donepezilformulierungen mit verzögerter Freisetzung |
JP5674786B2 (ja) * | 2010-07-23 | 2015-02-25 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
WO2012011192A1 (ja) * | 2010-07-23 | 2012-01-26 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
CN102552253A (zh) * | 2012-01-17 | 2012-07-11 | 唯美度科技(北京)有限公司 | 一种祛痘用皮肤外用剂 |
WO2013111817A1 (ja) * | 2012-01-25 | 2013-08-01 | マルホ株式会社 | タクロリムスを含有する水中油型クリーム状組成物 |
ES2797376T3 (es) * | 2013-01-24 | 2020-12-02 | Palvella Therapeutics Inc | Composiciones para la administración transdérmica de inhibidores de mTOR |
MX367121B (es) * | 2013-08-02 | 2019-08-06 | Laboratorio Raam De Sahuayo S A De C V | Composición sólida estable de inmunosupresores. |
DE102013222164A1 (de) * | 2013-10-31 | 2015-04-30 | Deb Ip Limited | Stabilisierte multiple Emulsionen als Hautschutzprodukt |
US10765665B2 (en) * | 2015-11-24 | 2020-09-08 | Melin Jeffrey | Composition comprising combination of rapamycin and an activator of AMP kinase and use thereof for treating diseases |
CN105663027B (zh) * | 2016-04-01 | 2018-12-18 | 中国人民解放军广州军区武汉总医院 | 西罗莫司外用制剂、其制备方法及用途 |
JP6932180B2 (ja) * | 2016-04-04 | 2021-09-08 | エムシー2・セラピューティクス・リミテッドMC2 Therapeutics Limited | タクロリムスを含む局所組成物 |
EP3565520A4 (de) | 2017-01-06 | 2020-08-19 | Palvella Therapeutics, Inc. | Wasserfreie zusammensetzungen von mtor-hemmern und verfahren zur verwendung |
KR101973065B1 (ko) | 2017-09-13 | 2019-04-26 | (주)썬테크 | 풍력 발전기 및 풍력 발전기의 블레이드 팁 |
EP3542788A1 (de) | 2018-03-19 | 2019-09-25 | MC2 Therapeutics Limited | Topische zusammensetzung enthaltend calcipotriol und betamethason dipropionat |
KR101995905B1 (ko) | 2018-03-27 | 2019-07-04 | (주)썬테크 | 풍력 발전기 및 풍력 발전기의 발전모터 |
WO2019233722A1 (en) * | 2018-06-08 | 2019-12-12 | Almirall, S.A. | Pharmaceutical composition comprising tacrolimus |
JP2021530463A (ja) | 2018-07-02 | 2021-11-11 | パルヴェラ セラピューティクス、インク. | mTOR阻害剤の無水組成物および使用方法 |
WO2024213629A1 (en) * | 2023-04-11 | 2024-10-17 | Bausch Health Ireland Limited | Topical compositions |
Family Cites Families (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4299826A (en) | 1979-10-12 | 1981-11-10 | The Procter & Gamble Company | Anti-acne composition |
US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
PH26083A (en) | 1987-11-09 | 1992-02-06 | Sandoz Ltd | 11, 28-dioxa-4-azatricyclo [22.3.1.04.9) octacos-18-ene derivatives and pharmaceutical compositions containing them and method of use thereof |
EP0346427B1 (de) | 1987-12-09 | 1995-03-29 | FISONS plc | Makrozyklische verbindungen |
KR0159766B1 (ko) * | 1989-10-16 | 1998-12-01 | 후지사와 토모키치로 | 양모제 조성물 |
DE10299040I2 (de) * | 1989-11-09 | 2006-08-24 | Novartis Ag | Heteroatome enthaltende tricyclische Verbindungen |
US5061700A (en) | 1989-11-16 | 1991-10-29 | Gordon Jay Dow | Glyceryl acetate ointment vehicles |
WO1991013899A1 (en) | 1990-03-12 | 1991-09-19 | Fujisawa Pharmaceutical Co., Ltd. | Tricyclo compounds |
EP0533930A1 (de) | 1990-06-11 | 1993-03-31 | Fujisawa Pharmaceutical Co., Ltd. | Verwendung von einem makrolide sowie fk 506 zur herstellung von arzneimitteln für die behandlung von idiopathic thrombocytopenic purpura und basedow'schen krankheit |
MY110418A (en) | 1990-07-02 | 1998-05-30 | Novartis Ag | Heteroatoms-containing tricyclic compounds. |
ATE150304T1 (de) * | 1990-09-04 | 1997-04-15 | Fujisawa Pharmaceutical Co | Tricyclische verbindungen enthaltende salben |
US5143918A (en) * | 1990-10-11 | 1992-09-01 | Merck & Co., Inc. | Halomacrolides and derivatives having immunosuppressive activity |
PH31204A (en) * | 1990-11-02 | 1998-05-05 | Fujisawa Pharmaceutical Co | Pharmaceutical composition. |
IE65341B1 (en) | 1990-11-08 | 1995-10-18 | Fujisawa Pharmaceutical Co | Suspensions containing tricyclic compounds |
US5208241A (en) | 1991-09-09 | 1993-05-04 | Merck & Co., Inc. | N-heteroaryl, n-alkylheteroaryl, n-alkenylheteroaryl and n-alkynylheteroarylmacrolides having immunosuppressive activity |
US5252732A (en) | 1991-09-09 | 1993-10-12 | Merck & Co., Inc. | D-heteroaryl, O-alkylheteroaryl, O-alkenylheteroaryl and O-alkynylheteroarylmacrolides having immunosuppressive activity |
US5247076A (en) | 1991-09-09 | 1993-09-21 | Merck & Co., Inc. | Imidazolidyl macrolides having immunosuppressive activity |
HUT66531A (en) | 1992-05-07 | 1994-12-28 | Sandoz Ag | Heteroatoms-containing tricyclic compounds, pharmaceutical prepns contg. them and process for producing them |
GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
JPH06183970A (ja) * | 1992-12-16 | 1994-07-05 | Fujisawa Pharmaceut Co Ltd | 医薬用組成物 |
MY110603A (en) | 1993-05-27 | 1998-08-29 | Novartis Ag | Tetrahydropyran derivatives |
CH686761A5 (de) * | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
DE10199039I2 (de) | 1993-10-22 | 2008-08-07 | Hexal Ag Ind 25 | Pharmazeutische zusammensetzung mit cyclosporin a, einen vitamin e derivat und einen emulgator |
-
1995
- 1995-10-26 AU AU38451/95A patent/AU714254B2/en not_active Expired
- 1995-10-26 DK DK95936554T patent/DK0786986T3/da active
- 1995-10-26 GB GB9707484A patent/GB2308546B/en not_active Expired - Lifetime
- 1995-10-26 DK DK01117396T patent/DK1147766T3/da active
- 1995-10-26 NZ NZ331824A patent/NZ331824A/xx not_active IP Right Cessation
- 1995-10-26 PL PL95319599A patent/PL184750B1/pl unknown
- 1995-10-26 AT AT95936554T patent/ATE214593T1/de active
- 1995-10-26 DE DE19581804T patent/DE19581804T1/de not_active Ceased
- 1995-10-26 DE DE69534306T patent/DE69534306T2/de not_active Expired - Lifetime
- 1995-10-26 BR BR9509530A patent/BR9509530A/pt not_active Application Discontinuation
- 1995-10-26 KR KR1019970702752A patent/KR100434682B1/ko not_active IP Right Cessation
- 1995-10-26 ES ES01117396T patent/ES2243369T3/es not_active Expired - Lifetime
- 1995-10-26 PT PT01117396T patent/PT1147766E/pt unknown
- 1995-10-26 CN CNB021243700A patent/CN100335063C/zh not_active Expired - Lifetime
- 1995-10-26 WO PCT/EP1995/004208 patent/WO1996013249A1/en active IP Right Grant
- 1995-10-26 EP EP95936554A patent/EP0786986B1/de not_active Expired - Lifetime
- 1995-10-26 CN CN95195900A patent/CN1089233C/zh not_active Expired - Lifetime
- 1995-10-26 MX MX9702699A patent/MX9702699A/es active IP Right Grant
- 1995-10-26 PT PT95936554T patent/PT786986E/pt unknown
- 1995-10-26 AT AT01117396T patent/ATE299017T1/de active
- 1995-10-26 JP JP51431096A patent/JP4155593B2/ja not_active Expired - Lifetime
- 1995-10-26 DE DE69525957T patent/DE69525957T2/de not_active Expired - Lifetime
- 1995-10-26 SK SK520-97A patent/SK284591B6/sk not_active IP Right Cessation
- 1995-10-26 EP EP01117396A patent/EP1147766B1/de not_active Expired - Lifetime
- 1995-10-26 NZ NZ295170A patent/NZ295170A/xx not_active IP Right Cessation
- 1995-10-26 HU HU9701928A patent/HU223840B1/hu active IP Right Revival
- 1995-10-26 ES ES95936554T patent/ES2173978T3/es not_active Expired - Lifetime
- 1995-10-26 SI SI9530589T patent/SI0786986T1/xx unknown
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- 1995-10-26 CZ CZ19971232A patent/CZ289773B6/cs not_active IP Right Cessation
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1997
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- 1997-04-25 NO NO19971951A patent/NO316963B1/no not_active IP Right Cessation
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2000
- 2000-12-01 CY CY0000067A patent/CY2211B1/xx unknown
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2001
- 2001-01-23 US US09/767,656 patent/US6352998B2/en not_active Expired - Lifetime
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2003
- 2003-08-20 HK HK03105954A patent/HK1053611A1/xx not_active IP Right Cessation
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2004
- 2004-09-08 NO NO2004005C patent/NO2004005I2/no unknown
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2007
- 2007-02-27 JP JP2007047216A patent/JP2007145860A/ja not_active Withdrawn
- 2007-12-28 FI FI20071025A patent/FI119755B/fi not_active IP Right Cessation
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2012
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