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DE1900279C3 - Incubator for an automatic chemical analyzer - Google Patents

Incubator for an automatic chemical analyzer

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Publication number
DE1900279C3
DE1900279C3 DE1900279A DE1900279A DE1900279C3 DE 1900279 C3 DE1900279 C3 DE 1900279C3 DE 1900279 A DE1900279 A DE 1900279A DE 1900279 A DE1900279 A DE 1900279A DE 1900279 C3 DE1900279 C3 DE 1900279C3
Authority
DE
Germany
Prior art keywords
block
heat
container
temperature
shaped
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE1900279A
Other languages
German (de)
Other versions
DE1900279A1 (en
DE1900279B2 (en
Inventor
Donald Norman Whittier Calif. Martin (V.St.A.)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Beckman Instruments Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beckman Instruments Inc filed Critical Beckman Instruments Inc
Publication of DE1900279A1 publication Critical patent/DE1900279A1/en
Publication of DE1900279B2 publication Critical patent/DE1900279B2/en
Application granted granted Critical
Publication of DE1900279C3 publication Critical patent/DE1900279C3/en
Expired legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • B01L7/525—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones
    • B01L7/5255—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples with physical movement of samples between temperature zones by moving sample containers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/26—Inoculator or sampler
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • C12M1/34—Measuring or testing with condition measuring or sensing means, e.g. colony counters
    • C12M1/3446—Photometry, spectroscopy, laser technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/12—Well or multiwell plates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/12—Means for regulation, monitoring, measurement or control, e.g. flow regulation of temperature
    • C12M41/18—Heat exchange systems, e.g. heat jackets or outer envelopes
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
    • F04B43/1284—Means for pushing the backing-plate against the tubular flexible member
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/12—Machines, pumps, or pumping installations having flexible working members having peristaltic action
    • F04B43/1253—Machines, pumps, or pumping installations having flexible working members having peristaltic action by using two or more rollers as squeezing elements, the rollers moving on an arc of a circle during squeezing
    • F04B43/1292—Pumps specially adapted for several tubular flexible members
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/8483—Investigating reagent band
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00009—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with a sample supporting tape, e.g. with absorbent zones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/809—Incubators or racks or holders for culture plates or containers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/11—Automated chemical analysis
    • Y10T436/110833—Utilizing a moving indicator strip or tape

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sustainable Development (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Thermal Sciences (AREA)
  • Optics & Photonics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Description

3 43 4

Wärmekontakt mit dem becherförmigen Beliälter 18 gestreckten Block bilden, wobei jeder Blockabschnitt des Behälterkörpers 20 befindet. Der Behälterkörper seine eigene Heizvorrichtung hat und auf einer ge-20 ist auf zwei vertikal hin- und herbewegbaren wünschten Temperatur gehalten wird, so daß z.B. Schienen 26 angeordnet und ist durch horizontal hin- die Probensubstanz zunächst in dem Blockabschnitt und herbewegbare Zahnstangen 28 bewegbar, wobei 5 10 α einer höheren Temperatur unterworfen wird, die Bewegung des Blockes 10 mit der Bewegung der damit sie schnell auf die zum Brüten erforderliche Schienen 26 und der Zahnstangen 28 derart synchro- Temperatur erhitzt wird, worauf ein Übergang zu nisiert ist, daß der Behälterköiper 20 über einen dem Blockabschnitt 10 b erfolgt, der auf der zum zahnförmigen Vorsprung 14 hinwegbewegt wird, Brüten gewünschten Temperatur gehalten wird. Da wenn der Block 10 zurückgezogen ist. Auf diese io es ferner wünschenswert ist, während der letzten Weise wird während jedes Zyklus der Behälterkörper Phase des Brutvorganges die Probensubstanz abzu-20 jeweils zu dem nächsten zahnförmigen Vorsprung kühlen, ist der letzte Blockabschnitt 10 c zum Ab-14 bewegt, und der Inhalt des becherförmigen Behäl- kühlen ausgebildet, so daß der damit in Kontakt treters 18 wird während der Ruheperiode, die den groß- tende becherförmige Behälter 18 abgekühlt wird, ten Teil des Zyklus ausmacht, dem Erhitzungsvor- 15 Zweckmäßigerweise wird zwischen den einzelnen gang unterworfen. Indem man eine entsprechende Blockabschnitten eine Wärmeisolation 30 vorgese-Anzahl von Wärmeaustauschstationen vorsieht und hen.Form thermal contact with the cup-shaped reservoir 18 elongated block, each block portion of the container body 20 being located. The container body has its own heating device and is kept at a temperature of two vertically reciprocating desired temperature, so that, for example, rails 26 are arranged and is movable by horizontally reciprocating the sample substance first in the block section and movable racks 28, whereby 5 10 α is subjected to a higher temperature, the movement of the block 10 with the movement of the so that it is quickly heated to the rails 26 required for incubation and the racks 28 so synchro-temperature, whereupon a transition is to be nized that the container body 20 takes place via one of the block section 10 b , which is moved along the tooth-shaped projection 14, breeding desired temperature is maintained. Since when the block 10 is withdrawn. In this way it is also desirable during the last way during each cycle the container body phase of the incubation process cools the sample substance to the next tooth-shaped projection, the last block section 10c is moved to the Ab-14, and the contents of the Cup-shaped container cooling is designed so that the person who comes into contact therewith 18 is during the rest period, which the large cup-shaped container 18 is being cooled, constitutes part of the cycle, the heating process is expediently subjected between the individual courses. By providing heat insulation 30 to a number of heat exchange stations in appropriate block sections.

ferner die Temperatur, auf der der Block 10 gehalten Bei den vorstehend beschriebenen Figuren trat nuralso the temperature at which the block 10 is kept. In the figures described above, only occurred

wird, sowie die Dauer des Zyklus und der Ruhepe- jeweils ein becherförmiger Behälter 18 des Behälter-is, as well as the duration of the cycle and the rest period- each a cup-shaped container 18 of the container-

riode entsprechend wählt, kann man jedes ge- 20 körpers 20 in Wärmekontakt mit einer Wärmeaus-If the period is selected accordingly, each body 20 can be in thermal contact with a heat exchanger.

wünschte Maß des Brütens erreichen. Sieht man nur tauschstation. Es können jedoch gemäß F i g. 4 ne-wanted to reach degree of brooding. If you only see exchange station. However, according to FIG. 4 ne-

kurze Übergangszeiten zwischen den Ruheperioden ben dem Block 10 und Seite an Seite mit diesemshort transition times between the rest periods ben the block 10 and side by side with this

vor, so wird praktisch die gesamte Zeitdauer eines noch mehrere Blöcke 10', 10", 10'" vorgesehen wer-before, practically the entire period of one or more blocks 10 ', 10 ", 10'" will be provided

Zyklus für den Wärmeaustausch ausgenutzt. den, die erforderlichenfalls voneinander isoliert sind,Cycle used for heat exchange. those who are isolated from each other if necessary,

Gemäß Fig.3 besteht der die Wärmeaustausch- 25 so daß eine Mehrzahl becherförmiger Behälter 18According to FIG. 3, there is the heat exchange 25 so that a plurality of cup-shaped containers 18

Stationen tragende Block aus mehreren kürzeren Ab- eines Behälterkörpers 20 dem Brütvorgang gleichzei-Stations-carrying block of several shorter Ab- a container body 20 the incubation process at the same time-

schnitten 10 a, 10 b, 10 c, die zusammen einen lang- tig unterworfen wird.cuts 10 a, 10 b, 10 c, which together are subjected to a long length.

Hierzu 1 Blatt Zeichnungen1 sheet of drawings

Claims (4)

Es ist femer bekannt (USA.-Patentschrift Patentansprüche: 3 271112), einen temperaturgeregelten Metallblock mit Löchern zur Aufnahme von Reagenzröhrdien zuIt is also known (United States patent patent claims: 3 271112) to provide a temperature-controlled metal block with holes for receiving reagent tubes 1. Brutvorrichtung für einen automatischen versehen, um die Reagenzröhrchen auf einer genau chemischen Analysierapparat unter Anwendung 5 definierten Reaktionstemperatur halten zu können,
von Behälterkörpern, von denen jeder mindestens Die Aufgabe der Erfindung ist es, eine für das Areinen becherförmigen Behälter zur Aufnahme beiten innerhalb eines automatischen chemischen einer einem Brutvorgang zu unterwerfenden Pro- Analysierapparates geeignete Brutvorrichtung der bensubstanz aufweist, mit mehreren Wärmeaus- eingangs genannten Art zu schaffen, die in Hersteltauschstationen und mit einer Vorschubvorrich- io lung und Wartung einen möglichst geringen Aufwand tung, die für eine vorgebbare Zeitspanne einen erfordert.1. Incubation device for an automatic provided, in order to be able to keep the test tubes on an exactly chemical analyzer under application 5 defined reaction temperature,
of container bodies, each of which has at least The object of the invention is to create an incubation device of the benign substance suitable for the area, cup-shaped container to be received within an automatic chemical incubation device suitable for an incubation process, with several heat outputs mentioned at the beginning which, in manufacturing exchange stations and with a feed device and maintenance, require as little effort as possible, which requires one for a predeterminable period of time. Wärmeaustausch zwischen einer Wärmeaus- Die Aufgabe wird erfindungsgemäß dadurch ge-Heat exchange between a heat exchanger. tauschstation und einem becherförmigen Behäl- löst, daß die Wärmeaustauschstationen aus zahnför-exchange station and a cup-shaped container, that the heat exchange stations from tooth-conveying ter bewirkt, dadurch, gekennzeichnet, migen Vorsprängen bestehen, von denen jeder eineter causes, characterized, consist of moderate projections, each of which is one daß die Wärmeaustauschstationen aus zahn- i5 Vertiefung aufweist, die zwecks Aufnahme eines be-that the heat exchange stations from tooth i 5 has recess, which for the purpose of receiving a förmigen Vorsprängen (14) bestehen, von denen cherförmigen Behälters an diesen angepaßt ist, undshaped projections (14) exist, of which cher-shaped container is adapted to this, and jeder eine Vertiefung (t6) aufweist, die zwecks daß die Vorschubvorrichtung für eine schrittweiseeach has a recess (t6) which, in order that the feed device for a step-by-step Aufnahme eines becherförmigen Behälters (18) Arbeitsweise ausgebildet ist.Receiving a cup-shaped container (18) mode of operation is formed. an diesen angepaßt ist, und daß die Vorschubvor- Gegenüber Wärmebädern bietet die anmeldungs-is adapted to this, and that the feed front Opposite heat baths offers the registration richtung (26, 28) für eine schrittweise Arbeits- 20 gemäße Vorrichtung den Vorteil, daß das von Zeitdirection (26, 28) for a step-by-step work 20 according device the advantage that the time weise ausgebildet ist. zu Zeit vorzunehmende Erneuern der Wärmeflüssig-is trained wisely. Renewal of the thermal liquid that has to be carried out at 2. Bratvorrichtung nach Anspruch 1, dadurch keit sowie auch die Gefahr von durch die Wärmegekennzeichnet, daß die zahnförmigen Vor- flüssigkeit verursachten KorrosicnSbChäden entfällt. Sprünge (14) auf einem langgestreckten Block Sch'ieß'dch wird auch eine verbesserte Raumökono-(10) angeordnet sind. 25 mie erreicht.2. Roasting device according to claim 1, characterized speed as well as the risk of characterized by the heat, Corrosive damage caused by the tooth-like preliminary fluid is eliminated. Jumps (14) on an elongated block Sch'ieß'dch will also improve space economy (10) are arranged. 25 mie reached. 3. Bratvorrichtung nach Anspruch 1 oder 2, Aus- und Weiterbildungen der Erfindung sind in dadurch gekennzeichnet, daß die Wärmeaus- den Unteransprächen dargelegt,
tauschstationen unterschiedlich erhitzbar sind Ausführungsbeispiele der Erfindung werden nach- und die Vorschubvorrichtung (26, 28) zum fort- stehend an Hand der Zeichnungen näher erläutert, schreitenden Transport eines Behälters (18) von 30 Es zeigt3. Roasting device according to claim 1 or 2, training and further developments of the invention are characterized in that the heat from the subclaims set out,
Exchange stations can be heated differently. Embodiments of the invention will be explained in more detail afterwards and the advancing device (26, 28) will continue to be explained in more detail with reference to the drawings, stepping transport of a container (18) from FIG. 30 einer Wärmeaustauschstation zur nächsten ausge- F i g. 1 die auf einem Block befindlichen Wärmebildet ist. austauschstationen einer Bratvorrichtung,a heat exchange station to the next out- F i g. 1 which forms heat located on a block is. exchange stations of a roasting device, 4. Bratvorrichtung nach Ansprach 3, dadurch F i g. 2 einen Querschnitt durch die Anordnung gekennzeichnet, daß die Wärmeaustauschstatio- von Fig. 1, wobei das Zusammenwirken der Wärmenen in der Weise erhiizbar sind, daß die erste 35 austauschstationen mit einem Behälterkörper veran-Station (10 a) eine oberhalb der füi den Brutvor- schaulicht ist,4. Roasting device according to spoke 3, thereby F i g. 2 a cross section characterized by the arrangement that the Wärmeaustauschstatio- of Fig. 1, wherein the interaction of the Wärmenen are erhiizbar in such a way that the first 35 exchange stations having a container body veran station (10 a) above the Fuei the Brutvor- is clear, gang erforderlichen Temperatur, die weiteren F i g. 3 eine der F i g. 1 ähnliche Ansicht, wobei estransition required temperature, the other F i g. 3 one of the F i g. 1 similar view, being there Stationen (10 b) die für den Bratvorgang erfor- sich jedoch um einen in verschiedenen Stufen unter-Stations (10 b) that are necessary for the roasting process, however, are different in different stages. derliche Temperatur und die letzte Station (10 c) schiedlich aufheizbaren Block handelt,the same temperature and the last station (10 c) is a differently heatable block, eine unterhalb der Bruttemperatur liegende Tem- 40 Fig.4 eine der Fig.2 ähnliche Ansicht, bei dera temperature below the incubation temperature peratur aufweist. jedoch mehrere Blöcke nebeneinander angeordnethas temperature. however several blocks arranged side by side ~ sind, so daß gleichzeitig mehrere Behälter eines Be-~, so that several containers of a loading hälterkörpers wärmebehandelt werden können.container body can be heat treated. In F i g. 1 besteht der Block 10 aus einem geeigne-45 ten Material, beispielsweise Aluminium od. dgl., hatIn Fig. 1, the block 10 consists of a suitable material, for example aluminum or the like. Has Die Erfindung bezieht sich auf eine Brutvorrich- eine langgestreckte gezahnte Form und ist auf einem tung für einen automatischen chemischen Analysier- vertikalen pneumatischen Zylinder 12 angeordnet, apparat unter Anwendung von Behäiterkörpern, Jeder zahnförmige Vorsprang 14 des Blockes 10 ist von denen jeder mindestens einen becherförmigen ausgehöhlt unter Bildung einer Vertiefung 16, deren Behälter zur Aufnahme einer einem Bratvorgang zu 5» Innenfläche genau der äußeren Fläche eines becherunterwerfernden Probensubstanz aufweist, mit meh- förmigen Behälters 18 des Behälterkörpers 20 angereren Wärmeaustauschstationen und mit einer Vor- paßt ist, zu dem Zweck, eine Wärmeaustauschstation Schubvorrichtung, die für eine vorgebbare Zeit- zu bilden. Der Block 10 hat gemäß Fig.2 eine spanne einen Wärmeaustausch zwischen einer War- Längsbohrung 22, in der ein geeignetes Heizmittel meaustauschstation und einem becherförmigen Be- 55 angeordnet ist, durch das der Block auf einer gehälter bewirkt. wünschten Temperatur gehalten wird; es kann sich Bei einer bekannten Vorrichtung dieser Art (fran- beispielsweise um eine durch einen Thermostatenzösische Patentschrift 1459 696) werden in Gestellen Schalter gesteuerte Widerstandsheizung handeln,
befindliche Reagenzröhrchen, die Probensubstanz Der temperaturgeregelte Block 10 ist vertikal aufenthalten, mit kontinuierlich umlaufenden Ketten fin und abbewegbar, was durch den Doppelpfeil 24 in durch verschiedene Behandlungsstationen bewegt. F i g. 1 angedeutet ist. Auf diese Weise kann der Die Wärmebehandlung wird dabei in der Weise Block 10 gemäß F i g. 2 in Berührung mit einem bedurchgeführt, daß die die Reagenzröhrchen tragen- cherförmigen Behälter 18 eines Behälterkörpers 20 den Gestelle durch Wärmebäder hindurchgeführt gebrach* werden, in der sich die dem Brutvorgang zu werden. Durch eng verschachtelte Führung der 65 unterwerfende Probensubstanz befindet. Es wird Transportketten kann die Geschwindigkeit, mit der dann innerhalb jeder Minute während einer Ruhepedie Röhrchen an sich kontinuierlich bewegt werden, riode von etwa 58 Sekunden Wärme übertragen, woherabgesetzt werden. bei sich der Block 10 während dieser Zeitspanne inThe invention relates to an incubator - an elongated toothed shape and is arranged on a device for an automatic chemical analyzer vertical pneumatic cylinder 12, apparatus using container bodies, each tooth-shaped projection 14 of the block 10, each of which is hollowed out at least one cup-shaped with the formation of a recess 16, the container of which has an inner surface that is exactly the same as the outer surface of a sample substance to be subjected to a roasting process, with multi-shaped containers 18 of the container body 20 and is more suitable for heat exchange stations, for the purpose of providing a Heat exchange station pusher, which form for a predetermined time. According to FIG. 2, the block 10 has a span of heat exchange between a longitudinal bore 22, in which a suitable heating means is arranged, and a cup-shaped container 55, through which the block effects a container. desired temperature is maintained; In a known device of this type (French, for example, by a thermostat-French patent specification 1459 696) there will be resistance heating controlled in racks,
located reagent tubes, the sample substance The temperature-controlled block 10 is located vertically, with continuously circulating chains fin and movable, which is moved by the double arrow 24 in through different treatment stations. F i g. 1 is indicated. In this way, the heat treatment is carried out in the manner block 10 according to FIG. 2 in contact with one carried out that the reagent tube-shaped container 18 of a container body 20 carrying the test tubes are passed through the racks through heat baths, in which the incubation process takes place. The sample substance to be subjected to 65 is located by closely nested guidance. Transport chains can transfer the speed at which the tubes per se are continuously moved within each minute during a resting period, and heat is transferred over a period of around 58 seconds, whereupon it is reduced. in the case of the block 10 during this period of time in
DE1900279A 1964-08-31 1969-01-03 Incubator for an automatic chemical analyzer Expired DE1900279C3 (en)

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US393096A US3260413A (en) 1964-08-31 1964-08-31 Automatic chemical analyzer
US69956968A 1968-01-22 1968-01-22

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DE1900279B2 DE1900279B2 (en) 1974-01-03
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DE (2) DE1623006C3 (en)
FR (1) FR1455360A (en)
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SE344823B (en) 1972-05-02
GB1125301A (en) 1968-08-28
US3556731A (en) 1971-01-19
DE1900279A1 (en) 1969-09-18
DE1623006C3 (en) 1974-11-14
DE1900279B2 (en) 1974-01-03
FR1455360A (en) 1966-04-01
GB1125560A (en) 1968-08-28
US3260413A (en) 1966-07-12
DE1623006B2 (en) 1974-03-28
DE1623006A1 (en) 1970-12-03
GB1224864A (en) 1971-03-10

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