DE1667881A1 - Impfstoff gegen Brucellosen und Verfahren zu dessen Herstellung - Google Patents
Impfstoff gegen Brucellosen und Verfahren zu dessen HerstellungInfo
- Publication number
- DE1667881A1 DE1667881A1 DE19681667881 DE1667881A DE1667881A1 DE 1667881 A1 DE1667881 A1 DE 1667881A1 DE 19681667881 DE19681667881 DE 19681667881 DE 1667881 A DE1667881 A DE 1667881A DE 1667881 A1 DE1667881 A1 DE 1667881A1
- Authority
- DE
- Germany
- Prior art keywords
- excipient
- oil
- culture
- agar
- suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 title claims description 17
- 238000000034 method Methods 0.000 title claims description 15
- 206010006500 Brucellosis Diseases 0.000 title claims description 5
- 238000002360 preparation method Methods 0.000 title claims description 3
- 239000000725 suspension Substances 0.000 claims description 18
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 11
- 230000000813 microbial effect Effects 0.000 claims description 10
- 239000001963 growth medium Substances 0.000 claims description 9
- 239000002609 medium Substances 0.000 claims description 9
- 235000015097 nutrients Nutrition 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 229920001817 Agar Polymers 0.000 claims description 8
- 239000008272 agar Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 6
- 239000002480 mineral oil Substances 0.000 claims description 6
- 235000010446 mineral oil Nutrition 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 4
- 229930195725 Mannitol Natural products 0.000 claims description 4
- 235000002595 Solanum tuberosum Nutrition 0.000 claims description 4
- 244000061456 Solanum tuberosum Species 0.000 claims description 4
- 230000002421 anti-septic effect Effects 0.000 claims description 4
- 239000000594 mannitol Substances 0.000 claims description 4
- 235000010355 mannitol Nutrition 0.000 claims description 4
- 239000003921 oil Substances 0.000 claims description 4
- 235000019198 oils Nutrition 0.000 claims description 4
- 210000002966 serum Anatomy 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 3
- 230000036512 infertility Effects 0.000 claims description 3
- 235000019488 nut oil Nutrition 0.000 claims description 3
- 239000010466 nut oil Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 3
- 239000002202 Polyethylene glycol Substances 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 229920001223 polyethylene glycol Polymers 0.000 claims description 2
- 230000001143 conditioned effect Effects 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 238000010907 mechanical stirring Methods 0.000 claims 1
- 108010050327 trypticase-soy broth Proteins 0.000 claims 1
- 241000589562 Brucella Species 0.000 description 9
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 6
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 4
- 229960004279 formaldehyde Drugs 0.000 description 4
- 235000019256 formaldehyde Nutrition 0.000 description 4
- 239000011521 glass Substances 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 3
- 241000283707 Capra Species 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 241001494479 Pecora Species 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 239000011324 bead Substances 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- -1 polyoxyethylene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 1
- 241000700198 Cavia Species 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 206010015995 Eyelid ptosis Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- CWERGRDVMFNCDR-UHFFFAOYSA-N alpha-mercaptoacetic acid Natural products OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 239000011491 glass wool Substances 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 244000144980 herd Species 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 239000003317 industrial substance Substances 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 231100000636 lethal dose Toxicity 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 239000008174 sterile solution Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000010913 used oil Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/098—Brucella
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR94959 | 1967-02-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1667881A1 true DE1667881A1 (de) | 1971-07-22 |
Family
ID=8625301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19681667881 Pending DE1667881A1 (de) | 1967-02-15 | 1968-02-14 | Impfstoff gegen Brucellosen und Verfahren zu dessen Herstellung |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE710796A (nl) |
| DE (1) | DE1667881A1 (nl) |
| FR (1) | FR1604125A (nl) |
| GB (1) | GB1206718A (nl) |
| IT (1) | IT1034007B (nl) |
| LU (1) | LU55470A1 (nl) |
| NL (1) | NL145600B (nl) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2088231A1 (en) * | 1970-05-29 | 1972-01-07 | Pilet Charles | Brucella bacteria suspension - treatment of tumours |
-
1967
- 1967-02-15 FR FR1604125D patent/FR1604125A/fr not_active Expired
-
1968
- 1968-02-13 NL NL6802042A patent/NL145600B/nl not_active IP Right Cessation
- 1968-02-14 BE BE710796D patent/BE710796A/xx not_active IP Right Cessation
- 1968-02-14 DE DE19681667881 patent/DE1667881A1/de active Pending
- 1968-02-14 LU LU55470D patent/LU55470A1/xx unknown
- 1968-02-15 IT IT1278368A patent/IT1034007B/it active
- 1968-02-15 GB GB754668A patent/GB1206718A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR1604125A (nl) | 1971-07-12 |
| NL6802042A (nl) | 1968-08-16 |
| LU55470A1 (nl) | 1969-10-01 |
| GB1206718A (en) | 1970-09-30 |
| BE710796A (nl) | 1968-08-14 |
| IT1034007B (it) | 1979-09-10 |
| NL145600B (nl) | 1975-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OHN | Withdrawal |