DE1492910C3 - - Google Patents

Info

Publication number: DE1492910C3
Authority: DE; Germany
Prior art keywords: feed; acid; antibiotic; oxytetracycline; weight
Prior art date: 1951-01-28
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

DE1492910A

Other languages

German (de)

English (en)

Other versions

DE1492910B2 (pt

DE1492910A1 (de

Inventor

John Edward Gales Ferry Conn. Fahey (V.St.A.)

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Pfizer Inc

Original Assignee

Pfizer Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1951-01-28

Filing date

1951-01-28

Publication date

1974-05-02

1951-01-28 Application filed by Pfizer Inc filed Critical Pfizer Inc

1951-01-28 Priority to DE19511492910 priority Critical patent/DE1492910A1/de

1963-07-05 Priority claimed from US293167A external-priority patent/US3269908A/en

1969-02-13 Publication of DE1492910A1 publication Critical patent/DE1492910A1/de

1973-09-20 Publication of DE1492910B2 publication Critical patent/DE1492910B2/de

1974-05-02 Application granted granted Critical

1974-05-02 Publication of DE1492910C3 publication Critical patent/DE1492910C3/de

Status Granted legal-status Critical Current

Links

239000002253 acid Substances 0.000 claims description 30
239000004100 Oxytetracycline Substances 0.000 claims description 29
229960000625 oxytetracycline Drugs 0.000 claims description 29
IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 claims description 28
235000019366 oxytetracycline Nutrition 0.000 claims description 28
IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 claims description 28
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 21
239000003795 chemical substances by application Substances 0.000 claims description 20
CFPOJWPDQWJEMO-UHFFFAOYSA-N 2-(1,2-dicarboxyethoxy)butanedioic acid Chemical compound OC(=O)CC(C(O)=O)OC(C(O)=O)CC(O)=O CFPOJWPDQWJEMO-UHFFFAOYSA-N 0.000 claims description 18
230000003115 biocidal effect Effects 0.000 claims description 18
230000003389 potentiating effect Effects 0.000 claims description 14
241001465754 Metazoa Species 0.000 claims description 10
239000000203 mixture Substances 0.000 claims description 9
230000036765 blood level Effects 0.000 claims description 8
239000004098 Tetracycline Substances 0.000 claims description 7
CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 claims description 7
CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 claims description 7
239000004099 Chlortetracycline Substances 0.000 claims description 6
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 6
229960004475 chlortetracycline Drugs 0.000 claims description 6
235000019365 chlortetracycline Nutrition 0.000 claims description 6
229960002180 tetracycline Drugs 0.000 claims description 6
235000019364 tetracycline Nutrition 0.000 claims description 6
241000282472 Canis lupus familiaris Species 0.000 claims description 5
235000013312 flour Nutrition 0.000 claims description 5
229930101283 tetracycline Natural products 0.000 claims description 5
150000003522 tetracyclines Chemical class 0.000 claims description 5
239000003242 anti bacterial agent Substances 0.000 claims description 4
229940088710 antibiotic agent Drugs 0.000 claims description 4
244000144977 poultry Species 0.000 claims description 4
MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 claims description 3
MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 claims description 3
229960002442 glucosamine Drugs 0.000 claims description 3
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 2
229910052791 calcium Inorganic materials 0.000 claims description 2
239000011575 calcium Substances 0.000 claims description 2
239000001506 calcium phosphate Substances 0.000 claims description 2
PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 4
AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 4
235000013339 cereals Nutrition 0.000 claims 4
150000003839 salts Chemical class 0.000 claims 4
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 3
-1 tetracycline Chemical class 0.000 claims 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 2
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 2
102000016736 Cyclin Human genes 0.000 claims 2
108050006400 Cyclin Proteins 0.000 claims 2
AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
239000006227 byproduct Substances 0.000 claims 2
239000003814 drug Substances 0.000 claims 2
229960003512 nicotinic acid Drugs 0.000 claims 2
235000001968 nicotinic acid Nutrition 0.000 claims 2
239000011664 nicotinic acid Substances 0.000 claims 2
LVKZSFMYNWRPJX-UHFFFAOYSA-N phenylarsonic acid Chemical compound O[As](O)(=O)C1=CC=CC=C1 LVKZSFMYNWRPJX-UHFFFAOYSA-N 0.000 claims 2
230000036515 potency Effects 0.000 claims 2
235000018102 proteins Nutrition 0.000 claims 2
108090000623 proteins and genes Proteins 0.000 claims 2
102000004169 proteins and genes Human genes 0.000 claims 2
235000019192 riboflavin Nutrition 0.000 claims 2
229960002477 riboflavin Drugs 0.000 claims 2
239000002151 riboflavin Substances 0.000 claims 2
239000011573 trace mineral Substances 0.000 claims 2
235000013619 trace mineral Nutrition 0.000 claims 2
229940088594 vitamin Drugs 0.000 claims 2
235000013343 vitamin Nutrition 0.000 claims 2
239000011782 vitamin Substances 0.000 claims 2
229930003231 vitamin Natural products 0.000 claims 2
QYAPHLRPFNSDNH-MRFRVZCGSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]4(O)C(=O)C3=C(O)C2=C1O QYAPHLRPFNSDNH-MRFRVZCGSA-N 0.000 claims 1
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 1
239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims 1
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
235000019737 Animal fat Nutrition 0.000 claims 1
241000272517 Anseriformes Species 0.000 claims 1
108010001478 Bacitracin Proteins 0.000 claims 1
FAPWYRCQGJNNSJ-UHFFFAOYSA-L Calcium DL-pantothenate Chemical compound [Ca+2].OCC(C)(C)C(O)C(=O)NCCC([O-])=O.OCC(C)(C)C(O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UHFFFAOYSA-L 0.000 claims 1
235000019743 Choline chloride Nutrition 0.000 claims 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
235000008733 Citrus aurantifolia Nutrition 0.000 claims 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 1
RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 claims 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
235000019739 Dicalciumphosphate Nutrition 0.000 claims 1
108010082495 Dietary Plant Proteins Proteins 0.000 claims 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical class NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims 1
235000019733 Fish meal Nutrition 0.000 claims 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 claims 1
240000004658 Medicago sativa Species 0.000 claims 1
235000017587 Medicago sativa ssp. sativa Nutrition 0.000 claims 1
241000283973 Oryctolagus cuniculus Species 0.000 claims 1
229910019142 PO4 Inorganic materials 0.000 claims 1
241001494479 Pecora Species 0.000 claims 1
229930182555 Penicillin Natural products 0.000 claims 1
JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 1
241000286209 Phasianidae Species 0.000 claims 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
241000282887 Suidae Species 0.000 claims 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims 1
235000011941 Tilia x europaea Nutrition 0.000 claims 1
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
235000019742 Vitamins premix Nutrition 0.000 claims 1
240000008042 Zea mays Species 0.000 claims 1
235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims 1
235000002017 Zea mays subsp mays Nutrition 0.000 claims 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 1
229910052783 alkali metal Inorganic materials 0.000 claims 1
150000001340 alkali metals Chemical class 0.000 claims 1
229910052784 alkaline earth metal Inorganic materials 0.000 claims 1
150000001342 alkaline earth metals Chemical class 0.000 claims 1
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
229910052782 aluminium Inorganic materials 0.000 claims 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims 1
235000021120 animal protein Nutrition 0.000 claims 1
239000007900 aqueous suspension Substances 0.000 claims 1
229940072107 ascorbate Drugs 0.000 claims 1
235000010323 ascorbic acid Nutrition 0.000 claims 1
239000011668 ascorbic acid Substances 0.000 claims 1
229960003071 bacitracin Drugs 0.000 claims 1
229930184125 bacitracin Natural products 0.000 claims 1
CLKOFPXJLQSYAH-ABRJDSQDSA-N bacitracin A Chemical compound C1SC([C@@H](N)[C@@H](C)CC)=N[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]1C(=O)N[C@H](CCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2N=CNC=2)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCC1 CLKOFPXJLQSYAH-ABRJDSQDSA-N 0.000 claims 1
239000002585 base Substances 0.000 claims 1
229940036811 bone meal Drugs 0.000 claims 1
239000002374 bone meal Substances 0.000 claims 1
229910000019 calcium carbonate Inorganic materials 0.000 claims 1
SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims 1
229960003178 choline chloride Drugs 0.000 claims 1
FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims 1
150000001875 compounds Chemical class 0.000 claims 1
239000000470 constituent Substances 0.000 claims 1
229910052802 copper Inorganic materials 0.000 claims 1
239000010949 copper Substances 0.000 claims 1
235000005822 corn Nutrition 0.000 claims 1
235000012343 cottonseed oil Nutrition 0.000 claims 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 1
229940038472 dicalcium phosphate Drugs 0.000 claims 1
229910000390 dicalcium phosphate Inorganic materials 0.000 claims 1
239000003651 drinking water Substances 0.000 claims 1
235000020188 drinking water Nutrition 0.000 claims 1
239000004467 fishmeal Substances 0.000 claims 1
239000007903 gelatin capsule Substances 0.000 claims 1
229940050410 gluconate Drugs 0.000 claims 1
XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 claims 1
229960000930 hydroxyzine Drugs 0.000 claims 1
239000003701 inert diluent Substances 0.000 claims 1
239000004615 ingredient Substances 0.000 claims 1
229910052500 inorganic mineral Inorganic materials 0.000 claims 1
239000011630 iodine Substances 0.000 claims 1
229910052740 iodine Inorganic materials 0.000 claims 1
229910052742 iron Inorganic materials 0.000 claims 1
239000008101 lactose Substances 0.000 claims 1
239000004571 lime Substances 0.000 claims 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
229910052748 manganese Inorganic materials 0.000 claims 1
239000011572 manganese Substances 0.000 claims 1
235000012054 meals Nutrition 0.000 claims 1
235000013372 meat Nutrition 0.000 claims 1
235000010755 mineral Nutrition 0.000 claims 1
239000011707 mineral Substances 0.000 claims 1
235000013379 molasses Nutrition 0.000 claims 1
235000015097 nutrients Nutrition 0.000 claims 1
229940049954 penicillin Drugs 0.000 claims 1
JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 claims 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
239000010452 phosphate Substances 0.000 claims 1
229910052700 potassium Inorganic materials 0.000 claims 1
239000011591 potassium Substances 0.000 claims 1
239000000843 powder Substances 0.000 claims 1
239000000047 product Substances 0.000 claims 1
229910052708 sodium Inorganic materials 0.000 claims 1
239000011734 sodium Substances 0.000 claims 1
239000011780 sodium chloride Substances 0.000 claims 1
229940095064 tartrate Drugs 0.000 claims 1
229940040944 tetracyclines Drugs 0.000 claims 1
229940124597 therapeutic agent Drugs 0.000 claims 1
235000019157 thiamine Nutrition 0.000 claims 1
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 claims 1
229960003495 thiamine Drugs 0.000 claims 1
239000011721 thiamine Substances 0.000 claims 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 1
235000019155 vitamin A Nutrition 0.000 claims 1
239000011719 vitamin A Substances 0.000 claims 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
229940045997 vitamin a Drugs 0.000 claims 1
239000011701 zinc Substances 0.000 claims 1
229910052725 zinc Inorganic materials 0.000 claims 1
210000002966 serum Anatomy 0.000 description 11
229960004368 oxytetracycline hydrochloride Drugs 0.000 description 10
MWKJTNBSKNUMFN-UHFFFAOYSA-N trifluoromethyltrimethylsilane Chemical compound C[Si](C)(C)C(F)(F)F MWKJTNBSKNUMFN-UHFFFAOYSA-N 0.000 description 9
230000000694 effects Effects 0.000 description 8
210000004369 blood Anatomy 0.000 description 5
239000008280 blood Substances 0.000 description 5
239000000126 substance Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
241000287828 Gallus gallus Species 0.000 description 2
241000187747 Streptomyces Species 0.000 description 2
239000002775 capsule Substances 0.000 description 2
XMEVHPAGJVLHIG-FMZCEJRJSA-N chembl454950 Chemical compound [Cl-].C1=CC=C2[C@](O)(C)[C@H]3C[C@H]4[C@H]([NH+](C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O XMEVHPAGJVLHIG-FMZCEJRJSA-N 0.000 description 2
235000013330 chicken meat Nutrition 0.000 description 2
230000000052 comparative effect Effects 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
235000013305 food Nutrition 0.000 description 2
239000003102 growth factor Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
229960004989 tetracycline hydrochloride Drugs 0.000 description 2
OGQYJDHTHFAPRN-UHFFFAOYSA-N 2-fluoro-6-(trifluoromethyl)benzonitrile Chemical compound FC1=CC=CC(C(F)(F)F)=C1C#N OGQYJDHTHFAPRN-UHFFFAOYSA-N 0.000 description 1
FZIPCQLKPTZZIM-UHFFFAOYSA-N 2-oxidanylpropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O FZIPCQLKPTZZIM-UHFFFAOYSA-N 0.000 description 1
101100433727 Caenorhabditis elegans got-1.2 gene Proteins 0.000 description 1
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
241000700159 Rattus Species 0.000 description 1
235000019764 Soybean Meal Nutrition 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
238000012754 cardiac puncture Methods 0.000 description 1
229960003185 chlortetracycline hydrochloride Drugs 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000000855 fermentation Methods 0.000 description 1
230000004151 fermentation Effects 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
235000013594 poultry meat Nutrition 0.000 description 1
230000035939 shock Effects 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000004455 soybean meal Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
238000012353 t test Methods 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
229940078499 tricalcium phosphate Drugs 0.000 description 1
229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
235000019731 tricalcium phosphate Nutrition 0.000 description 1
230000036325 urinary excretion Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/195—Antibiotics

Landscapes

Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Polymers & Plastics (AREA)
Animal Husbandry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Food Science & Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fodder In General (AREA)

DE19511492910 1951-01-28 1951-01-28 Tierfutterzusaetze Granted DE1492910A1 (de)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
DE19511492910 DE1492910A1 (de)	1951-01-28	1951-01-28	Tierfutterzusaetze

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19511492910 DE1492910A1 (de)	1951-01-28	1951-01-28	Tierfutterzusaetze
US293167A US3269908A (en)	1963-07-05	1963-07-05	Antibiotic compositions

Publications (3)

Publication Number	Publication Date
DE1492910A1 DE1492910A1 (de)	1969-02-13
DE1492910B2 DE1492910B2 (pt)	1973-09-20
DE1492910C3 true DE1492910C3 (pt)	1974-05-02

Family

ID=25752376

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE19511492910 Granted DE1492910A1 (de)	1951-01-28	1951-01-28	Tierfutterzusaetze

Country Status (1)

Country	Link
DE (1)	DE1492910A1 (pt)

1951
- 1951-01-28 DE DE19511492910 patent/DE1492910A1/de active Granted

Also Published As

Publication number	Publication date
DE1492910B2 (pt)	1973-09-20
DE1492910A1 (de)	1969-02-13

Publication	Publication Date	Title
DE69812654T2 (de)	2003-09-25	Carbonsaüre enthaltendes tierfutter
EP0009688B1 (de)	1983-03-02	Medikiertes Tierfutter auf Basis Lebermehl und Verfahren zu seiner Herstellung
DE1443560B2 (de)	1973-03-08	3,5-bis(trifluorphenyl)-thioharnstoffe, verfahren zu ihrer herstellung und diese enthaltende futtermittel
DE2166085C3 (de)	1980-04-24	Verwendung von Isoflavonen als Futterzusatz
DE2835936C3 (de)	1980-10-23	Futtermittel für Haustiere mit einem festen oder flüssigen Träger und einem Antibiotikum
DE2822505A1 (de)	1978-12-07	Futter- und futterzusatzmittel
DE1492910C3 (pt)	1974-05-02
DE2618269C2 (pt)	1987-11-26
DE2839730C2 (pt)	1990-02-01
DE2809319A1 (de)	1978-09-07	Mittel und verfahren zur foerderung der tierernaehrung
DE2233117C3 (de)	1982-02-18	Tierfutter mit einem Gehalt an einem Benzodiazepin-Derivat
DE1140059B (de)	1962-11-22	Wachstumfoerderndes Futtermittel
DE2009222C3 (de)	1980-01-24	Neue Nitrofurfuryliden-methylchinolyl-harnstoff-Derivate
DE2717984C3 (de)	1980-12-04	Futter für das Züchten bzw. Halten von eierlegenden Hühnern und dessen Verwendung
DE2717985C3 (de)	1980-12-18	Futter zum Aufziehen von Ferkeln und dessen Verwendung
DE2936865A1 (de)	1981-04-02	Verwendung von pikromycin-derivaten als nutritiva
DE2717987C3 (de)	1980-12-04	Futter zum Züchten von Fleischgeflügel und dessen Verwendung
EP0073390A1 (de)	1983-03-09	Wirkstoffkombination aus Kitasamycin und Chinoxalin-di-N-oxiden
DE1692405C (de)	1972-09-14	Verfahren zur Herstellung wachstumsfördernder Futtermittel und Tränkgemische
AT229687B (de)	1963-10-10	Futtermittelzusammensetzung
DE2154049A1 (de)	1972-05-04	Coccidiostatisches Mittel
DE2306511A1 (de)	1973-08-16	Praeparate zur erhoehung der futteraufnahme und futterverwertung bei tieren
DE1228501B (de)	1966-11-10	Verwendung von Bis-(5-nitrofurfuryliden)-acetonguanyl-hydrazonen als Beifuttermittel
DE1147109B (de)	1963-04-11	Beifuttermittel
DE2507565A1 (de)	1975-08-28	Bekaempfung der laktischen acidose bei wiederkaeuern

Legal Events

Date	Code	Title	Description
1974-05-02	C3	Grant after two publication steps (3rd publication)