DE1205805B - In the aqueous phase emulsifiable feed additive cod liver oil preparation - Google Patents
In the aqueous phase emulsifiable feed additive cod liver oil preparationInfo
- Publication number
- DE1205805B DE1205805B DET16008A DET0016008A DE1205805B DE 1205805 B DE1205805 B DE 1205805B DE T16008 A DET16008 A DE T16008A DE T0016008 A DET0016008 A DE T0016008A DE 1205805 B DE1205805 B DE 1205805B
- Authority
- DE
- Germany
- Prior art keywords
- cod liver
- liver oil
- aqueous phase
- emulsifier
- oil preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003026 cod liver oil Substances 0.000 title claims description 15
- 235000012716 cod liver oil Nutrition 0.000 title claims description 15
- 238000002360 preparation method Methods 0.000 title claims description 13
- 239000008346 aqueous phase Substances 0.000 title claims description 4
- 239000003674 animal food additive Substances 0.000 title description 2
- 239000003995 emulsifying agent Substances 0.000 claims description 11
- -1 oleic acid ester Chemical class 0.000 claims description 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims description 9
- RKZXQQPEDGMHBJ-LIGJGSPWSA-N [(2s,3r,4r,5r)-2,3,4,5,6-pentakis[[(z)-octadec-9-enoyl]oxy]hexyl] (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC RKZXQQPEDGMHBJ-LIGJGSPWSA-N 0.000 claims description 5
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- 239000000600 sorbitol Substances 0.000 claims description 4
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims description 2
- 239000005642 Oleic acid Substances 0.000 claims description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims description 2
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
- 239000000839 emulsion Substances 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- 239000003921 oil Substances 0.000 description 9
- 235000019198 oils Nutrition 0.000 description 9
- 239000000126 substance Substances 0.000 description 7
- 239000000243 solution Substances 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- 235000019155 vitamin A Nutrition 0.000 description 4
- 239000011719 vitamin A Substances 0.000 description 4
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 230000000384 rearing effect Effects 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000012071 phase Substances 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 235000013619 trace mineral Nutrition 0.000 description 2
- 239000011573 trace mineral Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 150000003722 vitamin derivatives Chemical class 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 235000020244 animal milk Nutrition 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 239000002960 lipid emulsion Substances 0.000 description 1
- 235000013336 milk Nutrition 0.000 description 1
- 239000008267 milk Substances 0.000 description 1
- 210000004080 milk Anatomy 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000000505 pernicious effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05C9/00—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important
- B05C9/04—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important for applying liquid or other fluent material to opposite sides of the work
- B05C9/045—Apparatus or plant for applying liquid or other fluent material to surfaces by means not covered by any preceding group, or in which the means of applying the liquid or other fluent material is not important for applying liquid or other fluent material to opposite sides of the work in which the opposite sides of the work are the internal and external surfaces of hollow articles
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
- C09K23/00—Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
- C09K23/34—Higher-molecular-weight carboxylic acid esters
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Organic Chemistry (AREA)
- Materials Engineering (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Description
In wässeriger Phase emulgierbares Futterzusatz-Lebertranpräparat Die Erfindung hat ein in wässeriger Phase emulgierbares Futterzusatz-Lebertranpräparat zum Gegenstand, das als Emulgator einen mehrfachen Ölsäureester des Polyoxyäthylensorbits enthält. Tiermilchersatzprodukte werden heute vermehrt bei der Aufzucht von Jungtieren, insbesonders von Kälbern und Ferkeln, verwendet. Diese Produkte bezwecken, die Aufzucht der Jungtiere zu verbilligen. Meist handelt es sich um Trockenmilchprodukte, die unter anderem Milcheiweiß, Kohlenhydrate, Phosphate, Spurenelemente, vegetabilische und tierische Eiweißarten, Vitamine und Antibiotica enthalten können und die mit der entsprechenden Menge Wasser versetzt, ein gebrauchsfertiges Futtermittel ergeben. Es werden auch Präparate hergestellt, um Magermilch aufzuwerten, indem derselben Fettemulsionen zugesetzt werden. In dieser Fettemulsion sind auch meistens die öllöslichen Vitamine enthalten. Die wasserlöslichen oder nur suspendierbaren Komponenten, wie Kohlenhydrate, Phosphate, Spurenelemente, Vitamine und Antibiotica, werden als Suspension oder in trockener Form in entsprechender Menge der Magermilch zugesetzt. Diese Präparate können auch Säuren, wie z. B. Citronensäure, Bakterienkulturen oder Fermentzusätze, wie z. B. Lab, enthalten.Cod liver oil preparation that can be emulsified in the aqueous phase Invention has a feed additive cod liver oil preparation that can be emulsified in the aqueous phase on the subject, which as an emulsifier is a multiple oleic acid ester of polyoxyethylene sorbitol contains. Today, animal milk substitutes are increasingly used in the rearing of young animals, especially used by calves and piglets. The purpose of these products is rearing of young animals cheaper. Mostly it is dry milk products that including milk protein, carbohydrates, phosphates, trace elements, vegetable and animal proteins, vitamins and antibiotics can contain and those with the corresponding amount of water, resulting in a ready-to-use feed. Preparations are also made to add value to skimmed milk by adding the same Fat emulsions are added. The oil-soluble ones are also mostly in this fat emulsion Contain vitamins. The water-soluble or only suspendable components, such as Carbohydrates, phosphates, trace elements, vitamins and antibiotics, are used as a suspension or in dry form in the appropriate amount added to the skimmed milk. These preparations can also acids, such as. B. citric acid, bacterial cultures or fermentation additives, such as B. Lab included.
Seit vielen Jahren sind auch Lebertranemulsionen für die Tierernährung im Handel. Im Lebertran sind die lebensnotwendigen Vitamine A und D enthalten. Cod liver oil emulsions have also been used in animal nutrition for many years in trade. The vital vitamins A and D are contained in cod liver oil.
Lebertran ist nur zu etwa 400/o verdaulich, dementsprechend ist auch die Vitamin-A- und -D-Resorption schlecht, da beide Vitamine öllöslich sind. Bei Lebertranemulsionen sind je nach Qualität der Emulgatoren 80 bis 900/o verdaulich, dementsprechend ist auch die Vitaminresorption. Auch die bekannten Verdauungsbeschwerden fallen bei der Fütterung von Emulsionen weg. Außerdem hat die Verwendung von Lebertranemulsionen bei der Naßfütterung den großen Vorteil, daß sie sich mit dem Futter ohne weiteres vermischen und damit eine gleichmäßige Dosierung gewährleistet ist. Bei Verwendung von reinem Tran schwimmt dieser an der Futteroberfläche, die Dosierung schwankt daher in sehr großen Grenzen. Handelsübliche Lebertranemulsionen enthalten etwa 50 0/, Lebertran. Die Transportkosten werden daher verdoppelt. Tranemulsionen sind zweiphasige Systeme, die bei längerem Stehen zum Aufrahmen neigen, d. h. Trennen der wässerigen und öligen Phase. Bakterielle Infektionen können außerdem den Zerfall der Emulsion beschleunigen.Cod liver oil is only digestible to about 400 / o, which is also the case The absorption of vitamins A and D is poor, since both vitamins are oil-soluble. at Cod liver oil emulsions are 80 to 900 / o digestible depending on the quality of the emulsifiers, vitamin absorption is corresponding. Also the well-known digestive problems do not apply to the feeding of emulsions. Also has the use of cod liver oil emulsions with wet feeding the great advantage that they can easily deal with the feed mix and thus an even dosage is guaranteed. Using of pure oil it swims on the surface of the feed, the dosage fluctuates therefore within very large limits. Commercially available cod liver oil emulsions contain about 50 0 /, cod liver oil. The transport costs are therefore doubled. Tranemulsions are two-phase systems that tend to cream when standing for a long time, d. H. Separate the aqueous and oily phase. Bacterial infections can also cause the decay speed up the emulsion.
Bei Verwendung von Lebertranemulsionen in kleinen Gebinden werden diese vor Gebrauch nochmals umgeschüttelt, bei 100 bis 2001 Gebinden ist jedoch ein Umschütteln nicht mehr möglich. Es hat sich in der Praxis gezeigt, daß die Verwendung von Lebertranemulsionen in großen Gebieten vor allem zu den obenerwähnten Beanstandungen geführt hat.When using cod liver oil emulsions in small containers shake it again before use, but is for 100 to 2001 containers shaking is no longer possible. It turned out to be in the Practice demonstrated that the use of cod liver oil emulsions in large areas, especially on the above-mentioned complaints has led.
Für die Verträglichkeit der obenerwähnten Präparate ist es von großer Wichtigkeit, daß das Fett in einwandfreier Form dargereicht wird, d. h., es darf nicht ranzig und muß genügend fein dispergiert sein. It is of great importance for the tolerability of the preparations mentioned above The importance of the fat being served in perfect form, d. h., it may not rancid and must be sufficiently finely dispersed.
Die bisherigen Präparate haben daher oft zu Zwischenfällen in der Aufzucht geführt.The previous preparations have therefore often led to incidents in the Rearing led.
In der französischen Patentschrift 731 759 ist beispielsweise für diese Zwecke eine Paste, ein Gemisch fester Substanzen und obiger Stoffe vorgesehen. Die Paste stellt ein mehrphasiges Gebilde dar, mit welcher man weder eine Lösung noch eine Emulsion herstellen kann; nach Zugabe von Wasser entsteht höchstens eine schlecht verteilte Suspension. Die ungesättigten Öle und besonders Vitamin A in dieser Paste sind der Verderblichkeit im höchsten Maße ausgesetzt, und erfahrungsgemäß sind alle diese Substanzen oft nach einigen Stunden vernichtet. In French patent 731 759, for example, is for a paste, a mixture of solid substances and the above substances are provided for this purpose. The paste is a multiphase structure, with which you can neither find a solution can still produce an emulsion; after adding water, there is at most one poorly distributed suspension. The unsaturated oils and especially vitamin A in This paste is highly susceptible to perishability, and experience shows all these substances are often destroyed after a few hours.
Auch die schweizerische Patentschrift 298 861 verwendet als Emulgator eine acetonunlösliche Phosphatidfraktion und ein Lösungsmittel; ohne dieses Lösungsmittel ist die )>Vorratslösung« überhaupt nicht brauchbar. Swiss patent 298 861 also used as an emulsifier an acetone-insoluble phosphatide fraction and a solvent; without this solvent the "stock solution" is not usable at all.
Es sind einige weitere Herstellungsarten der Emulsionen offenbart worden, beispielsweise in der deutschen Auslegeschrift D 20 591/IVa/30h, wo die Herstellung einer verabreichungsfertigen, temperaturbeständigen Emulsion beschrieben wurde. Some other ways of making the emulsions are disclosed been, for example in the German Auslegeschrift D 20 591 / IVa / 30h, where the Production of a ready-to-use, temperature-resistant emulsion described became.
In der Werbeschrift »Sorbito, Dr. Hefti AG«, wird die Herstellung von in Wasser leicht dispergierbaren Öl-Emulgator-Lösungen offenbart, doch handelt es sich hierbei um einen wesentlich anders wirksamen Emulgator, nämlich Trioleat. In the advertising leaflet »Sorbito, Dr. Hefti AG «, the production of oil emulsifier solutions which are readily dispersible in water, but is this is a significantly different emulsifier, namely trioleate.
Die vorliegende Erfindung zeichnet sich dadurch aus, daß der Emulgator Polyoxyäthylensorbit-hexaoleat ist. Das erfindungsgemäße Präparat wird als Lösung des Polyoxyäthylensorbit-hexaoleat im Öl (Lebertran) zur Verwendung gebracht, um die Verpackungs- und Transportkosten zu sparen und ferner das Produkt gegen Temperatureinflüsse vollständig unabhängig zu machen, da bis kurz vor der Verwendung im Präparat kein Wasser vorhanden ist. The present invention is characterized in that the emulsifier Is polyoxyethylene sorbitol hexaoleate. The preparation according to the invention is used as a solution of the polyoxyethylene sorbitol hexaoleate in the oil (cod liver oil) brought to use to save packaging and transport costs and also to protect the product against the effects of temperature to make completely independent, as there was no in the preparation until shortly before use Water is available.
Die erfindungsgemäß hergestellte Lösung des Polyoxyäthylensorbit-hexaoleats in Lebertran hat vor einer jeden Emulsion noch einen weiteren Vorteil. Das Öl ist einerseits Vitamin A-haltig und andererseits eine stark ungesättigte Substanz, also in beiden Punkten stark der Verderblichkeit unterworfen. Da die obige Substanz in einer fertigen Emulsion im Wasser fein verteilt ist, ist ihre Oberfläche enorm vergrößert und schon aus dem Grunde den verderblichen Einflüssen stärker exponiert; auch das sauerstoffhaltige Wasser begünstigt die Oxydation des Öles und des Vitamins, und gleichzeitig werden im Wasser enthaltene Bakterien und Pilze dem Öl zugeführt. Alle diese Nachteile werden sowohl bei der erfindungsgemäßen öligen Lösung wie auch im fertigen Fettstoffpräparat eliminiert, da das Wasser im Fettstoffpräparat mit dem Öl nur für kurze Zeit vor dem Gebrauch zugemischt und nicht einer langen Lagerung mit dem Öl ausgesetzt wird. The solution of polyoxyethylene sorbitol hexaoleate prepared according to the invention in cod liver oil has another advantage over any emulsion. The oil is on the one hand containing vitamin A and on the other hand a highly unsaturated substance, that is highly perishable in both respects. Since the above substance is in a finished emulsion is finely dispersed in the water, its surface area is enormously enlarged and for that reason alone more exposed to pernicious influences; that too Oxygenated water favors the oxidation of the oil and the vitamin, and at the same time, bacteria and fungi contained in the water are added to the oil. All these disadvantages are both in the oily solution according to the invention as well as in finished fatty substance preparation eliminated, since the water in the fatty substance preparation with the Oil only mixed in for a short time before use and not after long storage exposed to the oil.
Die Lösung ist praktisch unbegrenzt haltbar, im Gegensatz zur Emulsion, die in kurzer Zeit die Zeichen der Verderblichkeit (Ranzigkeit, Bakterien-, Pilzgehalt usw.) zu zeigen beginnt. The solution has a practically unlimited shelf life, in contrast to the emulsion, which in a short time the signs of perishability (rancidity, bacterial, fungal content etc.) begins to show.
Das erfindungsgemäße Präparat läßt sich darum durch den Verbraucher durch Schütteln mit Wasser oder einem wässerigen Medium unmittelbar vor dem Gebrauch hinreichend in stabile Emulsionen überführen. The preparation according to the invention can therefore be used by the consumer by shaking with water or an aqueous medium immediately before use Sufficiently convert into stable emulsions.
Beispiel 1 9501o Tran und 501o Polyoxyäthylensorbit-hexaoleat lösen sich klar. Das Tranemulgatorgemisch gibt mit gleichen Teilen lauwarmen Wassers gemischt durch Schütteln in einem Gefäß sofort eine Emulsion. Example 1 Dissolve 95010 Tran and 5010 polyoxyethylene sorbitol hexaoleate clear up. The tranemulsifier mixture is mixed with equal parts of lukewarm water an emulsion immediately by shaking it in a jar.
Beispiel 2 50/, Polyoxyäthylensorbittrioleat mischt sich anfänglich klar mit 950/,Tran und gibt mit gleichen Teilen lauwarmen Wassers eine brauchbare Emulsion. Example 2 50 /, polyoxyethylene sorbitol trioleate initially mixes clear with 950 /, Tran and gives a usable one with equal parts of lukewarm water Emulsion.
Beim Stehenlassen des Tran-Emulgator-Gemisches scheidet sich jedoch der Emulgator als spezifisch schwerere Komponente ab.However, when the tran-emulsifier mixture is left to stand, it separates the emulsifier as a specifically heavier component.
Aus dem Beispiel 2 als Vergleichsversuch ist es klar ersichtlich, daß das Polyoxyäthylensorbittrioleat sich anfänglich mit 01o Tran klar mischt, daß sich aber nach kurzer Zeit zwei Schichten bilden, was bei dem Hexaoleat nicht der Fall ist. From Example 2 as a comparative experiment, it is clear that that the polyoxyethylene sorbitol trioleate initially mixes clearly with 01o Tran, that but after a short time two layers form, which is not the case with the hexaoleate Case is.
Claims (4)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH344893T | 1957-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1205805B true DE1205805B (en) | 1965-11-25 |
Family
ID=4507064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DET16008A Pending DE1205805B (en) | 1957-12-19 | 1958-12-16 | In the aqueous phase emulsifiable feed additive cod liver oil preparation |
Country Status (4)
| Country | Link |
|---|---|
| AT (1) | AT210726B (en) |
| CH (1) | CH344893A (en) |
| DE (1) | DE1205805B (en) |
| NL (1) | NL108795C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3808885A1 (en) * | 1988-03-17 | 1989-09-28 | Karl Dr Med Tauschwitz | Method for production of a higher grade pork |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1192504B (en) * | 1960-12-21 | 1965-05-06 | Fuu Ag | Complementary feed containing rennet |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR731759A (en) * | 1932-02-24 | 1932-09-08 | Product for animal feed and its manufacturing process | |
| CH298861A (en) * | 1951-07-31 | 1954-05-31 | Hoffmann La Roche | Spontaneously dispersible solution of fat-soluble vitamins. |
-
1957
- 1957-12-19 CH CH344893D patent/CH344893A/en unknown
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1958
- 1958-12-15 NL NL234263A patent/NL108795C/xx active
- 1958-12-16 DE DET16008A patent/DE1205805B/en active Pending
- 1958-12-19 AT AT877758A patent/AT210726B/en active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR731759A (en) * | 1932-02-24 | 1932-09-08 | Product for animal feed and its manufacturing process | |
| CH298861A (en) * | 1951-07-31 | 1954-05-31 | Hoffmann La Roche | Spontaneously dispersible solution of fat-soluble vitamins. |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3808885A1 (en) * | 1988-03-17 | 1989-09-28 | Karl Dr Med Tauschwitz | Method for production of a higher grade pork |
Also Published As
| Publication number | Publication date |
|---|---|
| NL108795C (en) | 1964-06-12 |
| CH344893A (en) | 1960-02-29 |
| NL234263A (en) | 1961-09-15 |
| AT210726B (en) | 1960-08-25 |
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