DE104237C - - Google Patents
Info
- Publication number
- DE104237C DE104237C DENDAT104237D DE104237DA DE104237C DE 104237 C DE104237 C DE 104237C DE NDAT104237 D DENDAT104237 D DE NDAT104237D DE 104237D A DE104237D A DE 104237DA DE 104237 C DE104237 C DE 104237C
- Authority
- DE
- Germany
- Prior art keywords
- tannin
- formaldehyde
- protein
- solution
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- WSFSSNUMVMOOMR-UHFFFAOYSA-N formaldehyde Substances O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 25
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 102000004169 proteins and genes Human genes 0.000 claims description 12
- 150000001875 compounds Chemical class 0.000 claims description 9
- VXMKYRQZQXVKGB-CWWHNZPOSA-N Tannin Chemical compound O([C@H]1[C@H]([C@@H]2OC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)O[C@H]([C@H]2O)O1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 VXMKYRQZQXVKGB-CWWHNZPOSA-N 0.000 claims description 6
- 230000000968 intestinal Effects 0.000 claims description 6
- 235000018553 tannin Nutrition 0.000 claims description 6
- 229920001864 tannin Polymers 0.000 claims description 6
- 239000001648 tannin Substances 0.000 claims description 6
- 239000002253 acid Substances 0.000 claims description 5
- 150000007513 acids Chemical class 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 4
- 230000002496 gastric Effects 0.000 claims description 3
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000001476 alcoholic Effects 0.000 claims description 2
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 210000004051 Gastric Juice Anatomy 0.000 claims 1
- 230000005591 charge neutralization Effects 0.000 claims 1
- 230000001264 neutralization Effects 0.000 claims 1
- 238000006386 neutralization reaction Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-N Carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000008098 formaldehyde solution Substances 0.000 description 2
- 230000001376 precipitating Effects 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 239000008207 working material Substances 0.000 description 2
- 239000001888 Peptone Substances 0.000 description 1
- 108010080698 Peptones Proteins 0.000 description 1
- 230000001427 coherent Effects 0.000 description 1
- 235000014103 egg white Nutrition 0.000 description 1
- 210000000969 egg white Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000019319 peptone Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001187 sodium carbonate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Compounds Of Unknown Constitution (AREA)
- Medicines Containing Plant Substances (AREA)
Description
KAISERLICHESIMPERIAL
PATENTAMT.PATENT OFFICE.
KLASSE 30: Gesundheitspflege.CLASS 30: Health Care.
Das nach dem Verfahren der Patentschrift Nr. 88082 dargestellte Tannin - Formaldehyd (Tannoform) ist wegen seiner allzu grofsen Löslichkeit im Darmsafte für die innere Anwendung nicht geeignet. Es wurde nun gefunden, dafs im Gegensatz zu den Angaben in der Patentschrift Nr. 88082, wonach Tannin-Formaldehyd sich gegen Eiweifsstoffe, Leim und Pepton indifferent verhalten und keine kohärenten, festen, unlöslichen Verbindungen eingehen soll, das Formaldehyd-Tannin sich mit Eiweifskörpern zu verbinden befähigt ist. Werden diese Tannin-Formaldehyd-Eiweifsverbindungen sodann mit den in den Patentschriften Nr. 8802g und Nr. 9021 5 angegebenen Arbeitsmitteln des längeren Erhitzens bezw. der Behandlung mit Alkoholen oder Säuren unterworfen, so werden sie in Präparate übergeführt, welche infolge ihrer gröfseren Widerstandsfähigkeit dem Darmsafte gegenüber zur inneren Darreichung geeignet sind.The tannin - formaldehyde prepared by the process of patent specification no. 88082 (Tannoform) is, because of its too great solubility in the intestinal juice, for internal use not suitable. It has now been found that, in contrast to the information in patent specification No. 88082, according to which tannin-formaldehyde behave indifferently to protein substances, glue and peptone and no coherent, solid, insoluble compounds should enter, the formaldehyde tannin is able to combine with protein bodies. Are these tannin-formaldehyde-protein compounds then with the in the patents No. 8802g and No. 9021 5 specified working materials of longer heating respectively. subjected to treatment with alcohols or acids, they are converted into preparations, which due to their greater resistance to the intestinal juice to the internal administration are suitable.
Der gewerbliche Fortschritt bei diesen so behandelten Tannin -Foraialdehyd - Eiweifsverbindungen gegenüber dem Tannin-Formaldehyd ergiebt sich aus deren Verhalten gegen ι proc. Sodalösung.The commercial progress in these treated tannin-faialdehyde-protein compounds towards the tannin-formaldehyde results from their behavior towards ι proc. Soda solution.
Wird ι g Tannin-Formaldehyd mit 100 ecm ι proc. Sodalösung (1 g Na2 C0& in 100 g Wasser) bei 400 C. verrührt, so löst es sich darin vollständig auf, während 1 g der nach vorliegendem Verfahren dargestellten Tannin-Formaldehyd - Eiweifsverbindungen beim Digeriren mit 100 ecm 1 proc. Sodalösung bei 400 C. während 3 Stunden noch etwa 67 pCt. ungelösten Rückstand hinterläfst.If ι g tannin-formaldehyde with 100 ecm ι proc. Soda solution (1 g of Na 2 CO & in 100 g of water) is stirred at 40 ° C., it dissolves in it completely, while 1 g of the tannin-formaldehyde protein compounds prepared according to the present process is digested with 100 ecm 1 per cent. Sodium carbonate solution at 40 0 C. for 3 hours or about 67 per cent. leaves undissolved residue.
Die erhaltenen Verbindungen sind weifslichröthliche Pulver; sie sind unlöslich in Wasser und den üblichen Lösungsmitteln, allmälig löslich in Alkalien.The compounds obtained are whitish-red powders; they are insoluble in water and the usual solvents, gradually soluble in alkalis.
Mit chemisch reiner Schwefelsäure erhitzt, werden sie ebenso wie Tannin-Formaldehyd erst grün und dann blau gefärbt. Sie enthalten etwa 43 pCt. Tannin-Formaldehyd.Just like tannin-formaldehyde, they are only heated with chemically pure sulfuric acid colored green and then blue. They contain about 43 pCt. Tannic formaldehyde.
1. Eine Lösung von 10 kg Tannin-Formaldehyd in 50 kg 5 proc. Sodalösung wird in eine Lösung von iokgEiweifs in 50 1 Wasser einlaufen gelassen. Das hierbei entstehende Tannin-Formaldehyd-Eiweifs wird durch Neutralisiren mit Säuren zur Ausscheidung gebracht, abfiltrirt, einige Male mit Wasser gewaschen, getrocknet und, wie unter 5. angegeben, weiter behandelt.1. A solution of 10 kg of tannin-formaldehyde in 50 kg 5 proc. Soda solution is converted into a solution of iokgEiweifs in 50 l of water let in. The resulting tannin-formaldehyde protein is neutralized precipitated with acids, filtered off, washed a few times with water, dried and, as indicated under 5., treated further.
2. Eine Lösung von 10 kg Tannin-Formaldehyd in 50 1 Alkohol wird allmälig in eine Lösung von iokgEiweifs in 30 1 Wasser einlaufen gelassen. Das ausgeschiedene Tannin-Formaldehyd-Eiweifs wird entweder 24 Stunden lang unmittelbar mit der Fälllauge behandelt, um ihm die Schwerlöslichkeit im Magen- und Darmsafte zu geben, oder das Tannin-Formaldehyd-Eiweifs wird abfiltrirt, mit Wasser gewaschen, getrocknet und nach 5. weiter behandelt.2. A solution of 10 kg of tannin-formaldehyde in 50 liters of alcohol will gradually run into a solution of iokgEiweifs in 30 liters of water calmly. The excreted tannin-formaldehyde protein is either 24 hours treated directly with the precipitating liquor for a long time in order to make it difficult to dissolve in gastric and intestinal juices, or that Tannin-formaldehyde protein is filtered off, washed with water, dried and after 5 treated further.
3. Eine Lösung von 10 kg Tannin in 50 1 Wasser wird mit 2,5 1 40 proc. Formaldehydlösung versetzt und diese Mischung in eine Lösung von 10 kg Eiweifs in 50 1 Wasser unter Rühren in der Kälte oder in der Wärme3. A solution of 10 kg of tannin in 50 1 Water is with 2.5 1 40 proc. Formaldehyde solution added and this mixture in a Dissolve 10 kg of egg white in 50 liters of water while stirring in the cold or in the warm
allmälig einlaufen gelassen. Die entstandene Verbindung wird abfiltrirt, mit Wasser ausgewaschen, getrocknet und nach 5. weiter behandelt. gradually run in. The resulting compound is filtered off, washed out with water, dried and treated further after 5.
4. In eine Lösung von 10 kg Tannin in 50 1 Alkohol werden 0,5 kg Formaldehydgas eingeleitet, und mit dieser alkoholischen Tannin-Formaldehydlösung wird eine Lösung von 10 kg Eiweifs in 30 1 Wasser behandelt. Das ausgeschiedene Tannin - Formaldehyd - Eiweifs wird entweder 24 Stunden lang unmittelbar mit der Fälllauge behandelt, um ihm die Schweriöslichkeit im Magen- und Darmsafte zu geben, oder das Tannin-Formaldehyd-Eiweifs wird abfiltrirt, mit Wasser gewaschen, getrocknet und nach 5. weiter behandelt.4. In a solution of 10 kg of tannin in 50 l of alcohol, 0.5 kg of formaldehyde gas is added initiated, and with this alcoholic tannin-formaldehyde solution a solution of Treated 10 kg of protein in 30 liters of water. The excreted tannin - formaldehyde - protein is either treated directly with the precipitating liquor for 24 hours to make it difficult to remove to give in gastric and intestinal juices, or the tannin-formaldehyde protein becomes filtered off, washed with water, dried and treated further after 5.
5. Die nach den Verfahren der Beispiele 1., 2., 3. und 4. darstellbaren Tannin-Formaldehyd-Eiweifsverbindungen werden mit den in den Patentschriften Nr. 88029 und Nr. 90215 angegebenen Arbeitsmitteln behandelt, indem sie entweder längere Zeit, z. B. 6 Stunden lang, auf 1300 erhitzt oder aber 10 Stunden lang einer Behandlung mit Alkohol oder Säuren, z. B. mit der fünffachen Menge Alkohol oder der fünffachen Menge ι ο proc. Salzsäure, unterzogen werden. Sowohl die Wärmegrade als auch die Mengen an Alkohol oder an Säuren können innerhalb beträchtlicher Grenzen abgeändert werden.5. The tannin-formaldehyde protein compounds which can be represented by the methods of Examples 1, 2, 3 and 4 are treated with the working materials specified in patents No. 88029 and No. 90215, either by using them for a long time, e.g. B. heated to 130 0 for 6 hours or 10 hours of treatment with alcohol or acids, for. B. with five times the amount of alcohol or five times the amount of ι ο proc. Hydrochloric acid. Both the degrees of warmth and the amounts of alcohol or acids can be varied within considerable limits.
Claims (1)
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE104237C true DE104237C (en) |
Family
ID=374642
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DENDAT104237D Active DE104237C (en) |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE104237C (en) |
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0
- DE DENDAT104237D patent/DE104237C/de active Active
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