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DD268943A5 - Verfahren fuer die herstellung von 1(-hydroxystryry)-5h-2,3-benzodiazepin-derivaten - Google Patents

Verfahren fuer die herstellung von 1(-hydroxystryry)-5h-2,3-benzodiazepin-derivaten Download PDF

Info

Publication number
DD268943A5
DD268943A5 DD87303005A DD30300587A DD268943A5 DD 268943 A5 DD268943 A5 DD 268943A5 DD 87303005 A DD87303005 A DD 87303005A DD 30300587 A DD30300587 A DD 30300587A DD 268943 A5 DD268943 A5 DD 268943A5
Authority
DD
German Democratic Republic
Prior art keywords
atoms
general formula
compounds
alkyl group
ethanol
Prior art date
Application number
DD87303005A
Other languages
German (de)
English (en)
Inventor
Tibor Lang
Jeno Koroesi
Gyoergy Rabloczky
Tamas Hamori
Maria Kuhar
Istvan Polgari
Istvan Elekes
Gabor Zolyomi
Krisztina Heltai
Judit Sarossy
Zsuzsanna Lang
Imre Moravcsik
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@������������k�� filed Critical ������@������������k��
Publication of DD268943A5 publication Critical patent/DD268943A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DD87303005A 1986-05-21 1987-05-21 Verfahren fuer die herstellung von 1(-hydroxystryry)-5h-2,3-benzodiazepin-derivaten DD268943A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU862140A HU195788B (en) 1986-05-21 1986-05-21 Process for producing 1-/hydroxy-stiryl/-5h-2,3-benzobiazepines and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
DD268943A5 true DD268943A5 (de) 1989-06-14

Family

ID=10957976

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87303005A DD268943A5 (de) 1986-05-21 1987-05-21 Verfahren fuer die herstellung von 1(-hydroxystryry)-5h-2,3-benzodiazepin-derivaten

Country Status (24)

Country Link
US (1) US4840948A (fi)
JP (1) JPS6322082A (fi)
AT (1) AT395009B (fi)
BE (1) BE1000573A4 (fi)
BG (1) BG46003A3 (fi)
CA (1) CA1280748C (fi)
CH (1) CH671226A5 (fi)
CS (1) CS262690B2 (fi)
DD (1) DD268943A5 (fi)
DE (1) DE3717080C2 (fi)
DK (1) DK258187A (fi)
ES (1) ES2005582A6 (fi)
FI (1) FI91964C (fi)
FR (1) FR2599034B1 (fi)
GB (1) GB2190677B (fi)
HU (1) HU195788B (fi)
IL (1) IL82613A (fi)
IT (1) IT1205665B (fi)
NL (1) NL8701213A (fi)
PL (1) PL147687B1 (fi)
PT (1) PT84923B (fi)
SE (1) SE468560B (fi)
SU (1) SU1503681A3 (fi)
YU (1) YU46675B (fi)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5380721A (en) * 1990-09-10 1995-01-10 Sterling Winthrop Inc. Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
SK283859B6 (sk) * 1995-02-09 2004-03-02 EGIS Gyógyszergyár Rt. 1-[2'-(Substituovaný)vinyl]-5H-2,3-benzodiazepínové deriváty, spôsob ich prípravy a medziprodukty na ich prípravu, liečivá ich obsahujúce a ich použitie
HU224435B1 (hu) * 1995-02-09 2005-10-28 EGIS Gyógyszergyár Rt. Benzodiazepin-származékok, eljárás előállításukra, alkalmazásukra és ezeket tartalmazó gyógyászati készítmények
EP0726257B1 (en) * 1995-02-09 2001-04-11 Egis Gyogyszergyar Rt. 1-(Hetero)Arylvinyl-5H-2,3-benzodiazepine derivatives useful for the treatment of central nervous system disorders, and benzopyrylium intermediates for their preparation
ES2111493B1 (es) * 1996-02-08 1999-08-01 Egyt Gyogyszervegyeszeti Gyar Derivados de 1-(2- (vinilo substituido ) ) -5h-2,3-benzo-diazepina, procedimiento para su preparacion, composiciones farmaceuticas que los contienen y utilizaciones correspondientes.
HU227128B1 (en) * 1999-07-07 2010-07-28 Egyt Gyogyszervegyeszeti Gyar New 2,3-benzodiazepine derivatives
EP1575521A4 (en) * 2002-12-03 2008-04-30 Vela Acquisition Corp PHARMACEUTICAL COMPOSITION OF 1- (3-HYDROXY-4-METHOXYPHENYL) -4-METHYL-5-ETHYL-7,8-DIMETHOXY-5H-2,3-BENZODIAZEPINE AND ITS USE
US7022700B2 (en) * 2002-12-03 2006-04-04 Vela Pharmaceuticals, Inc. Method of increasing neutrophil production using optically-pure (R)-2,3-benzodiazepines
US6864251B2 (en) * 2002-12-03 2005-03-08 Vela Pharmaceuticals, Inc. Treatment of LTB4-mediated inflammatory disorders with optically-pure (R)-2,3-benzodiazepines
US6638928B1 (en) 2002-12-03 2003-10-28 Vela Pharmaceuticals, Inc. Treatment of irritable bowel syndrome and nonulcer dyspepsia with substituted 2,3-benzodiazepines
JP2006510634A (ja) * 2002-12-03 2006-03-30 ヴェラ ファーマスーティカルズ インコーポレイテッド １−（３，４−ジメトキシフェニル）−４−メチル−５−エチル−７−メトキシ−８−ヒドロキシ−５ｈ−２，３−ベンゾジアゼピンの製薬組成物及びその用途
US20040224943A1 (en) * 2003-02-19 2004-11-11 Leventer Steven M. Method of lowering body temperature with (R) - 2,3-benzodiazepines
US20040162284A1 (en) * 2003-02-19 2004-08-19 Harris Herbert W. Method of lowering body temperature with (S) tofisopam
HUP0302449A3 (en) * 2003-08-04 2005-06-28 Egis Gyogyszergyar Nyilvanosan 8-chloro-2,3-benzodiazepine derivatives, pharmaceutical compositions containing them and process for producing them

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK118660B (da) * 1966-12-09 1970-09-21 Egyt Gyogyszervegyeszeti Gyar Analogifremgangsmåde til fremstilling af 1-(3',4'-dimethoxyphenyl)-3-methyl-4-ethyl-6,7-dimethoxy-isoquinolin-N-imid.
HU179018B (en) * 1978-10-19 1982-08-28 Gyogyszerkutato Intezet Process for producing new 5h-2,3-benzodiazepine derivatives
HU191698B (en) * 1984-07-27 1987-03-30 Gyogyszerkutato Intezet Process for producing new 1-aryl-5h-2beta-benzodiazepines

Also Published As

Publication number Publication date
IL82613A (en) 1991-03-10
FR2599034A1 (fr) 1987-11-27
GB2190677B (en) 1990-01-10
CH671226A5 (fi) 1989-08-15
AT395009B (de) 1992-08-25
JPS6322082A (ja) 1988-01-29
HUT44521A (en) 1988-03-28
ES2005582A6 (es) 1989-03-16
DE3717080A1 (de) 1987-11-26
DE3717080C2 (de) 1996-02-08
DK258187A (da) 1987-11-22
US4840948A (en) 1989-06-20
BG46003A3 (en) 1989-09-15
SE8702120L (sv) 1987-11-22
DK258187D0 (da) 1987-05-21
HU195788B (en) 1988-07-28
SE468560B (sv) 1993-02-08
IT1205665B (it) 1989-03-31
IL82613A0 (en) 1987-11-30
FI91964B (fi) 1994-05-31
FR2599034B1 (fr) 1989-06-09
IT8720619A0 (it) 1987-05-21
FI91964C (fi) 1994-09-12
GB2190677A (en) 1987-11-25
BE1000573A4 (fr) 1989-02-07
SU1503681A3 (ru) 1989-08-23
CS369087A2 (en) 1988-08-16
CA1280748C (en) 1991-02-26
CS262690B2 (en) 1989-03-14
YU90687A (en) 1988-08-31
PT84923A (en) 1987-06-01
NL8701213A (nl) 1987-12-16
SE8702120D0 (sv) 1987-05-21
YU46675B (sh) 1994-01-20
FI872255A (fi) 1987-11-22
FI872255A0 (fi) 1987-05-21
ATA130287A (de) 1992-01-15
PT84923B (pt) 1990-02-08
GB8712005D0 (en) 1987-06-24
PL265812A1 (en) 1988-05-12
PL147687B1 (en) 1989-07-31

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