DD246481A5 - Verfahren zur herstellung einer zusammensetzung auf der basis eines feinverteilten wirkstoffes von geringer wasserloeslichkeit - Google Patents

Verfahren zur herstellung einer zusammensetzung auf der basis eines feinverteilten wirkstoffes von geringer wasserloeslichkeit Download PDF

Info

Publication number: DD246481A5
Authority: DD; German Democratic Republic
Prior art keywords: milk powder; mixture; particles; items; water
Prior art date: 1985-03-20

Application number

DD86287992A

Other languages

German (de)

English (en)

Inventor

Pierre Hirsbrunner

Original Assignee

��K@��@��@��@�K@��Kk��

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-03-20

Filing date

1986-03-18

Publication date

1987-06-10

1986-03-18 Application filed by ��K@��@��@��@�K@��Kk�� filed Critical ��K@��@��@��@�K@��Kk��

1987-06-10 Publication of DD246481A5 publication Critical patent/DD246481A5/de

Links

239000000203 mixture Substances 0.000 title claims abstract description 29
238000004519 manufacturing process Methods 0.000 title abstract description 3
239000000843 powder Substances 0.000 claims abstract description 37
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 29
238000000034 method Methods 0.000 claims abstract description 19
235000020183 skimmed milk Nutrition 0.000 claims abstract description 19
239000002245 particle Substances 0.000 claims abstract description 16
235000009470 Theobroma cacao Nutrition 0.000 claims abstract description 14
239000004480 active ingredient Substances 0.000 claims abstract description 14
239000013543 active substance Substances 0.000 claims abstract description 13
230000015572 biosynthetic process Effects 0.000 claims abstract description 7
239000002244 precipitate Substances 0.000 claims abstract description 6
230000009885 systemic effect Effects 0.000 claims abstract description 4
235000013861 fat-free Nutrition 0.000 claims abstract 2
244000299461 Theobroma cacao Species 0.000 claims description 13
238000002360 preparation method Methods 0.000 claims description 7
229960002871 tenoxicam Drugs 0.000 claims description 6
WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 claims description 6
230000003110 anti-inflammatory effect Effects 0.000 claims description 4
239000003795 chemical substances by application Substances 0.000 claims description 3
238000002156 mixing Methods 0.000 claims description 3
229960002702 piroxicam Drugs 0.000 claims description 3
QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 claims description 3
238000003756 stirring Methods 0.000 claims description 3
150000001875 compounds Chemical class 0.000 claims description 2
239000008177 pharmaceutical agent Substances 0.000 claims description 2
229920000161 Locust bean gum Polymers 0.000 claims 1
235000010420 locust bean gum Nutrition 0.000 claims 1
239000000711 locust bean gum Substances 0.000 claims 1
235000013336 milk Nutrition 0.000 abstract description 11
239000008267 milk Substances 0.000 abstract description 11
210000004080 milk Anatomy 0.000 abstract description 11
235000013305 food Nutrition 0.000 abstract description 2
239000007787 solid Substances 0.000 abstract description 2
230000001028 anti-proliverative effect Effects 0.000 abstract 1
244000240602 cacao Species 0.000 abstract 1
239000000825 pharmaceutical preparation Substances 0.000 abstract 1
239000000021 stimulant Substances 0.000 abstract 1
238000004062 sedimentation Methods 0.000 description 11
239000000047 product Substances 0.000 description 9
239000000725 suspension Substances 0.000 description 9
239000006185 dispersion Substances 0.000 description 5
239000003814 drug Substances 0.000 description 5
229940079593 drug Drugs 0.000 description 5
239000000654 additive Substances 0.000 description 4
238000012360 testing method Methods 0.000 description 4
239000000796 flavoring agent Substances 0.000 description 3
235000012041 food component Nutrition 0.000 description 3
235000013355 food flavoring agent Nutrition 0.000 description 3
239000005417 food ingredient Substances 0.000 description 3
239000011521 glass Substances 0.000 description 3
239000000126 substance Substances 0.000 description 3
108010011485 Aspartame Proteins 0.000 description 2
230000000996 additive effect Effects 0.000 description 2
239000000605 aspartame Substances 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
229960003438 aspartame Drugs 0.000 description 2
235000010357 aspartame Nutrition 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
235000003599 food sweetener Nutrition 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
239000008194 pharmaceutical composition Substances 0.000 description 2
239000013558 reference substance Substances 0.000 description 2
239000000523 sample Substances 0.000 description 2
239000003765 sweetening agent Substances 0.000 description 2
238000007669 thermal treatment Methods 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
235000013912 Ceratonia siliqua Nutrition 0.000 description 1
240000008886 Ceratonia siliqua Species 0.000 description 1
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 1
206010000059 abdominal discomfort Diseases 0.000 description 1
235000019658 bitter taste Nutrition 0.000 description 1
235000008429 bread Nutrition 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000005018 casein Substances 0.000 description 1
BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
235000021240 caseins Nutrition 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000013068 control sample Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
239000002270 dispersing agent Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
238000007580 dry-mixing Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
229960004279 formaldehyde Drugs 0.000 description 1
235000019256 formaldehyde Nutrition 0.000 description 1
239000003349 gelling agent Substances 0.000 description 1
230000005484 gravity Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
239000000463 material Substances 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000000149 penetrating effect Effects 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
239000013049 sediment Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
230000000153 supplemental effect Effects 0.000 description 1
238000011287 therapeutic dose Methods 0.000 description 1
238000012546 transfer Methods 0.000 description 1
MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 1
FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 1
235000012141 vanillin Nutrition 0.000 description 1
235000008939 whole milk Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G1/00—Cocoa; Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/30—Cocoa products, e.g. chocolate; Substitutes therefor
- A23G1/56—Liquid products; Solid products in the form of powders, flakes or granules for making liquid products, e.g. for making chocolate milk, drinks and the products for their preparation, pastes for spreading or milk crumb
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Food Science & Technology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Botany (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Dairy Products (AREA)
Colloid Chemistry (AREA)
Confectionery (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
General Preparation And Processing Of Foods (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

DD86287992A 1985-03-20 1986-03-18 Verfahren zur herstellung einer zusammensetzung auf der basis eines feinverteilten wirkstoffes von geringer wasserloeslichkeit DD246481A5 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH1235/85A CH663899A5 (fr)	1985-03-20	1985-03-20	Procede pour la preparation d'une composition a base d'un principe actif de faible hydrosolubilite finement divise.

Publications (1)

Publication Number	Publication Date
DD246481A5 true DD246481A5 (de)	1987-06-10

Family

ID=4205639

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DD86287992A DD246481A5 (de)	1985-03-20	1986-03-18	Verfahren zur herstellung einer zusammensetzung auf der basis eines feinverteilten wirkstoffes von geringer wasserloeslichkeit

Country Status (27)

Country	Link
US (1)	US4839179A (el)
EP (1)	EP0196434B1 (el)
JP (1)	JPH0618634B2 (el)
CN (1)	CN1011659B (el)
AR (1)	AR242090A1 (el)
AT (1)	ATE44232T1 (el)
AU (1)	AU586668B2 (el)
CA (1)	CA1270761A (el)
CH (1)	CH663899A5 (el)
DD (1)	DD246481A5 (el)
DE (1)	DE3664105D1 (el)
DK (1)	DK165389C (el)
ES (1)	ES8800054A1 (el)
FI (1)	FI87623C (el)
GB (1)	GB2172487B (el)
GR (1)	GR860699B (el)
IE (1)	IE58841B1 (el)
IN (1)	IN162568B (el)
MX (1)	MX168423B (el)
MY (1)	MY106405A (el)
NO (1)	NO166757C (el)
NZ (1)	NZ215529A (el)
PH (1)	PH23025A (el)
PT (1)	PT82222B (el)
SG (1)	SG42089G (el)
SU (1)	SU1621804A3 (el)
ZA (1)	ZA861810B (el)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH01316314A (ja) *	1988-06-16	1989-12-21	Taisho Pharmaceut Co Ltd	湿布剤
JPH01316315A (ja) *	1988-06-16	1989-12-21	Taisho Pharmaceut Co Ltd	硬膏剤
HU200926B (en) *	1988-10-28	1990-09-28	Egyt Gyogyszervegyeszeti Gyar	Pharmaceutical composition comprising piroxicam and lactose for use in making tablets or capsules
US5143737A (en) *	1989-10-13	1992-09-01	The Regents Of The University Of California	Method to produce unsaturated milk fat and meat from ruminant animals
WO1991005482A1 (en) *	1989-10-13	1991-05-02	The Regents Of The University Of California	Method to produce unsaturated milk fat and meat from ruminant animals
GB2261372A (en) *	1991-11-15	1993-05-19	Gregor Reid	Lactobacillus and skim milk compositions for prevention of urogenital infection
IT1286496B1 (it) *	1996-11-20	1998-07-15	Leetrim Ltd Dublin	Composizione farmaceutica orale ad attivita' antipiretica,analgesica ed antiinfiammatoria
EP1875812B1 (en) *	2005-04-28	2017-11-01	Meiji Co., Ltd.	Rapidly soluble granule and method for producing the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE442390A (el) *
DE868491C (de) *	1949-10-11	1953-02-26	Carl Schuster	Verfahren zur Herstellung eines Heilmittels
US3243347A (en) *	1962-07-18	1966-03-29	Packaged Products Corp	Instantly assimilable vitamin product
US3591584A (en) *	1968-08-27	1971-07-06	Pfizer	Benzothiazine dioxides
GB1235540A (en) *	1968-12-02	1971-06-16	Armour Pharma	Oral preparations containing proteolytic enzymes suitable for pediatric use
US3591854A (en) *	1968-12-30	1971-07-06	Gen Electric	Signal phase and magnitude measurement circuit
JPS4926497A (el) *	1972-07-13	1974-03-08
US3928560A (en) *	1973-04-19	1975-12-23	Procter & Gamble	Compositions of matter containing paramethoxycinnamaldehyde as a flavoring agent and sweetener
US4358464A (en) *	1977-08-02	1982-11-09	Superior Dairy, Inc.	Process for converting sour whey into sweet whey and product
JPS551778A (en) *	1978-06-20	1980-01-08	Matsushita Electric Ind Co Ltd	Tuning indicator
US4427701A (en) *	1980-11-26	1984-01-24	Landwide Foods, Inc.	Frozen yogurt product
JPS58205477A (ja) *	1982-05-24	1983-11-30	Asahi Chem Ind Co Ltd	人工栄養補給食

1985
- 1985-03-20 CH CH1235/85A patent/CH663899A5/fr not_active IP Right Cessation
1986
- 1986-02-15 DE DE8686101951T patent/DE3664105D1/de not_active Expired
- 1986-02-15 AT AT86101951T patent/ATE44232T1/de not_active IP Right Cessation
- 1986-02-15 EP EP86101951A patent/EP0196434B1/fr not_active Expired
- 1986-02-19 GB GB8604135A patent/GB2172487B/en not_active Expired
- 1986-02-25 IN IN129/MAS/86A patent/IN162568B/en unknown
- 1986-02-28 CA CA000502996A patent/CA1270761A/en not_active Expired - Fee Related
- 1986-03-06 IE IE58986A patent/IE58841B1/en not_active IP Right Cessation
- 1986-03-08 AR AR86303414A patent/AR242090A1/es active
- 1986-03-10 CN CN86101476A patent/CN1011659B/zh not_active Expired
- 1986-03-11 ZA ZA861810A patent/ZA861810B/xx unknown
- 1986-03-11 AU AU54500/86A patent/AU586668B2/en not_active Ceased
- 1986-03-12 MX MX026895A patent/MX168423B/es unknown
- 1986-03-14 FI FI861052A patent/FI87623C/fi not_active IP Right Cessation
- 1986-03-14 PH PH33531A patent/PH23025A/en unknown
- 1986-03-14 GR GR860699A patent/GR860699B/el unknown
- 1986-03-18 DK DK125086A patent/DK165389C/da not_active Application Discontinuation
- 1986-03-18 ES ES553101A patent/ES8800054A1/es not_active Expired
- 1986-03-18 DD DD86287992A patent/DD246481A5/de not_active IP Right Cessation
- 1986-03-19 SU SU864027147A patent/SU1621804A3/ru active
- 1986-03-19 NO NO861061A patent/NO166757C/no unknown
- 1986-03-19 JP JP61061936A patent/JPH0618634B2/ja not_active Expired - Lifetime
- 1986-03-19 PT PT82222A patent/PT82222B/pt not_active IP Right Cessation
- 1986-03-19 NZ NZ215529A patent/NZ215529A/xx unknown
1987
- 1987-09-03 MY MYPI87001540A patent/MY106405A/en unknown
1988
- 1988-06-10 US US07/206,910 patent/US4839179A/en not_active Expired - Fee Related
1989
- 1989-07-12 SG SG420/89A patent/SG42089G/en unknown

Also Published As

Publication number	Publication date
GB2172487A (en)	1986-09-24
FI87623B (fi)	1992-10-30
EP0196434B1 (fr)	1989-06-28
DE3664105D1 (en)	1989-08-03
IE58841B1 (en)	1993-11-17
GB2172487B (en)	1989-04-05
AU5450086A (en)	1986-09-25
DK165389B (da)	1992-11-23
NO166757B (no)	1991-05-27
GB8604135D0 (en)	1986-03-26
ZA861810B (en)	1986-10-29
FI87623C (fi)	1993-02-10
DK125086A (da)	1986-09-21
DK125086D0 (da)	1986-03-18
CN86101476A (zh)	1986-09-17
US4839179A (en)	1989-06-13
JPS61222532A (ja)	1986-10-03
IE860589L (en)	1986-09-20
CH663899A5 (fr)	1988-01-29
CA1270761A (en)	1990-06-26
DK165389C (da)	1993-04-13
ATE44232T1 (de)	1989-07-15
CN1011659B (zh)	1991-02-20
MX168423B (es)	1993-05-24
AR242090A1 (es)	1993-03-31
NZ215529A (en)	1989-03-29
ES8800054A1 (es)	1987-11-01
FI861052A0 (fi)	1986-03-14
IN162568B (el)	1988-06-11
NO861061L (no)	1986-09-22
SG42089G (en)	1990-07-06
AU586668B2 (en)	1989-07-20
PT82222B (pt)	1988-04-21
ES553101A0 (es)	1987-11-01
EP0196434A1 (fr)	1986-10-08
NO166757C (no)	1991-09-04
PH23025A (en)	1989-03-10
PT82222A (fr)	1986-04-01
FI861052A (fi)	1986-09-21
MY106405A (en)	1995-05-30
JPH0618634B2 (ja)	1994-03-16
SU1621804A3 (ru)	1991-01-15
GR860699B (en)	1986-07-11

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DE3123453C2 (de)	1986-06-19	Veredelte Stärke, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln
DE2437845A1 (de)	1975-02-27	Pharmazeutisches, dispergierbares, sitosterine enthaltendes pulver und verfahren zu seiner herstellung
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DE3215844A1 (de)	1982-12-02	Mischsalz aus glucosaminsulfat und natriumchlorid
DE3306622C2 (el)	1990-02-22
AT399277B (de)	1995-04-25	Festes pharmazeutisches piroxicam-präparat und verfahren zu seiner herstellung
DE69327745T2 (de)	2000-09-21	Tablette zur langsamen Freisetzung von Natriumvalproat
DE69008107T2 (de)	1994-08-04	Zubereitung mit verzögerter Freigabe eines Hydrochlorids eines basischen Arzneistoffs.
DD246481A5 (de)	1987-06-10	Verfahren zur herstellung einer zusammensetzung auf der basis eines feinverteilten wirkstoffes von geringer wasserloeslichkeit
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CH683824A5 (de)	1994-05-31	Zusammensetzung als Mittel zur Behandlung von Entzündungen.
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Legal Events

Date	Code	Title	Description
1995-07-20	ENJ	Ceased due to non-payment of renewal fee