CY2017022I2 - Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων - Google Patents

Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων

Info

Publication number: CY2017022I2
Authority: CY; Cyprus
Prior art keywords: antibodies against; clostridium difficile; difficile toxins; against clostridium; toxins
Prior art date: 2004-02-06

Application number

CY2017022C

Other languages

English (en)

Other versions

CY2017022I1 (el

Original Assignee

University Of Massachusetts

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-02-06

Filing date

2017-06-28

Publication date

2017-11-14

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36928722&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2017022(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2017-06-28 Application filed by University Of Massachusetts filed Critical University Of Massachusetts

2017-11-14 Publication of CY2017022I2 publication Critical patent/CY2017022I2/el

2017-11-14 Publication of CY2017022I1 publication Critical patent/CY2017022I1/el

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1282—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Clostridium (G)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/08—Clostridium, e.g. Clostridium tetani
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
- G01N2333/33—Assays involving biological materials from specific organisms or of a specific nature from bacteria from Clostridium (G)
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/809—Drug, bio-affecting and body treating compositions involving immunoglobulin or antibody fragment, e.g. fab', fv, fc, heavy chain or light chain

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Microbiology (AREA)
Biomedical Technology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Mycology (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Cell Biology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Analytical Chemistry (AREA)
Pathology (AREA)
Tropical Medicine & Parasitology (AREA)
Virology (AREA)
General Physics & Mathematics (AREA)
Physics & Mathematics (AREA)
Food Science & Technology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)

CY2017022C 2004-02-06 2017-06-28 Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων CY2017022I1 (el)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US54235704P	2004-02-06	2004-02-06
US61385404P	2004-09-28	2004-09-28
EP05857759A EP1766093B1 (en)	2004-02-06	2005-02-04	Antibodies against clostridium difficile toxins and uses thereof

Publications (2)

Publication Number	Publication Date
CY2017022I2 true CY2017022I2 (el)	2017-11-14
CY2017022I1 CY2017022I1 (el)	2017-11-14

Family

ID=36928722

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
CY20111100872T CY1111860T1 (el)	2004-02-06	2011-09-13	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων
CY2017022C CY2017022I1 (el)	2004-02-06	2017-06-28	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων
CY20171101001T CY1119416T1 (el)	2004-02-06	2017-09-21	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ' αυτων

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CY20111100872T CY1111860T1 (el)	2004-02-06	2011-09-13	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
CY20171101001T CY1119416T1 (el)	2004-02-06	2017-09-21	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ' αυτων

Country Status (28)

Country	Link
US (8)	US7625559B2 (el)
EP (3)	EP1766093B1 (el)
JP (3)	JP4588763B2 (el)
KR (3)	KR101332927B1 (el)
CN (1)	CN101014620B (el)
AT (1)	ATE512986T1 (el)
AU (1)	AU2005320349C1 (el)
BE (1)	BE2017C023I2 (el)
BR (1)	BRPI0507433C1 (el)
CA (1)	CA2553946C (el)
CY (3)	CY1111860T1 (el)
DK (3)	DK2270045T3 (el)
ES (3)	ES2643760T3 (el)
FR (1)	FR17C1025I2 (el)
HR (1)	HRP20110599T1 (el)
HU (3)	HUE024962T2 (el)
LT (2)	LT2857418T (el)
LU (1)	LUC00025I2 (el)
MX (1)	MXPA06008839A (el)
NL (1)	NL300881I2 (el)
NO (2)	NO340300B1 (el)
NZ (2)	NZ580828A (el)
PL (3)	PL1766093T3 (el)
PT (3)	PT1766093E (el)
RS (1)	RS51908B (el)
SI (3)	SI2857418T1 (el)
WO (1)	WO2006121422A2 (el)
ZA (1)	ZA200606516B (el)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR045563A1 (es)	2003-09-10	2005-11-02	Warner Lambert Co	Anticuerpos dirigidos a m-csf
ES2643760T3 (es) *	2004-02-06	2017-11-24	University Of Massachusetts	Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos
CN101068560B (zh) *	2004-06-28	2011-03-09	独立行政法人科学技术振兴机构	毒素中和性肽的筛选方法和STX2抑制性肽以及Vero毒素中和剂
EP1833510A4 (en) *	2004-12-27	2010-02-10	Progenics Pharmaceuticals Neva	ORAL ADMINISTRATION ANTITOXIN ANTIBODIES AND METHODS OF MAKING AND USING THE SAME
EP2054044B1 (de)	2006-08-02	2014-07-23	Johannes Gutenberg-Universität Mainz	Arzneimittel gegen lct-vergiftungen
AU2014201846B2 (en) *	2007-01-30	2016-07-07	Epivax, Inc.	Regulatory t cell epitopes, compositions and uses thereof
EP2450372B1 (en)	2007-01-30	2015-04-22	Epivax, Inc.	Regulatory T cell epitopes, compositions and uses thereof
US20080188007A1 (en) *	2007-02-06	2008-08-07	Meridian Life Science, Inc.	Fluorescent single chain antibody and its use in detection of analytes
CN101363867B (zh) *	2008-05-26	2012-12-19	北京庄笛浩禾生物医学科技有限公司	一种艰难梭菌a、b毒素胶体金检测试纸条及其制备方法
JP2011524741A (ja) *	2008-05-27	2011-09-08	協和発酵キリン株式会社	インターロイキン１０受容体（ｉｌ−１０ｒ）抗体及び使用方法
DE102008029688B4 (de) *	2008-06-24	2016-06-23	Biodics Gmbh	Verfahren zum Nachweis und zur Identifikation eines varianten C. difficile Stammes in einer Probe
CN102365097A (zh) *	2009-02-20	2012-02-29	卫生防护机构	艰难梭菌毒素的抗体
US8889363B2 (en)	2009-07-27	2014-11-18	Biodics	Method for the detection and identification of a variant C. difficile strain in a sample
JP5591332B2 (ja) *	2009-07-27	2014-09-17	バイオディクスゲゼルシャフトミットベシュレンクテルハフツング	試料中における変異したｃ．ディフィシル菌株を検出および同定するための方法
WO2011063346A1 (en) *	2009-11-20	2011-05-26	Northshore University Health System Research Institute	Targeting of the c-terminal segment of c. difficile toxin b for improved clinical diagnosis, prevention, and treatment
GB0921288D0 (en) *	2009-12-04	2010-01-20	Health Prot Agency	Therapies for preventing or suppressing clostridium difficile infection
WO2011130650A2 (en)	2010-04-15	2011-10-20	Progenics Pharmaceuticals, Inc.	Antibodies for the treatment of clostridium difficile-associated infection and disease
RU2630663C9 (ru) *	2010-04-15	2017-11-29	Проджиникс Фармасьютикалс, Инк.	Антитела для лечения ассоциированных с clostridium difficile инфекции и заболеваний
ES2867375T3 (es)	2010-09-03	2021-10-20	Valneva Austria Gmbh	Polipéptido aislado de las proteínas de la toxina A y la toxina B de C. difficile y sus usos
GB201016742D0 (en) *	2010-10-05	2010-11-17	Health Prot Agency	Clostridium difficile antigens
WO2012055030A1 (en) *	2010-10-25	2012-05-03	National Research Council Of Canada	Clostridium difficile-specific antibodies and uses thereof
US20140127215A1 (en) *	2010-12-29	2014-05-08	Cangene Corporation	Clostridium difficile antigens
WO2012118693A1 (en)	2011-02-28	2012-09-07	Northshore University Healthsystem	Methods of diagnosing clostridium difficile infection
BR112013027229B1 (pt)	2011-04-22	2020-10-27	Wyeth Llc	polipeptídeo imunogênico isolado e seu uso, composição imunogênica e seu uso, célula recombinante ou progênie da mesma, e método de produção de uma toxina de clostridium difficile mutante
KR101955365B1 (ko)	2011-07-12	2019-03-07	필라델피아 헬스 앤드 에듀케이션 코포레이션 디/비/에이 드렉셀 유니버시티 컬리지 오브 메디슨	신규한 클로스트리듐 디피실(Clostridium Difficile) DNA 백신
AU2012298877B2 (en)	2011-08-22	2018-01-04	Emergent Biosolutions Canada Inc.	Clostridium difficile antibodies
PH12014500456A1 (en) *	2011-09-16	2014-04-14	Ucb Pharma Sa	Neutralising antibodies to the major exotoxins tcda and tcdb of clostridium difficile
WO2013071409A1 (en)	2011-11-18	2013-05-23	National Research Council Of Canada (Nrc)	Clostridium difficile lipoteichoic acid and uses thereof
JP6084631B2 (ja)	2011-12-08	2017-02-22	ノバルティスアーゲー	Ｃｌｏｓｔｒｉｄｉｕｍｄｉｆｆｉｃｉｌｅ毒素ベースのワクチン
DE102011121238A1 (de) *	2011-12-14	2013-06-20	Universitätsklinikum Hamburg-Eppendorf	Einzeldomänen-antikörper gegen clostridium difficile toxine
AR089797A1 (es)	2012-01-27	2014-09-17	Merck Sharp & Dohme	Vacunas contra clostridum difficile que comprenden toxinas recombinantes
SG10201610123UA (en) *	2012-03-02	2017-01-27	Regeneron Pharma	Human antibodies to clostridium difficile toxins
GB201206070D0 (en)	2012-04-04	2012-05-16	Health Prot Agency	Clostridium difficile antigens
US20150259402A1 (en) *	2012-10-19	2015-09-17	Evec Inc.	Human antibody specific to toxin produced from clostridium difficile, or antigen-binding fragment thereof
BR122016023101B1 (pt)	2012-10-21	2022-03-22	Pfizer Inc	Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile
AU2013352034B2 (en) *	2012-11-28	2018-08-02	Emergent Biosolutions Canada Inc.	Antibodies against Clostridium difficile
EP4079760A3 (en) *	2013-03-15	2023-01-25	Sanofi Pasteur Inc.	Antibodies against clostridium difficile toxins and methods of using the same
US10144775B2 (en) *	2013-04-19	2018-12-04	Immuron Limited	Methods and compositions for the treatment and/or prophylaxis of Clostridium difficile associated disease
US9181632B1 (en)	2013-09-09	2015-11-10	Merck Sharp & Dohme Corp.	C.difficile toxin B CROP domain peptides, antibodies and complexes thereof
WO2015100409A2 (en) *	2013-12-26	2015-07-02	Tufts University	Methods, compositions and kits for treating a subject using a recombinant neutralizing binding protein
CN105992772A (zh) *	2014-02-10	2016-10-05	Igm生命科学股份有限公司	IgA多特异性结合分子
SG11201606051YA (en)	2014-02-19	2016-09-29	Jody Berry	Marburg monoclonal antibodies
SG11201607258SA (en)	2014-04-10	2016-10-28	Obi Pharma Inc	Antibodies, pharmaceutical compositions and uses thereof
WO2015184454A1 (en) *	2014-05-30	2015-12-03	Case Western Reserve University	Clostridium difficile culture medium
EP2957570B1 (en)	2014-06-20	2019-04-17	Immunimed Inc.	Polyclonal antibodies against clostridium difficile and uses thereof
US10513552B2 (en)	2014-06-20	2019-12-24	Immunimed Inc.	Use of polyclonal antibodies against clostridium difficile for treatment of inflammatory bowel disease
ES2870506T3 (es) *	2015-02-19	2021-10-27	Immune Biosolutions Inc	Antígeno y anticuerpo del epítopo de las toxinas a y/o b de clostridium difficile, y sus usos farmacéuticos
WO2016156474A1 (en)	2015-03-31	2016-10-06	Vhsquared Limited	Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin a
WO2016156475A1 (en)	2015-03-31	2016-10-06	Vhsquared Limited	Polypeptide comprising an immunoglobulin chain variable domain which binds to clostridium difficile toxin b
CN105039262B (zh) *	2015-07-10	2018-07-03	北京科兴中维生物技术有限公司	破伤风类毒素单克隆抗体及其应用
CA3002789A1 (en)	2015-09-04	2017-03-09	Primatope Therapeutics Inc.	Humanized anti-cd40 antibodies and uses thereof
MY186414A (en)	2015-12-15	2021-07-22	Gilead Sciences Inc	Human immunodeficiency virus neutralizing antibodies
EP3448987A4 (en) *	2016-04-29	2020-05-27	Voyager Therapeutics, Inc.	COMPOSITIONS FOR TREATING A DISEASE
WO2018035407A1 (en) *	2016-08-19	2018-02-22	Enbiotix, Inc.	Bacteriophages for neutralizing toxins and methods of use thereof
KR102324568B1 (ko)	2017-06-21	2021-11-10	길리애드 사이언시즈, 인코포레이티드	HIV gp120 및 CD3을 표적화하는 다중특이적 항체
US12031985B2 (en) *	2018-04-19	2024-07-09	First Light Diagnostics, Inc.	Detection of targets
AU2019353145B2 (en)	2018-10-04	2025-12-04	First Light Diagnostics, Inc.	Microbial analysis without cell purification
US12161691B2 (en)	2019-05-11	2024-12-10	The Texas A&M University System	Protein inhibitors of clostridium difficile toxin b
WO2021219786A1 (en) *	2020-04-30	2021-11-04	Gottfried Himmler	Anti-toxin secretory iga2 preparation
CN111499738B (zh) *	2020-06-03	2022-04-05	郑州师范学院	一种抗艰难梭菌肠毒素a的抗体
CN114853896B (zh) *	2020-11-30	2023-05-09	四川大学华西医院	一种抗糖基转移酶a亚单位的纳米抗体及其应用
CN116239683B (zh) *	2023-02-15	2024-12-27	兰州生物制品研究所有限责任公司	一种抗艰难梭菌毒素b的单克隆抗体及其制备方法和应用
CN117720651B (zh) *	2023-12-13	2024-05-31	北京新兴四寰生物技术有限公司	抗艰难梭菌毒素b的单克隆抗体及其应用
WO2025140549A1 (en) *	2023-12-29	2025-07-03	Etinpro (Beijing) Co. Ltd.	Immune stimulating anti-hbsag antibody conjugates, pharmaceutical compositions, and therapeutic applications

Family Cites Families (63)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4879218A (en)	1982-09-13	1989-11-07	Virginia Tech Intellectual Properties, Inc.	Antibody for C.difficile
US4816567A (en)	1983-04-08	1989-03-28	Genentech, Inc.	Recombinant immunoglobin preparations
JPS6147500A (ja)	1984-08-15	1986-03-07	Res Dev Corp Of Japan	キメラモノクロ−ナル抗体及びその製造法
EP0173494A3 (en)	1984-08-27	1987-11-25	The Board Of Trustees Of The Leland Stanford Junior University	Chimeric receptors by dna splicing and expression
GB8422238D0 (en)	1984-09-03	1984-10-10	Neuberger M S	Chimeric proteins
JPS61134325A (ja)	1984-12-04	1986-06-21	Teijin Ltd	ハイブリツド抗体遺伝子の発現方法
GB8601597D0 (en)	1986-01-23	1986-02-26	Wilson R H	Nucleotide sequences
US5225539A (en)	1986-03-27	1993-07-06	Medical Research Council	Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en)	1986-03-27	1986-04-30	Winter G P	Recombinant dna product
GB8717430D0 (en)	1987-07-23	1987-08-26	Celltech Ltd	Recombinant dna product
US5332583A (en)	1987-11-24	1994-07-26	Connaught Laboratories Limited	Vaccine containing genetically-detoxified pertussis holotoxin
GB8727489D0 (en)	1987-11-24	1987-12-23	Connaught Lab	Detoxification of pertussis toxin
US5358868A (en)	1987-11-24	1994-10-25	Connaught Laboratories Limited	Genetic detoxification of pertussis toxin
US5244657A (en)	1987-11-24	1993-09-14	Connaught Laboratories Limited	Genetic detoxification of pertussis toxin
US5221618A (en)	1987-11-24	1993-06-22	Connaught Laboratories Limited	Genetic detoxification of pertussis toxin
GB8809129D0 (en)	1988-04-18	1988-05-18	Celltech Ltd	Recombinant dna methods vectors and host cells
GB8823869D0 (en)	1988-10-12	1988-11-16	Medical Res Council	Production of antibodies
US5530101A (en)	1988-12-28	1996-06-25	Protein Design Labs, Inc.	Humanized immunoglobulins
US5601823A (en) *	1989-10-31	1997-02-11	Ophidian Pharmaceuticals, Inc.	Avian antitoxins to clostridium difficle toxin A
US5736139A (en) *	1989-10-31	1998-04-07	Ochidian Pharmaceuticals, Inc.	Treatment of Clostridium difficile induced disease
US5919665A (en) *	1989-10-31	1999-07-06	Ophidian Pharmaceuticals, Inc.	Vaccine for clostridium botulinum neurotoxin
US5231003A (en)	1990-05-11	1993-07-27	Cambridge Bioscience Corporation	Monoclonal antibodies specific for toxin b of clostridium difficile
US5625126A (en)	1990-08-29	1997-04-29	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
US5661016A (en)	1990-08-29	1997-08-26	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5789650A (en)	1990-08-29	1998-08-04	Genpharm International, Inc.	Transgenic non-human animals for producing heterologous antibodies
US5874299A (en)	1990-08-29	1999-02-23	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5770429A (en)	1990-08-29	1998-06-23	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US6300129B1 (en)	1990-08-29	2001-10-09	Genpharm International	Transgenic non-human animals for producing heterologous antibodies
US5814318A (en)	1990-08-29	1998-09-29	Genpharm International Inc.	Transgenic non-human animals for producing heterologous antibodies
DE69127627T2 (de)	1990-08-29	1998-02-19	Genpharm Int	Produktion und Nützung nicht-menschliche transgentiere zur Produktion heterologe Antikörper
US5633425A (en)	1990-08-29	1997-05-27	Genpharm International, Inc.	Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en)	1990-08-29	1996-08-13	Genpharm International, Inc.	Ransgenic non-human animals for producing heterologous antibodies
US5877397A (en)	1990-08-29	1999-03-02	Genpharm International Inc.	Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
EP0519596B1 (en)	1991-05-17	2005-02-23	Merck & Co. Inc.	A method for reducing the immunogenicity of antibody variable domains
CA2113113A1 (en)	1991-07-08	1993-01-21	Simon W. Kantor	Thermotropic liquid crystal segmented block copolymer
AU668374B2 (en) *	1991-12-10	1996-05-02	Dana-Farber Cancer Institute	Reactive neutralizing human anti-GP120 recombinant antibody, DNA coding the same and use thereof
US5466672A (en)	1992-12-04	1995-11-14	Ophidian Pharmaceuticals, Inc.	Therapeutic use of clostridium difficile toxin A
EP0754225A4 (en)	1993-04-26	2001-01-31	Genpharm Int	HETEROLOGIC ANTIBODY-PRODUCING TRANSGENIC NON-HUMAN ANIMALS
US5625825A (en)	1993-10-21	1997-04-29	Lsi Logic Corporation	Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
PL320214A1 (en)	1994-10-24	1997-09-15	Ophidian Pharmaceuticals	Vaccine and antitoxin for treating and preventing a disease caused by c.difficile
GB9621295D0 (en) *	1995-12-07	1996-11-27	Cambridge Antibody Tech	Specific binding members,materials and methods
WO1998059053A1 (en)	1997-06-20	1998-12-30	Queen Mary & Westfield College	Immonogenic fragments of toxin a of clostridium difficile
DE19739685A1 (de) *	1997-09-10	1999-03-11	Eichel Streiber Christoph Von	Monoklonale Antikörper zur Therapie und Prophylaxe von Erkrankungen durch Clostridium difficile
EP2305293A3 (en)	1997-10-20	2013-11-06	Sanofi Pasteur Biologics Co.	Immunization against Clostridium difficile disease
US6733760B1 (en) *	1999-04-09	2004-05-11	Techlab, Inc.	Recombinant toxin A/toxin B vaccine against Clostridium difficile
JP2003516718A (ja)	1999-07-29	2003-05-20	メダレックスインク	ＨＥＲ２／ｎｅｕに対するヒトモノクローナル抗体
CA2589418A1 (en)	1999-08-24	2001-03-01	Medarex, Inc.	Human ctla-4 antibodies and their uses
GB0001448D0 (en) *	2000-01-21	2000-03-08	Novartis Ag	Organic compounds
EP3190126A1 (en)	2000-05-26	2017-07-12	Immunex Corporation	Use of interleukin-4 receptor (il-4r) antibodies and compositions thereof
UA81743C2 (uk) *	2000-08-07	2008-02-11	Центокор, Инк.	МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ
TWI327597B (en) *	2001-08-01	2010-07-21	Centocor Inc	Anti-tnf antibodies, compositions, methods and uses
WO2003064606A2 (en) *	2002-01-28	2003-08-07	Medarex, Inc.	Human monoclonal antibodies to prostate specific membrane antigen (psma)
EP1487856B1 (en) *	2002-03-04	2010-07-28	Imclone LLC	Human antibodies specific to kdr and uses thereof
WO2003079750A2 (en) *	2002-03-21	2003-10-02	Eli Lilly And Company	ANTAGONISTIC ANTI-hFAS LIGAND HUMAN ANTIBODIES AND FRAGMENTS THEREOF
EP1554392A4 (en) *	2002-05-06	2007-08-08	Us Gov Health & Human Serv	IDENTIFICATION OF NEW NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES WITH WIDE CROSS-REACTIVITY USING SEQUENTIAL ANTIGEN PANNING OF PHAG DISPLAY LIBRARIES
US7396913B2 (en) *	2002-10-14	2008-07-08	Abbott Laboratories	Erythropoietin receptor binding antibodies
TWI320716B (en) *	2002-10-14	2010-02-21	Abbott Lab	Erythropoietin receptor binding antibodies
EP1578799B8 (en) *	2002-12-02	2011-03-23	Amgen Fremont Inc.	Antibodies directed to tumor necrosis factor and uses thereof
AU2003300680A1 (en)	2002-12-10	2004-07-09	Centre National De La Recherche Scientifique Cnrs	Thap proteins as nuclear receptors for chemokines and roles in transcriptional regulation, cell proliferation and cell differentiation
US20070003561A1 (en) *	2003-07-08	2007-01-04	Sorensen Anders P	Binding member towards pneumococcus surface adhesin a protein (psaa)
BRPI0417429A (pt) *	2003-12-10	2007-04-03	Medarex Inc	anticorpo monoclonal isolado ou uma porção de ligação de antìgeno deste, composição, imunoconjugado, molécula biespecìfica, vetor de expressão, célula hospedeira, camundongo transgênico, hibridoma, e, métodos de inibir uma resposta inflamatória ou autoimune, de tratar uma doença inflamatória ou autoimune, de tratar uma infecção viral ou bacteriana e de preparar um anticorpo anti-ip-10
ES2643760T3 (es)	2004-02-06	2017-11-24	University Of Massachusetts	Anticuerpos contra toxinas de Clostridium difficile y usos de los mismos
IT1395574B1 (it)	2009-09-14	2012-10-16	Guala Dispensing Spa	Dispositivo di erogazione

2005
- 2005-02-04 ES ES14194551.9T patent/ES2643760T3/es not_active Expired - Lifetime
- 2005-02-04 PL PL05857759T patent/PL1766093T3/pl unknown
- 2005-02-04 PL PL14194551T patent/PL2857418T3/pl unknown
- 2005-02-04 DK DK10010733.3T patent/DK2270045T3/en active
- 2005-02-04 SI SI200532173T patent/SI2857418T1/en unknown
- 2005-02-04 EP EP05857759A patent/EP1766093B1/en not_active Expired - Lifetime
- 2005-02-04 EP EP14194551.9A patent/EP2857418B1/en not_active Expired - Lifetime
- 2005-02-04 SI SI200531344T patent/SI1766093T1/sl unknown
- 2005-02-04 KR KR1020117029761A patent/KR101332927B1/ko not_active Expired - Lifetime
- 2005-02-04 PL PL10010733T patent/PL2270045T3/pl unknown
- 2005-02-04 CN CN2005800041265A patent/CN101014620B/zh not_active Expired - Lifetime
- 2005-02-04 BR BRPI0507433A patent/BRPI0507433C1/pt not_active IP Right Cessation
- 2005-02-04 DK DK05857759.4T patent/DK1766093T3/da active
- 2005-02-04 DK DK14194551.9T patent/DK2857418T3/en active
- 2005-02-04 LT LTEP14194551.9T patent/LT2857418T/lt unknown
- 2005-02-04 AT AT05857759T patent/ATE512986T1/de active
- 2005-02-04 JP JP2007527193A patent/JP4588763B2/ja not_active Expired - Lifetime
- 2005-02-04 MX MXPA06008839A patent/MXPA06008839A/es active IP Right Grant
- 2005-02-04 US US11/051,453 patent/US7625559B2/en active Active
- 2005-02-04 AU AU2005320349A patent/AU2005320349C1/en active Active
- 2005-02-04 WO PCT/US2005/003725 patent/WO2006121422A2/en not_active Ceased
- 2005-02-04 ES ES05857759T patent/ES2366626T3/es not_active Expired - Lifetime
- 2005-02-04 PT PT05857759T patent/PT1766093E/pt unknown
- 2005-02-04 PT PT141945519T patent/PT2857418T/pt unknown
- 2005-02-04 NZ NZ580828A patent/NZ580828A/en not_active IP Right Cessation
- 2005-02-04 ES ES10010733.3T patent/ES2533492T3/es not_active Expired - Lifetime
- 2005-02-04 KR KR1020127017138A patent/KR20120083534A/ko not_active Withdrawn
- 2005-02-04 KR KR1020067017771A patent/KR101332994B1/ko not_active Expired - Lifetime
- 2005-02-04 NZ NZ548821A patent/NZ548821A/en not_active IP Right Cessation
- 2005-02-04 RS RS20110361A patent/RS51908B/sr unknown
- 2005-02-04 HU HUE10010733A patent/HUE024962T2/en unknown
- 2005-02-04 EP EP10010733.3A patent/EP2270045B8/en not_active Expired - Lifetime
- 2005-02-04 CA CA2553946A patent/CA2553946C/en not_active Expired - Lifetime
- 2005-02-04 PT PT100107333T patent/PT2270045E/pt unknown
- 2005-02-04 HR HR20110599T patent/HRP20110599T1/hr unknown
- 2005-02-04 SI SI200531949T patent/SI2270045T1/sl unknown
- 2005-02-04 HU HUE14194551A patent/HUE034552T2/en unknown
2006
- 2006-08-04 ZA ZA2006/06516A patent/ZA200606516B/en unknown
- 2006-08-23 NO NO20063767A patent/NO340300B1/no active Protection Beyond IP Right Term
2009
- 2009-07-31 US US12/533,501 patent/US8236311B2/en not_active Expired - Lifetime
- 2009-07-31 US US12/533,552 patent/US8257709B2/en not_active Expired - Lifetime
2010
- 2010-07-28 JP JP2010169364A patent/JP5319622B2/ja not_active Expired - Lifetime
2011
- 2011-09-13 CY CY20111100872T patent/CY1111860T1/el unknown
2012
- 2012-06-07 US US13/490,757 patent/US8609111B2/en not_active Expired - Fee Related
2013
- 2013-02-27 JP JP2013036855A patent/JP5717300B2/ja not_active Expired - Lifetime
- 2013-11-14 US US14/080,598 patent/US9217029B2/en not_active Expired - Lifetime
2015
- 2015-10-29 US US14/926,706 patent/US20160152694A1/en not_active Abandoned
2017
- 2017-06-27 NL NL300881C patent/NL300881I2/nl unknown
- 2017-06-27 HU HUS1700028C patent/HUS1700028I1/hu unknown
- 2017-06-28 CY CY2017022C patent/CY2017022I1/el unknown
- 2017-06-28 BE BE2017C023C patent/BE2017C023I2/fr unknown
- 2017-07-04 FR FR17C1025C patent/FR17C1025I2/fr active Active
- 2017-07-04 LU LU00025C patent/LUC00025I2/en unknown
- 2017-07-07 NO NO2017032C patent/NO2017032I1/no unknown
- 2017-07-11 LT LTPA2017022 patent/LTC2270045I2/lt unknown
- 2017-09-21 CY CY20171101001T patent/CY1119416T1/el unknown
2018
- 2018-03-19 US US15/924,703 patent/US20180208643A1/en not_active Abandoned
2020
- 2020-09-16 US US17/022,766 patent/US20210269511A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US9217029B2 (en)	2015-12-22
BRPI0507433C1 (pt)	2021-05-25
JP5319622B2 (ja)	2013-10-16
FR17C1025I1 (fr)	2017-08-09
SI2857418T1 (en)	2018-01-31
US20210269511A1 (en)	2021-09-02
JP2011019516A (ja)	2011-02-03
LTC2270045I2 (lt)	2019-12-10
JP5717300B2 (ja)	2015-05-13
BRPI0507433B1 (pt)	2018-03-20
KR20070050863A (ko)	2007-05-16
WO2006121422A8 (en)	2007-04-26
PT2857418T (pt)	2017-10-20
NL300881I2 (nl)	2024-07-16
CN101014620A (zh)	2007-08-08
SI2270045T1 (sl)	2015-06-30
DK2857418T3 (en)	2017-10-23
US20050287150A1 (en)	2005-12-29
SI1766093T1 (sl)	2011-12-30
CN101014620B (zh)	2012-05-09
EP2270045B1 (en)	2014-12-31
BRPI0507433A (pt)	2007-07-03
US20100233181A1 (en)	2010-09-16
PL2270045T3 (pl)	2015-06-30
US20180208643A1 (en)	2018-07-26
HUE034552T2 (en)	2018-02-28
ES2643760T3 (es)	2017-11-24
ZA200606516B (en)	2011-01-26
DK1766093T3 (da)	2011-10-03
BE2017C023I2 (el)	2024-08-08
FR17C1025I2 (fr)	2019-11-15
CA2553946A1 (en)	2005-08-06
HRP20110599T1 (hr)	2011-10-31
US8236311B2 (en)	2012-08-07
LTPA2017022I1 (lt)	2017-09-11
AU2005320349A8 (en)	2008-08-07
NZ548821A (en)	2009-12-24
WO2006121422A2 (en)	2006-11-16
MXPA06008839A (es)	2008-03-07
AU2005320349B2 (en)	2010-04-08
ATE512986T1 (de)	2011-07-15
PT2270045E (pt)	2015-04-08
LUC00025I2 (el)	2017-09-08
HK1208873A1 (en)	2016-03-18
EP2857418A1 (en)	2015-04-08
US20140120614A1 (en)	2014-05-01
EP2857418B1 (en)	2017-07-26
LUC00025I1 (el)	2017-07-06
PL2857418T3 (pl)	2017-10-31
AU2005320349B8 (en)	2010-04-22
US20100233182A1 (en)	2010-09-16
JP2007533330A (ja)	2007-11-22
BRPI0507433B8 (pt)	2018-04-10
HUS1700028I1 (hu)	2017-07-28
CA2553946C (en)	2019-02-26
US20120288508A1 (en)	2012-11-15
RS51908B (sr)	2012-02-29
PT1766093E (pt)	2011-08-24
NO20063767L (no)	2006-10-02
HK1102287A1 (en)	2007-11-09
US8257709B2 (en)	2012-09-04
PL1766093T3 (pl)	2011-11-30
WO2006121422A3 (en)	2007-03-15
KR101332994B1 (ko)	2013-11-26
JP2013153750A (ja)	2013-08-15
ES2533492T3 (es)	2015-04-10
EP2270045A1 (en)	2011-01-05
CY1119416T1 (el)	2018-03-07
EP2270045B8 (en)	2015-02-25
US7625559B2 (en)	2009-12-01
CY1111860T1 (el)	2015-11-04
EP1766093B1 (en)	2011-06-15
HK1152048A1 (en)	2012-02-17
US20160152694A1 (en)	2016-06-02
KR20120083534A (ko)	2012-07-25
ES2366626T3 (es)	2011-10-24
AU2005320349C1 (en)	2019-06-13
US8609111B2 (en)	2013-12-17
NZ580828A (en)	2011-09-30
CY2017022I1 (el)	2017-11-14
EP1766093A2 (en)	2007-03-28
LT2857418T (lt)	2017-09-25
KR101332927B1 (ko)	2013-11-26
AU2005320349A1 (en)	2006-08-24
JP4588763B2 (ja)	2010-12-01
NO340300B1 (no)	2017-03-27
DK2270045T3 (en)	2015-04-07
KR20120003017A (ko)	2012-01-09
HUE024962T2 (en)	2016-02-29
NO2017032I1 (no)	2017-07-07

Publication	Publication Date	Title
CY2017022I1 (el)	2017-11-14	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων
CY2018013I2 (el)	2018-09-05	Ανθρωπινα anti-il-23 αντισωματα, συνθεσεις, μεθοδοι και χρησεις
HUS2300026I1 (hu)	2023-09-28	Anti-CTLA-4 ellenanyag készítmények
NO20073192L (no)	2007-09-06	Antistoffer rettet mot angiopoietin-2 og anvendelser derav
IS8026A (is)	2005-09-14	Mótefni gegn amýlóíðum, samsetningar, aðferðir ognotkun
PT2061814E (pt)	2012-09-10	Anticorpos e imunoconjugados e suas utilizações
DK3620171T3 (da)	2022-06-07	Anti-GM-CSF-antistoffer og anvendelser af disse
EP1895838A4 (en)	2013-03-06	COMPOSITIONS AND METHODS
NO20080692L (no)	2008-04-03	SP35 antistoffer og anvendelse derav
NO20071430L (no)	2007-05-15	Anti-OX4OL antistoffer
IS8266A (is)	2006-01-26	Breytt mennsk IGF-1R mótefni
EP1784209A4 (en)	2009-06-10	SP22-BASED CONTRACEPTIVES AND SP22 ANTIBODIES
NO20052061D0 (no)	2005-04-27	Barnesete for bruk i kjoretoy.
WO2006116319A3 (en)	2007-01-04	Reagents that bind ccx-ckr2
CY1116371T1 (el)	2017-02-08	Αντισωματα εναντι των τοξινων toy clostridium difficile (κλωστηριδιο το δυσκολο) και χρησεις εξ αυτων
ES1057339Y (es)	2004-11-01	Libro educativo infantil.
ES1054806Y (es)	2003-12-16	Juguete didactico.
UA13696S (uk)	2007-03-15	Фігурка іграшкова. бабуся -груша
UA13698S (uk)	2007-03-15	Фігурка іграшкова. студентка-горошина
ES1058802Y (es)	2005-06-01	Juguete lanzador
HK1118932A (en)	2009-02-20	Anti-ox40l antibodies and methods using same
ITRM20040183A1 (it)	2004-07-09	Miscela erboristica e fitofarmaco comprendente la stessa.
TH1501000078B (th)	2016-04-12	ระบบจำลองการขับขี่