CY2016031I1 - Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων - Google Patents

Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων

Info

Publication number: CY2016031I1
Authority: CY; Cyprus
Prior art keywords: ivermectin; treatment; pharmaceutical form; topical pharmaceutical; dermatological conditions
Prior art date: 2003-04-24

Application number

CY2016031C

Other languages

English (en)

Other versions

CY2016031I2 (el

Original Assignee

Galderma S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-24

Filing date

2016-09-09

Publication date

2017-03-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33312271&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY2016031(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2003-04-24 Priority claimed from FR0305048A external-priority patent/FR2854074B1/fr

2016-09-09 Application filed by Galderma S.A. filed Critical Galderma S.A.

2017-03-15 Publication of CY2016031I2 publication Critical patent/CY2016031I2/el

2017-03-15 Publication of CY2016031I1 publication Critical patent/CY2016031I1/el

Links

AZSNMRSAGSSBNP-XPNPUAGNSA-N 22,23-dihydroavermectin B1a Chemical compound C1C[C@H](C)[C@@H]([C@@H](C)CC)O[C@@]21O[C@H](C\C=C(C)\[C@@H](O[C@@H]1O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C1)[C@@H](C)\C=C\C=C/1[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\1)O)C[C@H]4C2 AZSNMRSAGSSBNP-XPNPUAGNSA-N 0.000 title 1
AZSNMRSAGSSBNP-UHFFFAOYSA-N 22,23-dihydroavermectin B1a Natural products C1CC(C)C(C(C)CC)OC21OC(CC=C(C)C(OC1OC(C)C(OC3OC(C)C(O)C(OC)C3)C(OC)C1)C(C)C=CC=C1C3(C(C(=O)O4)C=C(C)C(O)C3OC1)O)CC4C2 AZSNMRSAGSSBNP-UHFFFAOYSA-N 0.000 title 1
229960002418 ivermectin Drugs 0.000 title 1
230000000699 topical effect Effects 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Dermatology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

CY2016031C 2003-04-24 2016-09-09 Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων CY2016031I1 (el)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
FR0305048A FR2854074B1 (fr)	2003-04-24	2003-04-24	Utilisation de l'ivermectine pour le traitement de desordres dermatologiques
US46899403P	2003-05-09	2003-05-09
PCT/EP2004/004950 WO2004093886A1 (en)	2003-04-24	2004-04-22	Topical formulation of ivermectin for the treatment of dermatological conditions

Publications (2)

Publication Number	Publication Date
CY2016031I2 CY2016031I2 (el)	2017-03-15
CY2016031I1 true CY2016031I1 (el)	2017-03-15

Family

ID=33312271

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
CY20111100856T CY1111797T1 (el)	2003-04-24	2011-09-07	Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων
CY2016031C CY2016031I1 (el)	2003-04-24	2016-09-09	Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
CY20111100856T CY1111797T1 (el)	2003-04-24	2011-09-07	Τοπικη φαρμακοτεχνικη μορφη ιβερμεκτινης για την θεραπεια δερματολογικων καταστασεων

Country Status (16)

Country	Link
US (6)	US7550440B2 (el)
EP (1)	EP1620113B1 (el)
JP (2)	JP5711867B2 (el)
KR (1)	KR101187231B1 (el)
AU (1)	AU2004231323C1 (el)
BR (1)	BRPI0410503B8 (el)
CA (1)	CA2522579C (el)
CY (2)	CY1111797T1 (el)
FR (1)	FR15C0069I2 (el)
HU (1)	HUS1500048I1 (el)
LT (1)	LTC1620113I2 (el)
LU (1)	LU92915I2 (el)
MX (1)	MXPA05011208A (el)
PL (2)	PL378932A1 (el)
RU (1)	RU2350333C3 (el)
WO (1)	WO2004093886A1 (el)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
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FR2854074B1 (fr)	2003-04-24	2007-11-23	Galderma Res & Dev	Utilisation de l'ivermectine pour le traitement de desordres dermatologiques
MXPA05011208A (es) *	2003-04-24	2005-12-14	Galderma Sa	Uso de ivermectina para el tratamiento de desordenes dermatologicos.
BR0318319A (pt) *	2003-05-25	2006-07-18	Yuwan Wang	métodos de preparação e formulações/composições sustentadas pelo uso de dimeticona como veìculo
DE602005020912D1 (de)	2004-03-18	2010-06-10	Galderma Sa	Ivermectin enthaltende creme
FR2867684B1 (fr) *	2004-03-18	2006-05-05	Galderma Sa	Gel creme contenant de l'ivermectine
FR2883181B1 (fr)	2005-03-17	2007-05-18	Galderma Sa	Composition a base d'une avermectine et d'acide azelaique notamment pour le traitement de la rosacee
FR2886852B1 (fr) *	2005-06-10	2007-11-23	Galderma Sa	Composition a base d'une avermectine et d'hydrocortisone notamment pour le traitement de la rosacee
FR2886850B1 (fr) *	2005-06-10	2007-10-05	Galderma Sa	Composition a base d'une avermectine et de peroxyde de benzoyle notamment pour le traitement de la rosacee
FR2886851B1 (fr) *	2005-06-10	2007-10-05	Galderma Sa	Composition a base d'une avermectine et de metronidazole notamment pour le traitement de la rosacee
FR2894823B1 (fr)	2005-12-20	2008-02-29	Galderma Sa	Composition de type emulsion inverse comprenant de l'ivermectine, et ses utilisations en cosmetique et en dermatologie
FR2900052B1 (fr) *	2006-04-19	2011-02-18	Galderma Sa	Composition comprenant au moins une phase aqueuse et au moins une phase grasse comprenant de l'ivermectine
FR2906468B1 (fr) *	2006-09-28	2012-09-21	Galderma Sa	Utilisation de composes de la famille des avermectines pour le traitement de desordres dermatologiques
FR2907013B1 (fr)	2006-10-12	2012-09-21	Galderma Sa	Produits de soin cutane a double compartiment comprenant de l'ivermectine, et leurs utilisations
WO2008067054A2 (en) *	2006-10-12	2008-06-05	Topaz Pharmaceuticals Llc	Topical avermectin formulations and methods for elimination and prophylaxis of susceptible and treatment-resistant strains of head lice
FR2907012B1 (fr) *	2006-10-12	2012-09-21	Galderma Sa	Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation
US8901163B2 (en) *	2007-01-03	2014-12-02	Galderma S.A.	Method of treating hyperesthesia, paresthesia, dolor, and pruritus caused by insect stings or noxious weeds or plants using avermectin compound
DE102007056424A1 (de) *	2007-11-23	2009-05-28	Neopharmacie Gmbh	Pharmazeutische Zusammensetzung, enthaltend eine Öl/Wasser-Emulsion
ES2719200T3 (es) *	2008-10-29	2019-07-09	Arbor Pharmaceuticals Llc	Sistema conservante para formulaciones tópicas terapéuticas basadas en emulsión
EP2419082B1 (fr) *	2008-12-23	2020-01-22	Galderma S.A.	Composition pharmaceutique topique comprenant un principe actif sensible a l'eau
US8642665B2 (en)	2011-12-16	2014-02-04	Conopco, Inc.	Environmentally friendly, low whitening compositions
JP5717034B2 (ja) *	2012-08-27	2015-05-13	丸和バイオケミカル株式会社	マクロライド系化合物を含有する土壌線虫防除用薬剤
FR3000397A1 (fr) *	2012-12-31	2014-07-04	Galderma Res & Dev	Combinaison de laropiprant et d'ivermectine pour le traitement de la rosacee
CN103356687B (zh)	2012-10-19	2016-06-01	厦门大学	一种伊维菌素及其衍生物的用途
FR3003761B1 (fr) *	2013-03-29	2016-01-01	Galderma Sa	Utilisation d'une lactone macrocyclique pour le traitement d'une infection par un papillomavirus
US9782425B2 (en)	2013-07-08	2017-10-10	Galderma S.A.	Treatment of papulopustular rosacea with ivermectin
US9233117B2 (en)	2013-07-08	2016-01-12	Galderma S. A.	Treatment of inflammatory lesions of rosacea with ivermectin
KR102428738B1 (ko)	2013-08-08	2022-08-02	노반, 인크.	국소 조성물 및 그의 사용 방법
JP6448641B2 (ja) *	2013-11-29	2019-01-09	ガルデルマ・ソシエテ・アノニム	アトピー性皮膚炎の治療及び／又は予防のためのアベルメクチンファミリー又はミルベマイシンファミリーの化合物
CN104706584A (zh) *	2013-12-16	2015-06-17	天津迈迪瑞康生物医药科技有限公司	一种伊维菌素脂肪乳浓缩液、其制备方法及用途
US10322082B2 (en)	2014-07-11	2019-06-18	Novan, Inc.	Topical antiviral compositions and methods of using the same
US20170232024A1 (en) *	2014-08-04	2017-08-17	Jerry Tan Eye Surgery Pte Ltd	Pharmaceutical compositions for demodex related blepharitis and eyelid crusting
FR3026010B1 (fr)	2014-09-18	2016-11-04	Galderma Sa	Compositions comprenant un compose de la famille des avermectines et de la doxycycline pour le traitement de la rosacee
WO2016096795A1 (en) *	2014-12-15	2016-06-23	Galderma Sa	Compound of the avermectin family for treating and/or preventing inflammatory dermatoses
WO2016096797A1 (en)	2014-12-15	2016-06-23	Galderma Sa	Compound of the avermectin family in combination with an other active compound for treating and/or preventing inflammatory dermatoses
WO2017064206A1 (en)	2015-10-13	2017-04-20	Galderma Sa	A process for preparing a composition comprising a high concentration of one or more avermectins
WO2017064205A1 (en)	2015-10-13	2017-04-20	Galderma Sa	A process for preparing a stable emulsion comprising one or more avermectins
RU2738932C2 (ru) *	2016-08-04	2020-12-18	Нестле Скин Хелт Са	Композиции и их применение для лечения или профилактики розацеа
US11160780B2 (en) *	2016-09-30	2021-11-02	Aurobindo Pharma Ltd.	Pharmaceutical composition of ivermectin and process for preparation thereof
WO2018083196A1 (en)	2016-11-03	2018-05-11	Nestlé Skin Health Sa	Compositions comprising a compound of the avermectin family for the treatment and/or prevention of hand eczema
EP3326609A1 (en)	2016-11-24	2018-05-30	Nestlé Skin Health SA	Composition comprising avermectin compounds without gelling agents
EP3326608A1 (en)	2016-11-24	2018-05-30	Nestlé Skin Health SA	Composition comprising avermectin compounds without solid fatty substances
EP3326614A1 (en)	2016-11-24	2018-05-30	Nestlé Skin Health SA	Composition comprising avermectin compounds without solvents and propenetrating agents of avermectin compounds
CN110753549A (zh) *	2017-06-12	2020-02-04	莱克伍德阿美达克斯股份有限公司	双磷脂素凝胶制剂及其用途
US10835517B2 (en)	2017-12-15	2020-11-17	Tarsus Pharmaceuticals, Inc.	Methods for treating ocular demodex using isoxazoline parasiticide formulations
WO2020064843A1 (en) *	2018-09-28	2020-04-02	Galderma Research & Development	Pharmaceutical composition in the form of a water-in-oil emulsion (w/o) and its uses
WO2020210784A1 (en)	2019-04-12	2020-10-15	Ecolab Usa Inc.	Antimicrobial multi-purpose cleaner and methods of making and using the same
US12161752B2 (en)	2019-08-20	2024-12-10	Vishwanath Padmanabhan	Compositions and methods for the treatment of anterior blepharitis and posterior blepharitis
AU2020333860A1 (en) *	2019-08-21	2022-04-07	Leo Pharma A/S	Solvent delivery system for topical delivery of active agents
KR102480430B1 (ko)	2020-10-21	2022-12-21	순천향대학교 산학협력단	주사증 진단을 위한 마이크로RNA-31-5p 및 이의 용도
KR20220052474A (ko)	2020-10-21	2022-04-28	순천향대학교 산학협력단	주사증 진단을 위한 마이크로RNA-21-3p 및 이의 용도
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US5952372A (en) *	1998-09-17	1999-09-14	Mcdaniel; William Robert	Method for treating rosacea using oral or topical ivermectin
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US6399651B1 (en)	2000-06-29	2002-06-04	L. Dean Parks	Method of treating dermatoses using avermectin compound
US20030064940A1 (en) *	2001-10-02	2003-04-03	Parks L. Dean	Kit for treating acne vulgaris using avermectin compound
US6319945B1 (en) *	2000-06-29	2001-11-20	L. Dean Parks	Method of treatment of seborrheic dermatitis
US6399652B1 (en) *	2000-06-29	2002-06-04	L. Dean Parks	Method of treating acne vulgaris using avermectin compound
DE10063946A1 (de) *	2000-12-20	2002-07-04	Basf Ag	Verwendung von Lichtschutzmittelkombinationen, die als wesentlichen Bestandteil 2,2'-p-Phenylen-bis(3,1-benzoxazin-4-on) enthalten als photostabile UV-Filter in kosmetischen und pharmazeutischen Zubereitungen
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EP1480633A2 (en) *	2002-03-04	2004-12-01	Divergence, Inc.	Nematicidal fatty acid and fatty acid ester related compounds
MXPA05011208A (es) *	2003-04-24	2005-12-14	Galderma Sa	Uso de ivermectina para el tratamiento de desordenes dermatologicos.
FR2867684B1 (fr)	2004-03-18	2006-05-05	Galderma Sa	Gel creme contenant de l'ivermectine
DE602005020912D1 (de)	2004-03-18	2010-06-10	Galderma Sa	Ivermectin enthaltende creme

2004
- 2004-04-22 MX MXPA05011208A patent/MXPA05011208A/es active IP Right Grant
- 2004-04-22 AU AU2004231323A patent/AU2004231323C1/en active Active
- 2004-04-22 PL PL378932A patent/PL378932A1/pl not_active Application Discontinuation
- 2004-04-22 WO PCT/EP2004/004950 patent/WO2004093886A1/en active Application Filing
- 2004-04-22 JP JP2006505405A patent/JP5711867B2/ja not_active Expired - Lifetime
- 2004-04-22 RU RU2005136438A patent/RU2350333C3/ru active Protection Beyond IP Right Term
- 2004-04-22 PL PL04728811T patent/PL1620113T3/pl unknown
- 2004-04-22 CA CA2522579A patent/CA2522579C/en not_active Expired - Fee Related
- 2004-04-22 KR KR1020057019402A patent/KR101187231B1/ko not_active Expired - Lifetime
- 2004-04-22 BR BRPI0410503A patent/BRPI0410503B8/pt not_active IP Right Cessation
- 2004-04-22 EP EP04728811A patent/EP1620113B1/en not_active Expired - Lifetime
2005
- 2005-10-24 US US11/255,910 patent/US7550440B2/en not_active Expired - Lifetime
2009
- 2009-05-19 US US12/468,287 patent/US8080530B2/en not_active Expired - Lifetime
- 2009-06-12 US US12/483,604 patent/US8093219B2/en not_active Expired - Lifetime
2011
- 2011-09-07 CY CY20111100856T patent/CY1111797T1/el unknown
- 2011-12-02 US US13/310,633 patent/US8415311B2/en not_active Expired - Fee Related
2012
- 2012-03-22 JP JP2012065724A patent/JP5538461B2/ja not_active Expired - Lifetime
- 2012-06-21 US US13/529,971 patent/US8470788B2/en not_active Expired - Lifetime
2013
- 2013-03-27 US US13/851,816 patent/US8598129B2/en not_active Expired - Lifetime
2015
- 2015-09-22 HU HUS1500048C patent/HUS1500048I1/hu unknown
- 2015-09-24 LT LTPA2015033C patent/LTC1620113I2/lt unknown
- 2015-10-14 FR FR15C0069C patent/FR15C0069I2/fr active Active
- 2015-12-17 LU LU92915C patent/LU92915I2/xx unknown
2016
- 2016-09-09 CY CY2016031C patent/CY2016031I1/el unknown

Also Published As

Publication number	Publication date
RU2350333C2 (ru)	2009-03-27
PL1620113T3 (pl)	2011-10-31
US20090227668A1 (en)	2009-09-10
BRPI0410503A (pt)	2006-06-20
JP5538461B2 (ja)	2014-07-02
PL378932A1 (pl)	2006-06-12
US8093219B2 (en)	2012-01-10
WO2004093886A1 (en)	2004-11-04
JP2012126738A (ja)	2012-07-05
CY1111797T1 (el)	2015-10-07
LTC1620113I2 (lt)	2018-02-26
US20060100165A1 (en)	2006-05-11
US20120258062A1 (en)	2012-10-11
JP5711867B2 (ja)	2015-05-07
US7550440B2 (en)	2009-06-23
AU2004231323B2 (en)	2009-12-10
CY2016031I2 (el)	2017-03-15
CA2522579A1 (en)	2004-11-04
JP2006524212A (ja)	2006-10-26
US8470788B2 (en)	2013-06-25
AU2004231323A1 (en)	2004-11-04
LU92915I2 (fr)	2016-02-17
MXPA05011208A (es)	2005-12-14
FR15C0069I2 (fr)	2016-04-22
KR101187231B1 (ko)	2012-10-02
KR20060004667A (ko)	2006-01-12
AU2004231323C1 (en)	2016-11-03
EP1620113B1 (en)	2011-07-13
FR15C0069I1 (el)	2015-12-04
US8598129B2 (en)	2013-12-03
BRPI0410503B1 (pt)	2018-07-10
BRPI0410503B8 (pt)	2021-05-25
US20120077766A1 (en)	2012-03-29
EP1620113A1 (en)	2006-02-01
RU2005136438A (ru)	2006-05-27
US20130209381A1 (en)	2013-08-15
RU2350333C3 (ru)	2018-08-24
US8415311B2 (en)	2013-04-09
US8080530B2 (en)	2011-12-20
US20090252797A1 (en)	2009-10-08
CA2522579C (en)	2012-08-28
HUS1500048I1 (hu)	2017-10-30

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DK1553950T3 (da)	2007-10-15	Terapeutisk behandling
DE112004001618D2 (de)	2006-05-11	Pharmazeutischer Wirkstoff gegen Tumorerkrankungen
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ITRM20030442A0 (it)	2003-09-26	Composizione farmaceutica (stressen) per il trattamento di iperomocisteinemia.
ITMI20022263A1 (it)	2004-04-26	Composizioni per il trattamento delle emorroidi.
SE0400575D0 (sv)	2004-03-05	A novel pharmacentical composition for the treatment of skin conditions
ITMI20020055A1 (it)	2003-07-15	Composizione medicinale per il trattamento della degenerazione artilaginea