CY1122321T1 - Παραγωγα φθοροϊνδολιου ως θετικοι αλλοστερικοι διαμορφωτες του μουσκαρινικου υποδοχεα μ1 - Google Patents
Παραγωγα φθοροϊνδολιου ως θετικοι αλλοστερικοι διαμορφωτες του μουσκαρινικου υποδοχεα μ1Info
- Publication number
- CY1122321T1 CY1122321T1 CY20191101086T CY191101086T CY1122321T1 CY 1122321 T1 CY1122321 T1 CY 1122321T1 CY 20191101086 T CY20191101086 T CY 20191101086T CY 191101086 T CY191101086 T CY 191101086T CY 1122321 T1 CY1122321 T1 CY 1122321T1
- Authority
- CY
- Cyprus
- Prior art keywords
- muscarinic receptor
- positive allosteric
- allosteric modulators
- compounds
- muscarinic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μια ένωση του Χημικού Τύπου (I), ή στερεοϊσομερή και φαρμακευτικά αποδεκτά άλατα ως μουσκαρινικούς υποδοχείς αλλοστερόλης που είναι θετικοί στον υποδοχέα Μ1. Αυτή η εφεύρεση αναφέρεται επίσης σε μεθόδους παρασκευής τέτοιων ενώσεων και φαρμακευτικών συνθέσεων που περιλαμβάνουν τέτοιες ενώσεις. Οι ενώσεις αυτής της εφεύρεσης είναι χρήσιμες στη θεραπεία διαφόρων διαταραχών που σχετίζονται με τον μουσκαρινικό υποδοχέα Μ1 (Χημικός Τύπος I) (I).
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN4809CH2015 | 2015-09-10 | ||
| PCT/IB2016/054290 WO2017042643A1 (en) | 2015-09-10 | 2016-07-19 | Fluoroindole derivatives as muscarinic m1 receptor positive allosteric modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1122321T1 true CY1122321T1 (el) | 2021-01-27 |
Family
ID=56618200
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20191101086T CY1122321T1 (el) | 2015-09-10 | 2019-10-16 | Παραγωγα φθοροϊνδολιου ως θετικοι αλλοστερικοι διαμορφωτες του μουσκαρινικου υποδοχεα μ1 |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US10294217B2 (el) |
| EP (1) | EP3347349B1 (el) |
| JP (1) | JP6553811B2 (el) |
| KR (1) | KR102068237B1 (el) |
| CN (1) | CN108026073B (el) |
| AU (1) | AU2016320645B2 (el) |
| BR (1) | BR112018004719B1 (el) |
| CA (1) | CA2997956C (el) |
| CY (1) | CY1122321T1 (el) |
| DK (1) | DK3347349T3 (el) |
| EA (1) | EA033826B1 (el) |
| ES (1) | ES2750868T3 (el) |
| HK (1) | HK1247914A1 (el) |
| HR (1) | HRP20191869T1 (el) |
| HU (1) | HUE047056T2 (el) |
| IL (1) | IL257869A (el) |
| LT (1) | LT3347349T (el) |
| MA (1) | MA42769B1 (el) |
| MD (1) | MD3347349T2 (el) |
| ME (1) | ME03571B (el) |
| MX (1) | MX379454B (el) |
| NZ (1) | NZ740587A (el) |
| PL (1) | PL3347349T3 (el) |
| PT (1) | PT3347349T (el) |
| RS (1) | RS59473B1 (el) |
| SI (1) | SI3347349T1 (el) |
| SM (1) | SMT201900608T1 (el) |
| WO (1) | WO2017042643A1 (el) |
| ZA (1) | ZA201801463B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ764004A (en) * | 2017-10-18 | 2023-03-31 | Suven Life Sciences Ltd | Heteroaryl compounds as muscarinic m1 receptor positive allosteric modulators |
| US11278530B2 (en) | 2017-10-27 | 2022-03-22 | Suven Life Sciences Limited | Polycyclic amides as muscarinic M1 receptor positive allosteric modulators |
| MX2022009528A (es) * | 2020-02-04 | 2022-11-14 | Mindset Pharma Inc | Derivados de 3-pirrolidina-indol como agentes psicodélicos serotoninérgicos para el tratamiento de trastornos del snc. |
| WO2023114224A1 (en) | 2021-12-13 | 2023-06-22 | Sage Therapeutics, Inc. | Combination of muscarinic receptor positive modulators and nmda positive allosteric modulators |
| CN115385849B (zh) * | 2022-09-14 | 2024-01-26 | 南通瑞合达医药科技有限公司 | 一种N-Boc-3-氟-4-哌啶酮提纯的方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60123485A (ja) | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−３−カルボキサミド誘導体 |
| EP1254115A2 (en) | 2000-02-11 | 2002-11-06 | Bristol-Myers Squibb Company | Cannabinoid receptor modulators, their processes of preparation, and use of cannabinoid receptor modulators for treating respiratory and non-respiratory diseases |
| AU2006322045A1 (en) | 2005-12-05 | 2007-06-14 | Merck & Co., Inc. | Quinolone M1 receptor positive allosteric modulators |
| HUE026296T2 (en) * | 2009-08-31 | 2016-06-28 | Merck Sharp & Dohme | Positive allosteric pyranyl arylmethyl benzoquinazolinone M1 receptor modulators |
| HUE029734T2 (en) * | 2009-12-17 | 2017-03-28 | Merck Sharp & Dohme | Kinolin amide M1 receptor positive allosteric modulators |
| WO2011149801A1 (en) * | 2010-05-28 | 2011-12-01 | Merck Sharp & Dohme Corp. | Naphthalene carboxamide m1 receptor positive allosteric modulators |
| TW201512197A (zh) | 2013-08-30 | 2015-04-01 | Hoffmann La Roche | 吡咯并吡啶或吡唑并吡啶衍生物 |
| JP6185660B2 (ja) * | 2013-09-27 | 2017-08-23 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドール及びインダゾール誘導体 |
| GB201317363D0 (en) | 2013-10-01 | 2013-11-13 | Eisai Ltd | Novel compounds |
| WO2015080904A1 (en) | 2013-11-27 | 2015-06-04 | Vanderbilt University | Substituted 4-benzyl-3,4-dihydro-2h-benzo[b][1,4]oxazine-2carboxamide analogs as positive allosteric modulators of muscarinic acetycholine receptor m1 |
-
2016
- 2016-07-19 RS RS20191328A patent/RS59473B1/sr unknown
- 2016-07-19 AU AU2016320645A patent/AU2016320645B2/en active Active
- 2016-07-19 CN CN201680052764.2A patent/CN108026073B/zh active Active
- 2016-07-19 ME MEP-2019-288A patent/ME03571B/me unknown
- 2016-07-19 US US15/758,313 patent/US10294217B2/en active Active
- 2016-07-19 SM SM20190608T patent/SMT201900608T1/it unknown
- 2016-07-19 HU HUE16750259A patent/HUE047056T2/hu unknown
- 2016-07-19 MD MDE20180689 patent/MD3347349T2/ro unknown
- 2016-07-19 BR BR112018004719-8A patent/BR112018004719B1/pt active IP Right Grant
- 2016-07-19 DK DK16750259T patent/DK3347349T3/da active
- 2016-07-19 NZ NZ740587A patent/NZ740587A/en unknown
- 2016-07-19 CA CA2997956A patent/CA2997956C/en active Active
- 2016-07-19 JP JP2018512868A patent/JP6553811B2/ja active Active
- 2016-07-19 MX MX2018002821A patent/MX379454B/es unknown
- 2016-07-19 PL PL16750259T patent/PL3347349T3/pl unknown
- 2016-07-19 LT LT16750259T patent/LT3347349T/lt unknown
- 2016-07-19 ES ES16750259T patent/ES2750868T3/es active Active
- 2016-07-19 KR KR1020187009938A patent/KR102068237B1/ko active Active
- 2016-07-19 SI SI201630447T patent/SI3347349T1/sl unknown
- 2016-07-19 PT PT167502590T patent/PT3347349T/pt unknown
- 2016-07-19 MA MA42769A patent/MA42769B1/fr unknown
- 2016-07-19 WO PCT/IB2016/054290 patent/WO2017042643A1/en active Application Filing
- 2016-07-19 EP EP16750259.0A patent/EP3347349B1/en active Active
- 2016-07-19 EA EA201890684A patent/EA033826B1/ru unknown
-
2018
- 2018-03-02 ZA ZA2018/01463A patent/ZA201801463B/en unknown
- 2018-03-05 IL IL257869A patent/IL257869A/en active IP Right Grant
- 2018-06-04 HK HK18107271.5A patent/HK1247914A1/zh unknown
-
2019
- 2019-10-15 HR HRP20191869TT patent/HRP20191869T1/hr unknown
- 2019-10-16 CY CY20191101086T patent/CY1122321T1/el unknown
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