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CY1118365T1 - Διαμορφωτες διυδροπυραζολης του gpr40 - Google Patents

Διαμορφωτες διυδροπυραζολης του gpr40

Info

Publication number
CY1118365T1
CY1118365T1 CY20161101309T CY161101309T CY1118365T1 CY 1118365 T1 CY1118365 T1 CY 1118365T1 CY 20161101309 T CY20161101309 T CY 20161101309T CY 161101309 T CY161101309 T CY 161101309T CY 1118365 T1 CY1118365 T1 CY 1118365T1
Authority
CY
Cyprus
Prior art keywords
modulators
gpr40
dihydropyrazole
compounds
stereoisomer
Prior art date
Application number
CY20161101309T
Other languages
English (en)
Inventor
Bruce A Ellsworth
Jun Shi
William R Ewing
Elizabeth A Jurica
Andres S Hernandez
Ximao Wu
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1118365T1 publication Critical patent/CY1118365T1/el

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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D487/08—Bridged systems

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Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του Χημικού Τύπου I: ή ένα στερεοϊσομερές, ή ένα φαρμακευτικώς αποδεκτό άλας εξ' αυτών, όπου όλες οι μεταβλητές καθορίζονται ως εις το παρόν. Αυτές οι ενώσεις είναι διαμορφωτές του συζευγμένου σε πρωτεΐνη G υποδοχέα GPR40 οι οποίες μπορεί να χρησιμοποιηθούν ως φάρμακα.
CY20161101309T 2012-11-16 2016-12-16 Διαμορφωτες διυδροπυραζολης του gpr40 CY1118365T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261727262P 2012-11-16 2012-11-16
US201361777294P 2013-03-12 2013-03-12
PCT/US2013/070215 WO2014078610A1 (en) 2012-11-16 2013-11-15 Dihydropyrazole gpr40 modulators

Publications (1)

Publication Number Publication Date
CY1118365T1 true CY1118365T1 (el) 2017-06-28

Family

ID=49876965

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161101309T CY1118365T1 (el) 2012-11-16 2016-12-16 Διαμορφωτες διυδροπυραζολης του gpr40

Country Status (26)

Country Link
US (1) US9133163B2 (el)
EP (1) EP2920165B1 (el)
JP (1) JP6322203B2 (el)
KR (1) KR102204804B1 (el)
CN (1) CN104812748B (el)
AU (1) AU2013344604B2 (el)
BR (1) BR112015010779A2 (el)
CA (1) CA2891574A1 (el)
CY (1) CY1118365T1 (el)
DK (1) DK2920165T3 (el)
EA (1) EA026913B1 (el)
ES (1) ES2606685T3 (el)
HR (1) HRP20161631T1 (el)
HU (1) HUE032401T2 (el)
IL (1) IL238741A0 (el)
LT (1) LT2920165T (el)
MX (1) MX358499B (el)
PL (1) PL2920165T3 (el)
PT (1) PT2920165T (el)
RS (1) RS55363B1 (el)
SG (1) SG11201503558SA (el)
SI (1) SI2920165T1 (el)
SM (1) SMT201600410B (el)
TW (1) TW201427971A (el)
UY (1) UY35143A (el)
WO (1) WO2014078610A1 (el)

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