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CY1121304T1 - Μεθοδος καθαρισμου σαπωνινων - Google Patents

Μεθοδος καθαρισμου σαπωνινων

Info

Publication number
CY1121304T1
CY1121304T1 CY20191100047T CY191100047T CY1121304T1 CY 1121304 T1 CY1121304 T1 CY 1121304T1 CY 20191100047 T CY20191100047 T CY 20191100047T CY 191100047 T CY191100047 T CY 191100047T CY 1121304 T1 CY1121304 T1 CY 1121304T1
Authority
CY
Cyprus
Prior art keywords
saponin
solvent
cleaning soaps
solubilizing
soaps
Prior art date
Application number
CY20191100047T
Other languages
English (en)
Inventor
Juan Jose DIAZ GARCIA
Margit Theresia HOLZER
Original Assignee
Glaxosmithkline Biologicals S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals S.A. filed Critical Glaxosmithkline Biologicals S.A.
Publication of CY1121304T1 publication Critical patent/CY1121304T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • C07J71/0052—Nitrogen only at position 16(17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/256—Polyterpene radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει μεθόδους καθαρισμού τουλάχιστον μίας σαπωνίνης σε διάλυμα που περιλαμβάνουν τα στάδια: (a) παροχής τουλάχιστον μίας σαπωνίνης σε έναν πρώτο διαλύτη που περιλαμβάνει συστατικό διαλυτοποίησης· (b) αντικατάστασης τουλάχιστον ενός τμήματος του συστατικού διαλυτοποίησης με διαλύτη ανταλλαγής, παράγοντας έτσι αντικατασταθέντα διαλύτη και (c) απομάκρυνσης του αντικατασταθέντος διαλύτη, για παραγωγή ξηρανθέντος προϊόντος σαπωνίνης, που περιλαμβάνει τουλάχιστον μία σαπωνίνη.
CY20191100047T 2012-07-27 2019-01-15 Μεθοδος καθαρισμου σαπωνινων CY1121304T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1213364.1A GB201213364D0 (en) 2012-07-27 2012-07-27 Purification process
PCT/EP2013/065708 WO2014016374A1 (en) 2012-07-27 2013-07-25 Process for the purification of saponins

Publications (1)

Publication Number Publication Date
CY1121304T1 true CY1121304T1 (el) 2020-05-29

Family

ID=46881236

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20191100047T CY1121304T1 (el) 2012-07-27 2019-01-15 Μεθοδος καθαρισμου σαπωνινων

Country Status (18)

Country Link
US (1) US9540416B2 (el)
EP (1) EP2877479B1 (el)
JP (1) JP6360830B2 (el)
CN (1) CN104662031B (el)
BR (1) BR112015001655B1 (el)
CA (1) CA2879709C (el)
CY (1) CY1121304T1 (el)
DK (1) DK2877479T3 (el)
ES (1) ES2708783T3 (el)
GB (1) GB201213364D0 (el)
HR (1) HRP20190123T1 (el)
HU (1) HUE042179T2 (el)
LT (1) LT2877479T (el)
PL (1) PL2877479T3 (el)
PT (1) PT2877479T (el)
SI (1) SI2877479T1 (el)
TR (1) TR201901100T4 (el)
WO (1) WO2014016374A1 (el)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106461327B (zh) * 2014-06-09 2019-12-13 泰尔茂比司特公司 冻干法
WO2017088080A1 (es) 2015-11-25 2017-06-01 Natural Response S.A. Método para la obtención de saponinas a partir de plantas
WO2018057031A1 (en) 2016-09-26 2018-03-29 Natural Response, S.A. Production of biomass in ultra high density plantations
WO2019106192A1 (en) 2017-12-01 2019-06-06 Glaxosmithkline Biologicals Sa Saponin purification
BR112020010635A2 (pt) * 2017-12-01 2020-11-10 Glaxosmithkline Biologicals S.A. extração de saponina
US20220235095A1 (en) 2019-06-05 2022-07-28 Glaxosmithkline Biologicals Sa Saponin purification
CN110404113A (zh) * 2019-08-29 2019-11-05 上海白衣缘生物工程有限公司 一种制备无细胞医用植入材料的方法
AU2021321944A1 (en) 2020-08-07 2023-04-06 Access To Advanced Health Institute Purified saponins and chromatographic process for purification of same
US20240026407A1 (en) 2020-12-09 2024-01-25 Glaxosmithkline Biologicals Sa Modification of saponins
WO2023242187A1 (en) 2022-06-15 2023-12-21 Glaxosmithkline Biologicals Sa Enzymatic modification of saponins

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5057540A (en) 1987-05-29 1991-10-15 Cambridge Biotech Corporation Saponin adjuvant
US4912094B1 (en) 1988-06-29 1994-02-15 Ribi Immunochem Research Inc. Modified lipopolysaccharides and process of preparation
GB9106048D0 (en) 1991-03-21 1991-05-08 Smithkline Beecham Biolog Vaccines
UA56132C2 (uk) 1995-04-25 2003-05-15 Смітклайн Бічем Байолоджікалс С.А. Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
US6231859B1 (en) * 1996-12-02 2001-05-15 Aquila Biopharmaceuticals, Inc. Saponin adjuvant compositions
WO1998024319A1 (en) * 1996-12-02 1998-06-11 Aquila Biopharmaceuticals, Inc. Novel saponin compositions and uses thereof
EP0988053A1 (en) * 1997-06-11 2000-03-29 Aquila Biopharmaceuticals, Inc. Purified saponins as oral adjuvants
US6231858B1 (en) 1998-01-09 2001-05-15 Mochida Corporation Bolus for radiotherapy
CA2328946C (en) 1998-04-17 2008-02-12 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada Process for recovery and purification of saponins and sapogenins from quinoa (chenopodium quinoa)
GB2373743B (en) * 2001-03-27 2004-11-03 Membrane Extraction Tech Ltd Solvent exchange process
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
GB0525321D0 (en) * 2005-12-13 2006-01-18 Glaxosmithkline Biolog Sa Novel compositions
CN102462718A (zh) 2010-11-19 2012-05-23 苏州宝泽堂医药科技有限公司 一种青阳参皂苷的提取方法
CN102232977A (zh) 2011-05-06 2011-11-09 南京泽朗医药科技有限公司 一种从商陆中提取总皂苷的方法
CN102351938B (zh) 2011-09-01 2012-09-26 安徽农业大学 一种高纯度茶皂素的制备方法

Also Published As

Publication number Publication date
SI2877479T1 (sl) 2019-03-29
TR201901100T4 (tr) 2019-02-21
HRP20190123T1 (hr) 2019-03-08
JP2015522643A (ja) 2015-08-06
PL2877479T3 (pl) 2019-06-28
CA2879709C (en) 2020-10-06
DK2877479T3 (en) 2019-02-25
PT2877479T (pt) 2019-01-28
EP2877479A1 (en) 2015-06-03
EP2877479B1 (en) 2018-11-14
US9540416B2 (en) 2017-01-10
BR112015001655A2 (pt) 2017-07-04
CN104662031B (zh) 2017-11-03
ES2708783T3 (es) 2019-04-11
LT2877479T (lt) 2019-01-10
US20140030318A1 (en) 2014-01-30
JP6360830B2 (ja) 2018-07-18
GB201213364D0 (en) 2012-09-12
HUE042179T2 (hu) 2019-06-28
BR112015001655B1 (pt) 2021-08-17
CN104662031A (zh) 2015-05-27
CA2879709A1 (en) 2014-01-30
WO2014016374A1 (en) 2014-01-30

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