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CY1119944T1 - Ανασυνδυασμενα ανυσματα των hcmv και rhcmv και χρησεις eξ' αυτων - Google Patents

Ανασυνδυασμενα ανυσματα των hcmv και rhcmv και χρησεις eξ' αυτων

Info

Publication number
CY1119944T1
CY1119944T1 CY20181100226T CY181100226T CY1119944T1 CY 1119944 T1 CY1119944 T1 CY 1119944T1 CY 20181100226 T CY20181100226 T CY 20181100226T CY 181100226 T CY181100226 T CY 181100226T CY 1119944 T1 CY1119944 T1 CY 1119944T1
Authority
CY
Cyprus
Prior art keywords
recombinant
vectors
rhcmv
hcmv
examples
Prior art date
Application number
CY20181100226T
Other languages
English (en)
Inventor
Louis Picker
Jay A. Nelson
Klaus Frueh
Michael A. Jarvis
Scott G. Hansen
Original Assignee
Oregon Health And Science University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2011/029930 external-priority patent/WO2011119920A2/en
Application filed by Oregon Health And Science University filed Critical Oregon Health And Science University
Publication of CY1119944T1 publication Critical patent/CY1119944T1/el

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Abstract

Περιγράφονται εις το παρόν ανασυνδυασμένα ανύσματα κυτταρομεγαλοϊού «ρέζους» (RhCMV) και ανθρώπινου κυτταρομεγαλοϊού (HCMV) εγκωδικεύοντας ετερόλογα αντιγόνα, όπως είναι τα συγκεκριμένα για παθογόνα αντιγόνα ή τα αντιγόνα όγκων. Τα ανασυνδυασμένα ανύσματα εκμαιεύουν και διατηρούν υψηλού επιπέδου κυτταρικές και χυμικές ανοσιακές αποκρίσεις συγκεκριμένες για το ετερόλογο αντιγόνο. Τα ανασυνδυασμένα ανύσματα των RhCMV και HCMV μπορεί να χρησιμοποιηθούν, για παράδειγμα, για την αγωγή ή πρόληψη λοιμώδους πάθησης ή καρκίνου. Σε κάποια παραδείγματα, τα ανασυνδυασμένα ανύσματα των RhCMV ή HCMV μπορεί να συμπεριλάβουν απαλοιφές σε γονίδια εγκωδικεύοντας ανοσοδιαμορφωτικές πρωτεΐνες. Σε κάποια παραδείγματα, τα ανασυνδυασμένα ανύσματα των RhCMV ή HCMV μπορεί να είναι ανεπαρκή ή εξασθενημένα στη δυνατότητα των να αντιγραφούν στα πλαίσια ενός κυττάρου, να διασπαρθούν στα πλαίσια του ξενιστή ή να διαδοθούν μεταξύ ξενιστών από συμπερίληψη μιας απαλοιφής σε ένα ή περισσότερα γονίδια ουσιαστικά ή να επαυξήσουν αντιγραφή, διασπορά ή διάδοση του CMV.
CY20181100226T 2010-05-14 2018-02-26 Ανασυνδυασμενα ανυσματα των hcmv και rhcmv και χρησεις eξ' αυτων CY1119944T1 (el)

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WO2011143653A2 (en) 2011-11-17
PT3351636T (pt) 2020-09-24
HRP20180267T1 (hr) 2018-04-20
EP2772265A2 (en) 2014-09-03
RS57274B1 (sr) 2018-08-31
CA2798136A1 (en) 2011-11-17
EP3351636A1 (en) 2018-07-25
CA3040225A1 (en) 2011-11-17
ES2788198T3 (es) 2020-10-20
TR201802741T4 (tr) 2018-03-21
DK2569436T3 (en) 2018-03-05
DK2772265T3 (en) 2018-04-30
RS56958B1 (sr) 2018-05-31
WO2011143653A3 (en) 2012-05-31
EP2569436B8 (en) 2019-10-30
EP3351636B1 (en) 2020-07-01
EP2772265B1 (en) 2018-01-17
US20130136768A1 (en) 2013-05-30
AU2022201186A1 (en) 2022-03-17
HK1256651A1 (zh) 2019-09-27
HUE036122T2 (hu) 2018-06-28
HRP20201406T1 (hr) 2021-02-19
LT3351636T (lt) 2020-10-12
LT3333265T (lt) 2020-05-25
HK1257045A1 (zh) 2019-10-11
PL3333265T3 (pl) 2020-08-10
SI2569436T1 (en) 2018-05-31
HUE037227T2 (hu) 2018-08-28
HUE050909T2 (hu) 2021-01-28
ES2660615T3 (es) 2018-03-23
DK3333265T3 (da) 2020-04-27
AU2019204982B2 (en) 2021-11-25
PL2772265T3 (pl) 2018-07-31
SMT201800227T1 (it) 2018-07-17
CY1124015T1 (el) 2022-03-24
AU2011252792B2 (en) 2016-03-03
AU2018203259A1 (en) 2018-05-31
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PL2569436T3 (pl) 2018-05-30

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