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CY1117470T1 - Στερεα δοσολογικα σκευασματα με βελτιωμενη ενδοστοματικη προσροφηση - Google Patents

Στερεα δοσολογικα σκευασματα με βελτιωμενη ενδοστοματικη προσροφηση

Info

Publication number
CY1117470T1
CY1117470T1 CY20161100346T CY161100346T CY1117470T1 CY 1117470 T1 CY1117470 T1 CY 1117470T1 CY 20161100346 T CY20161100346 T CY 20161100346T CY 161100346 T CY161100346 T CY 161100346T CY 1117470 T1 CY1117470 T1 CY 1117470T1
Authority
CY
Cyprus
Prior art keywords
solid dosage
improved animal
dosage preparations
adjustment
animal adjustment
Prior art date
Application number
CY20161100346T
Other languages
English (en)
Inventor
Federico Stroppolo
Shahbaz Ardalan
Original Assignee
Alpex Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alpex Pharma Sa filed Critical Alpex Pharma Sa
Publication of CY1117470T1 publication Critical patent/CY1117470T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Biophysics (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Αποκαλύπτεται μια φαρμακευτική σύνθεση σε μορφή δισκίου κατάλληλη για διαλυτοποίηση στην στοματική κοιλότητα, η οποία σύνθεση περιέχει i) μια αποτελεσματική ποσότητα ενός ναρκωτικώς δραστικού συστατικού, και ii) μια φαρμακευτικώς αποδεκτή αμίνη που έχει pΚ περίπου 8 ή παραπάνω, όπου η μοριακή αναλογία αμίνης: δραστικό συστατικό είναι τουλάχιστον περίπου 5:1.
CY20161100346T 2005-07-22 2016-04-26 Στερεα δοσολογικα σκευασματα με βελτιωμενη ενδοστοματικη προσροφηση CY1117470T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/186,925 US20070020186A1 (en) 2005-07-22 2005-07-22 Solid dosage formulations of narcotic drugs having improved buccal adsorption
EP06776336.7A EP1906961B1 (en) 2005-07-22 2006-07-21 Solid dosage formulations of fentanyl having improved buccal adsorption

Publications (1)

Publication Number Publication Date
CY1117470T1 true CY1117470T1 (el) 2017-04-26

Family

ID=37440618

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20161100346T CY1117470T1 (el) 2005-07-22 2016-04-26 Στερεα δοσολογικα σκευασματα με βελτιωμενη ενδοστοματικη προσροφηση

Country Status (26)

Country Link
US (3) US20070020186A1 (el)
EP (1) EP1906961B1 (el)
JP (1) JP5714797B2 (el)
KR (1) KR101326206B1 (el)
CN (1) CN101208091A (el)
AU (1) AU2006271870B2 (el)
BR (1) BRPI0613769A2 (el)
CA (1) CA2607360C (el)
CY (1) CY1117470T1 (el)
DK (1) DK1906961T3 (el)
ES (1) ES2569228T3 (el)
HR (1) HRP20160327T1 (el)
HU (1) HUE027354T2 (el)
IL (1) IL187387A (el)
MA (1) MA29744B1 (el)
MX (1) MX2007015480A (el)
NO (1) NO20080827L (el)
NZ (1) NZ563511A (el)
PL (1) PL1906961T3 (el)
RS (1) RS54670B1 (el)
RU (1) RU2408373C2 (el)
SI (1) SI1906961T1 (el)
TW (1) TW200727922A (el)
UA (1) UA90518C2 (el)
WO (1) WO2007009806A2 (el)
ZA (1) ZA200710406B (el)

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US9289583B2 (en) * 2006-01-06 2016-03-22 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8252329B2 (en) 2007-01-05 2012-08-28 Acelrx Pharmaceuticals, Inc. Bioadhesive drug formulations for oral transmucosal delivery
US8865743B2 (en) 2006-01-06 2014-10-21 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
US8202535B2 (en) 2006-01-06 2012-06-19 Acelrx Pharmaceuticals, Inc. Small-volume oral transmucosal dosage forms
US8753308B2 (en) 2006-01-06 2014-06-17 Acelrx Pharmaceuticals, Inc. Methods for administering small volume oral transmucosal dosage forms using a dispensing device
US8535714B2 (en) 2006-01-06 2013-09-17 Acelrx Pharmaceuticals, Inc. Small volume oral transmucosal dosage forms containing sufentanil for treatment of pain
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US20070299687A1 (en) * 2006-06-23 2007-12-27 Pamela Palmer Inpatient system for patient-controlled delivery of oral transmucosal medications dosed as needed
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US8945592B2 (en) 2008-11-21 2015-02-03 Acelrx Pharmaceuticals, Inc. Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same
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WO2013158814A1 (en) 2012-04-18 2013-10-24 Mallinckrodt Llc Immediate release, abuse deterrent pharmaceutical compositions
PL2872121T3 (pl) 2012-07-12 2019-02-28 SpecGx LLC Kompozycje farmaceutyczne o przedłużonym uwalnianiu, zniechęcające do nadużywania
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Also Published As

Publication number Publication date
RS54670B1 (en) 2016-08-31
US20070020186A1 (en) 2007-01-25
US20070020187A1 (en) 2007-01-25
US20140018392A1 (en) 2014-01-16
DK1906961T3 (en) 2016-05-02
NZ563511A (en) 2011-03-31
CN101208091A (zh) 2008-06-25
ES2569228T3 (es) 2016-05-09
IL187387A0 (en) 2008-02-09
IL187387A (en) 2016-10-31
BRPI0613769A2 (pt) 2011-02-01
SI1906961T1 (sl) 2016-09-30
RU2408373C2 (ru) 2011-01-10
HRP20160327T1 (hr) 2016-05-20
MX2007015480A (es) 2008-04-29
AU2006271870B2 (en) 2011-11-24
TW200727922A (en) 2007-08-01
RU2007149044A (ru) 2009-06-27
JP5714797B2 (ja) 2015-05-07
KR101326206B1 (ko) 2013-11-08
WO2007009806A3 (en) 2007-04-05
UA90518C2 (ru) 2010-05-11
JP2009502761A (ja) 2009-01-29
WO2007009806A2 (en) 2007-01-25
HUE027354T2 (en) 2016-09-28
NO20080827L (no) 2008-02-15
US10258693B2 (en) 2019-04-16
EP1906961B1 (en) 2016-03-23
ZA200710406B (en) 2008-11-26
CA2607360A1 (en) 2007-01-25
MA29744B1 (fr) 2008-09-01
EP1906961A2 (en) 2008-04-09
CA2607360C (en) 2014-02-18
US8574552B2 (en) 2013-11-05
KR20080030608A (ko) 2008-04-04
AU2006271870A1 (en) 2007-01-25
PL1906961T3 (pl) 2016-07-29

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