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CY1115093T1 - BENZIMIDAZOLE PRODUCERS AND THEIR USE OF PROTEIN KINASES - Google Patents

BENZIMIDAZOLE PRODUCERS AND THEIR USE OF PROTEIN KINASES

Info

Publication number
CY1115093T1
CY1115093T1 CY20141100311T CY141100311T CY1115093T1 CY 1115093 T1 CY1115093 T1 CY 1115093T1 CY 20141100311 T CY20141100311 T CY 20141100311T CY 141100311 T CY141100311 T CY 141100311T CY 1115093 T1 CY1115093 T1 CY 1115093T1
Authority
CY
Cyprus
Prior art keywords
producers
benzimidazole
protein kinases
compound
vii
Prior art date
Application number
CY20141100311T
Other languages
Greek (el)
Inventor
Valerio Berdini
Michael Alistair O'brien
Maria Grazia Carr
Theresa Rachel Early
Eva Figueroa Navarro
Adrian Liam Gill
Steven Howard
Gary Trewartha
Alison Jo-Ann Woolford
Andrew James Woodhead
Paul Graham Wyatt
Original Assignee
Astex Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0315657.7A external-priority patent/GB0315657D0/en
Priority claimed from GB0324919A external-priority patent/GB0324919D0/en
Priority claimed from EP10195498.0A external-priority patent/EP2305250B1/en
Application filed by Astex Therapeutics Limited filed Critical Astex Therapeutics Limited
Publication of CY1115093T1 publication Critical patent/CY1115093T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Ένας συνδυασμός που περιλαμβάνει: (i) μία ένωση του τύπου (VII), ή ένα άλας, Ν-οξείδιο ή ένωση διαλύτη με διαλυμένη ουσία αυτού, και (ii) ένα ή περισσότερους άλλους θεραπευτικούς παράγοντες.A combination comprising: (i) a compound of formula (VII), or a salt, N-oxide or solvent compound thereof, and (ii) one or more other therapeutic agents.

CY20141100311T 2003-07-03 2014-04-28 BENZIMIDAZOLE PRODUCERS AND THEIR USE OF PROTEIN KINASES CY1115093T1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48468503P 2003-07-03 2003-07-03
GBGB0315657.7A GB0315657D0 (en) 2003-07-03 2003-07-03 Pharmaceutical compounds
US51437403P 2003-10-24 2003-10-24
GB0324919A GB0324919D0 (en) 2003-10-24 2003-10-24 Pharmaceutical compounds
EP10195498.0A EP2305250B1 (en) 2003-07-03 2004-07-05 Benzimidazole derivatives and their use as protein kinases inhibitors

Publications (1)

Publication Number Publication Date
CY1115093T1 true CY1115093T1 (en) 2016-12-14

Family

ID=33568694

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20141100070T CY1114846T1 (en) 2003-07-03 2014-01-28 BENZIMIDAZOLE PRODUCERS AND THEIR USE OF PROTEIN KINASES
CY20141100311T CY1115093T1 (en) 2003-07-03 2014-04-28 BENZIMIDAZOLE PRODUCERS AND THEIR USE OF PROTEIN KINASES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20141100070T CY1114846T1 (en) 2003-07-03 2014-01-28 BENZIMIDAZOLE PRODUCERS AND THEIR USE OF PROTEIN KINASES

Country Status (4)

Country Link
KR (1) KR101190964B1 (en)
CY (2) CY1114846T1 (en)
HK (1) HK1087925A1 (en)
IL (1) IL172840A (en)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0213562A (en) * 2001-10-26 2004-08-31 Aventis Pharma Inc Benzimidazoles and analogs and their use as protein kinase inhibitors

Also Published As

Publication number Publication date
IL172840A0 (en) 2006-06-11
KR20060082847A (en) 2006-07-19
CY1114846T1 (en) 2016-12-14
IL172840A (en) 2014-07-31
KR101190964B1 (en) 2012-10-12
HK1087925A1 (en) 2006-10-27

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