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CY1113486T1 - Συντηγμενες δικυκλικες πυριμιδινες - Google Patents

Συντηγμενες δικυκλικες πυριμιδινες

Info

Publication number
CY1113486T1
CY1113486T1 CY20121101220T CY121101220T CY1113486T1 CY 1113486 T1 CY1113486 T1 CY 1113486T1 CY 20121101220 T CY20121101220 T CY 20121101220T CY 121101220 T CY121101220 T CY 121101220T CY 1113486 T1 CY1113486 T1 CY 1113486T1
Authority
CY
Cyprus
Prior art keywords
pyramides
signed
bicycle
pi3k
tautomer
Prior art date
Application number
CY20121101220T
Other languages
English (en)
Inventor
Swen HÖLDER
Matthias Vennemann
Gerrit Beneke
Armin Zülch
Volker Gekeler
Thomas Beckers
Astrid Zimmermann
Hemant Joshi
Original Assignee
Bayer Intellectual Property Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP07118736A external-priority patent/EP2050748A1/en
Application filed by Bayer Intellectual Property Gmbh filed Critical Bayer Intellectual Property Gmbh
Publication of CY1113486T1 publication Critical patent/CY1113486T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ενώσεις του τύπου (I), ένα ταυτομερές ή στερεοϊσομερές αυτής, ή ένα άλας αυτής, όπου ο δακτύλιος Β και η πυριμιδίνη με την οποία συνενώνεται, τα R4, R5, R6 και R7 έχουν τις έννοιες που δίνονται στην περιγραφή και τις αξιώσεις, είναι αποτελεσματικοί αναστολείς της οδού Pi3K/Akt.
CY20121101220T 2007-08-14 2012-12-13 Συντηγμενες δικυκλικες πυριμιδινες CY1113486T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN1572MU2007 2007-08-14
EP07118736A EP2050748A1 (en) 2007-10-18 2007-10-18 Novel fused pyrimidines
EP08787224A EP2188291B1 (en) 2007-08-14 2008-08-14 Fused bicyclic pyrimidines

Publications (1)

Publication Number Publication Date
CY1113486T1 true CY1113486T1 (el) 2016-06-22

Family

ID=40153211

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121101220T CY1113486T1 (el) 2007-08-14 2012-12-13 Συντηγμενες δικυκλικες πυριμιδινες

Country Status (38)

Country Link
US (2) US7776864B2 (el)
EP (1) EP2188291B1 (el)
JP (1) JP5344637B2 (el)
KR (1) KR20100053556A (el)
CN (1) CN101778851B (el)
AR (1) AR067945A1 (el)
AU (1) AU2008288392B2 (el)
BR (1) BRPI0815207A2 (el)
CA (1) CA2694058C (el)
CL (1) CL2008002398A1 (el)
CO (1) CO6260077A2 (el)
CR (1) CR11270A (el)
CY (1) CY1113486T1 (el)
DK (1) DK2188291T3 (el)
DO (1) DOP2010000058A (el)
EA (1) EA020996B1 (el)
EC (1) ECSP109964A (el)
ES (1) ES2396177T3 (el)
HK (1) HK1146273A1 (el)
HN (1) HN2010000313A (el)
HR (1) HRP20121022T1 (el)
IL (1) IL203163A (el)
MA (1) MA31608B1 (el)
MX (1) MX2010001746A (el)
MY (1) MY169738A (el)
NZ (1) NZ583267A (el)
PA (1) PA8793201A1 (el)
PE (1) PE20090944A1 (el)
PL (1) PL2188291T3 (el)
PT (1) PT2188291E (el)
RS (1) RS52559B (el)
SI (1) SI2188291T1 (el)
SV (1) SV2010003483A (el)
TN (1) TN2010000070A1 (el)
TW (1) TWI439272B (el)
UA (1) UA99735C2 (el)
UY (1) UY31293A1 (el)
WO (1) WO2009021992A2 (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008050821A1 (en) * 2006-10-19 2008-05-02 Takeda Pharmaceutical Company Limited Indole compound
NZ583267A (en) 2007-08-14 2012-03-30 Bayer Schering Pharma Ag Fused bicyclic pyrimidines
WO2009155121A2 (en) 2008-05-30 2009-12-23 Amgen Inc. Inhibitors of pi3 kinase
CA2752114C (en) * 2009-02-13 2017-06-20 Bayer Pharma Aktiengesellschaft Fused pyrimidines as akt inhibitors
PE20120534A1 (es) * 2009-02-13 2012-05-10 Bayer Pharma AG PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt
US8691825B2 (en) 2009-04-01 2014-04-08 Merck Sharp & Dohme Corp. Inhibitors of AKT activity
TW201103943A (en) 2009-04-27 2011-02-01 Shionogi & Co Urea derivative having pi3k inhibitory activity
CA2805015A1 (en) 2010-07-13 2012-01-19 Stuart Ince Bicyclic pyrimidines
CN103384670B (zh) 2010-07-28 2016-05-25 拜耳知识产权有限责任公司 取代的咪唑并[1,2-b]哒嗪
PT2694510E (pt) 2011-04-07 2016-02-08 Bayer Pharma AG Imidazopiridazinas como inibidores da akt quinase
AU2014208964B2 (en) 2013-01-23 2016-09-01 Astrazeneca Ab Chemical compounds
US20140274685A1 (en) 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
WO2014146144A2 (en) * 2013-03-15 2014-09-18 Bayer Cropscience Lp Compositions, additives, and methods for mitigating or controlling seed dust
EP3681888A4 (en) 2017-09-15 2021-07-07 Aduro Biotech, Inc. PYRAZOLOPYRIMIDINONE COMPOUNDS AND THEIR USES

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7306201A (en) 2000-06-30 2002-01-14 American Home Prod Substituted-triazolopyrimidines as anticancer agents
US7449488B2 (en) * 2002-06-04 2008-11-11 Schering Corporation Pyrazolopyrimidines as protein kinase inhibitors
ATE512957T1 (de) 2003-04-24 2011-07-15 Merck Sharp & Dohme Hemmer der akt aktivität
DE602005026509D1 (de) * 2004-04-09 2011-04-07 Merck Sharp & Dohme Hemmer der akt aktivität
AR050188A1 (es) * 2004-08-03 2006-10-04 Uriach Y Compania S A J Compuestos heterociclicos condensados utiles en terapia como inhibidores de quinasas p38 y composiciones farmaceuticas que los contienen
AU2005290081B2 (en) * 2004-08-23 2010-12-02 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
AU2005316826A1 (en) 2004-12-15 2006-06-22 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
EP1848719B1 (en) * 2004-12-28 2012-02-01 Exelixis, Inc. [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases
JP2008530111A (ja) 2005-02-14 2008-08-07 メルク エンド カムパニー インコーポレーテッド Ａｋｔ活性の阻害剤
PT1898903E (pt) 2005-06-10 2013-06-28 Merck Sharp & Dohme Inibidores da atividade de akt
NZ583267A (en) 2007-08-14 2012-03-30 Bayer Schering Pharma Ag Fused bicyclic pyrimidines
PE20120534A1 (es) * 2009-02-13 2012-05-10 Bayer Pharma AG PIRIMIDINAS FUSIONADAS COMO INHIBIDORES DE Akt

Also Published As

Publication number Publication date
TWI439272B (zh) 2014-06-01
IL203163A (en) 2015-01-29
SI2188291T1 (sl) 2013-01-31
CR11270A (es) 2010-05-19
CN101778851B (zh) 2013-05-08
RS52559B (en) 2013-04-30
US20100184782A1 (en) 2010-07-22
BRPI0815207A2 (pt) 2017-03-28
EP2188291A2 (en) 2010-05-26
MA31608B1 (fr) 2010-08-02
HK1146273A1 (en) 2011-05-20
AU2008288392B2 (en) 2013-10-24
CA2694058A1 (en) 2009-02-19
ES2396177T3 (es) 2013-02-19
DK2188291T3 (da) 2013-01-07
AU2008288392A1 (en) 2009-02-19
CA2694058C (en) 2016-06-07
US20090137607A1 (en) 2009-05-28
US7776864B2 (en) 2010-08-17
US8614218B2 (en) 2013-12-24
HRP20121022T1 (hr) 2013-01-31
EA201000298A1 (ru) 2010-10-29
WO2009021992A2 (en) 2009-02-19
NZ583267A (en) 2012-03-30
SV2010003483A (es) 2010-07-06
HN2010000313A (es) 2013-03-18
CN101778851A (zh) 2010-07-14
PL2188291T3 (pl) 2013-06-28
PE20090944A1 (es) 2009-08-09
CO6260077A2 (es) 2011-03-22
DOP2010000058A (es) 2010-02-28
TN2010000070A1 (en) 2011-09-26
MX2010001746A (es) 2010-03-10
PA8793201A1 (es) 2009-04-23
AR067945A1 (es) 2009-10-28
MY169738A (en) 2019-05-14
ECSP109964A (es) 2010-03-31
UY31293A1 (es) 2009-03-31
JP5344637B2 (ja) 2013-11-20
EA020996B1 (ru) 2015-03-31
TW200922592A (en) 2009-06-01
KR20100053556A (ko) 2010-05-20
PT2188291E (pt) 2012-12-20
EP2188291B1 (en) 2012-09-19
JP2010535848A (ja) 2010-11-25
WO2009021992A3 (en) 2009-04-16
CL2008002398A1 (es) 2009-07-31
UA99735C2 (uk) 2012-09-25

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