CY1113224T1 - Νεο αντισωμα αντι-ρlgf - Google Patents
Νεο αντισωμα αντι-ρlgfInfo
- Publication number
- CY1113224T1 CY1113224T1 CY20121100535T CY121100535T CY1113224T1 CY 1113224 T1 CY1113224 T1 CY 1113224T1 CY 20121100535 T CY20121100535 T CY 20121100535T CY 121100535 T CY121100535 T CY 121100535T CY 1113224 T1 CY1113224 T1 CY 1113224T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pllgf
- antibody
- new anti
- fragments
- pigf
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Η παρούσα εφεύρεση παρέχει νέα μονοκλωνικά αντισώματα που στοχεύουν στον ΡΙGF και σε θραύσματα και παράγωγα αυτών, πιο συγκεκριμένα σε ανθρωποποιημένα αντισώματα και θραύσματα αυτών για χρήση στη θεραπεία και / ή στην πρόληψη της παθολογικής αγγειογένεσης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66476805P | 2005-03-24 | 2005-03-24 | |
EP06721544A EP1869085B1 (en) | 2005-03-24 | 2006-03-24 | Novel anti-plgf antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113224T1 true CY1113224T1 (el) | 2016-04-13 |
Family
ID=36928446
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100535T CY1113224T1 (el) | 2005-03-24 | 2012-06-12 | Νεο αντισωμα αντι-ρlgf |
Country Status (26)
Country | Link |
---|---|
US (3) | US7875704B2 (el) |
EP (2) | EP2447281B1 (el) |
JP (2) | JP5164829B2 (el) |
KR (1) | KR101314014B1 (el) |
CN (1) | CN101184776B (el) |
AT (1) | ATE549358T1 (el) |
AU (2) | AU2006227571B8 (el) |
BR (1) | BRPI0609151B8 (el) |
CA (1) | CA2601267C (el) |
CY (1) | CY1113224T1 (el) |
DK (1) | DK1869085T3 (el) |
EA (1) | EA013970B1 (el) |
ES (2) | ES2384110T3 (el) |
HR (1) | HRP20120477T1 (el) |
IL (1) | IL185754A (el) |
ME (1) | ME01446B (el) |
MX (1) | MX2007011735A (el) |
NO (1) | NO341877B1 (el) |
NZ (1) | NZ561763A (el) |
PL (1) | PL1869085T3 (el) |
PT (1) | PT1869085E (el) |
RS (1) | RS52372B (el) |
SI (1) | SI1869085T1 (el) |
UA (1) | UA94707C2 (el) |
WO (1) | WO2006099698A2 (el) |
ZA (1) | ZA200707258B (el) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE321069T1 (de) * | 2000-05-12 | 2006-04-15 | Vlaams Interuniv Inst Biotech | Verwendung von inhibitoren des plazenta wachstumsfactors für die behandlung einer pathologischen angiogenese, pathologischen arteriogenese, entzündung, tumorbildung und/oder gefässdurchlässigkeit (ödem) |
BRPI0609151B8 (pt) | 2005-03-24 | 2021-05-25 | Life Sciences Res Partners Vzw | molécula de ligação ao antígeno capaz de se ligar a plgf, usos da mesma, linhagem celular de hibridoma, composição farmacêutica e polinucleotídeo |
CN101534865A (zh) * | 2005-10-19 | 2009-09-16 | Ibc药品公司 | 生物活性装配体的制备方法及其用途 |
MX2010011955A (es) * | 2008-04-29 | 2011-01-21 | Abbott Lab | Inmunoglobulinas de dominio variable doble y usos de las mismas. |
CN102112494A (zh) | 2008-06-03 | 2011-06-29 | 雅培制药有限公司 | 双重可变结构域免疫球蛋白及其用途 |
SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
RU2011104348A (ru) | 2008-07-08 | 2012-08-20 | Эбботт Лэборетриз (Us) | Иммуноглобулины с двойным вариабельным доменом против простагландина е2 и их применение |
MX2011003428A (es) | 2008-10-02 | 2011-07-29 | Vib Vzw | Inhibicion del factor de crecimiento placentario (plgf) para tratar la leucemia con cromosoma filadelfia positivo. |
EP2382472B1 (en) * | 2008-12-23 | 2015-05-06 | F.Hoffmann-La Roche Ag | Methods and compositions for diagnostic use in cancer patients |
WO2010127294A2 (en) * | 2009-05-01 | 2010-11-04 | Abbott Laboratories | Dual variable domain immunoglobulins and uses thereof |
AR078254A1 (es) | 2009-09-01 | 2011-10-26 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
EP2488658A4 (en) | 2009-10-15 | 2013-06-19 | Abbvie Inc | IMMUNOGLOBULINE WITH DOUBLE VARIABLE DOMAIN AND ITS USE |
UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
ES2648264T3 (es) | 2010-03-10 | 2017-12-29 | F. Hoffmann-La Roche Ag | Procedimiento para la purificación de soluciones de inmunoglobulinas |
CA2804348A1 (en) * | 2010-07-19 | 2012-01-26 | F. Hoffmann-La Roche Ag | Blood plasma biomarkers for bevacizumab combination therapies for treatment of pancreatic cancer |
MX341579B (es) | 2010-08-03 | 2016-08-25 | Abbvie Inc * | Inmunoglobulinas de dominio variable doble y usos de las mismas. |
BR112013004581A2 (pt) | 2010-08-26 | 2017-06-27 | Abbvie Inc | imunoglobulinas de domínio variável dual e seus usos |
PL2785739T3 (pl) | 2011-12-01 | 2017-10-31 | Thrombogenics Nv | Poprawa wyniku trabekulektomii |
UY34558A (es) | 2011-12-30 | 2013-07-31 | Abbvie Inc | Proteínas de unión específicas duales dirigidas contra il-13 y/o il-17 |
MY194330A (en) | 2012-11-01 | 2022-11-28 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulin and uses thereof |
EP4154907A1 (en) | 2012-12-18 | 2023-03-29 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
BR112015023797A2 (pt) | 2013-03-15 | 2017-10-24 | Abbvie Inc | proteínas de ligação de especificidade dupla dirigidas contra il-1b e/ou il-17 |
WO2015051159A1 (en) * | 2013-10-02 | 2015-04-09 | The Rockefeller University | Amyloid protofibril antibodies and methods of use thereof |
WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
WO2016118937A1 (en) | 2015-01-23 | 2016-07-28 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
CN104930353B (zh) * | 2015-07-10 | 2017-08-15 | 浙江大学 | 一种城市供水管网的调压减漏评估系统 |
EP3426685A1 (en) * | 2016-03-10 | 2019-01-16 | Oxurion NV | Posterior ocular fibrosis inhibition by antagonizing placental growth factor |
EP3471767A4 (en) | 2016-06-15 | 2020-01-15 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS HEMAGGLUTININS AND USES THEREOF |
CA3029074A1 (en) | 2016-06-22 | 2018-01-25 | William Warren HARLESS | Cancer treatment and metastasis inhibition using an anti-cancer stem cell agent in combination with a neu1 sialidase inhibitor or a cytokine inhibitor after primary cancer treatment |
WO2018187706A2 (en) * | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
CN109134650A (zh) * | 2018-09-10 | 2019-01-04 | 宁波奥丞生物科技有限公司 | 抗人plgf单克隆抗体的制备方法 |
EP3976650A1 (en) | 2019-05-28 | 2022-04-06 | Vib Vzw | Cancer treatment by targeting plexins in the immune compartment |
EP3976067A1 (en) | 2019-05-28 | 2022-04-06 | Vib Vzw | Cd8+ t-cells lacking plexins and their application in cancer treatment |
WO2020260595A1 (en) | 2019-06-26 | 2020-12-30 | Oncurious Nv | Combination treatment of medulloblastoma using a placental growth factor inhibitor and a chemotherapeutic agent |
EP3936868A1 (en) | 2020-07-10 | 2022-01-12 | Charité - Universitätsmedizin Berlin | A ratio between plgf and sflt1 is predictive for neural invasion in patients suffering from pancreatic cancer |
WO2022063957A1 (en) | 2020-09-24 | 2022-03-31 | Vib Vzw | Biomarker for anti-tumor therapy |
WO2022099465A1 (zh) * | 2020-11-10 | 2022-05-19 | 宁波奥丞生物科技有限公司 | 杂交瘤细胞株9c1、plgf-1单克隆抗体及其制备方法和应用 |
CN112358546B (zh) * | 2020-11-10 | 2022-04-01 | 宁波奥丞生物科技有限公司 | 杂交瘤细胞株9c1、plgf-1单克隆抗体及其应用 |
JP2023554520A (ja) | 2020-12-22 | 2023-12-27 | コビオレス エヌヴイ | テトラペプチド部分を含む化合物 |
CN113999310A (zh) * | 2020-12-30 | 2022-02-01 | 江苏普若维生物技术有限责任公司 | 一种plgf单克隆抗体、试剂盒、其制备方法和应用 |
WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
CA3211257A1 (en) | 2021-02-17 | 2022-08-25 | Vib Vzw | Inhibition of slc4a4 in the treatment of cancer |
WO2023118294A1 (en) | 2021-12-22 | 2023-06-29 | Vib Vzw | Inhibition of mitoferrin 2 as means for inhibiting cancer and cancer metastasis |
WO2024033381A1 (en) | 2022-08-10 | 2024-02-15 | Vib Vzw | Inhibition of tcf4/itf2 in the treatment of cancer |
WO2024231348A1 (en) | 2023-05-11 | 2024-11-14 | Vib Vzw | Slc4a4/nbce1 inhibitors |
WO2024260720A1 (en) | 2023-06-20 | 2024-12-26 | Vib Vzw | Use of intra-tumoral cd8 temra cells for predicting response of a cancer patient to checkpoint inhibitor therapy |
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NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
US5770198A (en) | 1988-05-18 | 1998-06-23 | The Research Foundation Of The State Of New York | Platelet-specific chimeric 7E3 immunoglobulin |
US5545806A (en) * | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
IT1242149B (it) * | 1990-09-27 | 1994-02-16 | Consiglio Nazionale Ricerche | Sequenza di nucleotidi codificante per una proteina umana con proprieta' regolative dell'angiogenesi |
CA2132091C (en) | 1992-04-03 | 2008-09-16 | Kyung J. Kim | Antibodies to alphavbeta3 integrin |
US6177401B1 (en) * | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
US5861499A (en) | 1994-02-10 | 1999-01-19 | Imclone Systems Incorporated | Nucleic acid molecules encoding the variable or hypervariable region of a monoclonal antibody that binds to an extracellular domain |
IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
CN1209068A (zh) | 1995-10-23 | 1999-02-24 | 海欧制药澳大利亚有限公司 | 作为基因治疗所用的dna载体的透明质酸及治疗异常视网膜血管化的vegf反义dna |
DE69736860T2 (de) | 1996-09-24 | 2007-05-16 | Merck & Co., Inc. | Verbindungen zur hemmung der angiogenese durch gentherapie |
US6986890B1 (en) | 1996-11-21 | 2006-01-17 | Kyowa Hakko Kogyo Co., Ltd. | Anti-human VEGF receptor Flt-1 monoclonal antibody |
GB9723780D0 (en) | 1997-11-12 | 1998-01-07 | Univ Manchester | Regulation of ocular angiogenesis |
EP1064382B1 (en) | 1998-03-17 | 2008-08-20 | Genentech, Inc. | Polypeptides homologous to vegf and bmp1 |
JPH11302193A (ja) * | 1998-04-22 | 1999-11-02 | Toagosei Co Ltd | 血管新生阻害剤 |
CA2332336A1 (en) | 1998-05-26 | 1999-12-02 | Erik Depla | Method for expanding primate b cells selectively in immunocompromised mice and producing large numbers of antigen-specific b lymphocytes for the production of primate monoclonal antibodies |
JP2001086982A (ja) | 1999-07-16 | 2001-04-03 | Shunpei Niida | 骨吸収調節薬 |
JP2003528824A (ja) | 2000-02-04 | 2003-09-30 | スプラテック ファーマ インコーポレイティド | 血管内皮成長因子受容体のためのリガンド |
ATE321069T1 (de) | 2000-05-12 | 2006-04-15 | Vlaams Interuniv Inst Biotech | Verwendung von inhibitoren des plazenta wachstumsfactors für die behandlung einer pathologischen angiogenese, pathologischen arteriogenese, entzündung, tumorbildung und/oder gefässdurchlässigkeit (ödem) |
CN1511040A (zh) * | 2001-05-25 | 2004-07-07 | ����˹���ѷ��ѧ | 作为多种治疗模式基础的蛋白质的选择性剪接形式 |
US7139817B1 (en) * | 2001-06-12 | 2006-11-21 | Network Appliance, Inc. | Managing configuration information for multiple devices |
AU2002316305A1 (en) | 2001-06-20 | 2003-01-08 | Vlaams Interuniversitair Institut Voor Biotechnologie | Method of treating atherosclerosis and other inflammatory diseases |
EP1482975B1 (en) | 2002-01-29 | 2006-12-13 | Vlaams Interuniversitair Instituut voor Biotechnologie vzw. | Prevention of tissue adhesion |
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JP2005535634A (ja) | 2002-06-28 | 2005-11-24 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー(ヴェーイーベー・ヴェーゼットウェー) | Flt−1に対する抗体の骨粗鬆症の処置のための使用 |
CA2448769A1 (en) * | 2002-11-08 | 2004-05-08 | Primagen Holding B.V. | Method for quantifying a ratio between at least two nucleic acid sequences |
JP2006519842A (ja) * | 2003-03-10 | 2006-08-31 | カリスト・ファーマシューティカルズ・インコーポレイテッド | アザスピラン化合物による癌治療法 |
WO2005087812A1 (en) * | 2004-03-05 | 2005-09-22 | Ludwig Institute For Cancer Research | Multivalent antibody materials and methods for vegf/pdgf family of growth factors |
BRPI0609151B8 (pt) | 2005-03-24 | 2021-05-25 | Life Sciences Res Partners Vzw | molécula de ligação ao antígeno capaz de se ligar a plgf, usos da mesma, linhagem celular de hibridoma, composição farmacêutica e polinucleotídeo |
US7867490B2 (en) | 2005-06-30 | 2011-01-11 | Vib Vzw | Treatment of liver cirrhosis and its complications |
MX2011003428A (es) | 2008-10-02 | 2011-07-29 | Vib Vzw | Inhibicion del factor de crecimiento placentario (plgf) para tratar la leucemia con cromosoma filadelfia positivo. |
-
2006
- 2006-03-24 BR BRPI0609151A patent/BRPI0609151B8/pt not_active IP Right Cessation
- 2006-03-24 WO PCT/BE2006/000023 patent/WO2006099698A2/en active Application Filing
- 2006-03-24 AT AT06721544T patent/ATE549358T1/de active
- 2006-03-24 HR HRP20120477TT patent/HRP20120477T1/hr unknown
- 2006-03-24 EP EP11160897.2A patent/EP2447281B1/en not_active Not-in-force
- 2006-03-24 ME MEP-2012-73A patent/ME01446B/me unknown
- 2006-03-24 PL PL06721544T patent/PL1869085T3/pl unknown
- 2006-03-24 ES ES06721544T patent/ES2384110T3/es active Active
- 2006-03-24 CN CN2006800093279A patent/CN101184776B/zh not_active Expired - Fee Related
- 2006-03-24 MX MX2007011735A patent/MX2007011735A/es active IP Right Grant
- 2006-03-24 RS RS20120249A patent/RS52372B/en unknown
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