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EA200702634A1 - Гуманизированные антитела, специфичные в отношении nogo-a, и их фармацевтические применения - Google Patents

Гуманизированные антитела, специфичные в отношении nogo-a, и их фармацевтические применения

Info

Publication number
EA200702634A1
EA200702634A1 EA200702634A EA200702634A EA200702634A1 EA 200702634 A1 EA200702634 A1 EA 200702634A1 EA 200702634 A EA200702634 A EA 200702634A EA 200702634 A EA200702634 A EA 200702634A EA 200702634 A1 EA200702634 A1 EA 200702634A1
Authority
EA
Eurasian Patent Office
Prior art keywords
nogo
humanized antibodies
antibodies specific
pharmaceutical applications
antibodies
Prior art date
Application number
EA200702634A
Other languages
English (en)
Other versions
EA014291B1 (ru
Inventor
Джонатан Генри Эллис
Пол Эндрю Хэмблин
Фархана Хуссэйн
Алан Питер Льюис
Рут Макадам
Рабиндер Принджха
Пол Уилсон
Original Assignee
Глаксо Груп Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0513766A external-priority patent/GB0513766D0/en
Priority claimed from GB0525448A external-priority patent/GB0525448D0/en
Application filed by Глаксо Груп Лимитед filed Critical Глаксо Груп Лимитед
Publication of EA200702634A1 publication Critical patent/EA200702634A1/ru
Publication of EA014291B1 publication Critical patent/EA014291B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Настоящее изобретение относится к антителам против NOGO, к фармацевтическим препаратам, содержащим их, и к применению таких антител в лечении и/или профилактике неврологических заболеваний/расстройств.
EA200702634A 2005-07-05 2006-07-03 Гуманизированные антитела, специфичные в отношении nogo-a, и их фармацевтические применения EA014291B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0513766A GB0513766D0 (en) 2005-07-05 2005-07-05 Immunoglobulins
GB0525448A GB0525448D0 (en) 2005-12-14 2005-12-14 Immunoglobulins
PCT/EP2006/006535 WO2007003421A2 (en) 2005-07-05 2006-07-03 Humanised antibodies specific for nogo-a and pharmaceutical uses thereof

Publications (2)

Publication Number Publication Date
EA200702634A1 true EA200702634A1 (ru) 2008-06-30
EA014291B1 EA014291B1 (ru) 2010-10-29

Family

ID=37604821

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200702634A EA014291B1 (ru) 2005-07-05 2006-07-03 Гуманизированные антитела, специфичные в отношении nogo-a, и их фармацевтические применения

Country Status (21)

Country Link
EP (1) EP1899377B1 (ru)
JP (1) JP2009500363A (ru)
KR (1) KR20080030960A (ru)
AU (1) AU2006265276B2 (ru)
BR (1) BRPI0612734A2 (ru)
CA (1) CA2614076A1 (ru)
CR (1) CR9623A (ru)
CY (1) CY1113310T1 (ru)
DK (1) DK1899377T3 (ru)
EA (1) EA014291B1 (ru)
ES (1) ES2391902T3 (ru)
HR (1) HRP20120851T1 (ru)
IL (1) IL188282A (ru)
MA (1) MA29625B1 (ru)
NO (1) NO20076663L (ru)
NZ (1) NZ564567A (ru)
PL (1) PL1899377T3 (ru)
PT (1) PT1899377E (ru)
SG (1) SG162829A1 (ru)
SI (1) SI1899377T1 (ru)
WO (1) WO2007003421A2 (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2417065T3 (es) 2005-04-26 2013-08-05 Trion Pharma Gmbh Combinación de anticuerpos con glucocorticoides para el tratamiento del cáncer
DK2158315T3 (en) 2007-06-25 2016-06-06 Esbatech Alcon Biomed Res Unit Methods of modifying antibodies and modified antibodies with improved functional properties
RU2513697C2 (ru) * 2007-11-02 2014-04-20 Новартис Аг Улучшенные молекулы, связывающиеся с nogo-а и их фармацевтическое применение
WO2010004031A2 (en) * 2008-07-11 2010-01-14 Glaxo Group Limited Novel treatment
GB201709970D0 (en) 2017-06-22 2017-08-09 Kymab Ltd Bispecific antigen-binding molecules
WO2020128049A1 (en) 2018-12-21 2020-06-25 Kymab Limited Fixaxfx bispecific antibody with common light chain
GB2590642B (en) * 2019-12-20 2024-02-14 Kymab Ltd Improved lambda antibodies

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0228832D0 (en) * 2002-12-10 2003-01-15 Novartis Ag Organic compound
GB0321997D0 (en) * 2003-09-19 2003-10-22 Novartis Ag Organic compound
DK1711530T3 (da) * 2003-12-22 2009-12-14 Glaxo Group Ltd Nogo-A-neutraliserende immunoglobuliner til behandling af neurologiske sygdomme

Also Published As

Publication number Publication date
MA29625B1 (fr) 2008-07-01
SG162829A1 (en) 2010-07-29
SI1899377T1 (sl) 2012-12-31
HRP20120851T1 (hr) 2012-11-30
PL1899377T3 (pl) 2013-01-31
CY1113310T1 (el) 2016-04-13
DK1899377T3 (da) 2012-11-12
WO2007003421A3 (en) 2007-04-12
WO2007003421A2 (en) 2007-01-11
KR20080030960A (ko) 2008-04-07
NZ564567A (en) 2010-09-30
EP1899377A2 (en) 2008-03-19
AU2006265276A1 (en) 2007-01-11
CA2614076A1 (en) 2007-01-11
AU2006265276B2 (en) 2011-10-13
NO20076663L (no) 2008-02-27
HK1115598A1 (en) 2008-12-05
EP1899377B1 (en) 2012-08-22
JP2009500363A (ja) 2009-01-08
IL188282A (en) 2011-04-28
BRPI0612734A2 (pt) 2010-11-30
PT1899377E (pt) 2012-11-20
ES2391902T3 (es) 2012-11-30
CR9623A (es) 2008-04-10
IL188282A0 (en) 2008-04-13
EA014291B1 (ru) 2010-10-29

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU