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CY1112892T1 - Δισκιο λασοφοξιφαινης και επικαλυψη του - Google Patents

Δισκιο λασοφοξιφαινης και επικαλυψη του

Info

Publication number
CY1112892T1
CY1112892T1 CY20121100504T CY121100504T CY1112892T1 CY 1112892 T1 CY1112892 T1 CY 1112892T1 CY 20121100504 T CY20121100504 T CY 20121100504T CY 121100504 T CY121100504 T CY 121100504T CY 1112892 T1 CY1112892 T1 CY 1112892T1
Authority
CY
Cyprus
Prior art keywords
lasoxoxyphine
tablet
cover
lasofoxifene
active ingredient
Prior art date
Application number
CY20121100504T
Other languages
English (en)
Inventor
Daniel S Gierer
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of CY1112892T1 publication Critical patent/CY1112892T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Εδώ αποκαλύπτονται φαρμακευτικές συνθέσεις που έχουν ομοιόμορφη κατανομή φαρμάκου και δραστικότητα με τη χρησιμοποίηση λασοφοξιφαίνης ως ένα δραστικό συστατικό και που περιέχουν ένα διοξείδιο του πυριτίου για τη μείωση της απώλειας του δραστικού συστατικού κατά τη διάρκεια της παραγωγικής διαδικασίας και μέθοδοι για την παραγωγή τέτοιων συνθέσεων. Η επικάλυψη τριακετίνης ως πλαστικοποιητή αποδείχθηκε ότι παρέχει καλή σταθερότητα στη λασοφοξιφαίνη.
CY20121100504T 2002-07-10 2012-06-06 Δισκιο λασοφοξιφαινης και επικαλυψη του CY1112892T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39509002P 2002-07-10 2002-07-10
EP03764059A EP1534248B1 (en) 2002-07-10 2003-06-30 Lasofoxifene tablet and its coating

Publications (1)

Publication Number Publication Date
CY1112892T1 true CY1112892T1 (el) 2016-04-13

Family

ID=30115812

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100504T CY1112892T1 (el) 2002-07-10 2012-06-06 Δισκιο λασοφοξιφαινης και επικαλυψη του

Country Status (36)

Country Link
US (2) US20040057992A1 (el)
EP (1) EP1534248B1 (el)
JP (2) JP4446446B2 (el)
KR (1) KR100782693B1 (el)
CN (1) CN100344278C (el)
AP (1) AP2005003201A0 (el)
AR (1) AR040434A1 (el)
AT (1) ATE550017T1 (el)
AU (1) AU2003247017B2 (el)
BR (1) BR0312563A (el)
CA (1) CA2489407C (el)
CY (1) CY1112892T1 (el)
DK (1) DK1534248T3 (el)
EA (1) EA007268B1 (el)
EC (1) ECSP055528A (el)
ES (1) ES2395123T3 (el)
HK (1) HK1077747A1 (el)
HN (1) HN2003000206A (el)
HR (1) HRP20041196A2 (el)
IL (2) IL165746A0 (el)
IS (1) IS7594A (el)
MA (1) MA27318A1 (el)
MX (1) MXPA05000394A (el)
NO (1) NO20050018L (el)
NZ (1) NZ537278A (el)
OA (1) OA12883A (el)
PA (1) PA8576201A1 (el)
PE (1) PE20040104A1 (el)
PL (1) PL374913A1 (el)
PT (1) PT1534248E (el)
SI (1) SI1534248T1 (el)
TN (1) TNSN05006A1 (el)
TW (1) TW200406222A (el)
UY (1) UY27886A1 (el)
WO (1) WO2004006895A1 (el)
ZA (1) ZA200410196B (el)

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US20040253305A1 (en) * 2003-06-12 2004-12-16 Luner Paul E. Pharmaceutical compositions of atorvastatin
WO2006105806A1 (en) * 2005-04-07 2006-10-12 Miso Sabovic Delaying the ageing process and disorders caused by ageing
PT1878426E (pt) * 2005-04-26 2010-06-28 Dainippon Sumitomo Pharma Co Preparação granulada contendo um composto de biguanida
GB0516604D0 (en) * 2005-08-12 2005-09-21 Sandoz Ag Rapidly dispersing/disintegrating compositions
WO2007054550A1 (en) 2005-11-11 2007-05-18 Boehringer Ingelheim International Gmbh Quinazoline derivatives for the treatment of cancer diseases
CN101679325B (zh) 2007-02-23 2013-08-28 吉里德科学公司 治疗剂的药代动力学特性调节剂
CA2587805C (en) * 2007-04-25 2014-02-18 The Procter & Gamble Company Improved vitamin d content uniformity in pharmaceutical dosage forms
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
CA2702055C (en) * 2007-10-10 2017-12-12 Mallinckrodt Baker, Inc. Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
US20090274757A1 (en) * 2008-05-01 2009-11-05 Wyeth Pharmaceutical polish formulations
CN103479584A (zh) * 2008-05-02 2014-01-01 吉里德科学公司 固体载体颗粒在改善药物制剂加工性中的应用
DK2451445T3 (da) 2009-07-06 2019-06-24 Boehringer Ingelheim Int Fremgangsmåde til at tørre bibw2992, dets salte og faste farmaceutiske formuleringer omfattende denne aktive ingrediens
CA2851862C (en) * 2011-10-17 2020-04-14 Lexicon Pharmaceutical Inc. Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate
DK2851075T3 (da) 2012-05-14 2022-01-31 Shionogi & Co Præparat, der indeholder 6,7-umættet -7-carbamoylmorphinanderivat
WO2015036512A1 (en) * 2013-09-13 2015-03-19 Bayer Pharma Aktiengesellschaft Pharmaceutical compositions containing refametinib
RU2539375C1 (ru) * 2013-11-07 2015-01-20 Общество С Ограниченной Ответственностью "Валента-Интеллект" Фармацевтическая композиция в форме таблетки и способ ее получения
US9242965B2 (en) 2013-12-31 2016-01-26 Boehringer Ingelheim International Gmbh Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors
CN103830196A (zh) * 2014-03-14 2014-06-04 王志刚 一种酒石酸拉索昔芬分散片及其制备方法
TWI535784B (zh) 2014-08-26 2016-06-01 財團法人工業技術研究院 剪切增稠配方、及包含其之複合材料
CN105434444B (zh) * 2014-09-29 2021-02-05 上海奥奇医药科技有限公司 一种A-失碳-5α雄甾烷化合物的口服制剂
BR112019001528A8 (pt) * 2016-07-25 2019-07-09 Canopy Growth Corp novas formulações de comprimidos de cannabus e composições e métodos de produção do mesmo
JP6892151B2 (ja) 2016-10-11 2021-06-23 デューク ユニバーシティ Ｅｒ＋乳がんのラソフォキシフェン処置
WO2019199891A1 (en) 2018-04-10 2019-10-17 Duke University Lasofoxifene treatment of breast cancer
GB202116903D0 (en) 2021-11-18 2022-01-05 Sermonix Pharmaceuticals Inc Lasofoxifene treatment of aromatase-resistant er+ cancer
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PA8576201A1 (es) * 2002-07-10 2004-05-26 Pfizer Prod Inc Composicion farmaceutica que tiene una distribucion y potencia uniforme de farmaco

Also Published As

Publication number Publication date
WO2004006895A1 (en) 2004-01-22
AR040434A1 (es) 2005-04-06
PA8576201A1 (es) 2004-05-26
KR100782693B1 (ko) 2007-12-07
IL165746A0 (en) 2006-01-15
JP4446446B2 (ja) 2010-04-07
MXPA05000394A (es) 2005-03-23
JP2005535671A (ja) 2005-11-24
ES2395123T3 (es) 2013-02-08
IS7594A (is) 2004-12-13
OA12883A (en) 2006-09-15
ATE550017T1 (de) 2012-04-15
US20070110800A1 (en) 2007-05-17
PT1534248E (pt) 2012-05-25
CN1668285A (zh) 2005-09-14
HRP20041196A2 (en) 2005-04-30
JP2007031451A (ja) 2007-02-08
CA2489407A1 (en) 2004-01-22
EA007268B1 (ru) 2006-08-25
AU2003247017A1 (en) 2004-02-02
ECSP055528A (es) 2005-03-10
US7553500B2 (en) 2009-06-30
NO20050018L (no) 2005-01-12
TNSN05006A1 (fr) 2007-05-14
EP1534248B1 (en) 2012-03-21
EP1534248A1 (en) 2005-06-01
EA200401583A1 (ru) 2005-06-30
HK1077747A1 (en) 2006-02-24
BR0312563A (pt) 2005-04-19
US20040057992A1 (en) 2004-03-25
HN2003000206A (es) 2004-07-27
IL165746A (en) 2008-12-29
KR20050017102A (ko) 2005-02-21
MA27318A1 (fr) 2005-05-02
PE20040104A1 (es) 2004-02-27
CN100344278C (zh) 2007-10-24
AP2005003201A0 (en) 2005-03-31
PL374913A1 (en) 2005-11-14
UY27886A1 (es) 2004-02-27
ZA200410196B (en) 2006-07-26
SI1534248T1 (sl) 2012-07-31
CA2489407C (en) 2009-01-27
TW200406222A (en) 2004-05-01
DK1534248T3 (da) 2012-06-25
NZ537278A (en) 2007-07-27
AU2003247017B2 (en) 2008-03-06

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