[go: up one dir, main page]

CY1112885T1 - Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης - Google Patents

Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης

Info

Publication number
CY1112885T1
CY1112885T1 CY20121100566T CY121100566T CY1112885T1 CY 1112885 T1 CY1112885 T1 CY 1112885T1 CY 20121100566 T CY20121100566 T CY 20121100566T CY 121100566 T CY121100566 T CY 121100566T CY 1112885 T1 CY1112885 T1 CY 1112885T1
Authority
CY
Cyprus
Prior art keywords
azetidin
ethoxy
salts
production
propanoic
Prior art date
Application number
CY20121100566T
Other languages
English (en)
Inventor
Akihito Saitoh
Yoshiaki Suzuki
Kenji Yonezawa
Mitsuhide Kawamura
Takahiko Kusanagi
Takashi Nakai
Original Assignee
Toyama Chemical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toyama Chemical Co., Ltd. filed Critical Toyama Chemical Co., Ltd.
Publication of CY1112885T1 publication Critical patent/CY1112885T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Παράγωγο εστέρα προπιονικού οξέος που αναπαριστάται από το γενικό τύπο:
CY20121100566T 2005-03-28 2012-06-27 Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης CY1112885T1 (el)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2005090831 2005-03-28
JP2005174738 2005-06-15
JP2005206808 2005-07-15
JP2005230666 2005-08-09
EP10007872A EP2248809B1 (en) 2005-03-28 2006-03-27 Alkyl-3-[2-(benzo[b]thiophen-5-yl)-ethoxy]-propanoates as intermediates in the production of Azetidin-3-ol derivatives

Publications (1)

Publication Number Publication Date
CY1112885T1 true CY1112885T1 (el) 2016-04-13

Family

ID=37053344

Family Applications (3)

Application Number Title Priority Date Filing Date
CY20121100434T CY1112956T1 (el) 2005-03-28 2012-05-08 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου
CY20121100566T CY1112885T1 (el) 2005-03-28 2012-06-27 Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης
CY20131100075T CY1113571T1 (el) 2005-03-28 2013-01-25 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20121100434T CY1112956T1 (el) 2005-03-28 2012-05-08 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπιονικου οξεος ή αλατων αυτου

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20131100075T CY1113571T1 (el) 2005-03-28 2013-01-25 Μεθοδος για την παραγωγη 1-(3-(2-(1-βενζοθειοφαιν-5-υλ)-αιθοξυ)προπυλ)αζετιδιν-3-ολης ή αλατων αυτης

Country Status (22)

Country Link
US (2) US7951963B2 (el)
EP (4) EP2210884B1 (el)
JP (1) JP5031554B2 (el)
KR (2) KR101283930B1 (el)
CN (1) CN101151257B (el)
AT (2) ATE546443T1 (el)
AU (1) AU2006229271B2 (el)
BR (1) BRPI0609496C8 (el)
CA (2) CA2799659C (el)
CY (3) CY1112956T1 (el)
DK (2) DK2210884T3 (el)
ES (3) ES2380443T3 (el)
IL (2) IL186044A (el)
MX (1) MX2007011938A (el)
NO (3) NO340071B1 (el)
NZ (2) NZ583580A (el)
PL (3) PL2248809T3 (el)
PT (3) PT2248809E (el)
SG (1) SG155251A1 (el)
SI (3) SI2210884T1 (el)
WO (1) WO2006104088A1 (el)
ZA (1) ZA200708262B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE364604T1 (de) 2001-10-19 2007-07-15 Toyama Chemical Co Ltd Alkyletherderivate oder deren salze
EP2210884B1 (en) * 2005-03-28 2012-02-22 Toyama Chemical Co., Ltd. Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propionic acid or salts thereof
JP4902247B2 (ja) * 2005-04-08 2012-03-21 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの新規製造法およびその中間体
SI2674428T1 (sl) 2006-04-07 2016-07-29 Vertex Pharmaceuticals Incorporated Modulatorji transporterjev atp-vezavne kasete
US7645789B2 (en) 2006-04-07 2010-01-12 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
USRE50453E1 (en) 2006-04-07 2025-06-10 Vertex Pharmaceuticals Incorporated Indole derivatives as CFTR modulators
US10022352B2 (en) 2006-04-07 2018-07-17 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
BRPI0715056A2 (pt) * 2006-08-04 2013-05-28 Toyama Chemical Co Ltd intensificador de atividade de proteÍna cinase c
US8563573B2 (en) 2007-11-02 2013-10-22 Vertex Pharmaceuticals Incorporated Azaindole derivatives as CFTR modulators
JP5763313B2 (ja) * 2009-09-03 2015-08-12 富山化学工業株式会社 ２−（１−ベンゾチオフェン−５−イル）エタノールの製造法
JP5592205B2 (ja) * 2009-09-03 2014-09-17 富山化学工業株式会社 （１−ベンゾチオフェン−５−イル）酢酸またはその塩の製造法
US8802868B2 (en) 2010-03-25 2014-08-12 Vertex Pharmaceuticals Incorporated Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide
SG10201505700QA (en) * 2010-04-22 2015-08-28 Vertex Pharma Process of producing cycloalkylcarboxamido-indole compounds
JP6004307B2 (ja) * 2010-07-26 2016-10-05 富山化学工業株式会社 ３−（２−（１−ベンゾチオフェン−５−イル）エトキシ）プロピオン酸の塩またはその水和物およびその製造法
DK2681185T3 (en) 2011-03-02 2018-10-29 Bayer Cropscience Ag PROCEDURE FOR THE PREPARATION OF ARYL AND HETEROARY ACID ACID DERIVATIVES
JP6438199B2 (ja) 2011-09-30 2018-12-12 三菱ケミカル株式会社 重合性無機粒子分散剤、該重合性無機粒子分散剤を含む無機有機複合粒子、および無機有機樹脂複合材
IN2014DN06995A (el) 2012-02-22 2015-04-10 Toyama Chemical Co Ltd
CA2878057A1 (en) 2012-07-16 2014-01-23 Rossitza Gueorguieva Alargova Pharmaceutical compositions of (r)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide and administration thereof
BR112016017747A2 (pt) 2014-01-31 2017-08-08 Toyama Chemical Co Ltd Agente de intensificação de efeito de reabilitação pós lesão de nervo compreendendo derivados de éter de alquila ou sal do mesmo
ES2885181T3 (es) 2014-04-15 2021-12-13 Vertex Pharma Composiciones farmacéuticas para el tratamiento de enfermedades mediadas por el regulador de la conductancia transmembrana de fibrosis quística
CN109526218B (zh) * 2016-03-31 2021-07-06 富士胶片富山化学株式会社 5-溴甲基-1-苯并噻吩的制备方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA844616B (en) * 1983-06-20 1986-02-26 Merck & Co Inc 2-sulfamoylbenzo(b)thiophene derivatives for the treatment of elevated intraocular pressure
IL72070A (en) 1983-06-20 1988-11-30 Merck & Co Inc 2-sulfamoylbenzo(b)-thiophene derivatives,their preparation and pharmaceutical compositions containing them
US4668697A (en) 1983-10-31 1987-05-26 Merck & Co., Inc. Elevated intraocular pressure lowering benzo-[b]-thiophene-2-sulfonamide derivatives, compositions, and method of use therefor
CH673100A5 (el) 1987-08-10 1990-02-15 Josef Paul Huser
JPH04182463A (ja) 1990-11-17 1992-06-30 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノール類およびその誘導体の製造方法
JPH05140086A (ja) 1991-09-26 1993-06-08 Sumitomo Seika Chem Co Ltd ハロゲノチオフエノールの製造方法および精製方法
JPH05178816A (ja) 1991-12-28 1993-07-20 Sumitomo Seika Chem Co Ltd ハロゲノチオフェノールの製造方法
JP2641363B2 (ja) * 1992-04-22 1997-08-13 三共株式会社 新規なフェネチルアルコール及びその製法
GB9404775D0 (en) 1994-03-11 1994-04-27 Payne P P Ltd Improvements in or relating to article tagging
JPH08143533A (ja) 1994-11-24 1996-06-04 Sumitomo Seika Chem Co Ltd ハロチオフェノール類の製造方法
JPH1043967A (ja) 1996-08-06 1998-02-17 Calsonic Corp カシメ装置
AU6519798A (en) * 1997-03-31 1998-10-22 Toyama Chemical Co. Ltd. Process for producing 2-(benzo{b}thiophen-5-yl)-2-hydroxyacetic acid derivatives, optically active compounds thereof, or salts of both
GB9706574D0 (en) 1997-04-01 1997-05-21 Zeneca Ltd Cyano substituted cycloalkanes
JPH1112238A (ja) * 1997-06-23 1999-01-19 Kao Corp １−（β−ヒドロキシエチル）−２，５−ジアミノベンゼン又はその塩の製造法
JPH1143455A (ja) * 1997-07-25 1999-02-16 Mitsubishi Chem Corp ハロゲン化アルコールの製造方法
AU1506499A (en) 1997-12-12 1999-07-05 Toyama Chemical Co. Ltd. Alkyl ether derivatives or salts thereof and calcium antagonists containing the same
EP0993105B1 (en) 1998-10-07 2003-01-08 STMicroelectronics S.r.l. Control of power transfer in a flyback converter by modulating the off-phase in function of the load
JP4182463B2 (ja) 2000-07-19 2008-11-19 富士電機デバイステクノロジー株式会社 磁気ディスク評価装置およびその方法
WO2002100850A1 (fr) 2001-06-08 2002-12-19 Kuraray Co., Ltd. Procedes de preparation de composes heterocycliques
ATE364604T1 (de) 2001-10-19 2007-07-15 Toyama Chemical Co Ltd Alkyletherderivate oder deren salze
SI1614419T1 (sl) * 2003-04-17 2012-12-31 Toyama Chemical Co., Ltd. Preventivno sredstvo/zdravilo za bolezni vidnega ĺ˝ivca, vsebujoäśe derivate alkil etra ali soli le-teh
JP2005012291A (ja) 2003-06-17 2005-01-13 National Institute Of Information & Communication Technology Ｔｖ会議用モバイル動画通信端末
US20050032873A1 (en) 2003-07-30 2005-02-10 Wyeth 3-Amino chroman and 2-amino tetralin derivatives
WO2005019200A2 (en) 2003-08-14 2005-03-03 Icos Corporation Aryl piperidine derivatives as vla-1 integrin antagonists and uses thereof
EP2210884B1 (en) 2005-03-28 2012-02-22 Toyama Chemical Co., Ltd. Process for production of 1-(3-(2-(1-benzothiophen-5-yl)-ethoxy)propionic acid or salts thereof
US20090093453A1 (en) 2006-04-26 2009-04-09 Toyama Chemical Co., Ltd Neurogenesis inducer or neuropathy therapeutic agent comprising alkyl ether derivative or salt thereof

Also Published As

Publication number Publication date
CA2600381C (en) 2013-11-12
ATE546443T1 (de) 2012-03-15
EP2210884A2 (en) 2010-07-28
EP2348022A1 (en) 2011-07-27
MX2007011938A (es) 2008-03-14
ATE557020T1 (de) 2012-05-15
NO20161419A1 (no) 2016-06-07
US8273902B2 (en) 2012-09-25
NO20074618L (no) 2007-10-25
CA2600381A1 (en) 2006-10-05
US7951963B2 (en) 2011-05-31
KR101337382B1 (ko) 2013-12-06
IL214245A (en) 2014-12-31
NZ561672A (en) 2010-04-30
AU2006229271A1 (en) 2006-10-05
NO340071B1 (no) 2017-03-06
PL2210884T3 (pl) 2012-07-31
IL186044A (en) 2013-12-31
EP2248809B1 (en) 2012-05-09
WO2006104088A1 (ja) 2006-10-05
NO340420B1 (no) 2017-04-18
ZA200708262B (en) 2009-01-28
PL2248809T3 (pl) 2012-10-31
BRPI0609496B1 (pt) 2020-11-24
JP5031554B2 (ja) 2012-09-19
CN101151257B (zh) 2012-07-18
SI2210884T1 (sl) 2012-06-29
ES2398934T3 (es) 2013-03-22
IL214245A0 (en) 2011-08-31
EP2210884B1 (en) 2012-02-22
ES2384312T3 (es) 2012-07-03
SI2348022T1 (sl) 2013-05-31
US20110098484A1 (en) 2011-04-28
PL2348022T3 (pl) 2013-06-28
US20090069576A1 (en) 2009-03-12
ES2380443T3 (es) 2012-05-11
PT2210884E (pt) 2012-04-10
CY1113571T1 (el) 2016-06-22
BRPI0609496A2 (pt) 2011-10-18
CA2799659C (en) 2014-12-02
CY1112956T1 (el) 2016-04-13
SG155251A1 (en) 2009-09-30
BRPI0609496C1 (pt) 2021-05-11
NO20161418A1 (no) 2007-10-25
CN101151257A (zh) 2008-03-26
IL186044A0 (en) 2008-02-09
CA2799659A1 (en) 2006-10-05
DK2210884T3 (da) 2012-03-26
EP2248809A1 (en) 2010-11-10
SI2248809T1 (sl) 2012-09-28
BRPI0609496C8 (pt) 2021-05-25
EP2348022B1 (en) 2013-01-09
KR20080008334A (ko) 2008-01-23
KR20130010090A (ko) 2013-01-25
KR101283930B1 (ko) 2013-07-16
EP1864978A4 (en) 2009-07-01
EP1864978A1 (en) 2007-12-12
NZ583580A (en) 2010-10-29
EP2210884A3 (en) 2010-09-22
DK2248809T3 (da) 2012-06-18
NO340366B1 (no) 2017-04-10
PT2348022E (pt) 2013-02-13
JPWO2006104088A1 (ja) 2008-09-04
PT2248809E (pt) 2012-07-02
AU2006229271B2 (en) 2012-02-09

Similar Documents

Publication Publication Date Title
CY1112885T1 (el) Αλκυλ-3-[2-(βενζο[b]θειοφαιν-5-υλ)-αιθοξυ]-προπανοϊκα αλατα ως ενδιαμεσα στην παραγωγη παραγωγων αζετιδιν-3-ολης
MX2010008899A (es) Procedimiento para la sintesis regioselectiva de derivados de acido 1-alquil-3-haloalquil-pirazol-4-carboxilico.
PL2088218T3 (pl) Blacha stalowa gruba o wysokim module Younga i sposób jej wytwarzania
ZA200801950B (en) Regioselective process for preparing benzimidazole thiophenes
MX2007014172A (es) Procedimiento para la produccion de 4-bifenililacetidina-2-onas fenolicos.
TNSN07463A1 (en) Process for the synthesis of organic compounds
PH12012501205A1 (en) Process for preparing substituted 1-o-acyl-2-deoxy-2-fluoro-4-thio-ãŸ-d-arabinofuranoses
MX2009001816A (es) Procedimiento para la produccion de acido d,l-2-hidroxi-4-alquilti o butirico.
MX2009010363A (es) Compuestos de 1,3-tiazol-2(3h)-ilideno como ligandos del receptor canabinoide.
TW200738621A (en) Chemical process
IL209209A0 (en) Process of preparing derivatives of 1-(2-halobiphenyl-4-yl)-cyclopropanecarboxylic acid
BRPI0503815A (pt) processo para produção de mercaptoorganil (alcoxissilano)
WO2006120254A3 (de) Verfahren zur herstellung eines zahnersatzteils und ein derart hergestelltes zahnersatzteil sowie rohling zur herstellung eines zahnersatzteils
PL3284458T3 (pl) Sposób wytwarzania pastylek do ssania zawierających NLPZ
TW200734321A (en) Benzo [b] thiophen derivatives and a process for producing benzo [b] thiophen derivatives
DE602005010369D1 (de) 2-thiaquinolizidines als Glycosidase- und Glycosyltransferase-Inhibitoren
WO2006072334A3 (de) Verfahren zur herstellung von thiophenglycosidderivaten
JP2006223962A5 (el)
MX2010010880A (es) Derivados de 1,3-imidazolidina y su uso en la produccion de carbapenem.
UA85383C2 (ru) Способ получения меркаптоорганил(алкоксисиланов)
UA29160U (ru) Устройство для изготовления штапельного волокна из горных пород
MX2010003521A (es) Un proceso para la resolucion quiral de 1,3-oxatiolanos 2 sustituidos 4-sustituidos.