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CY1109331T1 - Παραγωγα αμινοφαινυλιου ως νεοι αναστολεις της αποακετυλασης ιστονης - Google Patents

Παραγωγα αμινοφαινυλιου ως νεοι αναστολεις της αποακετυλασης ιστονης

Info

Publication number
CY1109331T1
CY1109331T1 CY20091100896T CY091100896T CY1109331T1 CY 1109331 T1 CY1109331 T1 CY 1109331T1 CY 20091100896 T CY20091100896 T CY 20091100896T CY 091100896 T CY091100896 T CY 091100896T CY 1109331 T1 CY1109331 T1 CY 1109331T1
Authority
CY
Cyprus
Prior art keywords
new inhibitors
histone deacetylation
aminophenyl derivatives
aminophenyl
derivatives
Prior art date
Application number
CY20091100896T
Other languages
English (en)
Inventor
Patrick René Angibaud
Isabelle Noëlle Constance Pilatte
Bruno Roux
Janine Arts
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of CY1109331T1 publication Critical patent/CY1109331T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)

Abstract

Αυτή η εφεύρεση περιλαμβάνει τις νέες ενώσεις του τύπου (I) όπου τα R1, R2, R3, R4, R5, R6, R7, R8, R9, Χ και Υ έχουν καθορισμένες σημασίες, οι οποίες έχουν ενζυματική δράση αναστολής της αποακετυλάσης ιστόνης• την παρασκευή τους, συνθέσεις 15 που τις περιέχουν και τη χρήση τους ως φάρμακο.
CY20091100896T 2006-01-19 2009-08-27 Παραγωγα αμινοφαινυλιου ως νεοι αναστολεις της αποακετυλασης ιστονης CY1109331T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06100584 2006-01-19
EP07703891A EP1981874B1 (en) 2006-01-19 2007-01-16 Aminophenyl derivatives as novel inhibitors of histone deacetylase

Publications (1)

Publication Number Publication Date
CY1109331T1 true CY1109331T1 (el) 2014-07-02

Family

ID=36579211

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100896T CY1109331T1 (el) 2006-01-19 2009-08-27 Παραγωγα αμινοφαινυλιου ως νεοι αναστολεις της αποακετυλασης ιστονης

Country Status (19)

Country Link
US (1) US8119650B2 (el)
EP (1) EP1981874B1 (el)
JP (1) JP5225104B2 (el)
CN (1) CN101370804B (el)
AT (1) ATE432272T1 (el)
AU (1) AU2007206946B2 (el)
CA (1) CA2631876C (el)
CY (1) CY1109331T1 (el)
DE (1) DE602007001190D1 (el)
DK (1) DK1981874T3 (el)
ES (1) ES2327972T3 (el)
HK (1) HK1128283A1 (el)
HR (1) HRP20090459T1 (el)
ME (1) ME01060B (el)
PL (1) PL1981874T3 (el)
PT (1) PT1981874E (el)
RS (1) RS51191B (el)
SI (1) SI1981874T1 (el)
WO (1) WO2007082878A1 (el)

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EP1485354B1 (en) 2002-03-13 2008-05-28 Janssen Pharmaceutica N.V. Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
JP4674045B2 (ja) * 2002-03-13 2011-04-20 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼの新規な阻害剤としてのピペラジニル−、ピペリジニル−およびモルホリニル−誘導体
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PL1781639T3 (pl) 2004-07-28 2012-07-31 Janssen Pharmaceutica Nv Podstawione pochodne indolilo-alkiloaminowe jako nowe inhibitory deacetylazy histonowej
CA2605272C (en) 2005-05-18 2013-12-10 Janssen Pharmaceutica N.V. Substituted aminopropenyl piperidine or morpholine derivatives as novel inhibitors of histone deacetylase
WO2007048767A1 (en) * 2005-10-27 2007-05-03 Janssen Pharmaceutica N.V. Squaric acid derivatives as inhibitors of histone deacetylase
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US8119650B2 (en) 2006-01-19 2012-02-21 Janssen Pharmaceutica N.V. Aminophenyl derivatives as novel inhibitors of histone deacetylase
JP5137848B2 (ja) 2006-01-19 2013-02-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ヒストンデアセチラーゼのインヒビターとしてのピリジン及びピリミジン誘導体
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Also Published As

Publication number Publication date
ATE432272T1 (de) 2009-06-15
CA2631876A1 (en) 2007-07-26
JP5225104B2 (ja) 2013-07-03
CN101370804A (zh) 2009-02-18
CN101370804B (zh) 2013-05-29
ME01060B (me) 2012-10-20
ES2327972T3 (es) 2009-11-05
AU2007206946A1 (en) 2007-07-26
DE602007001190D1 (de) 2009-07-09
PL1981874T3 (pl) 2009-10-30
WO2007082878A1 (en) 2007-07-26
CA2631876C (en) 2014-05-27
US20090018152A1 (en) 2009-01-15
JP2009523760A (ja) 2009-06-25
DK1981874T3 (da) 2009-09-28
PT1981874E (pt) 2009-09-02
HRP20090459T1 (hr) 2009-09-30
RS51191B (sr) 2010-10-31
EP1981874B1 (en) 2009-05-27
SI1981874T1 (sl) 2009-10-31
EP1981874A1 (en) 2008-10-22
HK1128283A1 (en) 2009-10-23
US8119650B2 (en) 2012-02-21
AU2007206946B2 (en) 2011-12-15

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