[go: up one dir, main page]

CY1107695T1 - Μεθοδος παραγωγης επικαλυμμενων δισκιων με συγκαλυμμενη γευση και αμεση απελευθερωση του δραστικου παραγοντα - Google Patents

Μεθοδος παραγωγης επικαλυμμενων δισκιων με συγκαλυμμενη γευση και αμεση απελευθερωση του δραστικου παραγοντα

Info

Publication number
CY1107695T1
CY1107695T1 CY20071100919T CY071100919T CY1107695T1 CY 1107695 T1 CY1107695 T1 CY 1107695T1 CY 20071100919 T CY20071100919 T CY 20071100919T CY 071100919 T CY071100919 T CY 071100919T CY 1107695 T1 CY1107695 T1 CY 1107695T1
Authority
CY
Cyprus
Prior art keywords
production
coated tablets
active factor
granules
immediate determination
Prior art date
Application number
CY20071100919T
Other languages
English (en)
Inventor
Noureddine Nouri
Jean-Marc Zuccarelli
Charles Chauveau
Etienne Bruna
Original Assignee
Ethypharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ethypharm filed Critical Ethypharm
Publication of CY1107695T1 publication Critical patent/CY1107695T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Seasonings (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Formation And Processing Of Food Products (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Μέθοδος παραγωγής επικαλυμμένων κοκκίων με συγκαλυμμένη γεύση και άμεσης απελευθερώσεως του δραστικού παράγοντα σύμφωνα με την οποία: κατ' αρχάς, αναμιγνύονται εν ξηρώ τα συστατικά μίας κόνεως η οποία περιλαμβάνει τουλάχιστον το δραστικό παράγοντα και έναν κοκκώδη παράγοντα αποσυνθέσεως εν συνεχεία η λαμβανόμενη κόνη κοκκοποιείται, παρουσία ενός μίγματος εκδόχων περιλαμβάνοντος τουλάχιστον ένα συνδετικό παράγοντα ικανό να συνδέει τα σωματίδια μεταξύ τους για τη λήψη κόκκων· τότε οι έτσι σχηματιζόμενοι κόκκοι επικαλύπτονται δια κονιορτοποιήσεως ενός εναιωρήματος περιλαμβάνοντος τουλάχιστον έναν παράγοντα επικαλύψεως και έναν παράγοντα αποσυνθέσεως μεμβράνης· τέλος, τα λαμβανόμενα επικαλυμμένα κοκκία ξηραίνονται.
CY20071100919T 1999-07-08 2007-07-11 Μεθοδος παραγωγης επικαλυμμενων δισκιων με συγκαλυμμενη γευση και αμεση απελευθερωση του δραστικου παραγοντα CY1107695T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9909047A FR2795962B1 (fr) 1999-07-08 1999-07-08 Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif
EP00946045A EP1194125B1 (fr) 1999-07-08 2000-06-30 Procede de fabrication de granules enrobes a gout masque et liberation immediate du principe actif

Publications (1)

Publication Number Publication Date
CY1107695T1 true CY1107695T1 (el) 2013-04-18

Family

ID=9548029

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100919T CY1107695T1 (el) 1999-07-08 2007-07-11 Μεθοδος παραγωγης επικαλυμμενων δισκιων με συγκαλυμμενη γευση και αμεση απελευθερωση του δραστικου παραγοντα

Country Status (31)

Country Link
US (1) US6660382B2 (el)
EP (1) EP1194125B1 (el)
JP (1) JP4749639B2 (el)
KR (1) KR100767928B1 (el)
CN (1) CN1220485C (el)
AT (1) ATE360412T1 (el)
AU (1) AU760006B2 (el)
BG (1) BG65615B1 (el)
BR (1) BR0012250A (el)
CA (1) CA2375600C (el)
CY (1) CY1107695T1 (el)
CZ (1) CZ300154B6 (el)
DE (1) DE60034565T2 (el)
DK (1) DK1194125T3 (el)
DZ (1) DZ3257A1 (el)
EA (1) EA003161B1 (el)
ES (1) ES2284507T3 (el)
FR (1) FR2795962B1 (el)
HK (1) HK1049119B (el)
HU (1) HU229568B1 (el)
IL (2) IL147212A0 (el)
MA (1) MA25426A1 (el)
MX (1) MXPA01013354A (el)
NO (1) NO331256B1 (el)
NZ (1) NZ516594A (el)
PL (1) PL201782B1 (el)
PT (1) PT1194125E (el)
SK (1) SK287322B6 (el)
TR (1) TR200200013T2 (el)
WO (1) WO2001003672A1 (el)
ZA (1) ZA200200344B (el)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8071128B2 (en) 1996-06-14 2011-12-06 Kyowa Hakko Kirin Co., Ltd. Intrabuccally rapidly disintegrating tablet and a production method of the tablets
US20030203036A1 (en) 2000-03-17 2003-10-30 Gordon Marc S. Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
WO2002009669A2 (en) * 2000-08-01 2002-02-07 Inhale Therapeutic Systems, Inc. Apparatus and process to produce particles having a narrow size distribution and particles made thereby
GB0018968D0 (en) * 2000-08-02 2000-09-20 Pfizer Ltd Particulate composition
GB0027357D0 (en) 2000-11-09 2000-12-27 Bradford Particle Design Plc Particle formation methods and their products
EP1279402B1 (en) * 2001-07-26 2006-11-29 Ethypharm Coated granules of allylamine-or benzylamine-anti-mycotics, process for preparation thereof and orodispersible tablets containing said coated granules
US9358214B2 (en) 2001-10-04 2016-06-07 Adare Pharmaceuticals, Inc. Timed, sustained release systems for propranolol
FR2834212B1 (fr) * 2001-12-27 2004-07-09 Besins Int Belgique Utilisation d'une poudre a liberation immediate dans des compositions pharmaceutiques et nutraceutiques
GB0216562D0 (en) 2002-04-25 2002-08-28 Bradford Particle Design Ltd Particulate materials
US9339459B2 (en) 2003-04-24 2016-05-17 Nektar Therapeutics Particulate materials
JP4357422B2 (ja) * 2002-07-17 2009-11-04 ユーランド ファーマシューティカルズ リミテッド 強化味覚マスキング能および高溶出速度を有するマイクロカプセル製剤の製造方法
US20060233875A1 (en) * 2002-07-19 2006-10-19 Mathur Rajeev S Taste masked sumatriptan tablets and processes for their preparation
EP1396263A1 (en) * 2002-08-09 2004-03-10 Warner-Lambert Company Film coating for tablets and caplets
US8367111B2 (en) 2002-12-31 2013-02-05 Aptalis Pharmatech, Inc. Extended release dosage forms of propranolol hydrochloride
FR2850275B1 (fr) 2003-01-24 2005-04-08 Scherer Technologies Inc R P Capsules molles a macher contenant une substance active a gout masque
US20040151771A1 (en) 2003-02-04 2004-08-05 Gin Jerry B. Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth
US20040191326A1 (en) * 2003-03-31 2004-09-30 Reo Joseph P. Taste-masking vehicle for coated oxazolidinone particles
GB2401547B (en) 2003-05-08 2005-07-20 Nektar Therapeutics Uk Ltd Particulate materials
CA2527368A1 (en) * 2003-06-06 2004-12-23 Glaxo Group Limited Pharmaceutical composition
JP2007501810A (ja) * 2003-08-11 2007-02-01 メルク フロスト カナダ リミテツド 一段階被覆法を用いて作製された着香味遮蔽製薬製剤
US7390503B1 (en) 2003-08-22 2008-06-24 Barr Laboratories, Inc. Ondansetron orally disintegrating tablets
US8747895B2 (en) 2004-09-13 2014-06-10 Aptalis Pharmatech, Inc. Orally disintegrating tablets of atomoxetine
US9884014B2 (en) 2004-10-12 2018-02-06 Adare Pharmaceuticals, Inc. Taste-masked pharmaceutical compositions
EP1802285B1 (en) 2004-10-21 2013-02-27 Aptalis Pharmatech, Inc. Taste-masked pharmaceutical compositions with gastrosoluble pore-formers
US9161918B2 (en) 2005-05-02 2015-10-20 Adare Pharmaceuticals, Inc. Timed, pulsatile release systems
JP5123517B2 (ja) * 2005-11-14 2013-01-23 帝人ファーマ株式会社 アンブロキソール口腔内速崩性錠剤
PE20070698A1 (es) * 2005-11-14 2007-08-17 Teijin Pharma Ltd Comprimido de disgregacion rapida intraoral que contiene hidrocloruro de ambroxol
JP5405752B2 (ja) * 2007-01-31 2014-02-05 大日本住友製薬株式会社 被覆された薬物含有粒子および該粒子を含む固形製剤
DE102007019071A1 (de) * 2007-04-23 2008-10-30 Ratiopharm Gmbh Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin
US8703204B2 (en) 2007-05-03 2014-04-22 Bend Research, Inc. Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and anon-ionizable polymer
US8309129B2 (en) 2007-05-03 2012-11-13 Bend Research, Inc. Nanoparticles comprising a drug, ethylcellulose, and a bile salt
KR100895942B1 (ko) * 2007-05-08 2009-05-07 조선대학교산학협력단 생약 추출물을 함유하는 구강 내 속붕해성 제제 조성물 및그의 제조 방법
US9545384B2 (en) 2007-06-04 2017-01-17 Bend Research, Inc. Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate
US8974827B2 (en) 2007-06-04 2015-03-10 Bend Research, Inc. Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer
WO2009073215A1 (en) 2007-12-06 2009-06-11 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
EP2324826A1 (en) * 2008-08-11 2011-05-25 Ajinomoto Co., Inc. Hydrophilic amino acid-containing preparation having improved taste
FR2935084B1 (fr) * 2008-08-19 2011-05-06 Pancosma Sa Pour L Ind Des Produits Biochimiques Additif pour l'alimentation animale et son procede de preparation
KR101069118B1 (ko) 2008-10-22 2011-09-30 경상대학교산학협력단 장용해성 염화콜린의 제조방법 및 이의 방법에 따라 제조되는 염화콜린
CN101879141B (zh) * 2009-05-05 2013-07-17 烟台绿叶动物保健品有限公司 一种掩味替米考星胃溶颗粒制剂
WO2010150221A1 (en) 2009-06-25 2010-12-29 Wockhardt Research Centre Taste masked pharmaceutical compositions of pregabalin
EP2316433A1 (en) * 2009-10-22 2011-05-04 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Orally disintegrating tablets of flurbiprofen
PL2493312T3 (pl) * 2009-10-26 2022-01-03 Merck Sharp & Dohme Corp. Kompozycje farmaceutyczne w postaci ciała stałego zawierające inhibitor integrazy
AU2010315414B2 (en) * 2009-10-28 2015-07-09 Mcneil-Ppc, Inc. Fast dissolving/disintegrating coating compositions
EP2506836B1 (en) 2009-12-02 2018-02-14 Adare Pharmaceuticals S.R.L. Fexofenadine microcapsules and compositions containing them
TR200909613A1 (tr) * 2009-12-22 2011-07-21 Sanovel İlaç San. Ve Ti̇c. A.Ş. Pregabalinin farmasötik bileşimleri.
SG174658A1 (en) 2010-04-01 2011-10-28 Theravida Inc Pharmaceutical formulations for the treatment of overactive bladder
BR112013000300A2 (pt) 2010-07-09 2016-05-31 Teijin Pharma Ltd comprimido que se desintegra intraoralmente
JP4803686B2 (ja) * 2010-08-31 2011-10-26 協和発酵キリン株式会社 苦味を呈する薬物を含有する顆粒および口腔内崩壊錠
US9808030B2 (en) 2011-02-11 2017-11-07 Grain Processing Corporation Salt composition
KR101481772B1 (ko) 2012-06-19 2015-01-14 주식회사 아리바이오 추출물을 고농도로 함유하는 과립 또는 환의 제조방법
CN102908337B (zh) * 2012-10-12 2014-03-05 大连医诺生物有限公司 微囊化氨基酸组合物及其制备方法
US8993041B2 (en) * 2012-10-15 2015-03-31 New Jersey Institute Of Technology Taste masked active pharmaceutical powder compositions and processes for making them
JP6572244B2 (ja) 2014-02-25 2019-09-04 オービス バイオサイエンシズ， インク．Ｏｒｂｉｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． 味覚マスキング薬製剤
KR101601794B1 (ko) 2014-05-08 2016-03-10 주식회사 씨티씨바이오 클로미프라민 함유 맛 차폐된 구강 투여용 약학 제제
WO2015170939A1 (ko) * 2014-05-08 2015-11-12 주식회사 씨티씨바이오 클로미프라민 함유 맛 차폐된 구강 투여용 약학 제제
AU2016388308B2 (en) 2016-01-20 2022-08-04 Theravida, Inc. Methods and compositions for treating hyperhidrosis
JP6919119B2 (ja) * 2017-01-23 2021-08-18 日新製薬株式会社 ３位が置換されたγ−アミノ酪酸誘導体を含有する圧縮固形医薬組成物。
FR3078630B1 (fr) 2018-03-08 2021-05-14 Karim Ioualalen Mode de formulation sous forme de solide divise hydrophobe

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8524001D0 (en) * 1985-09-30 1985-11-06 Glaxo Group Ltd Pharmaceutical composition
JPS62126122A (ja) 1985-11-27 1987-06-08 Showa Shinyaku Kk 表面コ−テイングされたイブプロフエン顆粒の製法
SE457326B (sv) 1986-02-14 1988-12-19 Lejus Medical Ab Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
JPH0780754B2 (ja) 1986-08-06 1995-08-30 エーザイ株式会社 多顆粒型持続性錠剤
IT1200217B (it) * 1986-09-30 1989-01-05 Valducci Roberto Membrana per uso farmaceutico ed industriale
US5358717A (en) * 1989-12-22 1994-10-25 Syntex (U.S.A.) Inc. Directly-compressible naproxen or naproxen sodium compositions
JP2845342B2 (ja) * 1990-04-28 1999-01-13 大正製薬株式会社 ビタミンｄ▲下３▼誘導体含有固形製剤組成物
US5380535A (en) * 1991-05-28 1995-01-10 Geyer; Robert P. Chewable drug-delivery compositions and methods for preparing the same
DE4122217C2 (de) * 1991-07-04 1997-02-13 Merz & Co Gmbh & Co Verfahren zur Herstellung mechanisch stabiler, gut zerfallender Komprimate aus kleinen wirkstoffhaltigen Formkörpern
FR2679451B1 (fr) * 1991-07-22 1994-09-09 Prographarm Laboratoires Comprime multiparticulaire a delitement rapide.
TW271400B (el) * 1992-07-30 1996-03-01 Pfizer
AUPN605795A0 (en) * 1995-10-19 1995-11-09 F.H. Faulding & Co. Limited Analgesic pharmaceutical composition
AUPO637197A0 (en) 1997-04-23 1997-05-15 F.H. Faulding & Co. Limited Taste-masked pharmaceutical compositions
EP0941075B1 (en) * 1997-01-06 2003-05-02 Pfizer Inc. Rapidly releasing and taste-masking pharmaceutical dosage form
AR017512A1 (es) * 1997-08-22 2001-09-12 Smithkline Beecham Corp Tabletas de metilcelulosa rapidamente desintegrables para administracion por via oral y procedimiento para prepararlas
CA2315088A1 (en) * 1997-12-19 1999-07-01 Smithkline Beecham Corporation Process for manufacturing bite-dispersion tablets
FR2785539B1 (fr) 1998-11-06 2004-04-09 Prographarm Laboratoires Particules enrobees d'ibuprofene cristallin granule
US6451345B1 (en) * 2000-01-20 2002-09-17 Eurand Pharmaceuticals Ltd. Functional coating of linezolid microcapsules for taste-masking and associated formulation for oral administration

Also Published As

Publication number Publication date
CA2375600C (fr) 2011-05-10
ATE360412T1 (de) 2007-05-15
PL354257A1 (en) 2003-12-29
BG65615B1 (bg) 2009-03-31
US6660382B2 (en) 2003-12-09
HUP0202062A2 (hu) 2002-12-28
ES2284507T3 (es) 2007-11-16
EP1194125B1 (fr) 2007-04-25
HU229568B1 (hu) 2014-02-28
AU5993600A (en) 2001-01-30
FR2795962A1 (fr) 2001-01-12
EA200200136A1 (ru) 2002-06-27
NO20016308L (no) 2001-12-21
CN1220485C (zh) 2005-09-28
PT1194125E (pt) 2007-07-03
IL147212A0 (en) 2002-08-14
DE60034565D1 (de) 2007-06-06
JP2003504324A (ja) 2003-02-04
NO331256B1 (no) 2011-11-07
BG106398A (en) 2002-09-30
CZ300154B6 (cs) 2009-02-25
NO20016308D0 (no) 2001-12-21
MXPA01013354A (es) 2002-07-09
DK1194125T3 (da) 2007-07-30
AU760006B2 (en) 2003-05-08
US20020098227A1 (en) 2002-07-25
KR20020015062A (ko) 2002-02-27
HK1049119B (zh) 2006-05-12
CZ200218A3 (cs) 2002-04-17
PL201782B1 (pl) 2009-05-29
KR100767928B1 (ko) 2007-10-17
JP4749639B2 (ja) 2011-08-17
DZ3257A1 (fr) 2001-01-18
HK1049119A1 (en) 2003-05-02
MA25426A1 (fr) 2002-04-01
WO2001003672A1 (fr) 2001-01-18
NZ516594A (en) 2003-11-28
EA003161B1 (ru) 2003-02-27
DE60034565T2 (de) 2007-12-27
FR2795962B1 (fr) 2003-05-09
TR200200013T2 (tr) 2002-06-21
ZA200200344B (en) 2003-03-26
CN1373658A (zh) 2002-10-09
CA2375600A1 (fr) 2001-01-18
EP1194125A1 (fr) 2002-04-10
SK19392001A3 (sk) 2002-04-04
HUP0202062A3 (en) 2004-05-28
BR0012250A (pt) 2002-03-26
IL147212A (en) 2007-05-15
SK287322B6 (sk) 2010-07-07

Similar Documents

Publication Publication Date Title
CY1107695T1 (el) Μεθοδος παραγωγης επικαλυμμενων δισκιων με συγκαλυμμενη γευση και αμεση απελευθερωση του δραστικου παραγοντα
NZ512683A (en) Taste-masked pharmaceutical particles that are suitable for making chewable tablets
PT1166776E (pt) Processo para a preparacao de formas de apresentacao farmaceutica orais solidas com libertacao retardada da substancia activa
CA2306103A1 (en) Novel once-a-day controlled release sulfonylurea formulation
SE9803772D0 (sv) Pharmaceutical formulation
FR2665360B1 (fr) Procede de preparation de compositions a liberation prolongee et compositions ainsi obtenues.
DE69721489D1 (de) Herstellungsverfahren von löslichen verabreichungssystemen unter verwendung von flüchtigen salzen
IS6218A (is) Lyfjasamsetning sem inniheldur fenófíbrat og aðferðir til framleiðslu á því
NO20001670L (no) Fremgangsmate for fremstilling av en smaksmaskert farmasoytisk blanding og smaksmaskert farmasoytisk blanding fremstilt ifolge denne fremgangsmaten, samt smaksmaskerte tyggbare tabletter
JP2005516946A5 (el)
DE69209080D1 (de) Pharmazeutische zusammemsetzungen mit verzoegerter freigabe
DE59305700D1 (de) Verfahren zur Herstellung von festen pharmazeutischen Retardformen
HUP9904065A2 (hu) Olanzapint tartalmazó bevonatos gyógyszerkészítmények
GB2208602B (en) Process for the production of dried earthworm powder and antihyperlipemic,anti-diabetic,antihypertensive and antihypotensive preparations containing dried ear
ID24714A (id) Turunan tiazolidindion tersubstitusi, proses pembuatannya dan penggunaan bahan farmasinya
ATE185266T1 (de) Schnell auflösende orale darreichungsform
NO20005838D0 (no) Farmasöytisk multipartikkelform med programmert og styrt frigivning, samt fremstilling derav
DK1417960T3 (da) Mikropellets med vedvarende frisætning og fremgangsmåde til fremstilling heraf
CA2079934A1 (en) Taste mask coatings for preparing chewable pharmaceutical tablets
DE68907432D1 (de) Beschichtete granulierte duengemittelzusammensetzung und ihre herstellung.
ATE235892T1 (de) Neues verfahren zur herstellung von trockenen pharmazeutischen formen mit schnellaufloesbarkeit und so hergestellte pharmazeutische formen
FR2554718B1 (fr) Nouvelles formes galeniques du sulpiride utilisables par voie orale
EP1013271A3 (en) Nimodipine tablets
UA35669A (uk) Спосіб одержання твердої лікарської композиції індометацину
JP2002087959A5 (el)