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CY1105922T1 - Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimer - Google Patents

Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimer

Info

Publication number
CY1105922T1
CY1105922T1 CY20071100048T CY071100048T CY1105922T1 CY 1105922 T1 CY1105922 T1 CY 1105922T1 CY 20071100048 T CY20071100048 T CY 20071100048T CY 071100048 T CY071100048 T CY 071100048T CY 1105922 T1 CY1105922 T1 CY 1105922T1
Authority
CY
Cyprus
Prior art keywords
alzheimer
disease
treatment
substituted azetidinone
azetidinone derivatives
Prior art date
Application number
CY20071100048T
Other languages
English (en)
Inventor
Harry R. Davis
Eric Mcfee Parker
Margaret Van Heek
Gwendolyn Tse Wong
Laura B. Merkel
Original Assignee
Schering Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corporation filed Critical Schering Corporation
Publication of CY1105922T1 publication Critical patent/CY1105922T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Παρέχονται μέθοδοι αποτροπής, θεραπείας ή ανακούφισης συμπτωμάτων ασθένειας Alzheimer, ρύθμισης παραγωγής ή επιπέδων πεπτιδίων αμυλοειδούς β (Αβ) ή/και ρύθμισης της ποσότητας της ΑpοΕ ισομορφής 4 στο ρεύμα του αίματος ή/και τον εγκέφαλο, που περιλαμβάνουν το στάδιο χορήγησης σε ένα υποκείμενο που έχει ανάγκη μιας τέτοιας θεραπευτικής αγωγής, μιας αποτελεσματικής ποσότητας μιας σύνθεσης που περιλαμβάνει τουλάχιστον μια ένωση που αντιπροσωπεύεται από τους Τύπους (Ι-Χ) που αποκαλύπτονται εδώ.
CY20071100048T 2001-05-25 2007-01-15 Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimer CY1105922T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29365101P 2001-05-25 2001-05-25
US32391101P 2001-09-21 2001-09-21
PCT/US2002/016306 WO2002096415A2 (en) 2001-05-25 2002-05-22 Use of azetidinone substituted derivatives in the treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
CY1105922T1 true CY1105922T1 (el) 2011-04-06

Family

ID=26968071

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20071100048T CY1105922T1 (el) 2001-05-25 2007-01-15 Χρηση υποκατεστημενων παραγωγων αζετιδινονης στη θepαπεια ασθενειας alzheimer

Country Status (14)

Country Link
US (1) US20030013699A1 (el)
EP (1) EP1392287B8 (el)
JP (1) JP2004532868A (el)
AR (1) AR038956A1 (el)
AT (1) ATE345792T1 (el)
AU (1) AU2002308778A1 (el)
CA (1) CA2447884A1 (el)
CY (1) CY1105922T1 (el)
DE (1) DE60216275T2 (el)
DK (1) DK1392287T3 (el)
ES (1) ES2275007T3 (el)
MX (1) MXPA03010843A (el)
PT (1) PT1392287E (el)
WO (1) WO2002096415A2 (el)

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Also Published As

Publication number Publication date
EP1392287B8 (en) 2007-01-10
DE60216275D1 (de) 2007-01-04
US20030013699A1 (en) 2003-01-16
WO2002096415A3 (en) 2003-01-16
EP1392287B1 (en) 2006-11-22
PT1392287E (pt) 2007-02-28
WO2002096415A2 (en) 2002-12-05
MXPA03010843A (es) 2004-02-17
DE60216275T2 (de) 2007-06-21
DK1392287T3 (da) 2007-03-19
CA2447884A1 (en) 2002-12-05
EP1392287A2 (en) 2004-03-03
AR038956A1 (es) 2005-02-02
ES2275007T3 (es) 2007-06-01
ATE345792T1 (de) 2006-12-15
JP2004532868A (ja) 2004-10-28
AU2002308778A1 (en) 2002-12-09

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