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CU24385B1 - Compuestos éteres de arilo útiles para tratar cancer de célula renal - Google Patents

Compuestos éteres de arilo útiles para tratar cancer de célula renal

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Publication number
CU24385B1
CU24385B1 CU2016000030A CU20160030A CU24385B1 CU 24385 B1 CU24385 B1 CU 24385B1 CU 2016000030 A CU2016000030 A CU 2016000030A CU 20160030 A CU20160030 A CU 20160030A CU 24385 B1 CU24385 B1 CU 24385B1
Authority
CU
Cuba
Prior art keywords
compounds
formula
useful
renal cell
arilo
Prior art date
Application number
CU2016000030A
Other languages
English (en)
Other versions
CU20160030A7 (es
Inventor
Darryl David Dixon
Jonas Grina
John A Josey
James P Rizzi
Stephen T Schlachter
Eli M Wallace
Bin Wang
Paul Wehn
Rui Xu
Hanbiao Yang
Original Assignee
Peloton Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Peloton Therapeutics Inc filed Critical Peloton Therapeutics Inc
Publication of CU20160030A7 publication Critical patent/CU20160030A7/es
Publication of CU24385B1 publication Critical patent/CU24385B1/es

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    • A61K31/075—Ethers or acetals
    • A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
    • A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • C07C205/20—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/21—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C205/22—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups and hydroxy groups bound to carbon atoms of six-membered aromatic rings having nitro groups and hydroxy groups bound to carbon atoms of the same non-condensed six-membered aromatic ring having one nitro groups bound to the ring
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Abstract

<p>La invención se relaciona con compuestos de éteres de arilo de Fórmula I</p> <p>ESPACIO PARA FÓRMULA I</p> <p>o una sal farmacéuticamente aceptable del mismo preparada a partir de una base inorgánica, base orgánica, base inorgánica, base orgánica, ácido inorgánico o ácido orgánica, donde: R1; R2; R3; R4; y R5 son como se definen en el pliego reivindicatorio.</p> <p>Dichos compuestos de fórmula I son capaces de modular la actividad del factor 2 alfa inducible por hipoxia (HIF-2alfa), una proteína que juega un papel importante en la vía de respuesta hipóxica en tumores. Esta vía es una fuerza impulsora para la progresión del cáncer. De esta manera, los compuestos de fórmula I de la presente invención son útiles en el tratamiento del cáncer, tal como en el tratamiento del carcinoma celular renal.</p>
CU2016000030A 2013-09-09 2014-09-05 Compuestos éteres de arilo útiles para tratar cancer de célula renal CU24385B1 (es)

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