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CU23873B1 - Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida - Google Patents

Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida

Info

Publication number
CU23873B1
CU23873B1 CUP2008000213A CU20080213A CU23873B1 CU 23873 B1 CU23873 B1 CU 23873B1 CU P2008000213 A CUP2008000213 A CU P2008000213A CU 20080213 A CU20080213 A CU 20080213A CU 23873 B1 CU23873 B1 CU 23873B1
Authority
CU
Cuba
Prior art keywords
preparation
imidazotriazinones
sulfonamide
replaced
new procedure
Prior art date
Application number
CUP2008000213A
Other languages
English (en)
Other versions
CU20080213A7 (es
Inventor
Marc Nowakowski
Reinhold Gehring
Werner Heilmann
Karl-Heinz Wahl
Original Assignee
Bayer Ip Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ip Gmbh filed Critical Bayer Ip Gmbh
Publication of CU20080213A7 publication Critical patent/CU20080213A7/es
Publication of CU23873B1 publication Critical patent/CU23873B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a un intermediario para procedimiento para la preparación de imidazotriazinonas sustituídas con sulfonamida de fórmula general (I) caracterizado porque los compuestos de fórmula V se trasforman con compuestos de fórmula general VI en una reacción de dos etapas en el sistema metanol y cloruro de acetilo /ácido acético.
CUP2008000213A 2000-12-18 2008-11-17 Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida CU23873B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10063108A DE10063108A1 (de) 2000-12-18 2000-12-18 Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
PCT/EP2001/014239 WO2002050076A2 (de) 2000-12-18 2001-12-05 Verfahren zur herstellung von sulfonamid-substituierten imidazotriazinonen

Publications (2)

Publication Number Publication Date
CU20080213A7 CU20080213A7 (es) 2012-06-21
CU23873B1 true CU23873B1 (es) 2013-04-19

Family

ID=7667666

Family Applications (2)

Application Number Title Priority Date Filing Date
CU20030128A CU23341B7 (es) 2000-12-18 2003-06-09 Procedimiento para la preparación de imidazotriazínonas sustituidas con sulfonamida
CUP2008000213A CU23873B1 (es) 2000-12-18 2008-11-17 Nuevo procedimiento para la preparación de un intermediario útil en la preparación de imidazotriazinonas sustituidas con sulfonamida

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CU20030128A CU23341B7 (es) 2000-12-18 2003-06-09 Procedimiento para la preparación de imidazotriazínonas sustituidas con sulfonamida

Country Status (43)

Country Link
US (3) US6777551B2 (es)
EP (1) EP1345939B1 (es)
JP (1) JP4441175B2 (es)
KR (1) KR100787288B1 (es)
CN (1) CN1227253C (es)
AR (1) AR032775A1 (es)
AT (1) ATE328885T1 (es)
AU (2) AU2002217089B2 (es)
BG (1) BG66142B1 (es)
BR (1) BRPI0116227B8 (es)
CA (1) CA2431933C (es)
CU (2) CU23341B7 (es)
CY (1) CY1105197T1 (es)
CZ (1) CZ297005B6 (es)
DE (2) DE10063108A1 (es)
DK (1) DK1345939T3 (es)
DO (1) DOP2001000295A (es)
EC (1) ECSP034657A (es)
EE (1) EE05308B1 (es)
ES (1) ES2266098T3 (es)
GT (1) GT200100251A (es)
HK (1) HK1063799A1 (es)
HN (1) HN2001000278A (es)
HR (1) HRP20030583B1 (es)
HU (1) HU229296B1 (es)
IL (2) IL156278A0 (es)
MA (1) MA25927A1 (es)
MX (1) MXPA03005429A (es)
MY (1) MY126689A (es)
NO (1) NO325398B1 (es)
NZ (1) NZ526477A (es)
PE (1) PE20020590A1 (es)
PL (1) PL207294B1 (es)
PT (1) PT1345939E (es)
RU (1) RU2299211C2 (es)
SI (1) SI1345939T1 (es)
SK (1) SK286894B6 (es)
SV (1) SV2003000766A (es)
TW (1) TWI289562B (es)
UA (1) UA75109C2 (es)
UY (2) UY27070A1 (es)
WO (1) WO2002050076A2 (es)
ZA (1) ZA200304705B (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
DE202004006552U1 (de) * 2004-04-26 2004-07-08 Knürr AG Kühlungssystem für Geräte- und Netzwerkschränke
DE102004023069A1 (de) 2004-05-11 2005-12-08 Bayer Healthcare Ag Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil
US7977478B2 (en) * 2006-03-13 2011-07-12 Dr. Reddy's Laboratories Limited Polymorphic forms of vardenafil
CN101965348B (zh) * 2007-09-06 2013-11-13 上海特化医药科技有限公司 伐地那非的制备方法及其中间体
BRPI0722222A2 (pt) 2007-12-28 2015-06-16 Topharman Shangai Co Ltd N-{1-[3-(2-etóxi-5-(4-etilpiperazinil)sulfonilfenil)-4,5-di hidro-5-oxo-1,2,4-triazina-6-il]etil}butiramida, seu método de preparo e seu uso
WO2011016016A1 (en) 2009-08-07 2011-02-10 Ranbaxy Laboratories Limited Processes for the preparation of vardenafil
PL390079A1 (pl) * 2009-12-30 2011-07-04 Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli
CN102134242B (zh) 2011-01-21 2013-08-28 浙江大德药业集团有限公司 一种用于治疗阳痿的快速长效的化合物
CZ2011767A3 (cs) 2011-11-24 2013-06-05 Zentiva, K.S. Zpusob prípravy a izolace solí vardenafilu s kyselinami
EP3082428A4 (en) 2013-12-09 2017-08-02 Respira Therapeutics, Inc. Pde5 inhibitor powder formulations and methods relating thereto
PL223869B1 (pl) 2013-12-16 2016-11-30 Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna Sposób otrzymywania wardenafilu i jego soli
CN107383020A (zh) * 2017-07-29 2017-11-24 合肥创新医药技术有限公司 一种伐地那非杂质的制备方法
EP3727329A1 (en) 2017-12-20 2020-10-28 Klaria Pharma Holding AB Film formulation comprising vardenafil, method for its preparation, and use thereof
CN115043757B (zh) * 2022-07-27 2023-08-08 南京桦冠生物技术有限公司 一种连续化制备苄脒盐酸盐的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
EP2295436A1 (de) 1997-11-12 2011-03-16 Bayer Schering Pharma AG 2-Phenyl-substituierte Imidazotriazinone als Phosphodiesterase V Inhibitoren
DE10063108A1 (de) * 2000-12-18 2002-06-20 Bayer Ag Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen
DE10107639A1 (de) * 2001-02-15 2002-08-22 Bayer Ag 2-Alkoxyphenyl-substituierte Imidazotriazinone

Also Published As

Publication number Publication date
JP2004517849A (ja) 2004-06-17
UY37172A (es) 2017-06-30
US20050203298A1 (en) 2005-09-15
HU229296B1 (en) 2013-10-28
UY27070A1 (es) 2002-07-31
SK7502003A3 (en) 2003-10-07
HRP20030583B1 (en) 2011-09-30
TWI289562B (en) 2007-11-11
PL365310A1 (en) 2004-12-27
CA2431933A1 (en) 2002-06-27
BG66142B1 (bg) 2011-07-29
US6998483B2 (en) 2006-02-14
PL207294B1 (pl) 2010-11-30
ZA200304705B (en) 2004-08-12
ECSP034657A (es) 2003-07-25
DE50110080D1 (de) 2006-07-20
CU23341B7 (es) 2009-02-20
ES2266098T3 (es) 2007-03-01
AU2002217089B2 (en) 2006-01-12
WO2002050076A3 (de) 2002-08-29
NZ526477A (en) 2004-12-24
KR20030063430A (ko) 2003-07-28
BG107892A (bg) 2004-08-31
GT200100251A (es) 2002-10-01
CZ20031692A3 (cs) 2003-10-15
MXPA03005429A (es) 2004-05-04
DK1345939T3 (da) 2006-09-25
ATE328885T1 (de) 2006-06-15
SK286894B6 (sk) 2009-07-06
CU20080213A7 (es) 2012-06-21
EE05308B1 (et) 2010-06-15
IL156278A (en) 2009-06-15
EE200300294A (et) 2003-10-15
CZ297005B6 (cs) 2006-08-16
IL156278A0 (en) 2004-01-04
BRPI0116227B8 (pt) 2021-05-25
NO20032731L (no) 2003-06-16
EP1345939A2 (de) 2003-09-24
WO2002050076A2 (de) 2002-06-27
KR100787288B1 (ko) 2007-12-20
AR032775A1 (es) 2003-11-26
NO325398B1 (no) 2008-04-21
BR0116227A (pt) 2003-12-30
RU2299211C2 (ru) 2007-05-20
CN1481386A (zh) 2004-03-10
MA25927A1 (fr) 2003-10-01
HUP0302467A3 (en) 2004-11-29
MY126689A (en) 2006-10-31
HN2001000278A (es) 2002-01-30
CY1105197T1 (el) 2010-03-03
BR0116227B1 (pt) 2014-08-26
NO20032731D0 (no) 2003-06-16
PT1345939E (pt) 2006-08-31
HUP0302467A2 (hu) 2003-11-28
UA75109C2 (en) 2006-03-15
PE20020590A1 (es) 2002-07-13
EP1345939B1 (de) 2006-06-07
SV2003000766A (es) 2003-01-13
HRP20030583A2 (en) 2005-06-30
DE10063108A1 (de) 2002-06-20
DOP2001000295A (es) 2002-12-15
SI1345939T1 (sl) 2006-10-31
JP4441175B2 (ja) 2010-03-31
CN1227253C (zh) 2005-11-16
AU1708902A (en) 2002-07-01
US20020137930A1 (en) 2002-09-26
US20050014756A1 (en) 2005-01-20
HK1063799A1 (en) 2005-01-14
US6777551B2 (en) 2004-08-17
CA2431933C (en) 2009-12-01

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Legal Events

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FG Grant of patent