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CU20210006A7 - Derivados de fenil-n-quinolina y proceso para su preparación - Google Patents

Derivados de fenil-n-quinolina y proceso para su preparación

Info

Publication number
CU20210006A7
CU20210006A7 CU2021000006A CU20210006A CU20210006A7 CU 20210006 A7 CU20210006 A7 CU 20210006A7 CU 2021000006 A CU2021000006 A CU 2021000006A CU 20210006 A CU20210006 A CU 20210006A CU 20210006 A7 CU20210006 A7 CU 20210006A7
Authority
CU
Cuba
Prior art keywords
group
cycloalkyl
phenyl
orc
formula
Prior art date
Application number
CU2021000006A
Other languages
English (en)
Other versions
CU24674B1 (es
Inventor
Cécile Apolit
Florence Mahuteau-Betzer
Romain Najman
Julien Santo
Didier Scherrer
Jamal Tazi
Original Assignee
Centre Nat Rech Scient
Inst Curie
Univ Montpellier
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre Nat Rech Scient, Inst Curie, Univ Montpellier filed Critical Centre Nat Rech Scient
Publication of CU20210006A7 publication Critical patent/CU20210006A7/es
Publication of CU24674B1 publication Critical patent/CU24674B1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

<p>La presente invención se refiere a un compuesto de fórmula (I) o cualquiera de sus sales farmacéuticamente aceptables para usarse en el tratamiento y/o prevención de una infección por virus ARN, y en particular una infección por virus ARN del grupo IV o V de la clasificación de Baltimore.</p> <p>ESPACIO PARA LA FÓRMULA</p> <p>en donde R3 representa un átomo de cloro o un átomo de hidrógeno, R representa un grupo alquilo (C1-C4), un grupo cicloalquilo (C3-C6), un átomo de halógeno, un grupo alcoxi (C1-C5), un grupo -SO2-NRaRb, un grupo -SO3H, un grupo -OH, un grupo -O-SO2-ORc o un grupo -OP (= O) - (ORc) (ORd), R1 representa (i) un grupo CF3, (ii) un grupo alquilo (C1-C10), (iii) un grupo cicloalquilo (C3-C6) o un grupo heterocicloalquilo (C3-C6) o (iv) un grupo fenilo o un grupo naftilo, y R2 representa un átomo de hidrógeno, un grupo alquilo (C1-C10), un cicloalquilo (C3-C6) o un grupo heterocicloalquilo (C3-C6). La presente invención se refiere además a nuevos compuestos, a composiciones farmacéuticas que los contienen y al proceso de síntesis para manufacturarlos.</p>
CU2021000006A 2018-07-09 2019-07-09 Derivados de fenil-n-quinolina y proceso para su preparación CU24674B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18305910.4A EP3594206A1 (en) 2018-07-09 2018-07-09 Phenyl-n-quinoline derivatives for treating a rna virus infection
PCT/EP2019/068459 WO2020011810A1 (en) 2018-07-09 2019-07-09 Phenyl-n-quinoline derivatives for treating a rna virus infection

Publications (2)

Publication Number Publication Date
CU20210006A7 true CU20210006A7 (es) 2021-08-06
CU24674B1 CU24674B1 (es) 2023-08-08

Family

ID=63035966

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2021000006A CU24674B1 (es) 2018-07-09 2019-07-09 Derivados de fenil-n-quinolina y proceso para su preparación

Country Status (11)

Country Link
US (2) US12084422B2 (es)
EP (2) EP3594206A1 (es)
JP (2) JP7504409B2 (es)
KR (1) KR102758510B1 (es)
CN (1) CN112566899B (es)
AU (1) AU2019300100B2 (es)
BR (1) BR112021000331A2 (es)
CA (1) CA3103867A1 (es)
CU (1) CU24674B1 (es)
MX (1) MX2021000089A (es)
WO (1) WO2020011810A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230142547A1 (en) 2020-03-20 2023-05-11 Abivax Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection
EP3881844A1 (en) 2020-03-20 2021-09-22 Abivax Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection
EP3884946A1 (en) 2020-03-25 2021-09-29 Abivax Compounds for treating or preventing a coronaviridae infection & methods and uses for assessing the occurrence of a coronaviridae infection
WO2025045123A1 (zh) * 2023-08-30 2025-03-06 江苏正大丰海制药有限公司 用于调节微小rna-124活性的化合物

Family Cites Families (25)

* Cited by examiner, † Cited by third party
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US7429599B2 (en) 2000-12-06 2008-09-30 Signal Pharmaceuticals, Llc Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK
FR2830862A1 (fr) 2001-10-16 2003-04-18 Lipha Derives nitroso de la diphenylamine a fonction ether ou thioether, compositions pharmaceutiques les contenant et leur utilisation pour la preparation de medicaments
FR2836917B1 (fr) 2002-03-11 2006-02-24 Lipha Derives nitroso de la diphenylamine, compositions pharmaceutiques les contenant en tant que medicaments utilisables dans le traitement des pathologies caracterisees par une situation de stress oxydatif
CN1839132A (zh) 2003-08-21 2006-09-27 Osi制药公司 作为c－kit抑制剂的n3－取代的咪唑并吡啶衍生物
FR2859474B1 (fr) 2003-09-04 2006-01-13 Centre Nat Rech Scient Utilisation de composes derives d'indole pour la preparation d'un medicament utile pour le traitement de maladies genetiques resultant de l'alteration des processus d'epissage
DK1697343T3 (da) 2003-12-18 2009-10-05 Tibotec Pharm Ltd Aminobenzimidazoler og benzimidazoler som inhibitorer af replikation af respiratorisk syncytialvirus
FR2866647B1 (fr) * 2004-02-20 2006-10-27 Servier Lab Nouveaux derives azabicycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2005289426A1 (en) 2004-09-27 2006-04-06 Amgen Inc. Substituted heterocyclic compounds and methods of use
ES2574670T3 (es) 2005-03-17 2016-06-21 Janssen Sciences Ireland Uc 1,3-Dihidro-bencimidazol-2-ilidenoaminas como inhibidores de replicación del virus sincicial respiratorio
US9409856B2 (en) 2005-11-28 2016-08-09 Gtx, Inc. Estrogen receptor ligands and methods of use thereof
JP2009521480A (ja) 2005-12-21 2009-06-04 アボット・ラボラトリーズ 抗ウイルス化合物
EP1971611B1 (en) 2005-12-21 2012-10-10 Abbott Laboratories Anti-viral compounds
FR2901273B1 (fr) 2006-05-19 2010-12-24 Anaconda Pharma Inhibiteurs du virus du papillome humain et les compositions pharmaceutiques les contenant
FR2926297B1 (fr) 2008-01-10 2013-03-08 Centre Nat Rech Scient Molecules chimiques inhibitrices du mecanisme d'epissage pour traiter des maladies resultant d'anomalies d'epissage.
US20140187641A1 (en) 2012-08-23 2014-07-03 Gtx Estrogen receptor ligands and methods of use thereof
KR102016893B1 (ko) 2009-06-12 2019-08-30 아비박스 조기 노화, 구체적으로 조로증을 치료하는데 유용한 화합물
TWI546302B (zh) 2010-06-24 2016-08-21 武田藥品工業股份有限公司 稠合雜環化合物
EP2465502A1 (en) * 2010-12-15 2012-06-20 Société Splicos Compounds useful for treating AIDS
EP2505198A1 (en) 2011-04-01 2012-10-03 Société Splicos Compounds for use as therapeutic agents affecting p53 expression and/or activity
WO2014164667A1 (en) 2013-03-11 2014-10-09 Georgetown University Dengue and west nile virus protease inhibitors
CN105530938B (zh) * 2013-07-05 2019-10-22 Abivax公司 用于治疗由逆转录病毒引起的疾病的化合物
RU2628800C2 (ru) 2014-03-12 2017-08-22 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Амидные соединения, способы получения, применение в качестве средств для лечения и профилактики заболеваний, вызываемых рнк-содержащими вирусами
EP3058940A1 (en) * 2015-02-23 2016-08-24 Abivax Quinoline derivatives for use in the treatment or prevention of viral infection
EP3059591A1 (en) * 2015-02-23 2016-08-24 Abivax Methods for screening compounds for treating or preventing a viral infection or a virus-related condition
DK3429998T3 (da) 2016-03-18 2021-11-22 Prosynergia S A R L Fremgangsmåde til fremstilling af quinolin-2-yl-phenylaminderivater og disses salte

Also Published As

Publication number Publication date
CN112566899A (zh) 2021-03-26
US12084422B2 (en) 2024-09-10
AU2019300100A1 (en) 2021-01-21
CN112566899B (zh) 2024-01-30
KR102758510B1 (ko) 2025-01-22
CA3103867A1 (en) 2020-01-16
WO2020011810A1 (en) 2020-01-16
JP2024053563A (ja) 2024-04-15
US20240308964A1 (en) 2024-09-19
KR20210052432A (ko) 2021-05-10
EP3820852A1 (en) 2021-05-19
BR112021000331A2 (pt) 2021-04-06
US20210309611A1 (en) 2021-10-07
EP3594206A1 (en) 2020-01-15
AU2019300100B2 (en) 2024-10-24
JP7504409B2 (ja) 2024-06-24
JP2021524481A (ja) 2021-09-13
MX2021000089A (es) 2021-03-25
CU24674B1 (es) 2023-08-08

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