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CU20160159A7 - Proceso de cultivo celular regulado de células eucariotas y productos derivados y método de generación de material celular vegetal en forma de un paquete celular multicapa no tejido y estructurado poroso, privado del medio - Google Patents

Proceso de cultivo celular regulado de células eucariotas y productos derivados y método de generación de material celular vegetal en forma de un paquete celular multicapa no tejido y estructurado poroso, privado del medio

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Publication number
CU20160159A7
CU20160159A7 CUP2016000159A CU20160159A CU20160159A7 CU 20160159 A7 CU20160159 A7 CU 20160159A7 CU P2016000159 A CUP2016000159 A CU P2016000159A CU 20160159 A CU20160159 A CU 20160159A CU 20160159 A7 CU20160159 A7 CU 20160159A7
Authority
CU
Cuba
Prior art keywords
cellular
cell
eucariot
private
woven
Prior art date
Application number
CUP2016000159A
Other languages
English (en)
Inventor
Daniel Blessing
Matthias Buntru
Tanja Holland
Markus Sack
Simon Vogel
Original Assignee
Fraunhofer-Gelleschaft Zur Förderung Der Angewandten Forschung E V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer-Gelleschaft Zur Förderung Der Angewandten Forschung E V filed Critical Fraunhofer-Gelleschaft Zur Förderung Der Angewandten Forschung E V
Publication of CU20160159A7 publication Critical patent/CU20160159A7/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/36—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of biomass, e.g. colony counters or by turbidity measurements
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
    • C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0062—General methods for three-dimensional culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/14—Plant cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Botany (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Environmental Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Sustainable Development (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Reproductive Health (AREA)

Abstract

<p>La presente invención se relaciona con un nuevo cultivo celular y procesos de producción de producto celular y/o derivado de células que tienen ventajas sobre las estrategias de fermentación actualmente existentes. Los procesos y métodos de acuerdo con Ia presente descripción pueden usarse para un suministro eficiente de células eucariotas altamente viables y metabólicamente activas para las plataformas de producción transitoria, como un proceso de producción alternativo con ventajas sobre los procesos actualmente aplicados (estrategias por lotes, alimentación por lotes o perfusion) y para generar biomasa metabólica y altamente activa para el uso subsecuente para los sistemas de expresión transitorios o infección por un virus o pseudovirus o en los sistemas libres de células.</p>
CUP2016000159A 2014-04-28 2015-04-28 Proceso de cultivo celular regulado de células eucariotas y productos derivados y método de generación de material celular vegetal en forma de un paquete celular multicapa no tejido y estructurado poroso, privado del medio CU20160159A7 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14166157 2014-04-28
PCT/EP2015/000867 WO2015165583A1 (en) 2014-04-28 2015-04-28 Fermentation systems

Publications (1)

Publication Number Publication Date
CU20160159A7 true CU20160159A7 (es) 2017-12-08

Family

ID=50630601

Family Applications (1)

Application Number Title Priority Date Filing Date
CUP2016000159A CU20160159A7 (es) 2014-04-28 2015-04-28 Proceso de cultivo celular regulado de células eucariotas y productos derivados y método de generación de material celular vegetal en forma de un paquete celular multicapa no tejido y estructurado poroso, privado del medio

Country Status (11)

Country Link
US (1) US10988727B2 (es)
EP (1) EP3136841B1 (es)
JP (1) JP6723163B2 (es)
KR (1) KR102352104B1 (es)
CN (1) CN106459901A (es)
BR (1) BR112016025013B1 (es)
CA (1) CA2943198A1 (es)
CU (1) CU20160159A7 (es)
ES (1) ES2911309T3 (es)
PT (1) PT3136841T (es)
WO (1) WO2015165583A1 (es)

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WO2018115161A1 (en) * 2016-12-21 2018-06-28 F. Hoffmann-La Roche Ag Growth control of eukaryotic cells
EP3579845A4 (en) 2017-02-09 2020-12-30 Dow Agrosciences LLC NEW EUKARYOTE CELL FREE EXPRESSION SYSTEM THAT DOES NOT REQUIRE AN ARTIFICIAL ENERGY REGENERATION SYSTEM
BR112019025272A2 (pt) 2017-06-02 2020-06-16 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Métodos para transformação de células vegetais, para fornecer um lisado e para provocar a transcrição, célula, uso de uma célula, lisado de célula vegetal e matéria
US10774297B2 (en) * 2017-08-03 2020-09-15 Repligen Corporation Method of actuation of an alternating tangential flow diaphragm pump
CN107904167B (zh) * 2017-11-15 2023-06-06 中国航天员科研训练中心 细胞自动扩增培养设备
JP2022537650A (ja) * 2019-06-13 2022-08-29 アムジエン・インコーポレーテツド 生物製剤の製造における自動化された生物量に基づく灌流制御
CN110669722A (zh) * 2019-10-23 2020-01-10 长春生物制品研究所有限责任公司 一种用于mdck细胞的无血清全悬浮驯化方法
CN111944736B (zh) * 2020-07-06 2022-06-24 深圳大学 一种小立碗藓原生质体及其制备方法
US20240279702A1 (en) * 2021-06-30 2024-08-22 Corteva Agriscience Llc Soybean and maize cell-free expression systems
DK181562B1 (en) * 2021-11-11 2024-05-17 Dsm Ip Assets Bv Feed control system for a fermentation system, and related method
KR20250007697A (ko) 2022-05-23 2025-01-14 플루리 바이오텍 리미티드 대규모 면역 세포 확장 및 활성화를 위한 시스템 및 방법
GB202219254D0 (en) * 2022-12-20 2023-02-01 Cellularevolution Ltd Bioprocessing system
CN116064421A (zh) * 2023-01-04 2023-05-05 杭州明德生物医药技术有限公司 一种利用电容值确定病毒生产工艺节点的方法
IL303555B2 (en) * 2023-06-08 2024-07-01 Pluri Biotech Ltd A System For 3D Cultivation Of Plant Cells And Methods Of Use
CN119847104B (zh) * 2025-03-21 2025-06-20 汉中市黑金茶科技有限公司 基于物联网的蒲公英金花茶发酵过程智能监控方法

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US3958364A (en) * 1973-12-04 1976-05-25 American Bioculture, Inc. Production of algal bio-polymers
JPH02109973A (ja) 1988-10-19 1990-04-23 Shimadzu Corp 細胞培養装置
FR2690926B1 (fr) * 1992-05-06 1995-08-04 Lvmh Rech Dispositif du type reacteur a volume variable et procede de culture cellulaire.
EP2623603A1 (en) 2012-01-31 2013-08-07 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method for the generation and cultivation of a plant cell pack

Also Published As

Publication number Publication date
CA2943198A1 (en) 2015-11-05
US20170037421A1 (en) 2017-02-09
CN106459901A (zh) 2017-02-22
KR102352104B1 (ko) 2022-01-14
JP6723163B2 (ja) 2020-07-15
EP3136841A1 (en) 2017-03-08
US10988727B2 (en) 2021-04-27
ES2911309T3 (es) 2022-05-18
EP3136841B1 (en) 2022-03-09
WO2015165583A1 (en) 2015-11-05
BR112016025013B1 (pt) 2022-09-20
KR20160145746A (ko) 2016-12-20
PT3136841T (pt) 2022-06-20
JP2017513509A (ja) 2017-06-01
BR112016025013A2 (es) 2017-08-22

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