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CU20160145A7 - 3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2 - Google Patents

3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2

Info

Publication number
CU20160145A7
CU20160145A7 CUP2016000145A CU20160145A CU20160145A7 CU 20160145 A7 CU20160145 A7 CU 20160145A7 CU P2016000145 A CUP2016000145 A CU P2016000145A CU 20160145 A CU20160145 A CU 20160145A CU 20160145 A7 CU20160145 A7 CU 20160145A7
Authority
CU
Cuba
Prior art keywords
azetidin
piperidin
pirrol
indoles
usual
Prior art date
Application number
CUP2016000145A
Other languages
English (en)
Other versions
CU24398B1 (es
Inventor
James Robert Blinn
Andrew Christopher Flick
Göran Mattias Wennerstal
Peter Jones
Neelu Kaila
James Richard Kiefer Jr
Ravi G Kurumbail
Scot Richard Mente
Marvin Jay Meyers
Mark Edward Schnute
Atli Thorarensen
Li Xing
Edouard Zamaratski
Christoph Wolfgang Zapf
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CU20160145A7 publication Critical patent/CU20160145A7/es
Publication of CU24398B1 publication Critical patent/CU24398B1/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

La presente invención proporciona compuestos 3-(Piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores RORC2, y reduciendo la cantidad de IL-17 en un sujeto.
CU2016000145A 2013-08-02 2014-07-24 3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2 CU24398B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361861709P 2013-08-02 2013-08-02
PCT/IB2014/063383 WO2015015378A2 (en) 2013-08-02 2014-07-24 Rorc2 inhibitors and methods of use thereof

Publications (2)

Publication Number Publication Date
CU20160145A7 true CU20160145A7 (es) 2017-02-02
CU24398B1 CU24398B1 (es) 2019-04-04

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CU2016000015A CU24366B1 (es) 2013-08-02 2014-07-24 Compuestos que poseen un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores rorc2
CU2016000145A CU24398B1 (es) 2013-08-02 2014-07-24 3-(piperidin,pirrol o azetidin)-indoles sustituidos útiles como inhibidores rorc2

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CU2016000015A CU24366B1 (es) 2013-08-02 2014-07-24 Compuestos que poseen un anillo que contiene nitrógeno salicílico unido a un grupo heteroarilo bicíclico útiles como inhibidores rorc2

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EP (2) EP3428160A1 (es)
JP (1) JP6224832B2 (es)
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DK (1) DK3027603T3 (es)
DO (1) DOP2016000039A (es)
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Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA40759A (fr) * 2014-09-26 2017-08-01 Pfizer Modulateurs de rorc2 de type pyrrolopyridine substitué par un méthyle et trifluorométhyle et leurs procédés d'utilisation
WO2016120849A1 (en) * 2015-01-30 2016-08-04 Pfizer Inc. Methoxy-substituted pyrrolopyridine modulators of rorc2 and methods of use thereof
EP3250561A1 (en) 2015-01-30 2017-12-06 Pfizer Inc Sulfonamide-subsituted indole modulators of rorc2 and methods of use thereof
CN104672121B (zh) * 2015-02-16 2017-10-24 上海华默西医药科技有限公司 2r‑(2,5‑二氟苯基)吡咯烷盐酸盐的制备方法
UY36716A (es) 2015-06-09 2017-01-31 Abbvie Inc Moduladores de receptores nucleares
EP3558363A1 (en) 2016-12-21 2019-10-30 Amgen Inc. Anti-tnf alpha antibody formulations
GB201709456D0 (en) 2017-06-14 2017-07-26 Ucb Biopharma Sprl Therapeutic agents
CN109206401B (zh) * 2017-06-29 2021-03-05 南京柯菲平盛辉制药有限公司 一类甲基-1H-吲唑类RORγ调节剂及其用途
JP6557436B1 (ja) 2018-03-12 2019-08-07 アッヴィ・インコーポレイテッド チロシンキナーゼ２媒介性シグナル伝達の阻害剤
EP3997081A1 (en) 2019-07-11 2022-05-18 Escape Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
CN115298164A (zh) * 2020-04-16 2022-11-04 巴斯夫欧洲公司 制备4-氰基苯甲酰氯的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742057A (en) * 1985-12-05 1988-05-03 Fujisawa Pharmaceutical Co., Ltd. Antiallergic thiazole compounds
NZ305166A (en) * 1995-03-20 1998-12-23 Lilly Co Eli 5-substituted-3-(1,2,3,6-tetrahydropyridin-4-yl)- and 3-(piperidin-4-yl)-1h-indoles; preparation and medicaments
US5962473A (en) * 1996-08-16 1999-10-05 Eli Lilly And Company Methods of treating or ameliorating the symptoms of common cold or allergic rhinitis with serotonin 5-HT1F
WO1998011895A1 (en) * 1996-09-18 1998-03-26 Eli Lilly And Company A method for the prevention of migraine
ZA979961B (en) * 1996-11-15 1999-05-05 Lilly Co Eli 5-HT1F agonists
JP2001512727A (ja) * 1997-08-09 2001-08-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５ｈｔ−１受容体のリガンドとしてのニ環式化合物
AU4425399A (en) * 1998-06-08 1999-12-30 Advanced Medicine, Inc. Novel therapeutic agents that modulate 5-ht receptors
ES2187300B1 (es) * 2001-11-14 2004-06-16 Laboratorios Del Dr. Esteve, S.A. Derivados de sulfonamidas, su preparacion y su aplicacion como medicamentos.
PE20091561A1 (es) * 2008-02-29 2009-10-30 Array Biopharma Inc Compuestos inhibidores de raf y metodos para su uso
EP2638014B1 (en) * 2010-11-08 2017-01-04 Lycera Corporation N-sulfonylated tetrahydroquinolines and related bicyclic compounds for inhibition of ror-gamma activity and the treatment of diseases
EP2511263A1 (en) * 2011-04-14 2012-10-17 Phenex Pharmaceuticals AG Pyrrolo sulfonamide compounds for modulation of orphan nuclear receptor RAR-related orphan receptor-gamma (RORgamma, NR1F3) activity and for the treatment of chronic inflammatory and autoimmune diseases
WO2013064231A1 (en) * 2011-10-31 2013-05-10 Phenex Pharmaceuticals Ag SEVEN-MEMBERED SULFONAMIDES AS MODULATORS OF RAR-RELATED ORPHAN RECEPTOR-GAMMA (RORγ, NR1F3)
US10301272B2 (en) * 2012-05-31 2019-05-28 Phenex Pharmaceuticals Ag Carboxamide or sulfonamide substituted thiazoles and related derivatives as modulators for the orphan nuclear receptor ROR[γ]
WO2014026328A1 (en) * 2012-08-15 2014-02-20 Merck Sharp & Dohme Corp. 3-cyclohexenyl substituted indole and indazole compounds as rorgammat inhibitors and uses thereof
WO2013171729A2 (en) * 2013-01-08 2013-11-21 Glenmark Pharmaceuticals S.A. Aryl and heteroaryl amide compounds as rorgamat modulator

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